메뉴 건너뛰기




Volumn 2, Issue 5, 2013, Pages 397-411

Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury

Author keywords

Bone marrow; Chemotherapy; Hematopoietic stem cell; Ionizing radiation; Senescence; Suppression

Indexed keywords


EID: 84962643219     PISSN: 2218676X     EISSN: 22196803     Source Type: Journal    
DOI: 10.3978/j.issn.2218-676X.2013.10.05     Document Type: Article
Times cited : (75)

References (146)
  • 1
    • 0028903635 scopus 로고
    • Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy
    • Mauch P, Constine L, Greenberger J, et al. Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy. Int J Radiat Oncol Biol Phys 1995;31:1319-39.
    • (1995) Int J Radiat Oncol Biol Phys , vol.31 , pp. 1319-1339
    • Mauch, P.1    Constine, L.2    Greenberger, J.3
  • 2
    • 0021908880 scopus 로고
    • Long-term bone marrow damage in experimental systems and in patients after radiation or chemotherapy
    • Testa NG, Hendry JH, Molineux G. Long-term bone marrow damage in experimental systems and in patients after radiation or chemotherapy. Anticancer Res 1985;5:101-10.
    • (1985) Anticancer Res , vol.5 , pp. 101-110
    • Testa, N.G.1    Hendry, J.H.2    Molineux, G.3
  • 3
    • 0042809621 scopus 로고    scopus 로고
    • Regulation of hematopoietic stem cell self-renewal
    • Reya T. Regulation of hematopoietic stem cell self-renewal. Recent Prog Horm Res 2003;58:283-95.
    • (2003) Recent Prog Horm Res , vol.58 , pp. 283-295
    • Reya, T.1
  • 4
    • 0035182533 scopus 로고    scopus 로고
    • Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations
    • Weissman IL, Anderson DJ, Gage F. Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol 2001;17:387-403.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 387-403
    • Weissman, I.L.1    Anderson, D.J.2    Gage, F.3
  • 5
    • 56549128268 scopus 로고    scopus 로고
    • Hematopoietic stem cells reversibly Switch from dormancy to self-renewal during homeostasis and repair
    • Wilson A, Laurenti E, Oser G, et al. Hematopoietic stem cells reversibly Switch from dormancy to self-renewal during homeostasis and repair. Cell 2008;135:1118-29.
    • (2008) Cell , vol.135 , pp. 1118-1129
    • Wilson, A.1    Laurenti, E.2    Oser, G.3
  • 6
    • 21244463426 scopus 로고    scopus 로고
    • SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    • Kiel MJ, Yilmaz OH, Iwashita T, et al. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005;121:1109-21.
    • (2005) Cell , vol.121 , pp. 1109-1121
    • Kiel, M.J.1    Yilmaz, O.H.2    Iwashita, T.3
  • 7
    • 60149104597 scopus 로고    scopus 로고
    • Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells
    • Foudi A, Hochedlinger K, Van Buren D, et al. Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol 2009;27:84-90.
    • (2009) Nat Biotechnol , vol.27 , pp. 84-90
    • Foudi, A.1    Hochedlinger, K.2    Van Buren, D.3
  • 8
    • 70349611262 scopus 로고    scopus 로고
    • Estimating dormant and active hematopoietic stem cell kinetics through extensive modeling of bromodeoxyuridine label-retaining cell dynamics
    • van der Wath RC, Wilson A, Laurenti E, et al. Estimating dormant and active hematopoietic stem cell kinetics through extensive modeling of bromodeoxyuridine label-retaining cell dynamics. PLoS One 2009;4: e6972.
    • (2009) PLoS One , vol.4 , pp. e6972
    • van der Wath, R.C.1    Wilson, A.2    Laurenti, E.3
  • 9
    • 34547874440 scopus 로고    scopus 로고
    • Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche
    • Arai F, Suda T. Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Ann N Y Acad Sci 2007;1106:41-53.
    • (2007) Ann N Y Acad Sci , vol.1106 , pp. 41-53
    • Arai, F.1    Suda, T.2
  • 10
    • 28444486367 scopus 로고    scopus 로고
    • Stem cell niche: structure and function
    • Li L, Xie T. Stem cell niche: structure and function. Annu Rev Cell Dev Biol 2005;21:605-31.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 605-631
    • Li, L.1    Xie, T.2
  • 11
    • 34548405232 scopus 로고    scopus 로고
    • Dormant and self-renewing hematopoietic stem cells and their niches
    • Wilson A, Oser GM, Jaworski M, et al. Dormant and self-renewing hematopoietic stem cells and their niches. Ann N Y Acad Sci 2007;1106:64-75.
    • (2007) Ann N Y Acad Sci , vol.1106 , pp. 64-75
    • Wilson, A.1    Oser, G.M.2    Jaworski, M.3
  • 12
    • 0242363225 scopus 로고    scopus 로고
    • Identification of the haematopoietic stem cell niche and control of the niche size
    • Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003;425:836-41.
    • (2003) Nature , vol.425 , pp. 836-841
    • Zhang, J.1    Niu, C.2    Ye, L.3
  • 13
    • 0242268524 scopus 로고    scopus 로고
    • Osteoblastic cells regulate the haematopoietic stem cell niche
    • Calvi LM, Adams GB, Weibrecht KW, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003;425:841-6.
    • (2003) Nature , vol.425 , pp. 841-846
    • Calvi, L.M.1    Adams, G.B.2    Weibrecht, K.W.3
  • 14
    • 84864194496 scopus 로고    scopus 로고
    • Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche
    • Sugimura R, He XC, Venkatraman A, et al. Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell 2012;150:351-65.
    • (2012) Cell , vol.150 , pp. 351-365
    • Sugimura, R.1    He, X.C.2    Venkatraman, A.3
  • 15
    • 73349123461 scopus 로고    scopus 로고
    • BMP4 regulates the hematopoietic stem cell niche
    • Goldman DC, Bailey AS, Pfaffle DL, et al. BMP4 regulates the hematopoietic stem cell niche. Blood 2009;114:4393-401.
    • (2009) Blood , vol.114 , pp. 4393-4401
    • Goldman, D.C.1    Bailey, A.S.2    Pfaffle, D.L.3
  • 16
    • 36748999351 scopus 로고    scopus 로고
    • Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche
    • Yoshihara H, Arai F, Hosokawa K, et al. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 2007;1:685-97.
    • (2007) Cell Stem Cell , vol.1 , pp. 685-697
    • Yoshihara, H.1    Arai, F.2    Hosokawa, K.3
  • 17
    • 8144230239 scopus 로고    scopus 로고
    • Maintenance and self-renewal of long-term reconstituting hematopoietic stem cells supported by amniotic fluid
    • Barria E, Mikels A, Haas M. Maintenance and self-renewal of long-term reconstituting hematopoietic stem cells supported by amniotic fluid. Stem Cells Dev 2004;13:548-62.
