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Volumn 91, Issue , 2016, Pages 188-200

AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation

Author keywords

AMPK; Cardiac fibrosis; Cardiac metabolism; Cardiac remodeling; Hypertrophy; Ischemia

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ADENYLATE KINASE; ADIPONECTIN; ADRENERGIC RECEPTOR; BERBERINE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METFORMIN; RESVERATROL; TRANSFORMING GROWTH FACTOR BETA; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; RIBONUCLEOTIDE; SCLEROPROTEIN; STILBENE DERIVATIVE;

EID: 84961319891     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2016.01.001     Document Type: Review
Times cited : (106)

References (202)
  • 1
    • 0015918822 scopus 로고
    • Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation
    • Carlson C.A., Kim K.H. Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation. J. Biol. Chem. 1973, 248:378-380.
    • (1973) J. Biol. Chem. , vol.248 , pp. 378-380
    • Carlson, C.A.1    Kim, K.H.2
  • 2
    • 79955442316 scopus 로고    scopus 로고
    • AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure
    • Beauloye C., Bertrand L., Horman S., Hue L. AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure. Cardiovasc. Res. 2011, 90:224-233.
    • (2011) Cardiovasc. Res. , vol.90 , pp. 224-233
    • Beauloye, C.1    Bertrand, L.2    Horman, S.3    Hue, L.4
  • 3
    • 84869220736 scopus 로고    scopus 로고
    • Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase
    • Park C.S., Bang B.R., Kwon H.S., Moon K.A., Kim T.B., Lee K.Y., et al. Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase. Biochem. Pharmacol. 2012, 84:1660-1670.
    • (2012) Biochem. Pharmacol. , vol.84 , pp. 1660-1670
    • Park, C.S.1    Bang, B.R.2    Kwon, H.S.3    Moon, K.A.4    Kim, T.B.5    Lee, K.Y.6
  • 4
    • 84922255495 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis
    • Kim H., Moon S.Y., Kim J.S., Baek C.H., Kim M., Min J.Y., et al. Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis. Am. J. Physiol. Ren. Physiol. 2015, 308:F226-F236.
    • (2015) Am. J. Physiol. Ren. Physiol. , vol.308 , pp. F226-F236
    • Kim, H.1    Moon, S.Y.2    Kim, J.S.3    Baek, C.H.4    Kim, M.5    Min, J.Y.6
  • 5
    • 84155184239 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits TGF-beta-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300
    • Lim J.Y., Oh M.A., Kim W.H., Sohn H.Y., Park S.I. AMP-activated protein kinase inhibits TGF-beta-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300. J. Cell. Physiol. 2012, 227:1081-1089.
    • (2012) J. Cell. Physiol. , vol.227 , pp. 1081-1089
    • Lim, J.Y.1    Oh, M.A.2    Kim, W.H.3    Sohn, H.Y.4    Park, S.I.5
  • 6
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn T.A. Cellular and molecular mechanisms of fibrosis. J. Pathol. 2008, 214:199-210.
    • (2008) J. Pathol. , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 7
    • 84935515540 scopus 로고    scopus 로고
    • Fibrosis-a common pathway to organ injury and failure
    • Rockey D.C., Bell P.D., Hill J.A. Fibrosis-a common pathway to organ injury and failure. N. Engl. J. Med. 2015, 373:96.
    • (2015) N. Engl. J. Med. , vol.373 , pp. 96
    • Rockey, D.C.1    Bell, P.D.2    Hill, J.A.3
  • 8
    • 73349122017 scopus 로고    scopus 로고
    • Cardiac fibroblast: the renaissance cell
    • Souders C.A., Bowers S.L., Baudino T.A. Cardiac fibroblast: the renaissance cell. Circ. Res. 2009, 105:1164-1176.
    • (2009) Circ. Res. , vol.105 , pp. 1164-1176
    • Souders, C.A.1    Bowers, S.L.2    Baudino, T.A.3
  • 9
    • 11144346203 scopus 로고    scopus 로고
    • Structural and functional characterisation of cardiac fibroblasts
    • Camelliti P., Borg T.K., Kohl P. Structural and functional characterisation of cardiac fibroblasts. Cardiovasc. Res. 2005, 65:40-51.
    • (2005) Cardiovasc. Res. , vol.65 , pp. 40-51
    • Camelliti, P.1    Borg, T.K.2    Kohl, P.3
  • 10
    • 84896781804 scopus 로고    scopus 로고
    • Myocardial extracellular matrix: an ever-changing and diverse entity
    • Rienks M., Papageorgiou A.P., Frangogiannis N.G., Heymans S. Myocardial extracellular matrix: an ever-changing and diverse entity. Circ. Res. 2014, 114:872-888.
    • (2014) Circ. Res. , vol.114 , pp. 872-888
    • Rienks, M.1    Papageorgiou, A.P.2    Frangogiannis, N.G.3    Heymans, S.4
  • 13
    • 84902765162 scopus 로고    scopus 로고
    • Incremental prognostic value of myocardial fibrosis in patients with non-ischemic cardiomyopathy without congestive heart failure
    • Masci P.G., Doulaptsis C., Bertella E., Del Torto A., Symons R., Pontone G., et al. Incremental prognostic value of myocardial fibrosis in patients with non-ischemic cardiomyopathy without congestive heart failure. Circ. Heart Fail. 2014, 7:448-456.
    • (2014) Circ. Heart Fail. , vol.7 , pp. 448-456
    • Masci, P.G.1    Doulaptsis, C.2    Bertella, E.3    Del Torto, A.4    Symons, R.5    Pontone, G.6
  • 14
    • 84898657013 scopus 로고    scopus 로고
    • Cardiac (myo)fibroblast: novel strategies for its targeting following myocardial infarction
    • Daskalopoulos E.P., Hermans K.C., Blankesteijn W.M. Cardiac (myo)fibroblast: novel strategies for its targeting following myocardial infarction. Curr. Pharm. Des. 2014, 20:1987-2002.
    • (2014) Curr. Pharm. Des. , vol.20 , pp. 1987-2002
    • Daskalopoulos, E.P.1    Hermans, K.C.2    Blankesteijn, W.M.3
  • 15
    • 77955173404 scopus 로고    scopus 로고
    • Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction
    • Small E.M., Thatcher J.E., Sutherland L.B., Kinoshita H., Gerard R.D., Richardson J.A., et al. Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Circ. Res. 2010, 107:294-304.
    • (2010) Circ. Res. , vol.107 , pp. 294-304
    • Small, E.M.1    Thatcher, J.E.2    Sutherland, L.B.3    Kinoshita, H.4    Gerard, R.D.5    Richardson, J.A.6
  • 16
    • 0025783599 scopus 로고
    • Cardiac myofibroblasts express alpha smooth muscle actin during right ventricular pressure overload in the rabbit
    • Leslie K.O., Taatjes D.J., J S., M vT., RB L. Cardiac myofibroblasts express alpha smooth muscle actin during right ventricular pressure overload in the rabbit. Am. J. Pathol. 1991, 139:207-216.
    • (1991) Am. J. Pathol. , vol.139 , pp. 207-216
    • Leslie, K.O.1    Taatjes, D.J.2    J, S.3    M, V.4    RB, L.5
  • 17
    • 84875209318 scopus 로고    scopus 로고
    • Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts
    • Fowlkes V., Clark J., Fix C., Law B.A., Morales M.O., Qiao X., et al. Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts. Life Sci. 2013, 92:669-676.
    • (2013) Life Sci. , vol.92 , pp. 669-676
    • Fowlkes, V.1    Clark, J.2    Fix, C.3    Law, B.A.4    Morales, M.O.5    Qiao, X.6
  • 19
    • 84877064608 scopus 로고
    • Macrophages and fibrosis: how resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair
    • Lech M., Anders H.J. Macrophages and fibrosis: how resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair. Biochim. Biophys. Acta 1832, 2013:989-997.
    • (1832) Biochim. Biophys. Acta , vol.2013 , pp. 989-997
    • Lech, M.1    Anders, H.J.2
  • 20
    • 84940728384 scopus 로고    scopus 로고
    • M2 macrophage accumulation in the aortic wall during angiotensin II infusion in mice is associated with fibrosis, elastin loss and elevated blood pressure
    • (ajpheart 00821 2014)
    • Moore J.P., Vinh A., Tuck K.L., Sakkal S., Krishnan S.M., Chan C.T., et al. M2 macrophage accumulation in the aortic wall during angiotensin II infusion in mice is associated with fibrosis, elastin loss and elevated blood pressure. Am. J. Physiol. Heart Circ. Physiol. 2015, (ajpheart 00821 2014).
