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Volumn 9, Issue 8, 2009, Pages 581-593

Membrane vesicles as conveyors of immune responses

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN;

EID: 68849129712     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri2567     Document Type: Review
Times cited : (3264)

References (145)
  • 1
    • 0019496788 scopus 로고
    • Cell surface appearance of unexpected host MHC determinants on thymocytes from radiation bone marrow chimeras
    • Sharrow, S. O., Mathieson, B. J. & Singer, A. Cell surface appearance of unexpected host MHC determinants on thymocytes from radiation bone marrow chimeras. J. Immunol. 126, 1327-1335 (1981).
    • (1981) J. Immunol , vol.126 , pp. 1327-1335
    • Sharrow, S.O.1    Mathieson, B.J.2    Singer, A.3
  • 2
    • 33847180813 scopus 로고    scopus 로고
    • Intercellular transfer of cell-surface proteins is common and can affect many stages of an immune response
    • Davis, D. M. Intercellular transfer of cell-surface proteins is common and can affect many stages of an immune response. Nature Rev. Immunol. 7, 238-243 (2007).
    • (2007) Nature Rev. Immunol , vol.7 , pp. 238-243
    • Davis, D.M.1
  • 3
    • 0033485648 scopus 로고    scopus 로고
    • Activated platelets release two types of membrane vesicles: Microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules
    • Heijnen, H. F. , Schiel, A. E., Fijnheer, R., Geuze, H. J. & Sixma, J. J. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules. Blood 94, 3791-3799 (1999).
    • (1999) Blood , vol.94 , pp. 3791-3799
    • Heijnen, H.F.1    Schiel, A.E.2    Fijnheer, R.3    Geuze, H.J.4    Sixma, J.J.5
  • 4
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • Al-Nedawi, K. et al. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nature Cell Biol. 10, 619-624 (2008).
    • (2008) Nature Cell Biol , vol.10 , pp. 619-624
    • Al-Nedawi, K.1
  • 5
    • 0021926788 scopus 로고
    • Membrane vesicles shed by murine melanoma cells selectively inhibit the expression of Ia antigen by macrophages
    • Poutsiaka, D. D., Schroder, E. W., Taylor, D. D., Levy, E. M. & Black, P. H. Membrane vesicles shed by murine melanoma cells selectively inhibit the expression of Ia antigen by macrophages. J. Immunol. 134, 138-144 (1985).
    • (1985) J. Immunol , vol.134 , pp. 138-144
    • Poutsiaka, D.D.1    Schroder, E.W.2    Taylor, D.D.3    Levy, E.M.4    Black, P.H.5
  • 6
    • 0032828462 scopus 로고    scopus 로고
    • Ectosomes released by human neutrophils are specialized functional units
    • Hess, C., Sadallah, S., Hefti, A., Landmann, R. & Schifferli, J. A. Ectosomes released by human neutrophils are specialized functional units. J. Immunol. 163, 4564-4573 (1999).
    • (1999) J. Immunol , vol.163 , pp. 4564-4573
    • Hess, C.1    Sadallah, S.2    Hefti, A.3    Landmann, R.4    Schifferli, J.A.5
  • 7
    • 38749126175 scopus 로고    scopus 로고
    • Exovesicles from human activated dendritic cells fuse with resting dendritic cells, allowing them to present alloantigens
    • Obregon, C., Rothen-Rutishauser, B., Gitahi, S. K., Gehr, P. & Nicod, L. P. Exovesicles from human activated dendritic cells fuse with resting dendritic cells, allowing them to present alloantigens. Am. J. Pathol. 169, 2127-2136 (2006).
    • (2006) Am. J. Pathol , vol.169 , pp. 2127-2136
    • Obregon, C.1    Rothen-Rutishauser, B.2    Gitahi, S.K.3    Gehr, P.4    Nicod, L.P.5
  • 8
    • 23744470401 scopus 로고    scopus 로고
    • Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells
    • Marzesco, A. M. et al. Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells. J. Cell Sci. 11 8 , 2849-2858 (2005).
    • (2005) J. Cell Sci , vol.11 , Issue.8 , pp. 2849-2858
    • Marzesco, A.M.1
  • 9
    • 33644927263 scopus 로고    scopus 로고
    • Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane
    • Booth, A. M. et al. Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J. Cell Biol. 172, 923-935 (2006).
    • (2006) J. Cell Biol , vol.172 , pp. 923-935
    • Booth, A.M.1
  • 10
    • 0020804037 scopus 로고
    • Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
    • Harding, C., Heuser, J. & Stahl, P. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J. Cell Biol. 97, 329-339 (1983).
    • (1983) J. Cell Biol , vol.97 , pp. 329-339
    • Harding, C.1    Heuser, J.2    Stahl, P.3
  • 11
    • 0022201056 scopus 로고
    • Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
    • Pan, B. T. , Teng, K., Wu, C., Adam, M. & Johnstone, R. M. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J. Cell Biol. 101, 942-948 (1985).
    • (1985) J. Cell Biol , vol.101 , pp. 942-948
    • Pan, B.T.1    Teng, K.2    Wu, C.3    Adam, M.4    Johnstone, R.M.5
  • 12
    • 20444453596 scopus 로고    scopus 로고
    • Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: Role in immune escape
    • Huber, V. et al. Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape. Gastroenterology 128, 1796 - 1804 (2005).
    • (2005) Gastroenterology , vol.128 , pp. 1796-1804
    • Huber, V.1
  • 13
    • 0037141153 scopus 로고    scopus 로고
    • Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles
    • Andreola, G. et al. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J. Exp. Med. 195, 1303-1316 (2002).
    • (2002) J. Exp. Med , vol.195 , pp. 1303-1316
    • Andreola, G.1
  • 14
    • 0035892735 scopus 로고    scopus 로고
    • Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells
    • Monleon, I. et al. Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells. J. Immunol. 167, 6736-6744 (2001).
    • (2001) J. Immunol , vol.167 , pp. 6736-6744
    • Monleon, I.1
  • 15
    • 14844334129 scopus 로고    scopus 로고
    • Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
    • Taylor, D. D. & Gercel-Taylor, C. Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br. J. Cancer 92, 305-311 (2005).
    • (2005) Br. J. Cancer , vol.92 , pp. 305-311
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 16
    • 51349124857 scopus 로고    scopus 로고
    • Human tumor nanoparticles induce apoptosis of pancreatic cancer cells
    • Ristorcelli, E. et al. Human tumor nanoparticles induce apoptosis of pancreatic cancer cells. FASEB J. 22, 3358-3369 (2008).
