Adenosine A2A receptor mediates microglial process retraction

Nature Neuroscience

Volumn 12, Issue 7, 2009, Pages 872-878

  Orr, Anna G ^a   Orr, Adam L ^a   Li, Xiao Jiang ^a   Gross, Robert E ^a   Traynelis, Stephen F ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; ADENOSINE DEAMINASE; ADENOSINE TRIPHOSPHATE; COMPLEMENT COMPONENT C5A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4; ADENOSINE; ADENOSINE A2 RECEPTOR; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; DRUG DERIVATIVE; MESSENGER RNA; PHENETHYLAMINE DERIVATIVE; PURINERGIC P2 RECEPTOR; PURINERGIC P2Y12 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MOTILITY; CELL STRUCTURE; CONTROLLED STUDY; ENCEPHALITIS; IMMUNE RESPONSE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TISSUE INJURY; ANIMAL; ASTROCYTE; C57BL MOUSE; CELL CULTURE; CHEMOTAXIS; COCULTURE; CYTOLOGY; DRUG POTENTIATION; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VIDEORECORDING;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; ASTROCYTES; CELLS, CULTURED; CHEMOTAXIS; COCULTURE TECHNIQUES; HUMANS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; NEUROTRANSMITTER AGENTS; PHENETHYLAMINES; RECEPTORS, ADENOSINE A2; RECEPTORS, PURINERGIC P2; RNA, MESSENGER; SIGNAL TRANSDUCTION; VIDEO RECORDING;

EID: 67649797862     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2341     Document Type: Article

References (46)

