메뉴 건너뛰기




Volumn 66, Issue 1, 2006, Pages 9-16

Oligonucleotide IMT504 induces an immunogenic phenotype and apoptosis in chronic lymphocytic leukemia cells

Author keywords

Chronic lymphocytic leukemia; IL 2; Immunogenic phenotype; Immunostimulatory ODN; VH genes mutation

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; IMMUNOGLOBULIN; INTERLEUKIN 2 RECEPTOR ALPHA; OLIGODEOXYNUCLEOTIDE; RECOMBINANT INTERLEUKIN 2;

EID: 33645125512     PISSN: 00257680     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (11)

References (40)
  • 1
    • 0032532668 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
    • Fais F, Ghiotto F, Hashimoto S, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998; 102: 1515-25.
    • (1998) J Clin Invest , vol.102 , pp. 1515-1525
    • Fais, F.1    Ghiotto, F.2    Hashimoto, S.3
  • 2
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848-54.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 3
    • 0029133158 scopus 로고
    • Role of accessory cells in cytokine production by T cells in chronic B-cell lymphocytic leukemia
    • Decker T, Flohr T, Trautmann P, et al. Role of accessory cells in cytokine production by T cells in chronic B-cell lymphocytic leukemia. Blood 1995; 86: 1115-21
    • (1995) Blood , vol.86 , pp. 1115-1121
    • Decker, T.1    Flohr, T.2    Trautmann, P.3
  • 4
    • 0028927836 scopus 로고
    • Failure of B cells of chronic lymphocytic leukemia in presenting soluble and alloantigens
    • Dazzi F, D'Andrea E, Biasi G, et al. Failure of B cells of chronic lymphocytic leukemia in presenting soluble and alloantigens. Clin Immunol Immunopathol 1995; 75: 26-32.
    • (1995) Clin Immunol Immunopathol , vol.75 , pp. 26-32
    • Dazzi, F.1    D'Andrea, E.2    Biasi, G.3
  • 5
    • 0027499535 scopus 로고
    • Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal
    • Ranheim EA, Kipps TJ. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med 1993; 177: 925-35.
    • (1993) J Exp Med , vol.177 , pp. 925-935
    • Ranheim, E.A.1    Kipps, T.J.2
  • 6
    • 0030989818 scopus 로고    scopus 로고
    • CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules
    • Van den Hove LE, Van Gool SW, Vandenberghe P, et al. CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules. Leukemia. 1997; 11: 572-80.
    • (1997) Leukemia , vol.11 , pp. 572-580
    • Van den Hove, L.E.1    Van Gool, S.W.2    Vandenberghe, P.3
  • 7
    • 0032032524 scopus 로고    scopus 로고
    • Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells
    • Kato K, Cantwell MJ, Sharma S, Kipps TJ. Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells. J Clin Invest 1998; 101: 1133-41.
    • (1998) J Clin Invest , vol.101 , pp. 1133-1141
    • Kato, K.1    Cantwell, M.J.2    Sharma, S.3    Kipps, T.J.4
  • 8
    • 0034329352 scopus 로고    scopus 로고
    • CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia
    • Wierda WG, Cantwell MJ, Woods SJ, et al. CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia, Blood 2000; 96: 2917-24.
    • (2000) Blood , vol.96 , pp. 2917-2924
    • Wierda, W.G.1    Cantwell, M.J.2    Woods, S.J.3
  • 9
    • 0034141541 scopus 로고    scopus 로고
    • Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells
    • Decker T, Schneller F, Sparwasser T, et al. Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood 2000; 95: 999-1006.
    • (2000) Blood , vol.95 , pp. 999-1006
    • Decker, T.1    Schneller, F.2    Sparwasser, T.3
  • 10
    • 0035155134 scopus 로고    scopus 로고
    • CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens
    • Jahrsdorfer B, Hartmann G, Racila E, et al. CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens. J Leukoc Biol 2001; 69: 81-8.
    • (2001) J Leukoc Biol , vol.69 , pp. 81-88
    • Jahrsdorfer, B.1    Hartmann, G.2    Racila, E.3
  • 11
    • 0034018567 scopus 로고    scopus 로고
    • Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: Costimulation with IL-2 results in a highly immunogenic phenotype
    • Decker T, Scneller F, Kronschnabl M, et al. Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: Costimulation with IL-2 results in a highly immunogenic phenotype. Exp Hematol 2000; 28: 558-68.
    • (2000) Exp Hematol , vol.28 , pp. 558-568
    • Decker, T.1    Scneller, F.2    Kronschnabl, M.3
  • 12
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • Krieg AM, Yi AK, Matson S, et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995; 374: 546-9.
    • (1995) Nature , vol.374 , pp. 546-549
    • Krieg, A.M.1    Yi, A.K.2    Matson, S.3
  • 13
    • 0035865228 scopus 로고    scopus 로고
    • Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c- type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN
    • Kadowaki N, Antonenko S, Liu YJ. Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c- type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN. J Immunol 2001; 166: 2291-5.