    • (2004) Stem Cells Dev , vol.13 , pp. 548-562
    • Barria, E.1    Mikels, A.2    Haas, M.3
  • 18
    • 41449107903 scopus 로고    scopus 로고
    • N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells
    • Haug JS, He XC, Grindley JC, et al. N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells. Cell Stem Cell 2008;2:367-79.
    • (2008) Cell Stem Cell , vol.2 , pp. 367-379
    • Haug, J.S.1    He, X.C.2    Grindley, J.C.3
  • 19
    • 3242669145 scopus 로고    scopus 로고
    • Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    • Arai F, Hirao A, Ohmura M, et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 2004;118:149-61.
    • (2004) Cell , vol.118 , pp. 149-161
    • Arai, F.1    Hirao, A.2    Ohmura, M.3
  • 20
    • 77956217067 scopus 로고    scopus 로고
    • Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
    • Takubo K, Goda N, Yamada W, et al. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell 2010;7:391-402.
    • (2010) Cell Stem Cell , vol.7 , pp. 391-402
    • Takubo, K.1    Goda, N.2    Yamada, W.3
  • 21
    • 77955879913 scopus 로고    scopus 로고
    • Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches
    • Winkler IG, Barbier V, Wadley R, et al. Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches. Blood 2010;116:375-85.
    • (2010) Blood , vol.116 , pp. 375-385
    • Winkler, I.G.1    Barbier, V.2    Wadley, R.3
  • 22
    • 34248359065 scopus 로고    scopus 로고
    • Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    • Parmar K, Mauch P, Vergilio JA, et al. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci U S A 2007;104:5431-6.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5431-5436
    • Parmar, K.1    Mauch, P.2    Vergilio, J.A.3
  • 23
    • 78549254160 scopus 로고    scopus 로고
    • Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation
    • Shima H, Takubo K, Tago N, et al. Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation. Exp Hematol 2010;38:1231-40.
    • (2010) Exp Hematol , vol.38 , pp. 1231-1240
    • Shima, H.1    Takubo, K.2    Tago, N.3
  • 24
    • 84863376354 scopus 로고    scopus 로고
    • HIF-α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency
    • Du J, Chen Y, Li Q, et al. HIF-α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency. Blood 2012;119:2789-98.
    • (2012) Blood , vol.119 , pp. 2789-2798
    • Du, J.1    Chen, Y.2    Li, Q.3
  • 25
    • 77956205122 scopus 로고    scopus 로고
    • The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
    • Simsek T, Kocabas F, Zheng J, et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell 2010;7:380-90.
    • (2010) Cell Stem Cell , vol.7 , pp. 380-390
    • Simsek, T.1    Kocabas, F.2    Zheng, J.3
  • 26
    • 33646435309 scopus 로고    scopus 로고
    • The stem cell niches in bone
    • Yin T, Li L. The stem cell niches in bone. J Clin Invest 2006;116:1195-201.
    • (2006) J Clin Invest , vol.116 , pp. 1195-1201
    • Yin, T.1    Li, L.2
  • 27
    • 11144356721 scopus 로고    scopus 로고
    • Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
    • Avecilla ST, Hattori K, Heissig B, et al. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 2004;10:64-71.
    • (2004) Nat Med , vol.10 , pp. 64-71
    • Avecilla, S.T.1    Hattori, K.2    Heissig, B.3
  • 28
    • 26844520899 scopus 로고    scopus 로고
    • The bone marrow vascular niche: home of HSC differentiation and mobilization
    • Kopp HG, Avecilla ST, Hooper AT, et al. The bone marrow vascular niche: home of HSC differentiation and mobilization. Physiology (Bethesda) 2005;20:349-56.
    • (2005) Physiology (Bethesda) , vol.20 , pp. 349-356
    • Kopp, H.G.1    Avecilla, S.T.2    Hooper, A.T.3
  • 29
    • 77954709903 scopus 로고    scopus 로고
    • Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation
    • Shao L, Sun Y, Zhang Z, et al. Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood 2010;115:4707-14.
    • (2010) Blood , vol.115 , pp. 4707-4714
    • Shao, L.1    Sun, Y.2    Zhang, Z.3
  • 30
    • 0027283604 scopus 로고
    • Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents
    • Lotem J, Sachs L. Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood 1993;82:1092-6.
    • (1993) Blood , vol.82 , pp. 1092-1096
    • Lotem, J.1    Sachs, L.2
  • 31
    • 0032523012 scopus 로고    scopus 로고
    • Role of p53 in hematopoietic recovery after cytotoxic treatment
    • Wlodarski P, Wasik M, Ratajczak MZ, et al. Role of p53 in hematopoietic recovery after cytotoxic treatment. Blood 1998;91:2998-3006.
    • (1998) Blood , vol.91 , pp. 2998-3006
    • Wlodarski, P.1    Wasik, M.2    Ratajczak, M.Z.3
  • 32
    • 77951753647 scopus 로고    scopus 로고
    • Deletion of puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation
    • Yu H, Shen H, Yuan Y, et al. Deletion of puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation. Blood 2010;115:3472-80.
    • (2010) Blood , vol.115 , pp. 3472-3480
    • Yu, H.1    Shen, H.2    Yuan, Y.3
  • 33
    • 0032055166 scopus 로고    scopus 로고
    • Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the Consequences of lethal irradiation
    • Domen J, Gandy KL, Weissman IL. Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the Consequences of lethal irradiation. Blood 1998;91:2272-82.
    • (1998) Blood , vol.91 , pp. 2272-2282
    • Domen, J.1    Gandy, K.L.2    Weissman, I.L.3
  • 34
    • 0345528832 scopus 로고    scopus 로고
    • Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms
    • Meng A, Wang Y, Brown SA, et al. Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms. Exp Hematol 2003;31:1348-56.
    • (2003) Exp Hematol , vol.31 , pp. 1348-1356
    • Meng, A.1    Wang, Y.2    Brown, S.A.3
  • 35
    • 77956251480 scopus 로고    scopus 로고
    • Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
    • Mohrin M, Bourke E, Alexander D, et al. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell 2010;7:174-85.
    • (2010) Cell Stem Cell , vol.7 , pp. 174-185
    • Mohrin, M.1    Bourke, E.2    Alexander, D.3
  • 36
    • 0036286183 scopus 로고    scopus 로고
    • Hematologic Consequences of exposure to ionizing radiation
    • Dainiak N. Hematologic Consequences of exposure to ionizing radiation. Exp Hematol 2002;30:513-28.
