SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β

Journal of Neuroscience

Volumn 35, Issue 2, 2015, Pages 807-818

  Cho, Seo Hyun ^a,c   Chen, Jason A ^d   Sayed, Faten ^a,c   Ward, Michael E ^a,c   Gao, Fuying ^d   Nguyen, Thi A ^b   Krabbe, Grietje ^a,c   Sohn, Peter Dongmin ^a,c   Lo, Iris ^a   Minami, Sakura ^a,c   Devidze, Nino ^a   Zhou, Yungui ^a   Coppola, Giovanni ^d   Gan, Li ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Epigenetic; Innate immunity; Interleukin; Memory deficits; Neuroinflammation; NF B

Indexed keywords

DNA METHYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; SIRTUIN 1; SIRT1 PROTEIN, MOUSE;

AGING; AMNESIA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; COGNITIVE DEFECT; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ENZYME ACTIVITY; EPIGENETICS; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; MICROGLIA; MOUSE; NERVE CELL CULTURE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROFIBRILLARY TANGLE; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; NUCLEOTIDE SEQUENCE; PASSIVE AVOIDANCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PYROSEQUENCING; SENESCENCE; TAUOPATHY; ANIMAL; CASE CONTROL STUDY; COGNITION; DEFICIENCY; GENETIC EPIGENESIS; GENETICS; METABOLISM; UPREGULATION;

AGING; ANIMALS; CASE-CONTROL STUDIES; COGNITION; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; INTERLEUKIN-1BETA; MICE; MICROGLIA; SIRTUIN 1; TAUOPATHIES; UP-REGULATION;

EID: 84920937355     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2939-14.2015     Document Type: Article

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