    • (2008) FASEB J , vol.22 , pp. 3358-3369
    • Ristorcelli, E.1
  • 17
    • 0842277810 scopus 로고    scopus 로고
    • Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: A mechanism for generation of soluble cytokine receptors
    • Hawari, F. I. et al. Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors. Proc. Natl Acad. Sci. USA 101, 1297-1302 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 1297-1302
    • Hawari, F.I.1
  • 18
    • 40049112564 scopus 로고    scopus 로고
    • Ceramide triggers budding of exosome vesicles into multivesicular endosomes
    • Trajkovic, K. et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319, 1244-1247 (2008).
    • (2008) Science , vol.319 , pp. 1244-1247
    • Trajkovic, K.1
  • 20
    • 0035655395 scopus 로고    scopus 로고
    • Rapid secretion of interleukin-1β by microvesicle shedding
    • MacKenzie, A. et al. Rapid secretion of interleukin-1β by microvesicle shedding. Immunity 15, 825-835 (2001).
    • (2001) Immunity , vol.15 , pp. 825-835
    • MacKenzie, A.1
  • 21
    • 0024419921 scopus 로고
    • Molecules relevant for T cell-target cell interaction are present in cytolytic granules of human T lymphocytes
    • Peters, P. J. et al. Molecules relevant for T cell-target cell interaction are present in cytolytic granules of human T lymphocytes. Eur. J. Immunol. 19, 1469-1475 (1989).
    • (1989) Eur. J. Immunol , vol.19 , pp. 1469-1475
    • Peters, P.J.1
  • 22
    • 0036533633 scopus 로고    scopus 로고
    • TCR activation of human T cells induces the production of exosomes bearing the TCR/ CD3/ζ complex
    • Blanchard, N. et al. TCR activation of human T cells induces the production of exosomes bearing the TCR/ CD3/ζ complex. J. Immunol. 168, 3235-3241 (2002).
    • (2002) J. Immunol , vol.168 , pp. 3235-3241
    • Blanchard, N.1
  • 23
    • 0030687649 scopus 로고    scopus 로고
    • Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation
    • Raposo, G. et al. Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation. Mol. Biol. Cell 8, 2631-2645 (1997).
    • (1997) Mol. Biol. Cell , vol.8 , pp. 2631-2645
    • Raposo, G.1
  • 24
    • 33746944049 scopus 로고    scopus 로고
    • BCR-bound antigen is targeted to exosomes in human follicular lymphoma B-cells
    • Rialland, P. , Lankar, D., Raposo, G., Bonnerot, C. & Hubert, P. BCR-bound antigen is targeted to exosomes in human follicular lymphoma B-cells. Biol. Cell 98, 491-501 (2006).
    • (2006) Biol. Cell , vol.98 , pp. 491-501
    • Rialland, P.1    Lankar, D.2    Raposo, G.3    Bonnerot, C.4    Hubert, P.5
  • 25
    • 50949130683 scopus 로고    scopus 로고
    • Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor
    • Saunderson, S. C. et al. Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor. J. Immunol. 180, 8146-8152 (2008).
    • (2008) J. Immunol , vol.180 , pp. 8146-8152
    • Saunderson, S.C.1
  • 26
    • 47049109897 scopus 로고    scopus 로고
    • B cell activation regulates exosomal HLA production
    • Arita, S. et al. B cell activation regulates exosomal HLA production. Eur. J. Immunol. 38, 1423-1434 (2008).
    • (2008) Eur. J. Immunol , vol.38 , pp. 1423-1434
    • Arita, S.1
  • 27
    • 34948874323 scopus 로고    scopus 로고
    • T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes
    • Muntasell, A., Berger, A. C. & Roche, P. A. T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes. EMBO J. 26, 4263-4272 (2007).
    • (2007) EMBO J , vol.26 , pp. 4263-4272
    • Muntasell, A.1    Berger, A.C.2    Roche, P.A.3
  • 28
    • 0029989258 scopus 로고    scopus 로고
    • B lymphocytes secrete antigen-presenting vesicles
    • Raposo, G. et al. B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 183, 1161-1172 (1996).
    • (1996) J. Exp. Med , vol.183 , pp. 1161-1172
    • Raposo, G.1
  • 29
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes
    • Zitvogel, L. et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nature Med. 4, 594-600 (1998).
    • (1998) Nature Med , vol.4 , pp. 594-600
    • Zitvogel, L.1
  • 30
    • 36148959342 scopus 로고    scopus 로고
    • Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo
    • Bhatnagar, S., Shinagawa, K., Castellino, F. J. & Schorey, J. S. Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood 11 0 , 3234-3244 (2007).
    • (2007) Blood , vol.11 , pp. 3234-3244
    • Bhatnagar, S.1    Shinagawa, K.2    Castellino, F.J.3    Schorey, J.S.4
  • 31
    • 0040089526 scopus 로고    scopus 로고
    • Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73
    • Thery, C. et al. Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. J. Cell Biol. 147, 599-610 (1999).
    • (1999) J. Cell Biol , vol.147 , pp. 599-610
    • Thery, C.1
  • 32
    • 33748480677 scopus 로고    scopus 로고
    • Exosomes from bone marrow dendritic cells pulsed with diphtheria toxoid preferentially induce type 1 antigen-specific IgG responses in naive recipients in the absence of free antigen
    • Colino, J. & Snapper, C. M. Exosomes from bone marrow dendritic cells pulsed with diphtheria toxoid preferentially induce type 1 antigen-specific IgG responses in naive recipients in the absence of free antigen. J. Immunol. 177, 3757-3762 (2006).
    • (2006) J. Immunol , vol.177 , pp. 3757-3762
    • Colino, J.1    Snapper, C.M.2
  • 33
    • 22044447897 scopus 로고    scopus 로고
    • ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T cell priming
    • Segura, E. et al. ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T cell priming. Blood 106, 216-223 (2005).
    • (2005) Blood , vol.106 , pp. 216-223
    • Segura, E.1
  • 34
    • 33646416463 scopus 로고    scopus 로고
    • The regulation of exosome secretion: A novel function of the p53 protein
    • Yu, X., Harris, S. L. & Levine, A. J. The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res. 66, 4795-4801 (2006).
    • (2006) Cancer Res , vol.66 , pp. 4795-4801
    • Yu, X.1    Harris, S.L.2    Levine, A.J.3
  • 35
    • 54249125009 scopus 로고    scopus 로고
    • Senescence-associated exosome release from human prostate cancer cells
    • Lehmann, B. D. et al. Senescence-associated exosome release from human prostate cancer cells. Cancer Res. 68, 7864-7871 (2008).
    • (2008) Cancer Res , vol.68 , pp. 7864-7871
    • Lehmann, B.D.1
  • 36
    • 54049088501 scopus 로고    scopus 로고
    • Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice
    • Lespagnol, A. et al. Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ. 15, 1723-1733 (2008).
