Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation

Experimental Hematology

Volumn 38, Issue 12, 2010, Pages 1231-1240

  Shima, Haruko ^a   Takubo, Keiyo ^a   Tago, Naoko ^a   Iwasaki, Hiroko ^a   Arai, Fumio ^a   Takahashi, Takao ^a   Suda, Toshio ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CELL PROTEIN; CYCLIN C; INTERLEUKIN 2 RECEPTOR GAMMA; PROTEIN P107; RNA; UNCLASSIFIED DRUG; FLT3 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; BONE MARROW TRANSPLANTATION; CANCER STEM CELL; CELL CYCLE G0 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL HYPOXIA; CONTROLLED STUDY; CORD BLOOD STEM CELL; ENGRAFTMENT; FEMALE; GRAFT RECIPIENT; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; ANIMAL; CYTOLOGY; FETUS BLOOD; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN;

MUS;

ANIMALS; ANTIGENS, CD34; ANTIGENS, CD38; BONE MARROW TRANSPLANTATION; FEMALE; FETAL BLOOD; FMS-LIKE TYROSINE KINASE 3; G0 PHASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE;

EID: 78549254160     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2010.08.004     Document Type: Article

References (48)

1. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood 1993, 81:2844-2853.
2. Passegué E., Wagers A.J. Regulating quiescence: new insights into hematopoietic stem cell biology. Dev Cell 2006, 10:415-417.
3. Jetmore A., Plett P.A., Tong X., et al. Homing efficiency, cell cycle kinetics, and survival of quiescent human CD34+ cells transplanted into conditioned NOD/SCID recipients. Blood 2002, 99:1585-1593.
4. Plett P.A., Frankovitz S.M., Orschell-Traycoff C.M. In vivo trafficking, cell cycle activity, and engraftment potential of phenotypically defined primitive hematopoietic cells after transplantation into irradiated or nonirradiated recipients. Blood 2002, 100:3545-3552.
5. Avigdor A., Goichberg P., Shivtiel S., et al. CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood 2004, 103:2981-2989.
6. Broxmeyer H.E., Orschell C.M., Clapp D.W., et al. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med 2005, 201:1307-1318.
7. Parmar K., Mauch P., Vergilio J.A., Sackstein R., Down J.D. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci U S A 2007, 104:5431-5436.
8. Shima H., Takubo K., Iwasaki H., et al. Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice. Biochem Biophys Res Commun 2009, 378:467-472.
9. Lévesque J.P., Winkler I.G., Hendy J., et al. Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow. Stem Cells 2007, 25:1954-1965.
10. Suda T., Arai F., Hirao A. Hematopoietic stem cells and their niche. Trends Immunol 2005, 26:426-433.
11. Jang Y.Y., Sharkis S.J. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 2007, 110:3056-3063.
12. Ito M., Kobayashi K., Nakahata T. NOD/Shi-scid IL2rgamma (null) (NOG) mice more appropriate for humanized mouse models. Curr Top Microbiol Immunol 2008, 324:53-76.
13. Shultz L.D., Lyons B.L., Burzenski L.M., et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 2005, 174:6477-6489.
14. Arai F., Hirao A., Ohmura M., et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 2004, 118:149-161.
15. Kiel M.J., Morrison S.J. Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol 2008, 8:290-301.
16. Kubota Y., Takubo K., Suda T. Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochem Biophys Res Commun 2008, 366:335-339.
17. Ito K., Hirao A., Arai F., et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004, 431:997-1002.
18. Kopp H.G., Avecilla S.T., Hooper A.T., Rafii S. The bone marrow vascular niche: home of HSC differentiation and mobilization. Physiology 2005, 20:349-356.
19. Fliedner T.M., Graessle D., Paulsen C., Reimers K. Structure and function of bone marrow hemopoiesis: mechanisms of response to ionizing radiation exposure. Cancer Biother Radiopharm 2002, 17:405-426.
20. Shirota T., Tavassoli M. Cyclophosphamide-induced alterations of bone marrow endothelium: implications in homing of marrow cells after transplantation. Exp Hematol 1991, 19:369-373.