    • (2015) Am. J. Physiol. Heart Circ. Physiol.
    • Moore, J.P.1    Vinh, A.2    Tuck, K.L.3    Sakkal, S.4    Krishnan, S.M.5    Chan, C.T.6
  • 21
    • 84907485564 scopus 로고    scopus 로고
    • Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction
    • Shivshankar P., Halade G.V., Calhoun C., Escobar G.P., Mehr A.J., Jimenez F., et al. Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction. J. Mol. Cell. Cardiol. 2014, 76:84-93.
    • (2014) J. Mol. Cell. Cardiol. , vol.76 , pp. 84-93
    • Shivshankar, P.1    Halade, G.V.2    Calhoun, C.3    Escobar, G.P.4    Mehr, A.J.5    Jimenez, F.6
  • 22
    • 84908398089 scopus 로고    scopus 로고
    • RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis
    • Lauriol J., Keith K., Jaffre F., Couvillon A., Saci A., Goonasekera S.A., et al. RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis. Sci. Signal. 2014, 7:ra100.
    • (2014) Sci. Signal. , vol.7 , pp. ra100
    • Lauriol, J.1    Keith, K.2    Jaffre, F.3    Couvillon, A.4    Saci, A.5    Goonasekera, S.A.6
  • 23
    • 85004000488 scopus 로고    scopus 로고
    • Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice
    • Gogiraju R., Xu X., Bochenek M.L., Steinbrecher J.H., Lehnart S.E., Wenzel P., et al. Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice. J. Am. Heart Assoc. 2015, 4.
    • (2015) J. Am. Heart Assoc. , vol.4
    • Gogiraju, R.1    Xu, X.2    Bochenek, M.L.3    Steinbrecher, J.H.4    Lehnart, S.E.5    Wenzel, P.6
  • 24
    • 77950572303 scopus 로고    scopus 로고
    • Bone marrow-derived cells contribute to fibrosis in the chronically failing heart
    • Chu P.Y., Mariani J., Finch S., McMullen J.R., Sadoshima J., Marshall T., et al. Bone marrow-derived cells contribute to fibrosis in the chronically failing heart. Am. J. Pathol. 2010, 176:1735-1742.
    • (2010) Am. J. Pathol. , vol.176 , pp. 1735-1742
    • Chu, P.Y.1    Mariani, J.2    Finch, S.3    McMullen, J.R.4    Sadoshima, J.5    Marshall, T.6
  • 25
    • 74949085470 scopus 로고    scopus 로고
    • Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts
    • Liao C.H., Akazawa H., Tamagawa M., Ito K., Yasuda N., Kudo Y., et al. Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts. J. Clin. Invest. 2010, 120:242-253.
    • (2010) J. Clin. Invest. , vol.120 , pp. 242-253
    • Liao, C.H.1    Akazawa, H.2    Tamagawa, M.3    Ito, K.4    Yasuda, N.5    Kudo, Y.6
  • 27
    • 0141653901 scopus 로고    scopus 로고
    • Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?
    • Jugdutt B.I. Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?. Circulation 2003, 108:1395-1403.
    • (2003) Circulation , vol.108 , pp. 1395-1403
    • Jugdutt, B.I.1
  • 29
    • 1642542477 scopus 로고    scopus 로고
    • From inflammation to fibrosis: a stiff stretch of highway
    • Weber K.T. From inflammation to fibrosis: a stiff stretch of highway. Hypertension 2004, 43:716-719.
    • (2004) Hypertension , vol.43 , pp. 716-719
    • Weber, K.T.1
  • 30
    • 0037370168 scopus 로고    scopus 로고
    • Cross-linking influences the impact of quantitative changes in myocardial collagen on cardiac stiffness and remodelling in hypertension in rats
    • Badenhorst D., Maseko M., Tsotetsi O.J., Naidoo A., Brooksbank R., Norton G.R., et al. Cross-linking influences the impact of quantitative changes in myocardial collagen on cardiac stiffness and remodelling in hypertension in rats. Cardiovasc. Res. 2003, 57:632-641.
    • (2003) Cardiovasc. Res. , vol.57 , pp. 632-641
    • Badenhorst, D.1    Maseko, M.2    Tsotetsi, O.J.3    Naidoo, A.4    Brooksbank, R.5    Norton, G.R.6
  • 31
    • 84927173044 scopus 로고    scopus 로고
    • Osteoglycin prevents cardiac dilatation and dysfunction after myocardial infarction through infarct collagen strengthening
    • Van Aelst L.N., Voss S., Carai P., Van Leeuwen R., Vanhoutte D., Sanders-van Wijk S., et al. Osteoglycin prevents cardiac dilatation and dysfunction after myocardial infarction through infarct collagen strengthening. Circ. Res. 2015, 116:425-436.
    • (2015) Circ. Res. , vol.116 , pp. 425-436
    • Van Aelst, L.N.1    Voss, S.2    Carai, P.3    Van Leeuwen, R.4    Vanhoutte, D.5    Sanders-van Wijk, S.6
  • 32
    • 35748974863 scopus 로고    scopus 로고
    • Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function
    • Spinale F.G. Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol. Rev. 2007, 87:1285-1342.
    • (2007) Physiol. Rev. , vol.87 , pp. 1285-1342
    • Spinale, F.G.1
  • 33
    • 46149083476 scopus 로고    scopus 로고
    • Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy
    • Van Linthout S., Seeland U., Riad A., Eckhardt O., Hohl M., Dhayat N., et al. Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy. Basic Res. Cardiol. 2008, 103:319-327.
    • (2008) Basic Res. Cardiol. , vol.103 , pp. 319-327
    • Van Linthout, S.1    Seeland, U.2    Riad, A.3    Eckhardt, O.4    Hohl, M.5    Dhayat, N.6
  • 34
    • 84869389745 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 deletion attenuates myocardial fibrosis and diastolic dysfunction in ageing mice
    • Chiao Y.A., Ramirez T.A., Zamilpa R., Okoronkwo S.M., Dai Q., Zhang J., et al. Matrix metalloproteinase-9 deletion attenuates myocardial fibrosis and diastolic dysfunction in ageing mice. Cardiovasc. Res. 2012, 96:444-455.
    • (2012) Cardiovasc. Res. , vol.96 , pp. 444-455
    • Chiao, Y.A.1    Ramirez, T.A.2    Zamilpa, R.3    Okoronkwo, S.M.4    Dai, Q.5    Zhang, J.6
  • 35
    • 84904337178 scopus 로고    scopus 로고
    • Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction
    • Fan D., Takawale A., Basu R., Patel V., Lee J., Kandalam V., et al. Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction. Cardiovasc. Res. 2014, 103:268-280.
    • (2014) Cardiovasc. Res. , vol.103 , pp. 268-280
    • Fan, D.1    Takawale, A.2    Basu, R.3    Patel, V.4    Lee, J.5    Kandalam, V.6
  • 38
    • 84864814469 scopus 로고    scopus 로고
    • Embryonic expression of AMPK gamma subunits and the identification of a novel gamma2 transcript variant in adult heart
    • Pinter K., Grignani R.T., Czibik G., Farza H., Watkins H., Redwood C. Embryonic expression of AMPK gamma subunits and the identification of a novel gamma2 transcript variant in adult heart. J. Mol. Cell. Cardiol. 2012, 53:342-349.
    • (2012) J. Mol. Cell. Cardiol. , vol.53 , pp. 342-349
    • Pinter, K.1    Grignani, R.T.2    Czibik, G.3    Farza, H.4    Watkins, H.5    Redwood, C.6
  • 39
    • 79956298543 scopus 로고    scopus 로고
    • A small molecule AMPK activator protects the heart against ischemia-reperfusion injury
    • Kim A.S., Miller E.J., Wright T.M., Li J., Qi D., Atsina K., et al. A small molecule AMPK activator protects the heart against ischemia-reperfusion injury. J. Mol. Cell. Cardiol. 2011, 51:24-32.
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , pp. 24-32
    • Kim, A.S.1    Miller, E.J.2    Wright, T.M.3    Li, J.4    Qi, D.5    Atsina, K.6
  • 41
    • 84900800420 scopus 로고    scopus 로고
    • AMPK: regulating energy balance at the cellular and whole body levels
    • Hardie D.G., Ashford M.L. AMPK: regulating energy balance at the cellular and whole body levels. Physiology (Bethesda) 2014, 29:99-107.
    • (2014) Physiology (Bethesda) , vol.29 , pp. 99-107
    • Hardie, D.G.1    Ashford, M.L.2
  • 42
    • 84885168009 scopus 로고    scopus 로고
    • AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation
    • Gowans G.J., Hawley S.A., Ross F.A., Hardie D.G. AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. Cell Metab. 2013, 18:556-566.