    • (2008) Cell Death Differ , vol.15 , pp. 1723-1733
    • Lespagnol, A.1
  • 37
    • 23344439807 scopus 로고    scopus 로고
    • Diacylglycerol kinase α regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes
    • Alonso, R. et al. Diacylglycerol kinase α regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes. J. Biol. Chem. 280, 28439-28450 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 28439-28450
    • Alonso, R.1
  • 38
    • 34248155380 scopus 로고    scopus 로고
    • The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles
    • Islam, A. et al. The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles. J. Biol. Chem. 282, 9591-9599 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 9591-9599
    • Islam, A.1
  • 39
    • 0037096162 scopus 로고    scopus 로고
    • The exosome pathway in K562 cells is regulated by Rab11
    • Savina, A., Vidal, M. & Colombo, M. I. The exosome pathway in K562 cells is regulated by Rab11. J. Cell Sci. 11 5 , 2505-2515 (2002).
    • (2002) J. Cell Sci , vol.11 , Issue.5 , pp. 2505-2515
    • Savina, A.1    Vidal, M.2    Colombo, M.I.3
  • 40
    • 0034254524 scopus 로고    scopus 로고
    • Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface
    • Denzer, K. et al. Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface. J. Immunol. 165, 1259-1265 (2000).
    • (2000) J. Immunol , vol.165 , pp. 1259-1265
    • Denzer, K.1
  • 42
    • 31144445302 scopus 로고    scopus 로고
    • Pregnancy-associated exosomes and their modulation of T cell signaling
    • This study provides support for a physiological role of in vivo-secreted exosomes, showing that exosomes with T cell-inhibiting activity are increased in pregnant women who deliver at full term compared with women who deliver pre-term
    • Taylor, D. D., Akyol, S. & Gercel-Taylor, C. Pregnancy-associated exosomes and their modulation of T cell signaling. J. Immunol. 176, 1534-1542 (2006). This study provides support for a physiological role of in vivo-secreted exosomes, showing that exosomes with T cell-inhibiting activity are increased in pregnant women who deliver at full term compared with women who deliver pre-term.
    • (2006) J. Immunol , vol.176 , pp. 1534-1542
    • Taylor, D.D.1    Akyol, S.2    Gercel-Taylor, C.3
  • 43
    • 45449093192 scopus 로고    scopus 로고
    • MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    • Taylor, D. D. & Gercel-Taylor, C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol. Oncol. 110 , 13-21 (2008).
    • (2008) Gynecol. Oncol , vol.110 , pp. 13-21
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 44
    • 0141962590 scopus 로고    scopus 로고
    • Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid
    • Admyre, C. et al. Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur. Respir. J. 22, 578-583 (2003).
    • (2003) Eur. Respir. J , vol.22 , pp. 578-583
    • Admyre, C.1
  • 45
    • 49049116385 scopus 로고    scopus 로고
    • Exosomes from bronchoalveolar fluid of tolerized mice prevent allergic reaction
    • Prado, N. et al. Exosomes from bronchoalveolar fluid of tolerized mice prevent allergic reaction. J. Immunol. 181, 1519-1525 (2008).
    • (2008) J. Immunol , vol.181 , pp. 1519-1525
    • Prado, N.1
  • 46
    • 4444226979 scopus 로고    scopus 로고
    • Identification and proteomic profiling of exosomes in human urine
    • Pisitkun, T., Shen, R. F. & Knepper, M. A. Identification and proteomic profiling of exosomes in human urine. Proc. Natl Acad. Sci. USA 101, 13368-13373 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 13368-13373
    • Pisitkun, T.1    Shen, R.F.2    Knepper, M.A.3
  • 47
    • 0037183242 scopus 로고    scopus 로고
    • Malignant effusions and immunogenic tumour-derived exosomes
    • Andre, F. et al. Malignant effusions and immunogenic tumour-derived exosomes. Lancet 360, 295-305 (2002).
    • (2002) Lancet , vol.360 , pp. 295-305
    • Andre, F.1
  • 48
    • 18844430042 scopus 로고    scopus 로고
    • Identification proteomic profiling, and origin of ram epididymal fluid exosome-like vesicles
    • Gatti, J. L., Metayer, S., Belghazi, M., Dacheux, F. & Dacheux, J. L. Identification, proteomic profiling, and origin of ram epididymal fluid exosome-like vesicles. Biol. Reprod. 72, 1452-1465 (2005).
    • (2005) Biol. Reprod , vol.72 , pp. 1452-1465
    • Gatti, J.L.1    Metayer, S.2    Belghazi, M.3    Dacheux, F.4    Dacheux, J.L.5
  • 49
    • 53349178099 scopus 로고    scopus 로고
    • Heat shock protein-containing exosomes in mid-trimester amniotic fluids
    • Asea, A. et al. Heat shock protein-containing exosomes in mid-trimester amniotic fluids. J. Reprod. Immunol. 79, 12-17 (2008).
    • (2008) J. Reprod. Immunol , vol.79 , pp. 12-17
    • Asea, A.1
  • 50
    • 34548619487 scopus 로고    scopus 로고
    • Exosomes with immune modulatory features are present in human breast milk
    • Admyre, C. et al. Exosomes with immune modulatory features are present in human breast milk. J. Immunol. 179, 1969-1978 (2007).
    • (2007) J. Immunol , vol.179 , pp. 1969-1978
    • Admyre, C.1
  • 51
    • 0030993710 scopus 로고    scopus 로고
    • 5 integrins and anionic phospholipids through two domains
    • Andersen, M. H., Berglund, L., Rasmussen, J. T. & Petersen, T. E. Bovine PAS-6/7 binds αvβ5 integrins and anionic phospholipids through two domains. Biochemistry 36, 5441-5446 (1997).
    • (1997) Biochemistry , vol.36 , pp. 5441-5446
    • Andersen, M.H.1    Berglund, L.2    Rasmussen, J.T.3    Petersen, T.E.4
  • 52
    • 8644286802 scopus 로고    scopus 로고
    • Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells
    • Morelli, A. E. et al. Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood 104, 3257-3266 (2004).
    • (2004) Blood , vol.104 , pp. 3257-3266
    • Morelli, A.E.1
  • 53
    • 34548655590 scopus 로고    scopus 로고
    • + dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo
    • Segura, E., Guerin, C., Hogg, N., Amigorena, S. & Thery, C. CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo. J. Immunol. 179, 1489-1496 (2007)
    • (2007) J. Immunol , vol.179 , pp. 1489-1496
    • Segura, E.1    Guerin, C.2    Hogg, N.3    Amigorena, S.4    Thery, C.5
  • 54
    • 61849179182 scopus 로고    scopus 로고
    • Activated T-cells recruit exosomes secreted by dendritic cells via LFA-1
    • Nolte-?t Hoen, E. N., Buschow, S. I., Anderton, S. M., Stoorvogel, W. & Wauben, M. H. Activated T-cells recruit exosomes secreted by dendritic cells via LFA-1. Blood 11 3 , 1977-1981 (2009).