21. Hooper A.T., Butler J.M., Nolan D.J., et al. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell 2009, 4:263-274.
22. Dao M.A., Creer M.H., Nolta J.A., Verfaillie C.M. Biology of umbilical cord blood progenitors in bone marrow niches. Blood 2007, 110:74-81.
23. Eliasson P., Jönsson J.I. The hematopoietic stem cell niche: low in oxygen but a nice place to be. J Cell Physiol 2010, 222:17-22.
24. Koshiji M., Kageyama Y., Pete E.A., Horikawa I., Barrett J.C., Huang L.E. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J 2004, 23:1949-1956.
25. Passegué E., Wagers A.J., Giuriato S., Anderson W.C., Weissman I.L. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med 2005, 202:1599-1611.
26. Kip2 is expressed in quiescent mouse bone marrow side population cells. Biochem Biophys Res Commun 2005, 337:14-21.
27. Sage J. Cyclin C makes an entry into the cell cycle. Dev Cell 2004, 6:607-608.
28. Miyata Y., Liu Y., Jankovic V., et al. Cyclin C regulates human hematopoietic stem/progenitor cell quiescence. Stem Cells 2010, 28:308-317.
29. Takahashi Y., Rayman J.B., Dynlacht B.D. Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev 2000, 14:804-816.
30. Helin K. Regulation of cell proliferation by the E2F transcription factors. Curr Opin Genet Dev 1998, 8:28-35.
31. Huang L.E., Arany Z., Livingston D.M., Bunn H.F. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 1996, 271:32253-32259.
32. Kallio P.J., Pongratz I., Gradin K., McGuire J., Poellinger L. Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc Natl Acad Sci U S A 1997, 94:5667-5672.
33. Uchida T., Rossignol F., Matthay M.A., et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem 2004, 279:14871-14878.
34. Webster K.A. Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia. J Exp Biol 2003, 206:2911-2922.
35. Adolfsson J., Borge O.J., Bryder D., et al. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 2001, 15:659-669.
36. Christensen J.L., Weissman I.L. Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells. Proc Natl Acad Sci U S A 2001, 98:14541-14546.
37. Sitnicka E., Buza-Vidas N., Larsson S. Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells. Blood 2003, 102:881-886.
38. Kikushige Y., Yoshimoto G., Miyamoto T., et al. Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival. J Immunol 2008, 180:7358-7367.
39. Rusten L.S., Lyman S.D., Veiby O.P., Jacobsen S.E. The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro. Blood 1996, 87:1317-1325.
40. Namikawa R., Muench M.O., Firpo M.T., et al. Administration of Flk2/Flt3 ligand induces expansion of human high-proliferative potential colony-forming cells in the SCID-hu mouse. Exp Hematol 1999, 27:1029-1037.
41. Petzer A.L., Zandstra P.W., Piret J.M., Eaves C.J. Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin. J Exp Med 1996, 183:2551-2558.
42. Weisel K.C., Yildirim S., Schweikle E., Kanz L., Möhle R. Regulation of FLT3 and its ligand in normal hematopoietic progenitor cells. Ann Hematol 2009, 88:203-211.
43. Shah A.J., Smogorzewska E.M., Hannum C., Crooks G.M. Flt3 ligand induces proliferation of quiescent human bone marrow CD34+CD38- cells and maintains progenitor cells in vitro. Blood 1996, 87:3563-3570.
44. Yoshimoto G., Miyamoto T., Jabbarzadeh-Tabrizi, et al. FLT3-ITD upregulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. Blood 2009, 114:5034-5043.
45. Wilson A., Laurenti E., Oser G., et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 2008, 135:1118-1129.
46. Majeti R., Park C.Y., Weissman I.L. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 2007, 1:635-645.
47. + cord blood cells transplanted into NOD/SCID mice. Proc Natl Acad Sci U S A 2002, 99:413-418.
48. Bhatia M., Wang J.C., Kapp U., Bonnet D., Dick J.E. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci U S A 1997, 94:5320-5325.