Exosome reduction invivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

Neurobiology of Aging

Volumn 35, Issue 8, 2014, Pages 1792-1800

  Dinkins, Michael B ^a   Dasgupta, Somsankar ^a   Wang, Guanghu ^a   Zhu, Gu ^a   Bieberich, Erhard ^a  

^a AUGUSTA UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Amyloid beta; Astrocytes; Exosomes; GW4869; Neutral sphingomyelinase; Primary culture

Indexed keywords

3,3' (1,4 PHENYLENE)BIS[N [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ACRYLAMIDE]; CERAMIDE; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); ANILINE DERIVATIVE; BENZYLIDENE DERIVATIVE; PEPTIDE FRAGMENT; SMPD3 PROTEIN, MOUSE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; EXOSOME; FEMALE; GAS CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; MASS SPECTROMETRY; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; METABOLISM; MOLECULARLY TARGETED THERAPY; PHYSIOLOGY; PROTEINOSIS; SECRETION (PROCESS);

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANILINE COMPOUNDS; ANIMALS; ASTROCYTES; BENZYLIDENE COMPOUNDS; BRAIN; CELLS, CULTURED; CERAMIDES; DISEASE MODELS, ANIMAL; EXOSOMES; FEMALE; MALE; MICE, INBRED C57BL; MICROGLIA; MOLECULAR TARGETED THERAPY; PEPTIDE FRAGMENTS; PLAQUE, AMYLOID; PROTEIN AGGREGATION, PATHOLOGICAL; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84899968840     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.02.012     Document Type: Article

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