CD200 fusion protein decreases microglial activation in the hippocampus of aged rats

Brain, Behavior, and Immunity

Volumn 26, Issue 5, 2012, Pages 789-796

  Cox, F Fionnuala ^a   Carney, Donal ^a   Miller, Anne Marie ^a   Lynch, Marina A ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Age; CD200; Hippocampus; Lipopolysaccharide (LPS); Long term potentiation (LTP); Microglial activation

Indexed keywords

CD200 ANTIGEN; HYBRID PROTEIN; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

AGE DISTRIBUTION; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOREACTIVITY; LONG TERM POTENTIATION; MALE; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ACTINS; AGING; ANIMALS; ANTIGENS, CD; BLOTTING, WESTERN; CHEMOKINES; CYTOKINES; EXCITATORY POSTSYNAPTIC POTENTIALS; GENES, MHC CLASS II; HIPPOCAMPUS; INFLAMMATION; LIPOPOLYSACCHARIDES; LONG-TERM POTENTIATION; MACROPHAGE ACTIVATION; MALE; MEMBRANE PROTEINS; MICROGLIA; MICROINJECTIONS; NEURONAL PLASTICITY; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RECOMBINANT FUSION PROTEINS; SYNAPTOPHYSIN;

EID: 84861993323     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2011.10.004     Document Type: Article

References (49)