    • (2013) Cell Metab. , vol.18 , pp. 556-566
    • Gowans, G.J.1    Hawley, S.A.2    Ross, F.A.3    Hardie, D.G.4
  • 43
    • 84905472350 scopus 로고    scopus 로고
    • The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury
    • Qi D., Atsina K., Qu L., Hu X., Wu X., Xu B., et al. The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury. J. Clin. Invest. 2014, 124:3540-3550.
    • (2014) J. Clin. Invest. , vol.124 , pp. 3540-3550
    • Qi, D.1    Atsina, K.2    Qu, L.3    Hu, X.4    Wu, X.5    Xu, B.6
  • 44
    • 33751229931 scopus 로고    scopus 로고
    • A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
    • Xie M., Zhang D., Dyck J.R., Li Y., Zhang H., Morishima M., et al. A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:17378-17383.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 17378-17383
    • Xie, M.1    Zhang, D.2    Dyck, J.R.3    Li, Y.4    Zhang, H.5    Morishima, M.6
  • 45
    • 33646828975 scopus 로고    scopus 로고
    • Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491
    • Horman S., Vertommen D., Heath R., Neumann D., Mouton V., Woods A., et al. Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J. Biol. Chem. 2006, 281:5335-5340.
    • (2006) J. Biol. Chem. , vol.281 , pp. 5335-5340
    • Horman, S.1    Vertommen, D.2    Heath, R.3    Neumann, D.4    Mouton, V.5    Woods, A.6
  • 46
    • 84863012559 scopus 로고    scopus 로고
    • Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK
    • Lin Y.Y., Kiihl S., Suhail Y., Liu S.Y., Chou Y.H., Kuang Z., et al. Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Nature 2012, 482:251-255.
    • (2012) Nature , vol.482 , pp. 251-255
    • Lin, Y.Y.1    Kiihl, S.2    Suhail, Y.3    Liu, S.Y.4    Chou, Y.H.5    Kuang, Z.6
  • 47
    • 84893432818 scopus 로고    scopus 로고
    • A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation
    • Shao D., Oka S., Liu T., Zhai P., Ago T., Sciarretta S., et al. A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation. Cell Metab. 2014, 19:232-245.
    • (2014) Cell Metab. , vol.19 , pp. 232-245
    • Shao, D.1    Oka, S.2    Liu, T.3    Zhai, P.4    Ago, T.5    Sciarretta, S.6
  • 48
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: a nutrient and energy sensor that maintains energy homeostasis
    • Hardie D.G., Ross F.A., Hawley S.A. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 2012, 13:251-262.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 50
    • 84904556335 scopus 로고    scopus 로고
    • Mechanism of action of compound-13: an alpha1-selective small molecule activator of AMPK
    • Hunter R.W., Foretz M., Bultot L., Fullerton M.D., Deak M., Ross F.A., et al. Mechanism of action of compound-13: an alpha1-selective small molecule activator of AMPK. Chem. Biol. 2014, 21:866-879.
    • (2014) Chem. Biol. , vol.21 , pp. 866-879
    • Hunter, R.W.1    Foretz, M.2    Bultot, L.3    Fullerton, M.D.4    Deak, M.5    Ross, F.A.6
  • 51
    • 77956410464 scopus 로고    scopus 로고
    • Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
    • Hawley S.A., Ross F.A., Chevtzoff C., Green K.A., Evans A., Fogarty S., et al. Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab. 2010, 11:554-565.
    • (2010) Cell Metab. , vol.11 , pp. 554-565
    • Hawley, S.A.1    Ross, F.A.2    Chevtzoff, C.3    Green, K.A.4    Evans, A.5    Fogarty, S.6
  • 52
    • 50549090117 scopus 로고    scopus 로고
    • Alpha1-adrenergic receptors activate AMP-activated protein kinase in rat hearts
    • Xu M., Zhao Y.T., Song Y., Hao T.P., Lu Z.Z., Han Q.D., et al. Alpha1-adrenergic receptors activate AMP-activated protein kinase in rat hearts. Sheng Li Xue Bao 2007, 59:175-182.
    • (2007) Sheng Li Xue Bao , vol.59 , pp. 175-182
    • Xu, M.1    Zhao, Y.T.2    Song, Y.3    Hao, T.P.4    Lu, Z.Z.5    Han, Q.D.6
  • 54
    • 66949116367 scopus 로고    scopus 로고
    • AMP-activated protein kinase influences metabolic remodeling in H9c2 cells hypertrophied by arginine vasopressin
    • Saeedi R., Saran V.V., Wu S.S., Kume E.S., Paulson K., Chan A.P., et al. AMP-activated protein kinase influences metabolic remodeling in H9c2 cells hypertrophied by arginine vasopressin. Am. J. Physiol. Heart Circ. Physiol. 2009, 296:H1822-H1832.
    • (2009) Am. J. Physiol. Heart Circ. Physiol. , vol.296 , pp. H1822-H1832
    • Saeedi, R.1    Saran, V.V.2    Wu, S.S.3    Kume, E.S.4    Paulson, K.5    Chan, A.P.6
  • 55
    • 49649085586 scopus 로고    scopus 로고
    • AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase
    • Horman S., Morel N., Vertommen D., Hussain N., Neumann D., Beauloye C., et al. AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase. J. Biol. Chem. 2008, 283:18505-18512.
    • (2008) J. Biol. Chem. , vol.283 , pp. 18505-18512
    • Horman, S.1    Morel, N.2    Vertommen, D.3    Hussain, N.4    Neumann, D.5    Beauloye, C.6
  • 56
    • 27144457438 scopus 로고    scopus 로고
    • Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
    • Shibata R., Sato K., Pimentel D.R., Takemura Y., Kihara S., Ohashi K., et al. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat. Med. 2005, 11:1096-1103.
    • (2005) Nat. Med. , vol.11 , pp. 1096-1103
    • Shibata, R.1    Sato, K.2    Pimentel, D.R.3    Takemura, Y.4    Kihara, S.5    Ohashi, K.6
  • 57
    • 84929416512 scopus 로고    scopus 로고
    • C1q/tumor necrosis factor-related protein 9 protects against acute myocardial injury through an adiponectin receptor I-AMPK-dependent mechanism
    • Kambara T., Shibata R., Ohashi K., Matsuo K., Hiramatsu-Ito M., Enomoto T., et al. C1q/tumor necrosis factor-related protein 9 protects against acute myocardial injury through an adiponectin receptor I-AMPK-dependent mechanism. Mol. Cell. Biol. 2015, 35:2173-2185.
    • (2015) Mol. Cell. Biol. , vol.35 , pp. 2173-2185
    • Kambara, T.1    Shibata, R.2    Ohashi, K.3    Matsuo, K.4    Hiramatsu-Ito, M.5    Enomoto, T.6
  • 58
    • 84902602873 scopus 로고    scopus 로고
    • Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms
    • Kataoka Y., Shibata R., Ohashi K., Kambara T., Enomoto T., Uemura Y., et al. Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms. J. Am. Coll. Cardiol. 2014, 63:2722-2733.
    • (2014) J. Am. Coll. Cardiol. , vol.63 , pp. 2722-2733
    • Kataoka, Y.1    Shibata, R.2    Ohashi, K.3    Kambara, T.4    Enomoto, T.5    Uemura, Y.6
  • 59
    • 84885035437 scopus 로고    scopus 로고
    • Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart
    • Li J., Qi D., Cheng H., Hu X., Miller E.J., Wu X., et al. Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:16133-16138.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 16133-16138
    • Li, J.1    Qi, D.2    Cheng, H.3    Hu, X.4    Miller, E.J.5    Wu, X.6
  • 60
    • 38749137749 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart
    • Miller E.J., Li J., Leng L., McDonald C., Atsumi T., Bucala R., et al. Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature 2008, 451:578-582.
    • (2008) Nature , vol.451 , pp. 578-582
    • Miller, E.J.1    Li, J.2    Leng, L.3    McDonald, C.4    Atsumi, T.5    Bucala, R.6
  • 61
    • 84866994436 scopus 로고    scopus 로고
    • Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models
    • Ogura Y., Ouchi N., Ohashi K., Shibata R., Kataoka Y., Kambara T., et al. Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models. Circulation 2012, 126:1728-1738.