    • (2009) Blood , vol.11 , Issue.3 , pp. 1977-1981
    • Nolte-T Hoen, E.N.1    Buschow, S.I.2    Anderton, S.M.3    Stoorvogel, W.4    Wauben, M.H.5
  • 55
    • 0031888828 scopus 로고    scopus 로고
    • T cells expressing activated LFA-1 are more susceptible to infection with human immunodeficiency virus type 1 particles bearing host-encoded ICAM-1
    • Fortin, J. F., Cantin, R. & Tremblay, M. J. T cells expressing activated LFA-1 are more susceptible to infection with human immunodeficiency virus type 1 particles bearing host-encoded ICAM-1. J. Virol. 72, 2105-2112 (1998).
    • (1998) J. Virol , vol.72 , pp. 2105-2112
    • Fortin, J.F.1    Cantin, R.2    Tremblay, M.J.3
  • 56
    • 23244437985 scopus 로고    scopus 로고
    • +T lymphocytes
    • Tardif, M. R. & Tremblay, M. J. Regulation of LFA-1 activity through cytoskeleton remodeling and signaling components modulates the efficiency of HIV type-1 entry in activated CD4+ T lymphocytes. J. Immunol. 175, 926-935 (2005).
    • (2005) J. Immunol , vol.175 , pp. 926-935
    • Tardif, M.R.1    Tremblay, M.J.2
  • 57
    • 6944253946 scopus 로고    scopus 로고
    • Adhesion and signaling by B cell-derived exosomes: The role of integrins
    • Clayton, A. et al. Adhesion and signaling by B cell-derived exosomes: the role of integrins. FASEB J. 18, 977-979 (2004).
    • (2004) FASEB J , vol.18 , pp. 977-979
    • Clayton, A.1
  • 58
    • 0038790644 scopus 로고    scopus 로고
    • Exosomes released during reticulocyte maturation bind to fibronectin via integrin α4β1
    • Rieu, S., Geminard, C., Rabesandratana, H., Sainte-Marie, J. & Vidal, M. Exosomes released during reticulocyte maturation bind to fibronectin via integrin α4β1. Eur. J. Biochem. 267, 583-590 (2000).
    • (2000) Eur. J. Biochem , vol.267 , pp. 583-590
    • Rieu, S.1    Geminard, C.2    Rabesandratana, H.3    Sainte-Marie, J.4    Vidal, M.5
  • 59
    • 36248944555 scopus 로고    scopus 로고
    • Identification of Tim4 as a phosphatidylserine receptor
    • Miyanishi, M. et al. Identification of Tim4 as a phosphatidylserine receptor. Nature 450, 435-439 (2007).
    • (2007) Nature , vol.450 , pp. 435-439
    • Miyanishi, M.1
  • 60
    • 0037046580 scopus 로고    scopus 로고
    • Identification of a factor that links apoptotic cells to phagocytes
    • Hanayama, R. et al. Identification of a factor that links apoptotic cells to phagocytes. Nature 417, 182-187 (2002).
    • (2002) Nature , vol.417 , pp. 182-187
    • Hanayama, R.1
  • 61
    • 24644447311 scopus 로고    scopus 로고
    • Accumulation of MFG-E8/lactadherin on exosomes from immature dendritic cells
    • DOI 10.1016/j.bcmd.2005.05.001, PII S1079979605000628
    • Veron, P. , Segura, E., Sugano, G., Amigorena, S. & Thery, C. Accumulation of MFG-E8/lactadherin on exosomes from immature dendritic cells. Blood Cells Mol. Dis. 35, 81-88 (2005). (Pubitemid 41267033)
    • (2005) Blood Cells, Molecules, and Diseases , vol.35 , Issue.2 , pp. 81-88
    • Veron, P.1    Segura, E.2    Sugano, G.3    Amigorena, S.4    Thery, C.5
  • 62
    • 33646146422 scopus 로고    scopus 로고
    • Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: Evidence for horizontal transfer of mRNA and protein delivery
    • Ratajczak, J. et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 20, 847-856 (2006).
    • (2006) Leukemia , vol.20 , pp. 847-856
    • Ratajczak, J.1
  • 63
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog, J. et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nature Cell Biol. 10, 1470-1476 (2008).
    • (2008) Nature Cell Biol , vol.10 , pp. 1470-1476
    • Skog, J.1
  • 64
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi, H. et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nature Cell Biol. 9, 654-659 (2007).
    • (2007) Nature Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1
  • 65
    • 20244373139 scopus 로고    scopus 로고
    • Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
    • Wolfers, J. et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nature Med. 7, 297-303 (2001).
    • (2001) Nature Med , vol.7 , pp. 297-303
    • Wolfers, J.1
  • 66
    • 49249091823 scopus 로고    scopus 로고
    • + T cells in vitro and in vivo
    • Giri, P. K. & Schorey, J. S. Exosomes derived from M. bovis BCG infected macrophages activate antigen-specific CD4+ and CD8+ T cells in vitro and in vivo. PLoS ONE 3, e2461 (2008).
    • (2008) PLoS ONE , vol.3
    • Giri, P.K.1    Schorey, J.S.2
  • 67
    • 63149192294 scopus 로고    scopus 로고
    • + memory T cells by releasing antigenic exosomes
    • Walker, J. D., Maier, C. L. & Pober, J. S. Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomes. J. Immunol. 182, 1548-1559 (2009).
    • (2009) J. Immunol , vol.182 , pp. 1548-1559
    • Walker, J.D.1    Maier, C.L.2    Pober, J.S.3
  • 68
    • 61449135862 scopus 로고    scopus 로고
    • No significant CTL cross-priming by dendritic cell-derived exosomes during murine lymphocytic choriomeningitis virus infection
    • Coppieters, K. et al. No significant CTL cross-priming by dendritic cell-derived exosomes during murine lymphocytic choriomeningitis virus infection. J. Immunol. 182, 2213-2220 (2009).
    • (2009) J. Immunol , vol.182 , pp. 2213-2220
    • Coppieters, K.1
  • 69
    • 38449100732 scopus 로고    scopus 로고
    • Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL
    • Luketic, L. et al. Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL. J. Immunol. 179, 5024-5032 (2007).
    • (2007) J. Immunol , vol.179 , pp. 5024-5032
    • Luketic, L.1
  • 70
    • 33746238574 scopus 로고    scopus 로고
    • Direct exosome stimulation of peripheral human T cells detected by ELISPOT
    • Admyre, C., Johansson, S. M., Paulie, S. & Gabrielsson, S. Direct exosome stimulation of peripheral human T cells detected by ELISPOT. Eur. J. Immunol. 36, 1772-1781 (2006).