1. Banerjee D., Dick A.D. Blocking CD200-CD200 receptor axis augments NOS-2 expression and aggravates experimental autoimmune uveoretinitis in Lewis rats. Ocul. Immunol. Inflamm. 2004, 12:115-125.
2. Barclay A.N., Wright G.J., Brooke G., Brown M.H. CD200 and membrane protein interactions in the control of myeloid cells. Trends Immunol. 2002, 23:285-290.
3. Barry C.E., Nolan Y., Clarke R.M., Lynch A., Lynch M.A. Activation of c-Jun-N-terminal kinase is critical in mediating lipopolysaccharide-induced changes in the rat hippocampus. J. Neurochem. 2005, 93:221-231.
4. Bonomini F., Filippini F., Hayek T., Aviram M., Keidar S., Rodella L.F., Coleman R., Rezzani R. Apolipoprotein E and its role in aging and survival. Exp. Gerontol. 2010, 45:149-157.
5. Boudakov I., Liu J., Fan N., Gulay P., Wong K., Gorczynski R.M. Mice lacking CD200R1 show absence of suppression of lipopolysaccharide-induced tumor necrosis factor-alpha and mixed leukocyte culture responses by CD200. Transplantation 2007, 84:251-257.
6. Broderick C., Hoek R.M., Forrester J.V., Liversidge J., Sedgwick J.D., Dick A.D. Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am. J. Pathol. 2002, 161:1669-1677.
7. Chitnis T., Imitola J., Wang Y., Elyaman W., Chawla P., Sharuk M., Raddassi K., Bronson R.T., Khoury S.J. Elevated neuronal expression of CD200 protects Wlds mice from Inflammation-mediated neurodegeneration. Am. J. Pathol. 2007, 170:1695-1712.
8. Clarke R.M., Lyons A., O'Connell F., Deighan B.F., Barry C.E., Anyakoha N.G., Nicolaou A., Lynch M.A. A pivotal role for interleukin-4 in atorvastatin-associated neuroprotection in rat brain. J. Biol. Chem. 2008, 283:1808-1817.
9. Colton C.A. Heterogeneity of microglial activation in the innate immune response in the brain. J. Neuroimmune. Pharmacol. 2009, 4:399-418.
10. Copland D.A., Calder C.J., Raveney B.J., Nicholson L.B., Phillips J., Cherwinski H., Jenmalm M., Sedgwick J.D., Dick A.D. Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis. Am. J. Pathol. 2007, 171:580-588.
11. Costello D.A., Lyons A., Browne T., Denieffe S., Cox F.F., Lynch M.A. Long-term potentiation is impaired in CD200-deficient mice: a role for Toll-like receptor activation. J. Biol. Chem. 2011.
12. Cowley T.R., O'Sullivan J., Blau C., Deighan B.F., Jones R., Kerskens C., Richardson J.C., Virley D., Upton N., Lynch M.A. Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP. Neurobiol. Aging 2010, 986:191-195.
13. Davies H.A., Kelly A., Dhanrajan T.M., Lynch M.A., Rodriguez J.J., Stewart M.G. Synaptophysin immunogold labelling of synapses decreases in dentate gyrus of the hippocampus of aged rats. Brain Res. 2003, 986:191-195.
14. Deckert M., Sedgwick J.D., Fischer E., Schluter D. Regulation of microglial cell responses in murine Toxoplasma encephalitis by CD200/CD200 receptor interaction. Acta Neuropathol. (Berl) 2006, 111:548-558.
15. Downer E.J., Cowley T.R., Cox F., Maher F.O., Berezin V., Bock E., Lynch M.A. A synthetic NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory properties via IGF-1 and interferon-gamma modulation. J. Neurochem. 2009, 109:1516-1525.
16. Downer E.J., Cowley T.R., Lyons A., Mills K.H., Berezin V., Bock E., Lynch M.A. A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL. Neurobiol. Aging 2010, 31:118-128.
17. Duan R.S., Yang X., Chen Z.G., Lu M.O., Morris C., Winblad B., Zhu J. Decreased fractalkine and increased IP-10 expression in aged brain of APP(swe) transgenic mice. Neurochem. Res. 2008, 33:1085-1089.
18. Gavilan M.P., Revilla E., Pintado C., Castano A., Vizuete M.L., Moreno-Gonzalez I., Baglietto-Vargas D., Sanchez-Varo R., Vitorica J., Gutierrez A., Ruano D. Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons. J. Neurochem. 2007, 103:984-996.
19. Gorczynski R., Boudakov I., Khatri I. Peptides of CD200 modulate LPS-induced TNF-alpha induction and mortality in vivo. J. Surg. Res. 2008, 145:87-96.
20. Gorczynski R.M., Chen Z., Lee L., Yu K., Hu J. Anti-CD200R ameliorates collagen-induced arthritis in mice. Clin. Immunol. 2002, 104:256-264.
21. Gorczynski R.M., Chen Z., Yu K., Hu J. CD200 immunoadhesin suppresses collagen-induced arthritis in mice. Clin. Immunol. 2001, 101:328-334.
22. Hauss-Wegrzyniak B., Lynch M.A., Vraniak P.D., Wenk G.L. Chronic brain inflammation results in cell loss in the entorhinal cortex and impaired LTP in perforant path-granule cell synapses. Exp. Neurol. 2002, 176:336-341.
23. Hoek R.M., Ruuls S.R., Murphy C.A., Wright G.J., Goddard R., Zurawski S.M., Blom B., Homola M.E., Streit W.J., Brown M.H., Barclay A.N., Sedgwick J.D. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 2000, 290:1768-1771.
24. Jenmalm M.C., Cherwinski H., Bowman E.P., Phillips J.H., Sedgwick J.D. Regulation of myeloid cell function through the CD200 receptor. J. Immunol. 2006, 176:191-199.