    • (2001) J Immunol , vol.166 , pp. 2291-2295
    • Kadowaki, N.1    Antonenko, S.2    Liu, Y.J.3
  • 14
    • 0034933019 scopus 로고    scopus 로고
    • Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells
    • Krug A, Rothenfusser S, Hornung V, et al. Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol 2001; 31: 2154-63.
    • (2001) Eur J Immunol , vol.31 , pp. 2154-2163
    • Krug, A.1    Rothenfusser, S.2    Hornung, V.3
  • 15
    • 0034777579 scopus 로고    scopus 로고
    • Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
    • Krug A, Towarowski A, Britsch S, et al. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol 2001; 31: 3026-37.
    • (2001) Eur J Immunol , vol.31 , pp. 3026-3037
    • Krug, A.1    Towarowski, A.2    Britsch, S.3
  • 16
    • 0034650517 scopus 로고    scopus 로고
    • Mechanism and function of a newly identified CpG DNA motif in human primary B cells
    • Hartmann G, Krieg AM. Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J Immunol 2000; 164: 944-53.
    • (2000) J Immunol , vol.164 , pp. 944-953
    • Hartmann, G.1    Krieg, A.M.2
  • 17
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • Sparwasser T, Koch ES, Vabulas RM, et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 1998; 28: 2045-54.
    • (1998) Eur J Immunol , vol.28 , pp. 2045-2054
    • Sparwasser, T.1    Koch, E.S.2    Vabulas, R.M.3
  • 18
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas ZK, Rasmussen WL, Krieg AM. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 1996; 157: 1840-5.
    • (1996) J Immunol , vol.157 , pp. 1840-1845
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 19
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V, Rothenfusser S, Britsch S, et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002; 168: 4531-7.
    • (2002) J Immunol , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3
  • 20
    • 0030850462 scopus 로고    scopus 로고
    • CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
    • Lipford GB, Bauer M, Blank C, et al. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur J Immunol 1997; 27: 2340-4.
    • (1997) Eur J Immunol , vol.27 , pp. 2340-2344
    • Lipford, G.B.1    Bauer, M.2    Blank, C.3
  • 21
    • 0030613651 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
    • Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 1997; 186: 1623-31.
    • (1997) J Exp Med , vol.186 , pp. 1623-1631
    • Chu, R.S.1    Targoni, O.S.2    Krieg, A.M.3    Lehmann, P.V.4    Harding, C.V.5
  • 22
    • 0031800888 scopus 로고    scopus 로고
    • CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
    • Moldoveanu Z, Love-Homan L, Huang WQ, Krieg AM. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine 1998; 16: 1216-24.
    • (1998) Vaccine , vol.16 , pp. 1216-1224
    • Moldoveanu, Z.1    Love-Homan, L.2    Huang, W.Q.3    Krieg, A.M.4
  • 23
    • 0031964257 scopus 로고    scopus 로고
    • CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
    • Davis HL, Weeratna R, Waldschmidt TJ, et al. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J Immunol 1998; 160: 870-6.
    • (1998) J Immunol , vol.160 , pp. 870-876
    • Davis, H.L.1    Weeratna, R.2    Waldschmidt, T.J.3
  • 24
    • 0033997899 scopus 로고    scopus 로고
    • CpG DNA induces stronger immune responses with less toxicity than other adjuvants
    • Weeratna RD, McCluskie MJ, Xu Y, Davis HL. CpG DNA induces stronger immune responses with less toxicity than other adjuvants. Vaccine 2000; 18: 1755-62.
    • (2000) Vaccine , vol.18 , pp. 1755-1762
    • Weeratna, R.D.1    McCluskie, M.J.2    Xu, Y.3    Davis, H.L.4
  • 25
    • 0032521274 scopus 로고    scopus 로고
    • Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
    • Kline JN Waldschmidt TJ, Businga TR, et al. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol 1998; 160: 2555-9.
    • (1998) J Immunol , vol.160 , pp. 2555-2559
    • Kline, J.N.1    Waldschmidt, T.J.2    Businga, T.R.3
  • 26
    • 0033938275 scopus 로고    scopus 로고
    • Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis
    • Magone MT, Chan CC, Beck L, Whitcup SM, Raz E. Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis. Eur J Immunol 2000; 30: 1841-50.
    • (2000) Eur J Immunol , vol.30 , pp. 1841-1850
    • Magone, M.T.1    Chan, C.C.2    Beck, L.3    Whitcup, S.M.4    Raz, E.5
  • 27
    • 0030900680 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma
    • Wooldridge JE, Ballas Z, Krieg AM, Weiner GJ. Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. Blood 1997; 89: 2994-98.
    • (1997) Blood , vol.89 , pp. 2994-2998
    • Wooldridge, J.E.1    Ballas, Z.2    Krieg, A.M.3    Weiner, G.J.4
  • 28
    • 0033230505 scopus 로고    scopus 로고
    • Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastorna in mice