    • (2002) Exp Hematol , vol.30 , pp. 513-528
    • Dainiak, N.1
  • 37
    • 0034892426 scopus 로고    scopus 로고
    • The effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on primitive hematopoietic stem cell (PHSC) function and numbers, after chemotherapy
    • Gardner RV, Begue R, Mckinnon E. The effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on primitive hematopoietic stem cell (PHSC) function and numbers, after chemotherapy. Exp Hematol 2001;29:1053-9.
    • (2001) Exp Hematol , vol.29 , pp. 1053-1059
    • Gardner, R.V.1    Begue, R.2    Mckinnon, E.3
  • 38
    • 0032530347 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor enhances bone marrow stem cell damage caused by repeated administration of cytotoxic agents
    • van Os R, Robinson S, Sheridan T, et al. Granulocyte colony-stimulating factor enhances bone marrow stem cell damage caused by repeated administration of cytotoxic agents. Blood 1998;92:1950-6.
    • (1998) Blood , vol.92 , pp. 1950-1956
    • van Os, R.1    Robinson, S.2    Sheridan, T.3
  • 39
    • 84875804132 scopus 로고    scopus 로고
    • Vascular-derived TGF-β increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brain
    • Pineda JR, Daynac M, Chicheportiche A, et al. Vascular-derived TGF-β increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brain. EMBO Mol Med 2013;5:548-62.
    • (2013) EMBO Mol Med , vol.5 , pp. 548-562
    • Pineda, J.R.1    Daynac, M.2    Chicheportiche, A.3
  • 40
    • 0029549338 scopus 로고
    • Preparative regimens: chemotherapy versus chemoradiotherapy
    • Santos GW. Preparative regimens: chemotherapy versus chemoradiotherapy. A historical perspective. Ann N Y Acad Sci 1995;770:1-7.
    • (1995) A historical perspective. Ann N Y Acad Sci , vol.770 , pp. 1-7
    • Santos, G.W.1
  • 41
    • 0141482100 scopus 로고    scopus 로고
    • Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells
    • Meng A, Wang Y, Van Zant G, et al. Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells. Cancer Res 2003;63:5414-9.
    • (2003) Cancer Res , vol.63 , pp. 5414-5419
    • Meng, A.1    Wang, Y.2    Van Zant, G.3
  • 42
    • 30144439380 scopus 로고    scopus 로고
    • Total body irradiation selectively induces murine hematopoietic stem cell senescence
    • Wang Y, Schulte BA, Larue AC, et al. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood 2006;107:358-66.
    • (2006) Blood , vol.107 , pp. 358-366
    • Wang, Y.1    Schulte, B.A.2    Larue, A.C.3
  • 43
    • 0034073650 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor impedes recovery from damage caused by cytotoxic agents through increased differentiation at the expense of self-renewal
    • van Os R, Robinson S, Sheridan T, et al. Granulocyte-colony stimulating factor impedes recovery from damage caused by cytotoxic agents through increased differentiation at the expense of self-renewal. Stem Cells 2000;18:120-7.
    • (2000) Stem Cells , vol.18 , pp. 120-127
    • van Os, R.1    Robinson, S.2    Sheridan, T.3
  • 44
    • 84856076520 scopus 로고    scopus 로고
    • Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis
    • Carbonneau CL, Despars G, Rojas-Sutterlin S, et al. Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis. Blood 2012;119:717-26.
    • (2012) Blood , vol.119 , pp. 717-726
    • Carbonneau, C.L.1    Despars, G.2    Rojas-Sutterlin, S.3
  • 45
    • 84872168655 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: radio-resistant members of the bone marrow
    • Sugrue T, Lowndes NF, Ceredig R. Mesenchymal stromal cells: radio-resistant members of the bone marrow. Immunol Cell Biol 2013;91:5-11.
    • (2013) Immunol Cell Biol , vol.91 , pp. 5-11
    • Sugrue, T.1    Lowndes, N.F.2    Ceredig, R.3
  • 46
    • 84883571576 scopus 로고    scopus 로고
    • Megakaryocytes promote murine osteoblastic HSC niche expansion and stem cell engraftment after radioablative conditioning
    • Olson TS, Caselli A, Otsuru S, et al. Megakaryocytes promote murine osteoblastic HSC niche expansion and stem cell engraftment after radioablative conditioning. Blood 2013;121:5238-49.
    • (2013) Blood , vol.121 , pp. 5238-5249
    • Olson, T.S.1    Caselli, A.2    Otsuru, S.3
  • 47
    • 84858987918 scopus 로고    scopus 로고
    • The glutathione disulfide mimetic NOV-002 inhibits cyclophosphamide-induced hematopoietic and immune suppression by reducing oxidative stress
    • Diaz-Montero CM, Wang Y, Shao L, et al. The glutathione disulfide mimetic NOV-002 inhibits cyclophosphamide-induced hematopoietic and immune suppression by reducing oxidative stress. Free Radic Biol Med 2012;52:1560-8.
    • (2012) Free Radic Biol Med , vol.52 , pp. 1560-1568
    • Diaz-Montero, C.M.1    Wang, Y.2    Shao, L.3
  • 48
    • 79960077503 scopus 로고    scopus 로고
    • Reactive Oxygen species and hematopoietic stem cell senescence
    • Shao L, Li H, Pazhanisamy SK, et al. Reactive Oxygen species and hematopoietic stem cell senescence. Int J Hematol 2011;94:24-32.
    • (2011) Int J Hematol , vol.94 , pp. 24-32
    • Shao, L.1    Li, H.2    Pazhanisamy, S.K.3
  • 49
    • 84870376072 scopus 로고    scopus 로고
    • Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice
    • Zhang H, Zhai Z, Wang Y, et al. Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice. Free Radic Biol Med 2013;54:40-50.
    • (2013) Free Radic Biol Med , vol.54 , pp. 40-50
    • Zhang, H.1    Zhai, Z.2    Wang, Y.3
  • 50
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    • Park IK, Qian D, Kiel M, et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003;423:302-5.
    • (2003) Nature , vol.423 , pp. 302-305
    • Park, I.K.1    Qian, D.2    Kiel, M.3
  • 51
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003;423:255-60.
    • (2003) Nature , vol.423 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 52
    • 22344449361 scopus 로고    scopus 로고
    • Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways
    • Molofsky AV, He S, Bydon M, et al. Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev 2005;19:1432-7.
    • (2005) Genes Dev , vol.19 , pp. 1432-1437
    • Molofsky, A.V.1    He, S.2    Bydon, M.3
  • 53
    • 77956858165 scopus 로고    scopus 로고
    • Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape
    • Fleenor CJ, Marusyk A, Degregori J. Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape. Cell Cycle 2010;9:3005-11.