25. Koning N., Swaab D.F., Hoek R.M., Huitinga I. Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. J. Neuropathol. Exp. Neurol. 2009, 68:159-167.
26. Liu Y., Bando Y., Vargas-Lowy D., Elyaman W., Khoury S.J., Huang T., Reif K., Chitnis T. CD200R1 agonist attenuates mechanisms of chronic disease in a murine model of multiple sclerosis. J. Neurosci. 2010, 30:2025-2038.
27. Lynch A.M., Loane D.J., Minogue A.M., Clarke R.M., Kilroy D., Nally R.E., Roche O.J., O'Connell F., Lynch M.A. Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus. Neurobiol. Aging 2007, 28:845-855.
28. Lynch M.A. Age-related neuroinflammatory changes negatively impact on neuronal function. Front Aging Neurosci. 2010, 1:6.
29. Lyons A., Downer E.J., Crotty S., Nolan Y.M., Mills K.H., Lynch M.A. CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4. J. Neurosci. 2007, 27:8309-8313.
30. Lyons A., Griffin R.J., Costelloe C.E., Clarke R.M., Lynch M.A. IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro. J. Neurochem. 2007, 101:771-781.
31. Lyons A., McQuillan K., Deighan B.F., O'Reilly J.A., Downer E.J., Murphy A.C., Watson M., Piazza A., O'Connell F., Griffin R., Mills K.H., Lynch M.A. Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide. Brain Behav. Immun. 2009, 23:1020-1027.
32. Lyons A., Murphy K.J., Clarke R., Lynch M.A. Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain. J. Neuroinflammation 2011, 8:27.
33. Martin D.S., Lonergan P.E., Boland B., Fogarty M.P., Brady M., Horrobin D.F., Campbell V.A., Lynch M.A. Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid. J. Biol. Chem. 2002, 277:34239-34246.
34. Masocha W. Systemic lipopolysaccharide (LPS)-induced microglial activation results in different temporal reduction of CD200 and CD200 receptor gene expression in the brain. J. Neuroimmunol. 2009, 214:78-82.
35. Moreno-Gonzalez I., Baglietto-Vargas D., Sanchez-Varo R., Jimenez S., Trujillo-Estrada L., Sanchez-Mejias E., Del Rio J.C., Torres M., Romero-Acebal M., Ruano D., Vizuete M., Vitorica J., Gutierrez A. Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice. J. Alzheimers Dis. 2009, 18:755-776.
36. Mullany P., Lynch M.A. Changes in protein synthesis and synthesis of the synaptic vesicle protein, synaptophysin, in entorhinal cortex following induction of long-term potentiation in dentate gyrus: an age-related study in the rat. Neuropharmacology 1997, 36:973-980.
37. Nolan Y., Maher F.O., Martin D.S., Clarke R.M., Brady M.T., Bolton A.E., Mills K.H., Lynch M.A. Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus. J. Biol. Chem. 2005, 280:9354-9362.
38. Ojo, B., Rezaie, P., Gabbott, P.L., Davies, H., Colyer, F., Cowley, T.R., Lynch, M.A. Stewart, M.G., 2011. Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL. Brain. Behav. Immun. [Epub ahead of print; PMID: 21986303].
39. Rosi S., Vazdarjanova A., Ramirez-Amaya V., Worley P.F., Barnes C.A., Wenk G.L. Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat. Neuroscience 2006, 142:1303-1315.
40. Ruan L., Kang Z., Pei G., Le Y. Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease. Curr. Alzheimer Res. 2009, 6:531-540.
41. Sanchez-Guajardo V., Febbraro F., Kirik D., Romero-Ramos M. Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease. PLoS One 2010, 5:e8784.
42. Shinohara H., Inoue A., Toyama-Sorimachi N., Nagai Y., Yasuda T., Suzuki H., Horai R., Iwakura Y., Yamamoto T., Karasuyama H., Miyake K., Yamanashi Y. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J. Exp. Med. 2005, 201:333-339.
43. Simelyte E., Criado G., Essex D., Uger R.A., Feldmann M., Williams R.O. CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis. Arthritis Rheum. 2008, 58:1038-1043.
44. Snelgrove R.J., Goulding J., Didierlaurent A.M., Lyonga D., Vekaria S., Edwards L., Gwyer E., Sedgwick J.D., Barclay A.N., Hussell T. A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nat. Immunol. 2008, 9:1074-1083.
45. Solovjov D.A., Pluskota E., Plow E.F. Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2. J. Biol. Chem. 2005, 280:1336-1345.
46. Wright G.J., Puklavec M.J., Willis A.C., Hoek R.M., Sedgwick J.D., Brown M.H., Barclay A.N. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity 2000, 13:233-242.
47. Yin J.X., Turner G.H., Lin H.J., Coons S.W., Shi J. Deficits in Spatial Learning and Memory is Associated with Hippocampal Volume Loss in Aged Apolipoprotein E4 Mice. J. Alzheimers Dis. 2011, 179:87-93.
48. Zhang R., Gascon R., Miller R.G., Gelinas D.F., Mass J., Lancero M., Narvaez A., McGrath M.S. MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS). J. Neuroimmunol. 2006, 179:87-93.
49. Zhang S., Cherwinski H., Sedgwick J.D., Phillips J.H. Molecular mechanisms of CD200 inhibition of mast cell activation. J. Immunol. 2004, 173:6786-6793.