    • (2012) Circulation , vol.126 , pp. 1728-1738
    • Ogura, Y.1    Ouchi, N.2    Ohashi, K.3    Shibata, R.4    Kataoka, Y.5    Kambara, T.6
  • 62
  • 63
    • 34147168105 scopus 로고    scopus 로고
    • Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and beclin 1 in mediating autophagy
    • Matsui Y., Takagi H., Qu X., Abdellatif M., Sakoda H., Asano T., et al. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and beclin 1 in mediating autophagy. Circ. Res. 2007, 100:914-922.
    • (2007) Circ. Res. , vol.100 , pp. 914-922
    • Matsui, Y.1    Takagi, H.2    Qu, X.3    Abdellatif, M.4    Sakoda, H.5    Asano, T.6
  • 65
    • 27144489669 scopus 로고    scopus 로고
    • AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress
    • Terai K., Hiramoto Y., Masaki M., Sugiyama S., Kuroda T., Hori M., et al. AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Mol. Cell. Biol. 2005, 25:9554-9575.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 9554-9575
    • Terai, K.1    Hiramoto, Y.2    Masaki, M.3    Sugiyama, S.4    Kuroda, T.5    Hori, M.6
  • 66
    • 84858983392 scopus 로고    scopus 로고
    • Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
    • Song P., Zou M.H. Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems. Free Radic. Biol. Med. 2012, 52:1607-1619.
    • (2012) Free Radic. Biol. Med. , vol.52 , pp. 1607-1619
    • Song, P.1    Zou, M.H.2
  • 68
    • 84906227277 scopus 로고    scopus 로고
    • AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation
    • Zordoky B.N., Nagendran J., Pulinilkunnil T., Kienesberger P.C., Masson G., Waller T.J., et al. AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation. Circ. Res. 2014, 115:518-524.
    • (2014) Circ. Res. , vol.115 , pp. 518-524
    • Zordoky, B.N.1    Nagendran, J.2    Pulinilkunnil, T.3    Kienesberger, P.C.4    Masson, G.5    Waller, T.J.6
  • 69
    • 78149279712 scopus 로고    scopus 로고
    • AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
    • Russell R.R., Li J., Coven D.L., Pypaert M., Zechner C., Palmeri M., et al. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J. Clin. Invest. 2004, 114:495-503.
    • (2004) J. Clin. Invest. , vol.114 , pp. 495-503
    • Russell, R.R.1    Li, J.2    Coven, D.L.3    Pypaert, M.4    Zechner, C.5    Palmeri, M.6
  • 70
    • 61949363051 scopus 로고    scopus 로고
    • AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin
    • Wang Y., Gao E., Tao L., Lau W.B., Yuan Y., Goldstein B.J., et al. AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin. Circulation 2009, 119:835-844.
    • (2009) Circulation , vol.119 , pp. 835-844
    • Wang, Y.1    Gao, E.2    Tao, L.3    Lau, W.B.4    Yuan, Y.5    Goldstein, B.J.6
  • 71
  • 72
    • 84904758023 scopus 로고    scopus 로고
    • Reduced scar maturation and contractility lead to exaggerated left ventricular dilation after myocardial infarction in mice lacking AMPKalpha1
    • Noppe G., Dufeys C., Buchlin P., Marquet N., Castanares-Zapatero D., Balteau M., et al. Reduced scar maturation and contractility lead to exaggerated left ventricular dilation after myocardial infarction in mice lacking AMPKalpha1. J. Mol. Cell. Cardiol. 2014, 74:32-43.
    • (2014) J. Mol. Cell. Cardiol. , vol.74 , pp. 32-43
    • Noppe, G.1    Dufeys, C.2    Buchlin, P.3    Marquet, N.4    Castanares-Zapatero, D.5    Balteau, M.6
  • 73
    • 0002537440 scopus 로고    scopus 로고
    • Cardiac hypertrophy: the good, the bad, and the ugly
    • Frey N., Olson E.N. Cardiac hypertrophy: the good, the bad, and the ugly. Annu. Rev. Physiol. 2003, 65:45-79.
    • (2003) Annu. Rev. Physiol. , vol.65 , pp. 45-79
    • Frey, N.1    Olson, E.N.2
  • 75
    • 0035797839 scopus 로고    scopus 로고
    • Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy
    • Tian R., Musi N., D'Agostino J., Hirshman M.F., Goodyear L.J. Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy. Circulation 2001, 104:1664-1669.
    • (2001) Circulation , vol.104 , pp. 1664-1669
    • Tian, R.1    Musi, N.2    D'Agostino, J.3    Hirshman, M.F.4    Goodyear, L.J.5
  • 76
    • 33947574510 scopus 로고    scopus 로고
    • Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy
    • Li H.L., Yin R., Chen D., Liu D., Wang D., Yang Q., et al. Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy. J. Cell. Biochem. 2007, 100:1086-1099.
    • (2007) J. Cell. Biochem. , vol.100 , pp. 1086-1099
    • Li, H.L.1    Yin, R.2    Chen, D.3    Liu, D.4    Wang, D.5    Yang, Q.6
  • 77
    • 55949114398 scopus 로고    scopus 로고
    • AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice
    • Zhang P., Hu X., Xu X., Fassett J., Zhu G., Viollet B., et al. AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice. Hypertension 2008, 52:918-924.
    • (2008) Hypertension , vol.52 , pp. 918-924
    • Zhang, P.1    Hu, X.2    Xu, X.3    Fassett, J.4    Zhu, G.5    Viollet, B.6
  • 78
    • 84872224969 scopus 로고    scopus 로고
    • 3,3'-Diindolylmethane protects against cardiac hypertrophy via 5'-adenosine monophosphate-activated protein kinase-alpha2
    • Zong J., Deng W., Zhou H., Bian Z.Y., Dai J., Yuan Y., et al. 3,3'-Diindolylmethane protects against cardiac hypertrophy via 5'-adenosine monophosphate-activated protein kinase-alpha2. PLoS ONE 2013, 8.
    • (2013) PLoS ONE , vol.8
    • Zong, J.1    Deng, W.2    Zhou, H.3    Bian, Z.Y.4    Dai, J.5    Yuan, Y.6
  • 79
    • 84935121882 scopus 로고    scopus 로고
    • Cardiac fibrosis alleviated by exercise training is AMPK-dependent
    • Ma X., Fu Y., Xiao H., Song Y., Chen R., Shen J., et al. Cardiac fibrosis alleviated by exercise training is AMPK-dependent. PLoS ONE 2015, 10.
    • (2015) PLoS ONE , vol.10
    • Ma, X.1    Fu, Y.2    Xiao, H.3    Song, Y.4    Chen, R.5    Shen, J.6
  • 80
    • 84921387454 scopus 로고    scopus 로고
    • AMP-activated protein kinase alpha1 regulates cardiac gap junction protein connexin 43 and electrical remodeling following pressure overload
    • Alesutan I., Voelkl J., Stockigt F., Mia S., Feger M., Primessnig U., et al. AMP-activated protein kinase alpha1 regulates cardiac gap junction protein connexin 43 and electrical remodeling following pressure overload. Cell. Physiol. Biochem. 2015, 35:406-418.
    • (2015) Cell. Physiol. Biochem. , vol.35 , pp. 406-418
    • Alesutan, I.1    Voelkl, J.2    Stockigt, F.3    Mia, S.4    Feger, M.5    Primessnig, U.6
  • 81
    • 84919967502 scopus 로고    scopus 로고
    • Murine models of diastolic dysfunction and heart failure with preserved ejection fraction
    • Horgan S., Watson C., Glezeva N., Baugh J. Murine models of diastolic dysfunction and heart failure with preserved ejection fraction. J. Card. Fail. 2014, 20:984-995.
    • (2014) J. Card. Fail. , vol.20 , pp. 984-995
    • Horgan, S.1    Watson, C.2    Glezeva, N.3    Baugh, J.4
  • 82
    • 0041707843 scopus 로고    scopus 로고
    • Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase
    • Xing Y., Musi N., Fujii N., Zou L., Luptak I., Hirshman M.F., et al. Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase. J. Biol. Chem. 2003, 278:28372-28377.
    • (2003) J. Biol. Chem. , vol.278 , pp. 28372-28377
    • Xing, Y.1    Musi, N.2    Fujii, N.3    Zou, L.4    Luptak, I.5    Hirshman, M.F.6
  • 83
    • 84938861015 scopus 로고    scopus 로고
    • AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism
    • Sung M.M., Zordoky B.N., Bujak A.L., Lally J.S., Fung D., Young M.E., et al. AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism. Cardiovasc. Res. 2015, 107:235-245.