    • (2010) Cell Cycle , vol.9 , pp. 3005-3011
    • Fleenor, C.J.1    Marusyk, A.2    Degregori, J.3
  • 54
    • 70349748523 scopus 로고    scopus 로고
    • Irradiation alters selection for oncogenic mutations in hematopoietic progenitors
    • Marusyk A, Casás-Selves M, Henry CJ, et al. Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Res 2009;69:7262-9.
    • (2009) Cancer Res , vol.69 , pp. 7262-7269
    • Marusyk, A.1    Casás-Selves, M.2    Henry, C.J.3
  • 55
    • 79957968764 scopus 로고    scopus 로고
    • Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression
    • Li H, Wang Y, Pazhanisamy SK, et al. Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression. Free Radic Biol Med 2011;51:30-7.
    • (2011) Free Radic Biol Med , vol.51 , pp. 30-37
    • Li, H.1    Wang, Y.2    Pazhanisamy, S.K.3
  • 57
    • 0028908916 scopus 로고
    • Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function
    • Spangrude GJ, Brooks DM, Tumas DB. Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function. Blood 1995;85:1006-16.
    • (1995) Blood , vol.85 , pp. 1006-1016
    • Spangrude, G.J.1    Brooks, D.M.2    Tumas, D.B.3
  • 58
    • 0027163483 scopus 로고
    • Assessing permanent damage to primitive hematopoietic stem cells after chemotherapy using the competitive repopulation assay
    • Gardner RV, Lerner C, Astle CM, et al. Assessing permanent damage to primitive hematopoietic stem cells after chemotherapy using the competitive repopulation assay. Cancer Chemother Pharmacol 1993;32:450-4.
    • (1993) Cancer Chemother Pharmacol , vol.32 , pp. 450-454
    • Gardner, R.V.1    Lerner, C.2    Astle, C.M.3
  • 59
    • 0023685196 scopus 로고
    • Permanent loss in stem cell self renewal capacity following stress to the marrow
    • Mauch P, Rosenblatt M, Hellman S. Permanent loss in stem cell self renewal capacity following stress to the marrow. Blood 1988;72:1193-6.
    • (1988) Blood , vol.72 , pp. 1193-1196
    • Mauch, P.1    Rosenblatt, M.2    Hellman, S.3
  • 60
    • 0027888222 scopus 로고
    • Hematopoietic stem cell deficit of transplanted bone marrow previously exposed to cytotoxic agents
    • Neben S, Hellman S, Montgomery M, et al. Hematopoietic stem cell deficit of transplanted bone marrow previously exposed to cytotoxic agents. Exp Hematol 1993;21:156-62.
    • (1993) Exp Hematol , vol.21 , pp. 156-162
    • Neben, S.1    Hellman, S.2    Montgomery, M.3
  • 61
    • 72649103214 scopus 로고    scopus 로고
    • Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells
    • Wang Y, Liu L, Pazhanisamy SK, et al. Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. Free Radic Biol Med 2010;48:348-56.
    • (2010) Free Radic Biol Med , vol.48 , pp. 348-356
    • Wang, Y.1    Liu, L.2    Pazhanisamy, S.K.3
  • 62
    • 77953283847 scopus 로고    scopus 로고
    • AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive Oxygen species
    • Juntilla MM, Patil VD, Calamito M, et al. AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive Oxygen species. Blood 2010;115:4030-8.
    • (2010) Blood , vol.115 , pp. 4030-4038
    • Juntilla, M.M.1    Patil, V.D.2    Calamito, M.3
  • 63
    • 77954666269 scopus 로고    scopus 로고
    • Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism
    • Kinder M, Wei C, Shelat SG, et al. Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism. Blood 2010;115:5012-22.
    • (2010) Blood , vol.115 , pp. 5012-5022
    • Kinder, M.1    Wei, C.2    Shelat, S.G.3
  • 64
    • 70349446465 scopus 로고    scopus 로고
    • Reactive Oxygen species prime Drosophila haematopoietic progenitors for differentiation
    • Owusu-Ansah E, Banerjee U. Reactive Oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature 2009;461:537-41.
    • (2009) Nature , vol.461 , pp. 537-541
    • Owusu-Ansah, E.1    Banerjee, U.2
  • 65
    • 77449094614 scopus 로고    scopus 로고
    • In vivo cellular imaging pinpoints the role of reactive Oxygen species in the early steps of adult hematopoietic reconstitution
    • Lewandowski D, Barroca V, Ducongé F, et al. In vivo cellular imaging pinpoints the role of reactive Oxygen species in the early steps of adult hematopoietic reconstitution. Blood 2010;115:443-52.
    • (2010) Blood , vol.115 , pp. 443-452
    • Lewandowski, D.1    Barroca, V.2    Ducongé, F.3
  • 66
    • 33645730667 scopus 로고    scopus 로고
    • Reactive Oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
    • Ito K, Hirao A, Arai F, et al. Reactive Oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med 2006;12:446-51.
    • (2006) Nat Med , vol.12 , pp. 446-451
    • Ito, K.1    Hirao, A.2    Arai, F.3
  • 67
    • 33845969499 scopus 로고    scopus 로고
    • Regulation of reactive Oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes
    • Ito K, Takubo K, Arai F, et al. Regulation of reactive Oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes. J Immunol 2007;178:103-10.
    • (2007) J Immunol , vol.178 , pp. 103-110
    • Ito, K.1    Takubo, K.2    Arai, F.3
  • 68
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    • Tothova Z, Kollipara R, Huntly BJ, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007;128:325-39.
    • (2007) Cell , vol.128 , pp. 325-339
    • Tothova, Z.1    Kollipara, R.2    Huntly, B.J.3
  • 69
    • 78049499084 scopus 로고    scopus 로고
    • Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity
    • Abbas HA, Maccio DR, Coskun S, et al. Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell 2010;7:606-17.
    • (2010) Cell Stem Cell , vol.7 , pp. 606-617
    • Abbas, H.A.1    Maccio, D.R.2    Coskun, S.3
  • 70
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive Oxygen species
    • Chen C, Liu Y, Liu R, et al. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive Oxygen species. J Exp Med 2008;205:2397-408.
    • (2008) J Exp Med , vol.205 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3
  • 71
    • 67349156082 scopus 로고    scopus 로고
    • Bmi1 regulates mitochondrial function and the DNA damage response pathway
    • Liu J, Cao L, Chen J, et al. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature 2009;459:387-92.
    • (2009) Nature , vol.459 , pp. 387-392
    • Liu, J.1    Cao, L.2    Chen, J.3
  • 72
    • 34249882777 scopus 로고    scopus 로고
    • Foxo3a is essential for maintenance of the hematopoietic stem cell pool
    • Miyamoto K, Araki KY, Naka K, et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 2007;1:101-12.