    • (2006) Eur. J. Immunol , vol.36 , pp. 1772-1781
    • Admyre, C.1    Johansson, S.M.2    Paulie, S.3    Gabrielsson, S.4
  • 71
    • 0141862085 scopus 로고    scopus 로고
    • MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells
    • Utsugi-Kobukai, S., Fujimaki, H., Hotta, C., Nakazawa, M. & Minami, M. MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells. Immunol. Lett. 89, 125-131 (2003).
    • (2003) Immunol. Lett , vol.89 , pp. 125-131
    • Utsugi-Kobukai, S.1    Fujimaki, H.2    Hotta, C.3    Nakazawa, M.4    Minami, M.5
  • 72
    • 0141818345 scopus 로고    scopus 로고
    • Exosomes as a tumor vaccine: Enhancing potency through direct loading of antigenic peptides
    • Hsu, D. H. et al. Exosomes as a tumor vaccine: enhancing potency through direct loading of antigenic peptides. J. Immunother. 26, 440-450 (2003).
    • (2003) J. Immunother , vol.26 , pp. 440-450
    • Hsu, D.H.1
  • 73
    • 10744220836 scopus 로고    scopus 로고
    • Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection
    • Chaput, N. et al. Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection. J. Immunol. 172, 2137-2146 (2004).
    • (2004) J. Immunol , vol.172 , pp. 2137-2146
    • Chaput, N.1
  • 74
    • 0036906477 scopus 로고    scopus 로고
    • + T cells by dendritic cell-derived exosomes
    • Thery, C. et al. Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Nature Immunol. 3, 1156-1162 (2002).
    • (2002) Nature Immunol , vol.3 , pp. 1156-1162
    • Thery, C.1
  • 75
    • 49149111236 scopus 로고    scopus 로고
    • Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition
    • Montecalvo, A. et al. Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition. J. Immunol. 180, 3081-3090 (2008).
    • (2008) J. Immunol , vol.180 , pp. 3081-3090
    • Montecalvo, A.1
  • 76
    • 34247607233 scopus 로고    scopus 로고
    • T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells
    • Mallegol, J. et al. T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells. Gastroenterology 132, 1866-1876 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 1866-1876
    • Mallegol, J.1
  • 77
    • 0032717299 scopus 로고    scopus 로고
    • MHC class II molecules transferred between allogeneic dendritic cells stimulate primary mixed leukocyte reactions
    • Bedford, P. , Garner, K. & Knight, S. C. MHC class II molecules transferred between allogeneic dendritic cells stimulate primary mixed leukocyte reactions. Int. Immunol. 11 , 1739-1744 (1999).
    • (1999) Int. Immunol , vol.11 , pp. 1739-1744
    • Bedford, P.1    Garner, K.2    Knight, S.C.3
  • 78
    • 61849139471 scopus 로고    scopus 로고
    • Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells
    • Klibi, J. et al. Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells. Blood 11 3 , 1957-1966 (2009).
    • (2009) Blood , vol.11 , Issue.3 , pp. 1957-1966
    • Klibi, J.1
  • 79
    • 34547686145 scopus 로고    scopus 로고
    • Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2
    • Clayton, A., Mitchell, J. P. , Court, J., Mason, M. D. & Tabi, Z. Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Cancer Res. 67, 7458-7466 (2007).
    • (2007) Cancer Res , vol.67 , pp. 7458-7466
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Mason, M.D.4    Tabi, Z.5
  • 80
    • 31144451576 scopus 로고    scopus 로고
    • Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function
    • Liu, C. et al. Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J. Immunol. 176, 1375-1385 (2006).
    • (2006) J. Immunol , vol.176 , pp. 1375-1385
    • Liu, C.1
  • 81
    • 47249144117 scopus 로고    scopus 로고
    • Human tumor-derived exosomes down-modulate NKG2D expression
    • Clayton, A. et al. Human tumor-derived exosomes down-modulate NKG2D expression. J. Immunol. 180, 7249-7258 (2008).
    • (2008) J. Immunol , vol.180 , pp. 7249-7258
    • Clayton, A.1
  • 82
    • 34249792918 scopus 로고    scopus 로고
    • Tumor exosomes inhibit differentiation of bone marrow dendritic cells
    • Yu, S. et al. Tumor exosomes inhibit differentiation of bone marrow dendritic cells. J. Immunol. 178, 6867-6875 (2007).
    • (2007) J. Immunol , vol.178 , pp. 6867-6875
    • Yu, S.1
  • 83
    • 33749488765 scopus 로고    scopus 로고
    • Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-β-mediated suppressive activity on T lymphocytes
    • Valenti, R. et al. Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-β-mediated suppressive activity on T lymphocytes. Cancer Res. 66, 9290-9298 (2006).
    • (2006) Cancer Res , vol.66 , pp. 9290-9298
    • Valenti, R.1
  • 84
    • 54049106087 scopus 로고    scopus 로고
    • Thymus exosomes-like particles induce regulatory T cells
    • Wang, G. J. et al. Thymus exosomes-like particles induce regulatory T cells. J. Immunol. 181 , 5242-5248 (2008).
    • (2008) J. Immunol , vol.181 , pp. 5242-5248
    • Wang, G.J.1
  • 85
    • 64249115813 scopus 로고    scopus 로고
    • Induction of myeloid-derived suppressor cells by tumor exosomes
    • Xiang, X. et al. Induction of myeloid-derived suppressor cells by tumor exosomes. Int. J. Cancer 124, 2621-2633 (2009).
    • (2009) Int. J. Cancer , vol.124 , pp. 2621-2633
    • Xiang, X.1
  • 86
    • 40449131104 scopus 로고    scopus 로고
    • Polymorphonuclear neutrophil-derived ectosomes interfere with the maturation of monocyte-derived dendritic cells
    • Eken, C. et al. Polymorphonuclear neutrophil-derived ectosomes interfere with the maturation of monocyte-derived dendritic cells. J. Immunol. 180, 817-824 (2008).
    • (2008) J. Immunol , vol.180 , pp. 817-824
    • Eken, C.1
  • 87
    • 0036258785 scopus 로고    scopus 로고
    • Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells
    • Baj-Krzyworzeka, M. et al. Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells. Exp. Hematol. 30, 450-459 (2002).
    • (2002) Exp. Hematol , vol.30 , pp. 450-459
    • Baj-Krzyworzeka, M.1
  • 88
    • 35248821267 scopus 로고    scopus 로고
    • Tumour-derived microvesicles modulate biological activity of human monocytes
    • Baj-Krzyworzeka, M., Szatanek, R., Weglarczyk, K., Baran, J. & Zembala, M. Tumour-derived microvesicles modulate biological activity of human monocytes. Immunol. Lett. 11 3 , 76-82 (2007).