    • (2015) Cardiovasc. Res. , vol.107 , pp. 235-245
    • Sung, M.M.1    Zordoky, B.N.2    Bujak, A.L.3    Lally, J.S.4    Fung, D.5    Young, M.E.6
  • 84
    • 84879092835 scopus 로고    scopus 로고
    • Pioglitazone ameliorates systolic and diastolic cardiac dysfunction in rat model of angiotensin II-induced hypertension
    • Sakamoto A., Hongo M., Furuta K., Saito K., Nagai R., Ishizaka N. Pioglitazone ameliorates systolic and diastolic cardiac dysfunction in rat model of angiotensin II-induced hypertension. Int. J. Cardiol. 2013, 167:409-415.
    • (2013) Int. J. Cardiol. , vol.167 , pp. 409-415
    • Sakamoto, A.1    Hongo, M.2    Furuta, K.3    Saito, K.4    Nagai, R.5    Ishizaka, N.6
  • 85
    • 51549114941 scopus 로고    scopus 로고
    • Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt
    • Kato M.F., Shibata R., Obata K., Miyachi M., Yazawa H., Tsuboi K., et al. Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt. J. Hypertens. 2008, 26:1669-1676.
    • (2008) J. Hypertens. , vol.26 , pp. 1669-1676
    • Kato, M.F.1    Shibata, R.2    Obata, K.3    Miyachi, M.4    Yazawa, H.5    Tsuboi, K.6
  • 86
    • 84925030847 scopus 로고    scopus 로고
    • Resveratrol treatment of mice with pressure-overload-induced heart failure improves diastolic function and cardiac energy metabolism
    • Sung M.M., Das S.K., Levasseur J., Byrne N.J., Fung D., Kim T.T., et al. Resveratrol treatment of mice with pressure-overload-induced heart failure improves diastolic function and cardiac energy metabolism. Circ. Heart Fail. 2015, 8:128-137.
    • (2015) Circ. Heart Fail. , vol.8 , pp. 128-137
    • Sung, M.M.1    Das, S.K.2    Levasseur, J.3    Byrne, N.J.4    Fung, D.5    Kim, T.T.6
  • 87
    • 84920643340 scopus 로고    scopus 로고
    • Effects of pioglitazone on cardiac and adipose tissue pathology in rats with metabolic syndrome
    • Matsuura N., Asano C., Nagasawa K., Ito S., Sano Y., Minagawa Y., et al. Effects of pioglitazone on cardiac and adipose tissue pathology in rats with metabolic syndrome. Int. J. Cardiol. 2015, 179:360-369.
    • (2015) Int. J. Cardiol. , vol.179 , pp. 360-369
    • Matsuura, N.1    Asano, C.2    Nagasawa, K.3    Ito, S.4    Sano, Y.5    Minagawa, Y.6
  • 88
    • 84879358476 scopus 로고    scopus 로고
    • HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome
    • Hermida N., Markl A., Hamelet J., Van Assche T., Vanderper A., Herijgers P., et al. HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome. Cardiovasc. Res. 2013, 99:44-54.
    • (2013) Cardiovasc. Res. , vol.99 , pp. 44-54
    • Hermida, N.1    Markl, A.2    Hamelet, J.3    Van Assche, T.4    Vanderper, A.5    Herijgers, P.6
  • 89
    • 84881523187 scopus 로고    scopus 로고
    • AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction
    • Cieslik K.A., Taffet G.E., Crawford J.R., Trial J., Mejia Osuna P., Entman M.L. AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction. J. Mol. Cell. Cardiol. 2013, 63:26-36.
    • (2013) J. Mol. Cell. Cardiol. , vol.63 , pp. 26-36
    • Cieslik, K.A.1    Taffet, G.E.2    Crawford, J.R.3    Trial, J.4    Mejia Osuna, P.5    Entman, M.L.6
  • 90
    • 77957170282 scopus 로고    scopus 로고
    • Metformin is associated with improved left ventricular diastolic function measured by tissue Doppler imaging in patients with diabetes
    • Andersson C., Sogaard P., Hoffmann S., Hansen P.R., Vaag A., Major-Pedersen A., et al. Metformin is associated with improved left ventricular diastolic function measured by tissue Doppler imaging in patients with diabetes. Eur. J. Endocrinol. 2010, 163:593-599.
    • (2010) Eur. J. Endocrinol. , vol.163 , pp. 593-599
    • Andersson, C.1    Sogaard, P.2    Hoffmann, S.3    Hansen, P.R.4    Vaag, A.5    Major-Pedersen, A.6
  • 91
    • 0035199792 scopus 로고    scopus 로고
    • Pioglitazone improves left ventricular diastolic function and decreases collagen accumulation in prediabetic stage of a type II diabetic rat
    • Tsuji T., Mizushige K., Noma T., Murakami K., Ohmori K., Miyatake A., et al. Pioglitazone improves left ventricular diastolic function and decreases collagen accumulation in prediabetic stage of a type II diabetic rat. J. Cardiovasc. Pharmacol. 2001, 38:868-874.
    • (2001) J. Cardiovasc. Pharmacol. , vol.38 , pp. 868-874
    • Tsuji, T.1    Mizushige, K.2    Noma, T.3    Murakami, K.4    Ohmori, K.5    Miyatake, A.6
  • 92
    • 3342967512 scopus 로고    scopus 로고
    • Is the failing heart energy starved? On using chemical energy to support cardiac function
    • Ingwall J.S., Weiss R.G. Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ. Res. 2004, 95:135-145.
    • (2004) Circ. Res. , vol.95 , pp. 135-145
    • Ingwall, J.S.1    Weiss, R.G.2
  • 93
    • 84920596800 scopus 로고    scopus 로고
    • Is AMPK the savior of the failing heart?
    • Kim T.T., Dyck J.R. Is AMPK the savior of the failing heart?. Trends Endocrinol. Metab. 2015, 26:40-48.
    • (2015) Trends Endocrinol. Metab. , vol.26 , pp. 40-48
    • Kim, T.T.1    Dyck, J.R.2
  • 95
    • 84862568080 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment
    • Falcao-Pires I., Leite-Moreira A.F. Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment. Heart Fail. Rev. 2012, 17:325-344.
    • (2012) Heart Fail. Rev. , vol.17 , pp. 325-344
    • Falcao-Pires, I.1    Leite-Moreira, A.F.2
  • 96
    • 84866287052 scopus 로고    scopus 로고
    • Alpha-lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima fatty rats
    • Lee J.E., Yi C.O., Jeon B.T., Shin H.J., Kim S.K., Jung T.S., et al. Alpha-lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima fatty rats. Cardiovasc. Diabetol. 2012, 11:111.
    • (2012) Cardiovasc. Diabetol. , vol.11 , pp. 111
    • Lee, J.E.1    Yi, C.O.2    Jeon, B.T.3    Shin, H.J.4    Kim, S.K.5    Jung, T.S.6
  • 97
    • 84875450015 scopus 로고    scopus 로고
    • Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes
    • He C., Zhu H., Li H., Zou M.H., Xie Z. Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes. Diabetes 2013, 62:1270-1281.
    • (2013) Diabetes , vol.62 , pp. 1270-1281
    • He, C.1    Zhu, H.2    Li, H.3    Zou, M.H.4    Xie, Z.5
  • 98
    • 84897445541 scopus 로고    scopus 로고
    • Hypertension is a conditional factor for the development of cardiac hypertrophy in type 2 diabetic mice
    • van Bilsen M., Daniels A., Brouwers O., Janssen B.J., Derks W.J., Brouns A.E., et al. Hypertension is a conditional factor for the development of cardiac hypertrophy in type 2 diabetic mice. PLoS ONE 2014, 9.
    • (2014) PLoS ONE , vol.9
    • van Bilsen, M.1    Daniels, A.2    Brouwers, O.3    Janssen, B.J.4    Derks, W.J.5    Brouns, A.E.6
  • 99
    • 82955249843 scopus 로고    scopus 로고
    • Aging-associated cardiovascular changes and their relationship to heart failure
    • Strait J.B., Lakatta E.G. Aging-associated cardiovascular changes and their relationship to heart failure. Heart Fail. Clin. 2012, 8:143-164.
    • (2012) Heart Fail. Clin. , vol.8 , pp. 143-164
    • Strait, J.B.1    Lakatta, E.G.2
  • 100
    • 84898790765 scopus 로고    scopus 로고
    • Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function
    • Zhang Y., Mi S.L., Hu N., Doser T.A., Sun A., Ge J., et al. Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function. Free Radic. Biol. Med. 2014, 71:208-220.
    • (2014) Free Radic. Biol. Med. , vol.71 , pp. 208-220
    • Zhang, Y.1    Mi, S.L.2    Hu, N.3    Doser, T.A.4    Sun, A.5    Ge, J.6
  • 102
    • 80052819014 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-beta signaling in cardiac remodeling
    • Dobaczewski M., Chen W., Frangogiannis N.G. Transforming growth factor (TGF)-beta signaling in cardiac remodeling. J. Mol. Cell. Cardiol. 2011, 51:600-606.