    • (2007) Cell Stem Cell , vol.1 , pp. 101-112
    • Miyamoto, K.1    Araki, K.Y.2    Naka, K.3
  • 73
    • 54449092731 scopus 로고    scopus 로고
    • Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells
    • Yalcin S, Zhang X, Luciano JP, et al. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem 2008;283:25692-705.
    • (2008) J Biol Chem , vol.283 , pp. 25692-25705
    • Yalcin, S.1    Zhang, X.2    Luciano, J.P.3
  • 74
    • 33645125512 scopus 로고    scopus 로고
    • Oligonucleotide IMT504 induces an immunogenic phenotype and apoptosis in chronic lymphocytic leukemia cells
    • Rodriguez JM, Elias F, Montaner A, et al. Oligonucleotide IMT504 induces an immunogenic phenotype and apoptosis in chronic lymphocytic leukemia cells. Medicina 2006;66:9-16.
    • (2006) Medicina , vol.66 , pp. 9-16
    • Rodriguez, J.M.1    Elias, F.2    Montaner, A.3
  • 75
    • 7244250309 scopus 로고    scopus 로고
    • Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    • Ito K, Hirao A, Arai F, et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004;431:997-1002.
    • (2004) Nature , vol.431 , pp. 997-1002
    • Ito, K.1    Hirao, A.2    Arai, F.3
  • 76
    • 77954087743 scopus 로고    scopus 로고
    • Role of the polycomb group gene BMI1 in normal and leukemic hematopoietic stem and progenitor cells
    • Schuringa JJ, Vellenga E. Role of the polycomb group gene BMI1 in normal and leukemic hematopoietic stem and progenitor cells. Curr Opin Hematol 2010;17:294-9.
    • (2010) Curr Opin Hematol , vol.17 , pp. 294-299
    • Schuringa, J.J.1    Vellenga, E.2
  • 77
    • 51349138695 scopus 로고    scopus 로고
    • Oxidative stress in Fanconi anemia hematopoiesis and disease progression
    • Du W, Adam Z, Rani R, et al. Oxidative stress in Fanconi anemia hematopoiesis and disease progression. Antioxid Redox Signal 2008;10:1909-21.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1909-1921
    • Du, W.1    Adam, Z.2    Rani, R.3
  • 78
    • 75349113973 scopus 로고    scopus 로고
    • Age-related changes in niche cells influence hematopoietic stem cell function
    • Oakley EJ, Van Zant G. Age-related changes in niche cells influence hematopoietic stem cell function. Cell Stem Cell 2010;6:93-4.
    • (2010) Cell Stem Cell , vol.6 , pp. 93-94
    • Oakley, E.J.1    Van Zant, G.2
  • 79
    • 68149168943 scopus 로고    scopus 로고
    • Effects of aging on hematopoietic stem and progenitor cells
    • Waterstrat A, Van Zant G. Effects of aging on hematopoietic stem and progenitor cells. Curr Opin Immunol 2009;21:408-13.
    • (2009) Curr Opin Immunol , vol.21 , pp. 408-413
    • Waterstrat, A.1    Van Zant, G.2
  • 80
    • 33749365721 scopus 로고    scopus 로고
    • Increased hematopoietic stem cell mobilization in aged mice
    • Xing Z, Ryan MA, Daria D, et al. Increased hematopoietic stem cell mobilization in aged mice. Blood 2006;108:2190-7.
    • (2006) Blood , vol.108 , pp. 2190-2197
    • Xing, Z.1    Ryan, M.A.2    Daria, D.3
  • 81
    • 17044426724 scopus 로고    scopus 로고
    • Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element
    • Geiger H, Rennebeck G, Van Zant G. Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element. Proc Natl Acad Sci U S A 2005;102:5102-7.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 5102-5107
    • Geiger, H.1    Rennebeck, G.2    Van Zant, G.3
  • 82
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell 2005;120:483-95.
    • (2005) Cell , vol.120 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 83
    • 79955373156 scopus 로고    scopus 로고
    • NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability
    • Pazhanisamy SK, Li H, Wang Y, et al. NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability. Mutagenesis 2011;26:431-5.
    • (2011) Mutagenesis , vol.26 , pp. 431-435
    • Pazhanisamy, S.K.1    Li, H.2    Wang, Y.3
  • 84
    • 84887904057 scopus 로고    scopus 로고
    • Molecular mechanisms and treatment of radiation-induced lung fibrosis
    • Ding NH, Li JJ, Sun LQ. Molecular mechanisms and treatment of radiation-induced lung fibrosis. Curr Drug Targets 2013;14:1347-56.
    • (2013) Curr Drug Targets , vol.14 , pp. 1347-1356
    • Ding, N.H.1    Li, J.J.2    Sun, L.Q.3
  • 85
    • 84871202369 scopus 로고    scopus 로고
    • The TGF-β co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney
    • Scharpfenecker M, Floot B, Russell NS, et al. The TGF-β co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney. Radiother Oncol 2012;105:313-20.
    • (2012) Radiother Oncol , vol.105 , pp. 313-320
    • Scharpfenecker, M.1    Floot, B.2    Russell, N.S.3
  • 86
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical Generation, oxidative stress, and aging
    • Cadenas E, Davies KJ. Mitochondrial free radical Generation, oxidative stress, and aging. Free Radic Biol Med 2000;29:222-30.
    • (2000) Free Radic Biol Med , vol.29 , pp. 222-230
    • Cadenas, E.1    Davies, K.J.2
  • 87
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001;81:807-69.
    • (2001) Physiol Rev , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 88
    • 69449088578 scopus 로고    scopus 로고
    • MAPK signaling pathways in the regulation of hematopoiesis
    • Geest CR, Coffer PJ. MAPK signaling pathways in the regulation of hematopoiesis. J Leukoc Biol 2009;86:237-50.
    • (2009) J Leukoc Biol , vol.86 , pp. 237-250
    • Geest, C.R.1    Coffer, P.J.2
  • 89
    • 0036242247 scopus 로고    scopus 로고
    • Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
    • Wang W, Chen JX, Liao R, et al. Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol 2002;22:3389-403.
    • (2002) Mol Cell Biol , vol.22 , pp. 3389-3403
    • Wang, W.1    Chen, J.X.2    Liao, R.3
  • 90
    • 0346463059 scopus 로고    scopus 로고
    • High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts
    • Deng Q, Liao R, Wu BL, et al. High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J Biol Chem 2004;279:1050-9.
    • (2004) J Biol Chem , vol.279 , pp. 1050-1059
    • Deng, Q.1    Liao, R.2    Wu, B.L.3
  • 91
    • 0345932931 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway
    • Iwasa H, Han J, Ishikawa F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 2003;8:131-44.
    • (2003) Genes Cells , vol.8 , pp. 131-144
    • Iwasa, H.1    Han, J.2    Ishikawa, F.3
  • 92
    • 0036731380 scopus 로고    scopus 로고
    • Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence
    • Haq R, Brenton JD, Takahashi M, et al. Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Res 2002;62:5076-82.