    • (2007) Immunol. Lett , vol.11 , Issue.3 , pp. 76-82
    • Baj-Krzyworzeka, M.1    Szatanek, R.2    Weglarczyk, K.3    Baran, J.4    Zembala, M.5
  • 89
    • 46749157003 scopus 로고    scopus 로고
    • Platelet-mediated modulation of adaptive immunity: Unique delivery of CD154 signal by platelet-derived membrane vesicles
    • Sprague, D. L. et al. Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles. Blood 111 , 5028-5036 (2008).
    • (2008) Blood , vol.111 , pp. 5028-5036
    • Sprague, D.L.1
  • 90
    • 34548512488 scopus 로고    scopus 로고
    • Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory
    • Bhatnagar, S. & Schorey, J. S. Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory. J. Biol. Chem. 282, 25779-25789 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 25779-25789
    • Bhatnagar, S.1    Schorey, J.S.2
  • 91
    • 36248943078 scopus 로고    scopus 로고
    • Mycoplasma contaminants present in exosome preparations induce polyclonal B cell responses
    • Quah, B. J. & O?Neill, H. C. Mycoplasma contaminants present in exosome preparations induce polyclonal B cell responses. J. Leukoc. Biol. 82, 1070-1082 (2007).
    • (2007) J. Leukoc. Biol , vol.82 , pp. 1070-1082
    • Quah, B.J.1    Oneill, H.C.2
  • 92
    • 54449086268 scopus 로고    scopus 로고
    • Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function
    • Simhadri, V. R. et al. Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function. PLoS ONE 3, e3377 (2008).
    • (2008) PLoS ONE , vol.3
    • Simhadri, V.R.1
  • 93
    • 63449129623 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: A role for NKG2D ligands and IL-15Rα
    • Viaud, S. et al. Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Rα. PLoS ONE 4, e4942 (2009).
    • (2009) PLoS ONE , vol.4
    • Viaud, S.1
  • 94
    • 20444431560 scopus 로고    scopus 로고
    • Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells
    • Gastpar, R. et al. Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res. 65, 5238-5247 (2005).
    • (2005) Cancer Res , vol.65 , pp. 5238-5247
    • Gastpar, R.1
  • 95
    • 44849084963 scopus 로고    scopus 로고
    • Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages
    • Vega, V. L. et al. Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. J. Immunol. 180, 4299-4307 (2008).
    • (2008) J. Immunol , vol.180 , pp. 4299-4307
    • Vega, V.L.1
  • 96
    • 27144529107 scopus 로고    scopus 로고
    • More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells
    • Dai, S. et al. More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells. Clin. Cancer Res. 11 , 7554-7563 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 7554-7563
    • Dai, S.1
  • 97
    • 33744928376 scopus 로고    scopus 로고
    • A membrane form of TNF-α presented by exosomes delays T cell activation-induced cell death
    • Zhang, H. G. et al. A membrane form of TNF-α presented by exosomes delays T cell activation-induced cell death. J. Immunol. 176, 7385-7393 (2006).
    • (2006) J. Immunol , vol.176 , pp. 7385-7393
    • Zhang, H.G.1
  • 98
    • 3042643331 scopus 로고    scopus 로고
    • Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T. gondii infection
    • Aline, F., Bout, D., Amigorena, S., Roingeard, P. & Dimier-Poisson, I. Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T. gondii infection. Infect. Immun. 72, 4127-4137 (2004).
    • (2004) Infect. Immun , vol.72 , pp. 4127-4137
    • Aline, F.1    Bout, D.2    Amigorena, S.3    Roingeard, P.4    Dimier-Poisson, I.5
  • 99
    • 0345015348 scopus 로고    scopus 로고
    • Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection
    • Peche, H., Heslan, M., Usal, C., Amigorena, S. & Cuturi, M. C. Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection. Transplantation 76, 1503-1510 (2003).
    • (2003) Transplantation , vol.76 , pp. 1503-1510
    • Peche, H.1    Heslan, M.2    Usal, C.3    Amigorena, S.4    Cuturi, M.C.5
  • 100
    • 33745587596 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis
    • Miksa, M. et al. Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis. Shock 25, 586-593 (2006).
    • (2006) Shock , vol.25 , pp. 586-593
    • Miksa, M.1
  • 101
    • 34848915428 scopus 로고    scopus 로고
    • Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4
    • Kim, S. H., Bianco, N. R., Shufesky, W. J., Morelli, A. E. & Robbins, P. D. Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4. J. Immunol. 179, 2242-2249 (2007).
    • (2007) J. Immunol , vol.179 , pp. 2242-2249
    • Kim, S.H.1    Bianco, N.R.2    Shufesky, W.J.3    Morelli, A.E.4    Robbins, P.D.5
  • 102
    • 20844458756 scopus 로고    scopus 로고
    • Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis
    • Kim, S. H. et al. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J. Immunol. 174, 6440-6448 (2005).
    • (2005) J. Immunol , vol.174 , pp. 6440-6448
    • Kim, S.H.1
  • 103
    • 59549104365 scopus 로고    scopus 로고
    • MHC independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models
    • Cho, J. A., Lee, Y. S., Kim, S. H., Ko, J. K. & Kim, C. W. MHC independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models. Cancer Lett. 275, 256-265 (2009).
    • (2009) Cancer Lett , vol.275 , pp. 256-265
    • Cho, J.A.1    Lee, Y.S.2    Kim, S.H.3    Ko, J.K.4    Kim, C.W.5
  • 104
    • 34447549680 scopus 로고    scopus 로고
    • + CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells
    • Dai, S. et al. Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8+ CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells. J. Mol. Med. 84, 1067-1076 (2006).
    • (2006) J. Mol. Med , vol.84 , pp. 1067-1076
    • Dai, S.1
  • 105
    • 0034771968 scopus 로고    scopus 로고
    • "tolerosomes" are produced by intestinal epithelial cells
    • Karlsson, M. et al. "Tolerosomes" are produced by intestinal epithelial cells. Eur. J. Immunol. 31, 2892-2900 (2001).
    • (2001) Eur. J. Immunol , vol.31 , pp. 2892-2900
    • Karlsson, M.1
  • 106
    • 0344234267 scopus 로고    scopus 로고
    • Intestinal epithelial exosomes carry MHC class II/peptides able to inform the immune system in mice
    • Van Niel, G. et al. Intestinal epithelial exosomes carry MHC class II/peptides able to inform the immune system in mice. Gut 52, 1690-1697 (2003).
    • (2003) Gut , vol.52 , pp. 1690-1697
    • Van Niel, G.1
  • 107
    • 57249105222 scopus 로고    scopus 로고
    • More insights into the immunosuppressive potential of tumor exosomes
    • Huber, V., Filipazzi, P. , Iero, M., Fais, S. & Rivoltini, L. More insights into the immunosuppressive potential of tumor exosomes. J. Transl. Med. 6, 63 (2008).