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , pp. 600-606
    • Dobaczewski, M.1    Chen, W.2    Frangogiannis, N.G.3
  • 103
    • 0027212686 scopus 로고
    • Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
    • Desmouliere A., Geinoz A., Gabbiani F., Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J. Cell Biol. 1993, 122:103-111.
    • (1993) J. Cell Biol. , vol.122 , pp. 103-111
    • Desmouliere, A.1    Geinoz, A.2    Gabbiani, F.3    Gabbiani, G.4
  • 104
    • 44849096242 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation
    • Mishra R., Cool B.L., Laderoute K.R., Foretz M., Viollet B., Simonson M.S. AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation. J. Biol. Chem. 2008, 283:10461-10469.
    • (2008) J. Biol. Chem. , vol.283 , pp. 10461-10469
    • Mishra, R.1    Cool, B.L.2    Laderoute, K.R.3    Foretz, M.4    Viollet, B.5    Simonson, M.S.6
  • 105
    • 84948579774 scopus 로고    scopus 로고
    • CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation
    • Wu D., Lei H., Wang J.Y., Zhang C.L., Feng H., Fu F.Y., et al. CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation. J. Mol. Med. (Berl) 2015.
    • (2015) J. Mol. Med. (Berl)
    • Wu, D.1    Lei, H.2    Wang, J.Y.3    Zhang, C.L.4    Feng, H.5    Fu, F.Y.6
  • 106
    • 0025675680 scopus 로고
    • Remodeling of the rat right and left ventricles in experimental hypertension
    • Brilla C.G., Pick R., Tan L.B., Janicki J.S., Weber K.T. Remodeling of the rat right and left ventricles in experimental hypertension. Circ. Res. 1990, 67:1355-1364.
    • (1990) Circ. Res. , vol.67 , pp. 1355-1364
    • Brilla, C.G.1    Pick, R.2    Tan, L.B.3    Janicki, J.S.4    Weber, K.T.5
  • 107
    • 0028275578 scopus 로고
    • Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone
    • Brilla C.G., Zhou G., Matsubara L., Weber K.T. Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone. J. Mol. Cell. Cardiol. 1994, 26:809-820.
    • (1994) J. Mol. Cell. Cardiol. , vol.26 , pp. 809-820
    • Brilla, C.G.1    Zhou, G.2    Matsubara, L.3    Weber, K.T.4
  • 108
    • 84897959639 scopus 로고    scopus 로고
    • Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria
    • Hernandez J.S., Barreto-Torres G., Kuznetsov A.V., Khuchua Z., Javadov S. Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria. J. Cell. Mol. Med. 2014, 18:709-720.
    • (2014) J. Cell. Mol. Med. , vol.18 , pp. 709-720
    • Hernandez, J.S.1    Barreto-Torres, G.2    Kuznetsov, A.V.3    Khuchua, Z.4    Javadov, S.5
  • 109
    • 84862770709 scopus 로고    scopus 로고
    • Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction
    • Murca T.M., Moraes P.L., Capuruco C.A., Santos S.H., Melo M.B., Santos R.A., et al. Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction. Regul. Pept. 2012, 177:107-115.
    • (2012) Regul. Pept. , vol.177 , pp. 107-115
    • Murca, T.M.1    Moraes, P.L.2    Capuruco, C.A.3    Santos, S.H.4    Melo, M.B.5    Santos, R.A.6
  • 110
  • 111
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan C.Y., Nusse R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 2004, 20:781-810.
    • (2004) Annu. Rev. Cell Dev. Biol. , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 112
    • 84875891536 scopus 로고    scopus 로고
    • Targeting the Wnt/frizzled signaling pathway after myocardial infarction: a new tool in the therapeutic toolbox?
    • Daskalopoulos E.P., Hermans K.C., Janssen B.J., Matthijs B.W. Targeting the Wnt/frizzled signaling pathway after myocardial infarction: a new tool in the therapeutic toolbox?. Trends Cardiovasc. Med. 2013, 23:121-127.
    • (2013) Trends Cardiovasc. Med. , vol.23 , pp. 121-127
    • Daskalopoulos, E.P.1    Hermans, K.C.2    Janssen, B.J.3    Matthijs, B.W.4
  • 113
    • 84937540149 scopus 로고    scopus 로고
    • Loss of secreted frizzled-related protein-1 leads to deterioration of cardiac function in mice and plays a role in human cardiomyopathy
    • Sklepkiewicz P., Shiomi T., Kaur R., Sun J., Kwon S., Mercer B., et al. Loss of secreted frizzled-related protein-1 leads to deterioration of cardiac function in mice and plays a role in human cardiomyopathy. Circ. Heart Fail. 2015, 8:362-372.
    • (2015) Circ. Heart Fail. , vol.8 , pp. 362-372
    • Sklepkiewicz, P.1    Shiomi, T.2    Kaur, R.3    Sun, J.4    Kwon, S.5    Mercer, B.6
  • 114
    • 78650489190 scopus 로고    scopus 로고
    • Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction
    • He W., Zhang L., Ni A., Zhang Z., Mirotsou M., Mao L., et al. Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:21110-21115.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 21110-21115
    • He, W.1    Zhang, L.2    Ni, A.3    Zhang, Z.4    Mirotsou, M.5    Mao, L.6
  • 115
    • 84921539288 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy
    • Zhang M., Hagenmueller M., Riffel J.H., Kreusser M.M., Bernhold E., Fan J., et al. Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy. Hypertension 2015, 65:335-344.
    • (2015) Hypertension , vol.65 , pp. 335-344
    • Zhang, M.1    Hagenmueller, M.2    Riffel, J.H.3    Kreusser, M.M.4    Bernhold, E.5    Fan, J.6
  • 116
    • 84859179083 scopus 로고    scopus 로고
    • Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis
    • Akhmetshina A., Palumbo K., Dees C., Bergmann C., Venalis P., Zerr P., et al. Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis. Nat. Commun. 2012, 3:735.
    • (2012) Nat. Commun. , vol.3 , pp. 735
    • Akhmetshina, A.1    Palumbo, K.2    Dees, C.3    Bergmann, C.4    Venalis, P.5    Zerr, P.6
  • 117
    • 77951881189 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552
    • Zhao J., Yue W., Zhu M.J., Sreejayan N., Du M. AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552. Biochem. Biophys. Res. Commun. 2010, 395:146-151.
    • (2010) Biochem. Biophys. Res. Commun. , vol.395 , pp. 146-151
    • Zhao, J.1    Yue, W.2    Zhu, M.J.3    Sreejayan, N.4    Du, M.5
  • 118
    • 79958035489 scopus 로고    scopus 로고
    • AMP-activated protein kinase attenuates Wnt/beta-catenin signaling in human osteoblastic Saos-2 cells
    • Takatani T., Minagawa M., Takatani R., Kinoshita K., Kohno Y. AMP-activated protein kinase attenuates Wnt/beta-catenin signaling in human osteoblastic Saos-2 cells. Mol. Cell. Endocrinol. 2011, 339:114-119.
    • (2011) Mol. Cell. Endocrinol. , vol.339 , pp. 114-119
    • Takatani, T.1    Minagawa, M.2    Takatani, R.3    Kinoshita, K.4    Kohno, Y.5
  • 119
    • 79955873014 scopus 로고    scopus 로고
    • AICAR, an activator of AMPK, inhibits adipogenesis via the WNT/beta-catenin pathway in 3T3-L1 adipocytes
    • Lee H., Kang R., Bae S., Yoon Y. AICAR, an activator of AMPK, inhibits adipogenesis via the WNT/beta-catenin pathway in 3T3-L1 adipocytes. Int. J. Mol. Med. 2011, 28:65-71.
    • (2011) Int. J. Mol. Med. , vol.28 , pp. 65-71
    • Lee, H.1    Kang, R.2    Bae, S.3    Yoon, Y.4
  • 120
    • 33748153690 scopus 로고    scopus 로고
    • TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
    • Inoki K., Ouyang H., Zhu T., Lindvall C., Wang Y., Zhang X., et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 2006, 126:955-968.
    • (2006) Cell , vol.126 , pp. 955-968
    • Inoki, K.1    Ouyang, H.2    Zhu, T.3    Lindvall, C.4    Wang, Y.5    Zhang, X.6
  • 121
    • 84899129310 scopus 로고    scopus 로고
    • Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition
    • Murdoch C.E., Chaubey S., Zeng L., Yu B., Ivetic A., Walker S.J., et al. Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition. J. Am. Coll. Cardiol. 2014, 63:2734-2741.