    • (2002) Cancer Res , vol.62 , pp. 5076-5082
    • Haq, R.1    Brenton, J.D.2    Takahashi, M.3
  • 93
    • 49349083531 scopus 로고    scopus 로고
    • Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling
    • Matsuzawa A, Ichijo H. Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling. Biochim Biophys Acta 2008;1780:1325-36.
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 1325-1336
    • Matsuzawa, A.1    Ichijo, H.2
  • 94
    • 33646469353 scopus 로고    scopus 로고
    • Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive Oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide
    • Chiang E, Dang O, Anderson K, et al. Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive Oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. J Immunol 2006;176:5720-4.
    • (2006) J Immunol , vol.176 , pp. 5720-5724
    • Chiang, E.1    Dang, O.2    Anderson, K.3
  • 95
    • 43049101029 scopus 로고    scopus 로고
    • Dual-specificity MAP kinase phosphatases (MKPs) and Cancer
    • Keyse SM. Dual-specificity MAP kinase phosphatases (MKPs) and Cancer. Cancer Metastasis Rev 2008;27:253-61.
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 253-261
    • Keyse, S.M.1
  • 96
    • 62149114138 scopus 로고    scopus 로고
    • Dual-specificity phosphatases: critical regulators with diverse cellular targets
    • Patterson KI, Brummer T, O'brien PM, et al. Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J 2009;418:475-89.
    • (2009) Biochem J , vol.418 , pp. 475-489
    • Patterson, K.I.1    Brummer, T.2    O'brien, P.M.3
  • 97
    • 80053513183 scopus 로고    scopus 로고
    • Regulation of protein tyrosine phosphatases by reversible oxidation
    • Ostman A, FrijhoffJ, Sandin A, et al. Regulation of protein tyrosine phosphatases by reversible oxidation. J Biochem 2011;150:345-56.
    • (2011) J Biochem , vol.150 , pp. 345-356
    • Ostman, A.1    Frijhoff, J.2    Sandin, A.3
  • 98
    • 33845474265 scopus 로고    scopus 로고
    • Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors
    • Navas TA, Mohindru M, Estes M, et al. Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood 2006;108:4170-7.
    • (2006) Blood , vol.108 , pp. 4170-4177
    • Navas, T.A.1    Mohindru, M.2    Estes, M.3
  • 99
    • 33947309693 scopus 로고    scopus 로고
    • p38 MAP kinase regulates stem cell apoptosis in human hematopoietic failure
    • Zhou L, Opalinska J, Verma A. p38 MAP kinase regulates stem cell apoptosis in human hematopoietic failure. Cell Cycle 2007;6:534-7.
    • (2007) Cell Cycle , vol.6 , pp. 534-537
    • Zhou, L.1    Opalinska, J.2    Verma, A.3
  • 100
    • 82055166871 scopus 로고    scopus 로고
    • Mitigation of ionizing radiation-induced bone marrow suppression by p38 inhibition and G-CSF administration
    • Li D, Wang Y, Wu H, et al. Mitigation of ionizing radiation-induced bone marrow suppression by p38 inhibition and G-CSF administration. J Radiat Res (Tokyo) 2011;52:712-6.
    • (2011) J Radiat Res (Tokyo) , vol.52 , pp. 712-716
    • Li, D.1    Wang, Y.2    Wu, H.3
  • 101
    • 82955239883 scopus 로고    scopus 로고
    • Inhibition of p38 MAPK attenuates ionizing radiation-induced hematopoietic cell senescence and residual bone marrow injury
    • Wang Y, Liu L, Zhou D. Inhibition of p38 MAPK attenuates ionizing radiation-induced hematopoietic cell senescence and residual bone marrow injury. Radiat Res 2011;176:743-52.
    • (2011) Radiat Res , vol.176 , pp. 743-752
    • Wang, Y.1    Liu, L.2    Zhou, D.3
  • 102
    • 84876973130 scopus 로고    scopus 로고
    • The effects of p38 MAPK inhibition combined with G-CSF administration on the hematoimmune system in mice with irradiation injury
    • Li D, Wang Y, Wu H, et al. The effects of p38 MAPK inhibition combined with G-CSF administration on the hematoimmune system in mice with irradiation injury. PLoS One 2013;8: e62921.
    • (2013) PLoS One , vol.8 , pp. e62921
    • Li, D.1    Wang, Y.2    Wu, H.3
  • 103
    • 0037309326 scopus 로고    scopus 로고
    • Tumor suppression by Ink4a-Arf: progress and puzzles
    • Lowe SW, Sherr CJ. Tumor suppression by Ink4a-Arf: progress and puzzles. Curr Opin Genet Dev 2003;13:77-83.
    • (2003) Curr Opin Genet Dev , vol.13 , pp. 77-83
    • Lowe, S.W.1    Sherr, C.J.2
  • 104
    • 0033037541 scopus 로고    scopus 로고
    • The INK4A/ARF locus and its two gene products
    • Sharpless NE, Depinho RA. The INK4A/ARF locus and its two gene products. Curr Opin Genet Dev 1999;9:22-30.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 22-30
    • Sharpless, N.E.1    Depinho, R.A.2
  • 105
    • 5444225413 scopus 로고    scopus 로고
    • Cell cycle inhibitors in normal and tumor stem cells
    • Cheng T. Cell cycle inhibitors in normal and tumor stem cells. Oncogene 2004;23:7256-66.
    • (2004) Oncogene , vol.23 , pp. 7256-7266
    • Cheng, T.1
  • 106
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • Narita M, Nũnez S, Heard E, et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003;113:703-16.
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1    Nũnez, S.2    Heard, E.3
  • 107
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
    • Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005;120:513-22.
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 108
    • 0032485213 scopus 로고    scopus 로고
    • Agents that cause DNA double Strand breaks Lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
    • Robles SJ, Adami GR. Agents that cause DNA double Strand breaks Lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 1998;16:1113-23.
    • (1998) Oncogene , vol.16 , pp. 1113-1123
    • Robles, S.J.1    Adami, G.R.2
  • 109
    • 0037086268 scopus 로고    scopus 로고
    • DNA damage is able to induce senescence in tumor cells in vitro and in vivo
    • te Poele RH, Okorokov AL, Jardine L, et al. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res 2002;62:1876-83.
    • (2002) Cancer Res , vol.62 , pp. 1876-1883
    • te Poele, R.H.1    Okorokov, A.L.2    Jardine, L.3
  • 110
    • 0041966056 scopus 로고    scopus 로고
    • Reversal of human cellular senescence: roles of the p53 and p16 pathways
    • Beauséjour CM, Krtolica A, Galimi F, et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 2003;22:4212-22.