    • (2008) J. Transl. Med , vol.6 , pp. 63
    • Huber, V.1    Filipazzi, P.2    Iero, M.3    Fais, S.4    Rivoltini, L.5
  • 108
    • 39449101177 scopus 로고    scopus 로고
    • Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses
    • Zeelenberg, I. S. et al. Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Cancer Res. 68, 1228-1235 (2008).
    • (2008) Cancer Res , vol.68 , pp. 1228-1235
    • Zeelenberg, I.S.1
  • 109
    • 0037152162 scopus 로고    scopus 로고
    • Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node
    • Scheinecker, C., McHugh, R., Shevach, E. M. & Germain, R. N. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med. 196, 1079-1090 (2002).
    • (2002) J. Exp. Med , vol.196 , pp. 1079-1090
    • Scheinecker, C.1    McHugh, R.2    Shevach, E.M.3    Germain, R.N.4
  • 110
    • 3242794249 scopus 로고    scopus 로고
    • Peyer?s patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice
    • Fleeton, M. N. et al. Peyer?s patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice. J. Exp. Med. 200, 235-245 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 235-245
    • Fleeton, M.N.1
  • 111
    • 33746027329 scopus 로고    scopus 로고
    • Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming
    • Allan, R. S. et al. Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. Immunity 25, 153-162 (2006).
    • (2006) Immunity , vol.25 , pp. 153-162
    • Allan, R.S.1
  • 112
    • 46949109891 scopus 로고    scopus 로고
    • - but not plasmacytoid dendritic cells
    • GeurtsvanKessel, C. H. et al. Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells. J. Exp. Med. 205, 1621-1634 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 1621-1634
    • Geurtsvankessel, C.H.1
  • 113
    • 49249089853 scopus 로고    scopus 로고
    • Serum-derived exosomes from antigen-fed mice prevent allergic sensitization in a model of allergic asthma
    • Almqvist, N., Lonnqvist, A., Hultkrantz, S., Rask, C. & Telemo, E. Serum-derived exosomes from antigen-fed mice prevent allergic sensitization in a model of allergic asthma. Immunology 125, 21-27 (2008).
    • (2008) Immunology , vol.125 , pp. 21-27
    • Almqvist, N.1    Lonnqvist, A.2    Hultkrantz, S.3    Rask, C.4    Telemo, E.5
  • 114
    • 0033571095 scopus 로고    scopus 로고
    • Class II MHC/peptide complexes are released from APC and are acquired by T cell responders during specific antigen recognition
    • Patel, D. M., Arnold, P. Y., White, G. A., Nardella, J. P. & Mannie, M. D. Class II MHC/peptide complexes are released from APC and are acquired by T cell responders during specific antigen recognition. J. Immunol. 163, 5201-5210 (1999).
    • (1999) J. Immunol , vol.163 , pp. 5201-5210
    • Patel, D.M.1    Arnold, P.Y.2    White, G.A.3    Nardella, J.P.4    Mannie, M.D.5
  • 115
    • 51649113753 scopus 로고    scopus 로고
    • Antigen-specific T-T interactions regulate CD4 T-cell expansion
    • Helft, J. et al. Antigen-specific T-T interactions regulate CD4 T-cell expansion. Blood 11 2 , 1249-1258 (2008).
    • (2008) Blood , vol.11 , Issue.2 , pp. 1249-1258
    • Helft, J.1
  • 116
    • 18144372419 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: Results of the first phase i clinical trial
    • Escudier, B. et al. Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial. J. Transl. Med. 3, 10 (2005).
    • (2005) J. Transl. Med , vol.3 , pp. 10
    • Escudier, B.1
  • 117
    • 18144369346 scopus 로고    scopus 로고
    • A phase i study of dexosome immunotherapy in patients with advanced non-small cell lung cancer
    • Morse, M. A. et al. A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J. Transl. Med. 3, 9 (2005).
    • (2005) J. Transl. Med , vol.3 , pp. 9
    • Morse, M.A.1
  • 118
    • 0037114287 scopus 로고    scopus 로고
    • Production and characterization of clinical grade exosomes derived from dendritic cells
    • Lamparski, H. G. et al. Production and characterization of clinical grade exosomes derived from dendritic cells. J. Immunol. Methods 270, 211-226 (2002).
    • (2002) J. Immunol. Methods , vol.270 , pp. 211-226
    • Lamparski, H.G.1
  • 119
    • 41149172340 scopus 로고    scopus 로고
    • Phase i clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
    • Dai, S. et al. Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol. Ther. 16, 782-790 (2008).
    • (2008) Mol. Ther , vol.16 , pp. 782-790
    • Dai, S.1
  • 120
    • 14844303287 scopus 로고    scopus 로고
    • The rationale for combined chemo/ immunotherapy using a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes in advanced ovarian cancer
    • Adams, M. et al. The rationale for combined chemo/ immunotherapy using a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes in advanced ovarian cancer. Vaccine 23, 2374-2378 (2005).
    • (2005) Vaccine , vol.23 , pp. 2374-2378
    • Adams, M.1
  • 121
    • 33644531900 scopus 로고    scopus 로고
    • Chemoimmunotherapy of tumors: Cyclophosphamide synergizes with exosome based vaccines
    • Taieb, J. et al. Chemoimmunotherapy of tumors: cyclophosphamide synergizes with exosome based vaccines. J. Immunol. 176, 2722-2729 (2006).
    • (2006) J. Immunol , vol.176 , pp. 2722-2729
    • Taieb, J.1
  • 122
    • 34247898904 scopus 로고    scopus 로고
    • Surface anchorage of superantigen SEA promotes induction of specific antitumor immune response by tumor-derived exosomes
    • Xiu, F. et al. Surface anchorage of superantigen SEA promotes induction of specific antitumor immune response by tumor-derived exosomes. J. Mol. Med. 85, 511-521 (2007).
    • (2007) J. Mol. Med , vol.85 , pp. 511-521
    • Xiu, F.1
  • 123
    • 33344457763 scopus 로고    scopus 로고
    • DNA vaccines encoding retrovirus-based virus-like particles induce efficient immune responses without adjuvant
    • Bellier, B. et al. DNA vaccines encoding retrovirus-based virus-like particles induce efficient immune responses without adjuvant. Vaccine 24, 2643-2655 (2006).
    • (2006) Vaccine , vol.24 , pp. 2643-2655
    • Bellier, B.1
  • 124
  • 125
    • 0345701525 scopus 로고    scopus 로고
    • Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59
    • Clayton, A., Harris, C. L., Court, J., Mason, M. D. & Morgan, B. P. Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur. J. Immunol. 33, 522-531 (2003).