    • (2014) J. Am. Coll. Cardiol. , vol.63 , pp. 2734-2741
    • Murdoch, C.E.1    Chaubey, S.2    Zeng, L.3    Yu, B.4    Ivetic, A.5    Walker, S.J.6
  • 122
    • 84907212379 scopus 로고    scopus 로고
    • Myocardial fibrosis induced by exposure to subclinical lipopolysaccharide is associated with decreased miR-29c and enhanced NOX2 expression in mice
    • Lew W.Y., Bayna E., Dalle Molle E., Contu R., Condorelli G., Tang T. Myocardial fibrosis induced by exposure to subclinical lipopolysaccharide is associated with decreased miR-29c and enhanced NOX2 expression in mice. PLoS ONE 2014, 9.
    • (2014) PLoS ONE , vol.9
    • Lew, W.Y.1    Bayna, E.2    Dalle Molle, E.3    Contu, R.4    Condorelli, G.5    Tang, T.6
  • 124
    • 79952188332 scopus 로고    scopus 로고
    • Alpha1amp-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation
    • Schuhmacher S., Foretz M., Knorr M., Jansen T., Hortmann M., Wenzel P., et al. Alpha1amp-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation. Arterioscler. Thromb. Vasc. Biol. 2011, 31:560-566.
    • (2011) Arterioscler. Thromb. Vasc. Biol. , vol.31 , pp. 560-566
    • Schuhmacher, S.1    Foretz, M.2    Knorr, M.3    Jansen, T.4    Hortmann, M.5    Wenzel, P.6
  • 126
    • 78049259587 scopus 로고    scopus 로고
    • Effects of benazepril on cardiac fibrosis in STZ-induced diabetic rats
    • Li Q., Wang Y., Sun S.Z., Tian Y.J., Liu M.H. Effects of benazepril on cardiac fibrosis in STZ-induced diabetic rats. Acta Cardiol. 2010, 65:431-439.
    • (2010) Acta Cardiol. , vol.65 , pp. 431-439
    • Li, Q.1    Wang, Y.2    Sun, S.Z.3    Tian, Y.J.4    Liu, M.H.5
  • 127
    • 70349251728 scopus 로고    scopus 로고
    • Effects of AT1- and beta-adrenergic receptor antagonists on TGF-beta1-induced fibrosis in transgenic mice
    • Seeland U., Schaffer A., Selejan S., Hohl M., Reil J.C., Muller P., et al. Effects of AT1- and beta-adrenergic receptor antagonists on TGF-beta1-induced fibrosis in transgenic mice. Eur. J. Clin. Investig. 2009, 39:851-859.
    • (2009) Eur. J. Clin. Investig. , vol.39 , pp. 851-859
    • Seeland, U.1    Schaffer, A.2    Selejan, S.3    Hohl, M.4    Reil, J.C.5    Muller, P.6
  • 128
    • 84892578046 scopus 로고    scopus 로고
    • Effects of direct renin inhibition on myocardial fibrosis and cardiac fibroblast function
    • Zhi H., Luptak I., Alreja G., Shi J., Guan J., Metes-Kosik N., et al. Effects of direct renin inhibition on myocardial fibrosis and cardiac fibroblast function. PLoS ONE 2013, 8.
    • (2013) PLoS ONE , vol.8
    • Zhi, H.1    Luptak, I.2    Alreja, G.3    Shi, J.4    Guan, J.5    Metes-Kosik, N.6
  • 129
    • 84899619364 scopus 로고    scopus 로고
    • Eplerenone-mediated regression of electrical activation delays and myocardial fibrosis in heart failure
    • Tanaka-Esposito C., Varahan S., Jeyaraj D., Lu Y., Stambler B.S. Eplerenone-mediated regression of electrical activation delays and myocardial fibrosis in heart failure. J. Cardiovasc. Electrophysiol. 2014, 25:537-544.
    • (2014) J. Cardiovasc. Electrophysiol. , vol.25 , pp. 537-544
    • Tanaka-Esposito, C.1    Varahan, S.2    Jeyaraj, D.3    Lu, Y.4    Stambler, B.S.5
  • 130
    • 84877823830 scopus 로고    scopus 로고
    • ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis
    • AC S.e.S., KD S., AJ F., MM T. ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis. Br. J. Pharmacol. 2013, 169:477-492.
    • (2013) Br. J. Pharmacol. , vol.169 , pp. 477-492
    • AC, S.1    KD, S.2    AJ, F.3    MM, T.4
  • 131
    • 39749202869 scopus 로고    scopus 로고
    • Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology
    • Der Sarkissian S., Grobe J.L., Yuan L., Narielwala D.R., Walter G.A., Katovich M.J., et al. Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology. Hypertension 2008, 51:712-718.
    • (2008) Hypertension , vol.51 , pp. 712-718
    • Der Sarkissian, S.1    Grobe, J.L.2    Yuan, L.3    Narielwala, D.R.4    Walter, G.A.5    Katovich, M.J.6
  • 133
    • 61949300140 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure
    • Gundewar S., Calvert J.W., Jha S., Toedt-Pingel I., Ji S.Y., Nunez D., et al. Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ. Res. 2009, 104:403-411.
    • (2009) Circ. Res. , vol.104 , pp. 403-411
    • Gundewar, S.1    Calvert, J.W.2    Jha, S.3    Toedt-Pingel, I.4    Ji, S.Y.5    Nunez, D.6
  • 134
    • 45749114078 scopus 로고    scopus 로고
    • Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24hours after administration
    • Solskov L., Lofgren B., Kristiansen S.B., Jessen N., Pold R., Nielsen T.T., et al. Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24hours after administration. Basic Clin. Pharmacol. Toxicol. 2008, 103:82-87.
    • (2008) Basic Clin. Pharmacol. Toxicol. , vol.103 , pp. 82-87
    • Solskov, L.1    Lofgren, B.2    Kristiansen, S.B.3    Jessen, N.4    Pold, R.5    Nielsen, T.T.6
  • 135
    • 3543008912 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte
    • Chan A.Y., Soltys C.L., Young M.E., Proud C.G., Dyck J.R. Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. J. Biol. Chem. 2004, 279:32771-32779.
    • (2004) J. Biol. Chem. , vol.279 , pp. 32771-32779
    • Chan, A.Y.1    Soltys, C.L.2    Young, M.E.3    Proud, C.G.4    Dyck, J.R.5
  • 136
    • 84897353217 scopus 로고    scopus 로고
    • Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts
    • Bai J., Zhang N., Hua Y., Wang B., Ling L., Ferro A., et al. Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts. PLoS ONE 2013, 8.
    • (2013) PLoS ONE , vol.8
    • Bai, J.1    Zhang, N.2    Hua, Y.3    Wang, B.4    Ling, L.5    Ferro, A.6
  • 138
    • 66349105917 scopus 로고    scopus 로고
    • Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase
    • Sasaki H., Asanuma H., Fujita M., Takahama H., Wakeno M., Ito S., et al. Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase. Circulation 2009, 119:2568-2577.
    • (2009) Circulation , vol.119 , pp. 2568-2577
    • Sasaki, H.1    Asanuma, H.2    Fujita, M.3    Takahama, H.4    Wakeno, M.5    Ito, S.6
  • 139
    • 77954777802 scopus 로고    scopus 로고
    • Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway
    • Xiao H., Ma X., Feng W., Fu Y., Lu Z., Xu M., et al. Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway. Cardiovasc. Res. 2010, 87:504-513.
    • (2010) Cardiovasc. Res. , vol.87 , pp. 504-513
    • Xiao, H.1    Ma, X.2    Feng, W.3    Fu, Y.4    Lu, Z.5    Xu, M.6
  • 140
    • 12144291275 scopus 로고    scopus 로고
    • Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?
    • Brunmair B., Staniek K., Gras F., Scharf N., Althaym A., Clara R., et al. Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?. Diabetes 2004, 53:1052-1059.
    • (2004) Diabetes , vol.53 , pp. 1052-1059
    • Brunmair, B.1    Staniek, K.2    Gras, F.3    Scharf, N.4    Althaym, A.5    Clara, R.6
  • 141
    • 73849096181 scopus 로고    scopus 로고
    • Evidence for the importance of adiponectin in the cardioprotective effects of pioglitazone
    • Li P., Shibata R., Unno K., Shimano M., Furukawa M., Ohashi T., et al. Evidence for the importance of adiponectin in the cardioprotective effects of pioglitazone. Hypertension 2010, 55:69-75.