    • (2003) EMBO J , vol.22 , pp. 4212-4222
    • Beauséjour, C.M.1    Krtolica, A.2    Galimi, F.3
  • 112
    • 0242667922 scopus 로고    scopus 로고
    • Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
    • Molofsky AV, Pardal R, Iwashita T, et al. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 2003;425:962-7.
    • (2003) Nature , vol.425 , pp. 962-967
    • Molofsky, A.V.1    Pardal, R.2    Iwashita, T.3
  • 113
    • 23044461852 scopus 로고    scopus 로고
    • A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress
    • Stepanova L, Sorrentino BP. A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress. Blood 2005;106:827-32.
    • (2005) Blood , vol.106 , pp. 827-832
    • Stepanova, L.1    Sorrentino, B.P.2
  • 114
    • 33749172559 scopus 로고    scopus 로고
    • Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
    • Janzen V, Forkert R, Fleming HE, et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 2006;443:421-6.
    • (2006) Nature , vol.443 , pp. 421-426
    • Janzen, V.1    Forkert, R.2    Fleming, H.E.3
  • 115
    • 84855607470 scopus 로고    scopus 로고
    • The ATM protein kinase and cellular redox signaling: beyond the DNA damage response
    • Ditch S, Paull TT. The ATM protein kinase and cellular redox signaling: beyond the DNA damage response. Trends Biochem Sci 2012;37:15-22.
    • (2012) Trends Biochem Sci , vol.37 , pp. 15-22
    • Ditch, S.1    Paull, T.T.2
  • 116
    • 84859829553 scopus 로고    scopus 로고
    • Reactive oxygen species in cancer stem cells
    • Shi X, Zhang Y, Zheng J, et al. Reactive oxygen species in cancer stem cells. Antioxid Redox Signal 2012;16:1215-28.
    • (2012) Antioxid Redox Signal , vol.16 , pp. 1215-1228
    • Shi, X.1    Zhang, Y.2    Zheng, J.3
  • 117
    • 0036012789 scopus 로고    scopus 로고
    • ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage
    • Barzilai A, Rotman G, Shiloh Y. ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage. DNA Repair (Amst) 2002;1:3-25.
    • (2002) DNA Repair (Amst) , vol.1 , pp. 3-25
    • Barzilai, A.1    Rotman, G.2    Shiloh, Y.3
  • 118
    • 33846130574 scopus 로고    scopus 로고
    • Bone-marrow derived hematopoietic stem/progenitor cells Express multiple isoforms of NADPH oxidase and produce constitutively reactive Oxygen species
    • Piccoli C, D'aprile A, Ripoli M, et al. Bone-marrow derived hematopoietic stem/progenitor cells Express multiple isoforms of NADPH oxidase and produce constitutively reactive Oxygen species. Biochem Biophys Res Commun 2007;353:965-72.
    • (2007) Biochem Biophys Res Commun , vol.353 , pp. 965-972
    • Piccoli, C.1    D'aprile, A.2    Ripoli, M.3
  • 119
    • 22544446192 scopus 로고    scopus 로고
    • Characterization of mitochondrial and extra-mitochondrial oxygen consuming reactions in human hematopoietic stem cells
    • Piccoli C, Ria R, Scrima R, et al. Characterization of mitochondrial and extra-mitochondrial oxygen consuming reactions in human hematopoietic stem cells. Novel evidence of the occurrence of NAD(P)H oxidase activity. J Biol Chem 2005;280:26467-76.
    • (2005) Novel evidence of the occurrence of NAD(P)H oxidase activity. J Biol Chem , vol.280 , pp. 26467-26476
    • Piccoli, C.1    Ria, R.2    Scrima, R.3
  • 120
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology
    • Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007;87:245-313.
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 121
    • 34347257042 scopus 로고    scopus 로고
    • Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy
    • Lambeth JD. Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic Biol Med 2007;43:332-47.
    • (2007) Free Radic Biol Med , vol.43 , pp. 332-347
    • Lambeth, J.D.1
  • 122
    • 84880770790 scopus 로고    scopus 로고
    • Role of reactive oxygen species in the radiation response of human hematopoietic stem/progenitor cells
    • Yamaguchi M, Kashiwakura I. Role of reactive oxygen species in the radiation response of human hematopoietic stem/progenitor cells. PLoS One 2013;8: e70503.
    • (2013) PLoS One , vol.8 , pp. e70503
    • Yamaguchi, M.1    Kashiwakura, I.2
  • 123
    • 34547850670 scopus 로고    scopus 로고
    • NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS Generation
    • Serrander L, Cartier L, Bedard K, et al. NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS Generation. Biochem J 2007;406:105-14.
    • (2007) Biochem J , vol.406 , pp. 105-114
    • Serrander, L.1    Cartier, L.2    Bedard, K.3
  • 124
    • 79551557991 scopus 로고    scopus 로고
    • TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells
    • Michaeloudes C, Sukkar MB, Khorasani NM, et al. TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2011;300: L295-304.
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.300 , pp. L295-304
    • Michaeloudes, C.1    Sukkar, M.B.2    Khorasani, N.M.3
  • 125
    • 48449102079 scopus 로고    scopus 로고
    • Positive regulation of the NADPH oxidase NOX4 promoter in vascular smooth muscle cells by E2F
    • Zhang L, Sheppard OR, Shah AM, et al. Positive regulation of the NADPH oxidase NOX4 promoter in vascular smooth muscle cells by E2F. Free Radic Biol Med 2008;45:679-85.
    • (2008) Free Radic Biol Med , vol.45 , pp. 679-685
    • Zhang, L.1    Sheppard, O.R.2    Shah, A.M.3
  • 126
    • 71749086712 scopus 로고    scopus 로고
    • Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and reactive Oxygen species production in caveolin-enriched microdomains of the endothelium
    • Singleton PA, Pendyala S, Gorshkova IA, et al. Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and reactive Oxygen species production in caveolin-enriched microdomains of the endothelium. J Biol Chem 2009;284:34964-75.
    • (2009) J Biol Chem , vol.284 , pp. 34964-34975
    • Singleton, P.A.1    Pendyala, S.2    Gorshkova, I.A.3
  • 127
    • 75149174337 scopus 로고    scopus 로고
    • NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts
    • Bondi CD, Manickam N, Lee DY, et al. NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts. J Am Soc Nephrol 2010;21:93-102.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 93-102
    • Bondi, C.D.1    Manickam, N.2    Lee, D.Y.3
  • 128
    • 33646593852 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive Oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells
    • Sturrock A, Cahill B, Norman K, et al. Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive Oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2006;290: L661-73.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290 , pp. L661-L673
    • Sturrock, A.1    Cahill, B.2    Norman, K.3
  • 129
    • 84860418582 scopus 로고    scopus 로고
    • Correlation of different NADPH oxidase homologues with late endothelial progenitor cell senescence induced by angiotensin II: effect of telmisartan
    • Li H, Liu Q, Wang N, et al. Correlation of different NADPH oxidase homologues with late endothelial progenitor cell senescence induced by angiotensin II: effect of telmisartan. Intern Med 2011;50:1631-42.