    • (2003) Eur. J. Immunol , vol.33 , pp. 522-531
    • Clayton, A.1    Harris, C.L.2    Court, J.3    Mason, M.D.4    Morgan, B.P.5
  • 126
    • 34547770261 scopus 로고    scopus 로고
    • General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines
    • Kueng, H. J. et al. General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines. J. Virol. 81, 8666-8676 (2007).
    • (2007) J. Virol , vol.81 , pp. 8666-8676
    • Kueng, H.J.1
  • 127
    • 0019874126 scopus 로고
    • Exfoliation of membrane ecto-enzymes in the form of micro-vesicles
    • Trams, E. G., Lauter, C. J., Salem, N. Jr & Heine, U. Exfoliation of membrane ecto-enzymes in the form of micro-vesicles. Biochim. Biophys. Acta 645, 63-70 (1981).
    • (1981) Biochim. Biophys. Acta , vol.645 , pp. 63-70
    • Trams, E.G.1    Lauter, C.J.2    Jr, S.N.3    Heine, U.4
  • 129
    • 3042788972 scopus 로고    scopus 로고
    • Cells release prions in association with exosomes
    • Fevrier, B. et al. Cells release prions in association with exosomes. Proc. Natl Acad. Sci. USA 101, 9683-9688 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 9683-9688
    • Fevrier, B.1
  • 130
    • 33746593662 scopus 로고    scopus 로고
    • Alzheimer?s disease β-amyloid peptides are released in association with exosomes
    • Rajendran, L. et al. Alzheimer?s disease β-amyloid peptides are released in association with exosomes. Proc. Natl Acad. Sci. USA 103, 11172-11177 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 11172-11177
    • Rajendran, L.1
  • 131
    • 34547121209 scopus 로고    scopus 로고
    • Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: Redox-and hormone-dependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles
    • Aoki, N. et al. Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redox-and hormone-dependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles. Endocrinology 148, 3850-3862 (2007).
    • (2007) Endocrinology , vol.148 , pp. 3850-3862
    • Aoki, N.1
  • 132
    • 33751504617 scopus 로고    scopus 로고
    • Dendritic cell derived-exosomes: Biology and clinical implementations
    • Chaput, N. et al. Dendritic cell derived-exosomes: biology and clinical implementations. J. Leukoc. Biol. 80, 471-478 (2006).
    • (2006) J. Leukoc. Biol , vol.80 , pp. 471-478
    • Chaput, N.1
  • 133
    • 38048999426 scopus 로고    scopus 로고
    • Proteomic analysis of microvesicles derived from human colorectal cancer cells
    • Choi, D. S. et al. Proteomic analysis of microvesicles derived from human colorectal cancer cells. J. Proteome Res. 6, 4646-4655 (2007).
    • (2007) J. Proteome Res , vol.6 , pp. 4646-4655
    • Choi, D.S.1
  • 134
    • 61349173156 scopus 로고    scopus 로고
    • Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes
    • Conde-Vancells, J. et al. Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J. Proteome Res. 7, 5157-5166 (2008).
    • (2008) J. Proteome Res , vol.7 , pp. 5157-5166
    • Conde-Vancells, J.1
  • 135
    • 33645357271 scopus 로고    scopus 로고
    • Exosomes are released by cultured cortical neurones
    • Faure, J. et al. Exosomes are released by cultured cortical neurones. Mol. Cell. Neurosci. 31, 642-648 (2006).
    • (2006) Mol. Cell. Neurosci , vol.31 , pp. 642-648
    • Faure, J.1
  • 136
    • 23444448020 scopus 로고    scopus 로고
    • Proteomic analysis of microglia-derived exosomes: Metabolic role of the aminopeptidase CD13 in neuropeptide catabolism
    • Potolicchio, I. et al. Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism. J. Immunol. 175, 2237-2243 (2005).
    • (2005) J. Immunol , vol.175 , pp. 2237-2243
    • Potolicchio, I.1
  • 137
    • 10644236207 scopus 로고    scopus 로고
    • Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry
    • Mears, R. et al. Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Proteomics 4, 4019-4031 (2004).
    • (2004) Proteomics , vol.4 , pp. 4019-4031
    • Mears, R.1
  • 138
    • 0035863818 scopus 로고    scopus 로고
    • Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes
    • Skokos, D. et al. Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes. J. Immunol. 166, 868-876 (2001).
    • (2001) J. Immunol , vol.166 , pp. 868-876
    • Skokos, D.1
  • 139
    • 0013495952 scopus 로고    scopus 로고
    • Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation
    • Wubbolts, R. et al. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J. Biol. Chem. 278, 10963-10972 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 10963-10972
    • Wubbolts, R.1
  • 140
    • 11144353573 scopus 로고    scopus 로고
    • Proteomic analysis of exosomes secreted by human mesothelioma cells
    • Hegmans, J. P. et al. Proteomic analysis of exosomes secreted by human mesothelioma cells. Am. J. Pathol. 164, 1807-1815 (2004).
    • (2004) Am. J. Pathol , vol.164 , pp. 1807-1815
    • Hegmans, J.P.1
  • 141
    • 1942446664 scopus 로고    scopus 로고
    • Proteomic analysis of exosomes isolated from human malignant pleural effusions
    • Bard, M. P. et al. Proteomic analysis of exosomes isolated from human malignant pleural effusions. Am. J. Respir. Cell Mol. Biol. 31, 114-121 (2004).
    • (2004) Am. J. Respir. Cell Mol. Biol , vol.31 , pp. 114-121
    • Bard, M.P.1
  • 142
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • Chapter 3, Unit
    • Thery, C., Amigorena, S., Raposo, G. & Clayton, A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc. Cell Biol. Chapter 3, Unit 3 22 (2006).
    • (2006) Curr Protoc. Cell Biol. , vol.3 , pp. 22
    • Thery, C.1    Amigorena, S.2    Raposo, G.3    Clayton, A.4
  • 143
    • 0037402527 scopus 로고    scopus 로고
    • Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils
    • Gasser, O. et al. Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils. Exp. Cell Res. 285, 243-257 (2003).
    • (2003) Exp. Cell Res , vol.285 , pp. 243-257
    • Gasser, O.1
  • 144
    • 0035877018 scopus 로고    scopus 로고
    • Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles
    • Thery, C. et al. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J. Immunol. 166, 7309-7318 (2001).
    • (2001) J. Immunol , vol.166 , pp. 7309-7318
    • Thery, C.1
  • 145
    • 69249223795 scopus 로고    scopus 로고
    • MHC II in dendritic cells is sorted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways
    • Buschow, S. I. et al. MHC II in dendritic cells is sorted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways. Traffic (in the press).
    • Traffic
    • Buschow, S.I.1


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