Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: A microarray study

Journal of Neuroinflammation

Volumn 9, Issue , 2012, Pages

  Cribbs, David H ^a,b   Berchtold, Nicole C ^a   Perreau, Victoria ^c   Coleman, Paul D ^d   Rogers, Joseph ^e   Tenner, Andrea J ^a,b   Cotman, Carl W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^e SUN HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

Alarmin; Calgranulin; Calprotectin; Caspase 1; Complement; Cryopyrin; Endogenous danger signaling; Fractalkine; Inflammasome; Myeloid related protein; Toll like receptor

Indexed keywords

FC RECEPTOR; FRACTALKINE; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; INFLAMMASOME; PROTEIN TOLLIP; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; COGNITIVE DEFECT; CONTROLLED STUDY; DOWN REGULATION; ENTORHINAL CORTEX; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GROUPS BY AGE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MICROGLIA; NERVE DEGENERATION; POSTCENTRAL GYRUS; SIGNAL TRANSDUCTION; SUPERIOR FRONTAL GYRUS; UPREGULATION;

EID: 84865199264     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-179     Document Type: Article

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