    • (2011) Intern Med , vol.50 , pp. 1631-1642
    • Li, H.1    Liu, Q.2    Wang, N.3
  • 130
    • 0038148216 scopus 로고    scopus 로고
    • Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells
    • Gorin Y, Ricono JM, Kim NH, et al. Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. Am J Physiol Renal Physiol 2003;285: F219-29.
    • (2003) Am J Physiol Renal Physiol , vol.285 , pp. F219-F229
    • Gorin, Y.1    Ricono, J.M.2    Kim, N.H.3
  • 131
    • 84885430473 scopus 로고    scopus 로고
    • ClC-3 deficiency prevents apoptosis induced by angiotensin II in endothelial progenitor cells via inhibition of NADPH oxidase
    • Liu J, Zhang FF, Li L, et al. ClC-3 deficiency prevents apoptosis induced by angiotensin II in endothelial progenitor cells via inhibition of NADPH oxidase. Apoptosis 2013;18:1262-73.
    • (2013) Apoptosis , vol.18 , pp. 1262-1273
    • Liu, J.1    Zhang, F.F.2    Li, L.3
  • 132
    • 84880802251 scopus 로고    scopus 로고
    • Pharmacological induction of transforming growth factor-beta1 in rat models enhances radiation injury in the intestine and the heart
    • Boerma M, Wang J, Sridharan V, et al. Pharmacological induction of transforming growth factor-beta1 in rat models enhances radiation injury in the intestine and the heart. PLoS One 2013;8: e70479.
    • (2013) PLoS One , vol.8 , pp. e70479
    • Boerma, M.1    Wang, J.2    Sridharan, V.3
  • 133
    • 84866082606 scopus 로고    scopus 로고
    • mTOR complex 1 plays critical roles in hematopoiesis and pten-loss-evoked leukemogenesis
    • Kalaitzidis D, Sykes SM, Wang Z, et al. mTOR complex 1 plays critical roles in hematopoiesis and pten-loss-evoked leukemogenesis. Cell Stem Cell 2012;11:429-39.
    • (2012) Cell Stem Cell , vol.11 , pp. 429-439
    • Kalaitzidis, D.1    Sykes, S.M.2    Wang, Z.3
  • 134
    • 78049496814 scopus 로고    scopus 로고
    • mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion
    • Lee JY, Nakada D, Yilmaz OH, et al. mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell 2010;7:593-605.
    • (2010) Cell Stem Cell , vol.7 , pp. 593-605
    • Lee, J.Y.1    Nakada, D.2    Yilmaz, O.H.3
  • 135
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • Yilmaz OH, Valdez R, Theisen BK, et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 2006;441:475-82.
    • (2006) Nature , vol.441 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3
  • 136
    • 33646351002 scopus 로고    scopus 로고
    • PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
    • Zhang J, Grindley JC, Yin T, et al. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 2006;441:518-22.
    • (2006) Nature , vol.441 , pp. 518-522
    • Zhang, J.1    Grindley, J.C.2    Yin, T.3
  • 137
    • 58049196780 scopus 로고    scopus 로고
    • mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization
    • Gan B, Sahin E, Jiang S, et al. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A 2008;105:19384-9.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19384-19389
    • Gan, B.1    Sahin, E.2    Jiang, S.3
  • 138
    • 78650302424 scopus 로고    scopus 로고
    • ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice
    • Yalcin S, Marinkovic D, Mungamuri SK, et al. ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. EMBO J 2010;29:4118-31.
    • (2010) EMBO J , vol.29 , pp. 4118-4131
    • Yalcin, S.1    Marinkovic, D.2    Mungamuri, S.K.3
  • 139
    • 77749233738 scopus 로고    scopus 로고
    • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
    • Alexander A, Cai SL, Kim J, et al. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A 2010;107:4153-8.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4153-4158
    • Alexander, A.1    Cai, S.L.2    Kim, J.3
  • 140
    • 79951936969 scopus 로고    scopus 로고
    • Reactive Oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes
    • Handayaningsih AE, Iguchi G, Fukuoka H, et al. Reactive Oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes. Endocrinology 2011;152:912-21.
    • (2011) Endocrinology , vol.152 , pp. 912-921
    • Handayaningsih, A.E.1    Iguchi, G.2    Fukuoka, H.3
  • 141
    • 84891689987 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury
    • Eid AA, Ford BM, Bhandary B, et al. Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury. Diabetes 2013;62:2935-47.
    • (2013) Diabetes , vol.62 , pp. 2935-2947
    • Eid, A.A.1    Ford, B.M.2    Bhandary, B.3
  • 142
    • 58049216350 scopus 로고    scopus 로고
    • Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2
    • Toschi A, Lee E, Gadir N, et al. Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J Biol Chem 2008;283:34495-9.
    • (2008) J Biol Chem , vol.283 , pp. 34495-34499
    • Toschi, A.1    Lee, E.2    Gadir, N.3
  • 143
    • 84871861969 scopus 로고    scopus 로고
    • PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
    • Finlay DK, Rosenzweig E, Sinclair LV, et al. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J Exp Med 2012;209:2441-53.
    • (2012) J Exp Med , vol.209 , pp. 2441-2453
    • Finlay, D.K.1    Rosenzweig, E.2    Sinclair, L.V.3
  • 144
    • 77953518507 scopus 로고    scopus 로고
    • The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1
    • Diebold I, Petry A, Hess J, et al. The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1. Mol Biol Cell 2010;21:2087-96.
    • (2010) Mol Biol Cell , vol.21 , pp. 2087-2096
    • Diebold, I.1    Petry, A.2    Hess, J.3
  • 145
    • 34247187576 scopus 로고    scopus 로고
    • Reactive Oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site
    • Bonello S, Zähringer C, Belaiba RS, et al. Reactive Oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site. Arterioscler Thromb Vasc Biol 2007;27:755-61.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 755-761
    • Bonello, S.1    Zähringer, C.2    Belaiba, R.S.3
  • 146
    • 77950563135 scopus 로고    scopus 로고
    • Irradiation selects for p53-deficient hematopoietic progenitors
    • Marusyk A, Porter CC, Zaberezhnyy V, et al. Irradiation selects for p53-deficient hematopoietic progenitors. PLoS Biol 2010;8: e1000324.
    • (2010) PLoS Biol , vol.8 , pp. e1000324
    • Marusyk, A.1    Porter, C.C.2    Zaberezhnyy, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.