1. Hanisch, U.K. & Kettenmann, H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci. 10, 1387-1394 (2007).
2. Kreutzberg, G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19, 312-318 (1996).
3. Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318 (2005).
4. Davalos, D. et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 8, 752-758 (2005).
5. Haynes, S.E. et al. The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat. Neurosci. 9, 1512-1519 (2006).
6. Stence, N., Waite, M. & Dailey, M.E. Dynamics of microglial activation: a confocal timelapse analysis in hippocampal slices. Glia 33, 256-266 (2001).
7. Block, M.L., Zecca, L. & Hong, J.S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69 (2007).
8. Jakob, A. Handbuch der Psychiatrie 1 (Aschaffenburg, G.) 268 (Deuticke, Vienna, 1927).
9. Nasu-Tada, K., Koizumi, S. & Inoue, K. Involvement of b1 integrin in microglial chemotaxis and proliferation on fibronectin: different regulations by ADP through PKA. Glia 52, 98-107 (2005).
10. Honda, S. et al. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J. Neurosci. 21, 1975-1982 (2001). 11.Wang, C.X. & Shuaib, A. Involvement of inflammatory cytokines in central nervous system injury. Prog. Neurobiol. 67, 161-172 (2002).
11. Nolte, C., Moller, T., Walter, T. & Kettenmann, H. Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G protein and the rearrangement of the actin cytoskeleton. Neuroscience 73, 1091-1107 (1996). 13.Mö ller, T., Kann, O., Verkhratsky, A. & Kettenmann, H. Activation of mouse microglial cells affects P2 receptor signaling. Brain Res. 853, 49-59 (2000).
12. Burridge, K. & Wennerberg, K. Rho and Rac take center stage. Cell 116, 167-179 (2004).
13. Mitchison, T.J. & Cramer, L.P. Actin-based cell motility and cell locomotion. Cell 84, 371-379 (1996).
14. Nagasawa, S.Y., Takuwa, N., Sugimoto, N., Mabuchi, H. & Takuwa, Y. Inhibition of Rac activation as a mechanism for regulation of actin cytoskeletal reorganization and cell motility by cAMP. Biochem. J. 385, 737-744 (2005).
15. Hashmi, A.Z. et al. Adenosine inhibits cytosolic calcium signals and chemotaxis in hepatic stellate cells. Am. J. Physiol. Gastrointest. Liver Physiol. 292, G395-G401 (2007).
16. Fredholm, B.B., IJzerman, A.P., Jacobson, K.A., Klotz, K.N. & Linden, J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 53, 527-552 (2001).
17. Ongini, E. & Fredholm, B.B. Pharmacology of adenosine A2A receptors. Trends Pharmacol. Sci. 17, 364-372 (1996). 20.Wittendorp, M.C. & Boddeke, H.W.G.M. & Biber, K. Adenosine A3 receptor-induced CCL2 synthesis in cultured mouse astrocytes. Glia 46, 410-418 (2004).
18. Angulo, E. et al. A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer's disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. Brain Pathol. 13, 440-451 (2003). 22.Murphree, L.J., Sullivan, G.W., Marshall, M.A. & Linden, J. Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction. Biochem. J. 391, 575-580 (2005).
19. Braun, N., Lenz, C., Gillardon, F., Zimmermann, M. & Zimmermann, H. Focal cerebral ischemia enhances glial expression of ecto-5¢-nucleotidase. Brain Res. 766, 213-226 (1997).
20. Braun, N. et al. Assignment of ecto-nucleoside triphosphate diphosphohydrolase-1/ cd39 expression to microglia and vasculature of the brain. Eur. J. Neurosci. 12, 4357-4366 (2000).
21. Schoen, S.W., Graeber, M.B. & Kreutzberg, G.W. 5¢-Nucleotidase immunoreactivity of perineural microglia responding to rat facial nerve axotomy. Glia 6, 314-317 (1992).
22. Färber, K. et al. The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration. Glia 56, 331-341 (2008).
23. RodrI'guez-Nu'ñ ez, A. et al. Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis. J. Child Neurol. 16, 704-706 (2001).
24. Guthrie, P.B. et al. ATP released from astrocytes mediates glial calcium waves. J. Neurosci. 19, 520-528 (1999).
25. Koizumi, S., Fujishita, K., Tsuda, M., Shigemoto-Mogami, Y. & Inoue, K. Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures. Proc. Natl. Acad. Sci. USA 100, 11023-11028 (2003).
26. Verderio, C. & Matteoli, M. ATP mediates calcium signaling between astrocytes and microglial cells: modulation by IFN-gamma. J. Immunol. 166, 6383-6391 (2001).
27. Pedata, F., Corsi, C., Melani, A., Bordoni, F. & Latini, S. Adenosine extracellular brain concentrations and role of A2A receptors in ischemia. Ann. NY Acad. Sci. 939, 74-84 (2001).
28. Tomozawa, Y., Yabuuchi, K., Inoue, T. & Satoh, M. Participation of cAMP and cAMPdependent protein kinase in beta-adrenoceptor-mediated interleukin-1 beta mRNA induction in cultured microglia. Neurosci. Res. 22, 399-409 (1995).
29. Zhang, B. et al. Suppressive effects of phosphodiesterase type IV inhibitors on rat cultured microglial cells: comparison with other types of cAMP-elevating agents. Neuropharmacology 42, 262-269 (2002).
30. Min, K.J., Yang,M.S., Jou, I. & Joe, E.H. Protein kinase A mediates microglial activation induced by plasminogen and gangliosides. Exp. Mol. Med. 36, 461-467 (2004).
31. Schwarzschild, M.A., Agnati, L., Fuxe, K., Chen, J.F. & Morelli, M. Targeting adenosine A2A receptors in Parkinson's disease. Trends Neurosci. 29, 647-654 (2006).
32. Xu, K., Bastia, E. & Schwarzschild, M. Therapeutic potential of adenosine A(2A) receptor antagonism in Parkinson's disease. Pharmacol. Ther. 105, 267-310 (2005).
33. Popoli, P. et al. Functions, dysfunctions and possible therapeutic relevance of adenosine A2A receptors in Huntington's disease. Prog. Neurobiol. 81, 331-348 (2007).
34. Fiebich, B.L. et al. Cyclooxygenase 2 expression in rat microglia is induced by adenosine A2a receptors. Glia 18, 152-160 (1996).
35. Heese, K., Fiebich, B.L., Bauer, J. & Otten, U. Nerve growth factor (NGF) expression in rat microglia is induced by adenosine A2a receptors. Neurosci. Lett. 231, 83-86 (1997).
36. Kü st, B.M., Biber, K., van Calker, D. & Gebicke-Haerter, P.J. Regulation of K+ channel mRNA expression by stimulation of adenosine A2a receptors in cultured rat microglia. Glia 25, 120-130 (1999).
37. Klegeris, A., Bissonnette, C.J. & McGeer, P.L. Modulation of human microglia and THP-1 cell toxicity by cytokines endogenous to the nervous system. Neurobiol. Aging26, 673-682 (2005).
38. Bystrova, M.F., Yatzenko, Y.E., Fedorov, I.V., Rogachevskaja, O.A. & Kolesnikov, S.S. P2Y isoforms operative inmouse taste cells. Cell Tissue Res. 323, 377-382 (2006).
39. Bianco, F. et al. Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia. Brain Res. Brain Res. Rev. 48, 144-156 (2005).
40. Hoskin, D.W., Butler, J.J., Drapeau, D., Haeryfar, S.M. & Blay, J. Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3-activated killer T cells. Int. J. Cancer 99, 386-395 (2002).
41. Grijelmo, C. et al. Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. Cell. Signal. 19, 1722-1732 (2007).
42. Chen, Y., Shukla, A., Namiki, S., Insel, P.A. & Junger, W.G. A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. J. Leukoc. Biol. 76, 245-253 (2004).
43. Feng, C., Mery, A.G., Beller, E.M., Favot, C. & Boyce, J.A. Adenine nucleotides inhibit cytokine generation by human mast cells through a Gs-coupled receptor. J. Immunol.173, 7539-7547 (2004).
44. Kyrkanides, S. et al. Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. Brain Res. Mol. Brain Res. 104, 159-169 (2002).
45. Tha, K.K. et al. Changes in expression of proinflammatory cytokines IL-1beta, TNF-alpha and IL-6 in the brain of senescence accelerated mouse (SAM) P8. Brain Res. 885, 25-31 (2000).
46. Park, J.S., Woo, M.S., Kim, S.Y., Kim, W.K. & Kim, H.S. Repression of interferongamma- induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways. J. Neuroimmunol. 168, 56-64 (2005).