    • Carpentier AF, Chen L, Maltonti F, Delattre JY. Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastorna in mice. Cancer Res 1999; 59: 5429-32.
    • (1999) Cancer Res , vol.59 , pp. 5429-5432
    • Carpentier, A.F.1    Chen, L.2    Maltonti, F.3    Delattre, J.Y.4
  • 29
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002; 20: 709-60.
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 30
    • 0141886170 scopus 로고    scopus 로고
    • Strong cytosine-guanosine-independent immunostimulation in humans and other primates by synthetic oligodeoxynucleotides with PyNTTTTGT motifs
    • Elias F, Flo J, Lopez RA, et al. Strong cytosine-guanosine-independent immunostimulation in humans and other primates by synthetic oligodeoxynucleotides with PyNTTTTGT motifs. J Immunol 2003; 171: 3697-3704.
    • (2003) J Immunol , vol.171 , pp. 3697-3704
    • Elias, F.1    Flo, J.2    Lopez, R.A.3
  • 31
    • 0028822481 scopus 로고
    • Chronic lymphocytic leukemia
    • Rozman C, Montserrat E. Chronic lymphocytic leukemia. N Engl J Med 1995; 333: 1052-7.
    • (1995) N Engl J Med , vol.333 , pp. 1052-1057
    • Rozman, C.1    Montserrat, E.2
  • 32
    • 0029943190 scopus 로고    scopus 로고
    • Mantle cell lymphomaan entity comes of age
    • Weisenburger DD, Armitage JO. Mantle cell lymphomaan entity comes of age. Blood 1996; 87: 4483-94.
    • (1996) Blood , vol.87 , pp. 4483-4494
    • Weisenburger, D.D.1    Armitage, J.O.2
  • 33
    • 0030779512 scopus 로고    scopus 로고
    • Age-related changes of naive and memory CD4 rat lymphocyte subsets in mucosal and systemic lymphoid organs
    • Flo J, Massouh E. Age-related changes of naive and memory CD4 rat lymphocyte subsets in mucosal and systemic lymphoid organs. Dev Comp Immunol 1997; 21: 443-53.
    • (1997) Dev Comp Immunol , vol.21 , pp. 443-453
    • Flo, J.1    Massouh, E.2
  • 34
    • 0028986982 scopus 로고
    • The human immunoglobulin VH repertoire
    • Cook GP, Tomlinson IM. The human immunoglobulin VH repertoire. Immunol Today 1995; 16: 237-42.
    • (1995) Immunol Today , vol.16 , pp. 237-242
    • Cook, G.P.1    Tomlinson, I.M.2
  • 35
    • 0027932998 scopus 로고
    • The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement
    • Chang B, Casali P. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol Today 1994; 15: 367-73.
    • (1994) Immunol Today , vol.15 , pp. 367-373
    • Chang, B.1    Casali, P.2
  • 36
    • 0033560068 scopus 로고    scopus 로고
    • CD40-activated B-Cell chronic lymphocytic leukemia cells for tumor immunotherapy: Stimulation of allogeneic versus autologous T cells generate different types of effector cells
    • Buhmann R, Nolte A, Westhaus D, Emmerich B, Hallek M. CD40-activated B-Cell chronic lymphocytic leukemia cells for tumor immunotherapy: stimulation of allogeneic versus autologous T cells generate different types of effector cells. Blood 1999; 93: 1992-2002.
    • (1999) Blood , vol.93 , pp. 1992-2002
    • Buhmann, R.1    Nolte, A.2    Westhaus, D.3    Emmerich, B.4    Hallek, M.5
  • 37
    • 0024556599 scopus 로고
    • Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukemia cells following their culture in vitro
    • Collins RJ, Verschuer LA, Harmon BV, et al. Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukemia cells following their culture in vitro. Br J Haematol 1989; 71: 343-50.
    • (1989) Br J Haematol , vol.71 , pp. 343-350
    • Collins, R.J.1    Verschuer, L.A.2    Harmon, B.V.3
  • 38
    • 0026026426 scopus 로고
    • Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells
    • McConkey DJ, Aguilar-Santelises M, Hartzell P, et al. Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells. J Immunol 1991; 146: 1072-6.
    • (1991) J Immunol , vol.146 , pp. 1072-1076
    • McConkey, D.J.1    Aguilar-Santelises, M.2    Hartzell, P.3
  • 39
    • 0033406341 scopus 로고    scopus 로고
    • CpG DNA rescues B cells from apoptosis by activating NFkappaB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway
    • Yi AK, Peckham DW, Ashman RF, Krieg AM. CpG DNA rescues B cells from apoptosis by activating NFkappaB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway. Int Immunol 1999; 11: 2015-24.
    • (1999) Int Immunol , vol.11 , pp. 2015-2024
    • Yi, A.K.1    Peckham, D.W.2    Ashman, R.F.3    Krieg, A.M.4
  • 40
    • 0031572208 scopus 로고    scopus 로고
    • Unmethylated CpG motifs protect murine B lymphocytes against Fas-mediated apoptosis
    • Wang Z, Karras JG, Colarusso TP, Foote LC, Rothstein TL. Unmethylated CpG motifs protect murine B lymphocytes against Fas-mediated apoptosis. Cell Immunol 1997; 180: 162-7.
    • (1997) Cell Immunol , vol.180 , pp. 162-167
    • Wang, Z.1    Karras, J.G.2    Colarusso, T.P.3    Foote, L.C.4    Rothstein, T.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.