    • (2010) Hypertension , vol.55 , pp. 69-75
    • Li, P.1    Shibata, R.2    Unno, K.3    Shimano, M.4    Furukawa, M.5    Ohashi, T.6
  • 142
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen S.E., Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med. 2007, 356:2457-2471.
    • (2007) N. Engl. J. Med. , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 143
    • 64649102619 scopus 로고    scopus 로고
    • GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
    • Noyan-Ashraf M.H., Momen M.A., Ban K., Sadi A.M., Zhou Y.Q., Riazi A.M., et al. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 2009, 58:975-983.
    • (2009) Diabetes , vol.58 , pp. 975-983
    • Noyan-Ashraf, M.H.1    Momen, M.A.2    Ban, K.3    Sadi, A.M.4    Zhou, Y.Q.5    Riazi, A.M.6
  • 144
    • 84872055241 scopus 로고    scopus 로고
    • A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity
    • Noyan-Ashraf M.H., Shikatani E.A., Schuiki I., Mukovozov I., Wu J., Li R.K., et al. A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity. Circulation 2013, 127:74-85.
    • (2013) Circulation , vol.127 , pp. 74-85
    • Noyan-Ashraf, M.H.1    Shikatani, E.A.2    Schuiki, I.3    Mukovozov, I.4    Wu, J.5    Li, R.K.6
  • 145
    • 84929483826 scopus 로고    scopus 로고
    • A DPP-4 inhibitor suppresses fibrosis and inflammation on experimental autoimmune myocarditis in mice
    • Hirakawa H., Zempo H., Ogawa M., Watanabe R., Suzuki J., Akazawa H., et al. A DPP-4 inhibitor suppresses fibrosis and inflammation on experimental autoimmune myocarditis in mice. PLoS ONE 2015, 10.
    • (2015) PLoS ONE , vol.10
    • Hirakawa, H.1    Zempo, H.2    Ogawa, M.3    Watanabe, R.4    Suzuki, J.5    Akazawa, H.6
  • 146
    • 84964314896 scopus 로고    scopus 로고
    • DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure
    • Koibuchi N., Hasegawa Y., Katayama T., Toyama K., Uekawa K., Sueta D., et al. DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure. Cardiovasc. Diabetol. 2014, 13:157.
    • (2014) Cardiovasc. Diabetol. , vol.13 , pp. 157
    • Koibuchi, N.1    Hasegawa, Y.2    Katayama, T.3    Toyama, K.4    Uekawa, K.5    Sueta, D.6
  • 147
    • 80055110463 scopus 로고    scopus 로고
    • Effects of DPP-4 inhibition on cardiac metabolism and function in mice
    • Lenski M., Kazakov A., Marx N., Bohm M., Laufs U. Effects of DPP-4 inhibition on cardiac metabolism and function in mice. J. Mol. Cell. Cardiol. 2011, 51:906-918.
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , pp. 906-918
    • Lenski, M.1    Kazakov, A.2    Marx, N.3    Bohm, M.4    Laufs, U.5
  • 148
    • 74549184604 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine
    • Al-masri I.M., Mohammad M.K., Tahaa M.O. Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine. J. Enzyme Inhib. Med. Chem. 2009, 24:1061-1066.
    • (2009) J. Enzyme Inhib. Med. Chem. , vol.24 , pp. 1061-1066
    • Al-masri, I.M.1    Mohammad, M.K.2    Tahaa, M.O.3
  • 149
    • 33749336146 scopus 로고    scopus 로고
    • Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states
    • Lee Y.S., Kim W.S., Kim K.H., Yoon M.J., Cho H.J., Shen Y., et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006, 55:2256-2264.
    • (2006) Diabetes , vol.55 , pp. 2256-2264
    • Lee, Y.S.1    Kim, W.S.2    Kim, K.H.3    Yoon, M.J.4    Cho, H.J.5    Shen, Y.6
  • 150
    • 79958116611 scopus 로고    scopus 로고
    • Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes
    • Li Y., Wang P., Zhuang Y., Lin H., Li Y., Liu L., et al. Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes. FEBS Lett. 2011, 585:1735-1740.
    • (2011) FEBS Lett. , vol.585 , pp. 1735-1740
    • Li, Y.1    Wang, P.2    Zhuang, Y.3    Lin, H.4    Li, Y.5    Liu, L.6
  • 151
    • 84896735175 scopus 로고    scopus 로고
    • Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy
    • Li M.H., Zhang Y.J., Yu Y.H., Yang S.H., Iqbal J., Mi Q.Y., et al. Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy. Eur. J. Pharmacol. 2014, 728:67-76.
    • (2014) Eur. J. Pharmacol. , vol.728 , pp. 67-76
    • Li, M.H.1    Zhang, Y.J.2    Yu, Y.H.3    Yang, S.H.4    Iqbal, J.5    Mi, Q.Y.6
  • 152
    • 84912574268 scopus 로고    scopus 로고
    • Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: role of autophagy
    • Zhang Y.J., Yang S.H., Li M.H., Iqbal J., Bourantas C.V., Mi Q.Y., et al. Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: role of autophagy. Clin. Exp. Pharmacol. Physiol. 2014, 41:995-1002.
    • (2014) Clin. Exp. Pharmacol. Physiol. , vol.41 , pp. 995-1002
    • Zhang, Y.J.1    Yang, S.H.2    Li, M.H.3    Iqbal, J.4    Bourantas, C.V.5    Mi, Q.Y.6
  • 153
    • 39449108141 scopus 로고    scopus 로고
    • Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis
    • Kiriazis H., Wang K., Xu Q., Gao X.M., Ming Z., Su Y., et al. Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis. Br. J. Pharmacol. 2008, 153:684-692.
    • (2008) Br. J. Pharmacol. , vol.153 , pp. 684-692
    • Kiriazis, H.1    Wang, K.2    Xu, Q.3    Gao, X.M.4    Ming, Z.5    Su, Y.6
  • 154
    • 0021230054 scopus 로고
    • Effects of beta-adrenergic inhibition on scar formation after myocardial infarction
    • Ravindranathan M.P., Jenkins B., Haider B., Regan T.J. Effects of beta-adrenergic inhibition on scar formation after myocardial infarction. Am. Heart J. 1984, 108:25-30.
    • (1984) Am. Heart J. , vol.108 , pp. 25-30
    • Ravindranathan, M.P.1    Jenkins, B.2    Haider, B.3    Regan, T.J.4
  • 155
    • 79953177835 scopus 로고    scopus 로고
    • Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo
    • Pulinilkunnil T., He H., Kong D., Asakura K., Peroni O.D., Lee A., et al. Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. J. Biol. Chem. 2011, 286:8798-8809.
    • (2011) J. Biol. Chem. , vol.286 , pp. 8798-8809
    • Pulinilkunnil, T.1    He, H.2    Kong, D.3    Asakura, K.4    Peroni, O.D.5    Lee, A.6
  • 156
    • 33644750542 scopus 로고    scopus 로고
    • AMP-activated protein kinase activation by adrenoceptors in L6 skeletal muscle cells: mediation by alpha1-adrenoceptors causing glucose uptake
    • Hutchinson D.S., Bengtsson T. AMP-activated protein kinase activation by adrenoceptors in L6 skeletal muscle cells: mediation by alpha1-adrenoceptors causing glucose uptake. Diabetes 2006, 55:682-690.
    • (2006) Diabetes , vol.55 , pp. 682-690
    • Hutchinson, D.S.1    Bengtsson, T.2
  • 157
    • 84861762743 scopus 로고    scopus 로고
    • Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) rat
    • Ma L., Gul R., Habibi J., Yang M., Pulakat L., Whaley-Connell A., et al. Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) rat. Am. J. Physiol. Heart Circ. Physiol. 2012, 302:H2341-H2351.
    • (2012) Am. J. Physiol. Heart Circ. Physiol. , vol.302 , pp. H2341-H2351
    • Ma, L.1    Gul, R.2    Habibi, J.3    Yang, M.4    Pulakat, L.5    Whaley-Connell, A.6
  • 158
    • 77950466818 scopus 로고    scopus 로고
    • Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat
    • Zhou X., Ma L., Habibi J., Whaley-Connell A., Hayden M.R., Tilmon R.D., et al. Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat. Hypertension 2010, 55:880-888.
    • (2010) Hypertension , vol.55 , pp. 880-888
    • Zhou, X.1    Ma, L.2    Habibi, J.3    Whaley-Connell, A.4    Hayden, M.R.5    Tilmon, R.D.6
  • 159
    • 79251518319 scopus 로고    scopus 로고
    • Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional beta1-blockade
    • Sorrentino S.A., Doerries C., Manes C., Speer T., Dessy C., Lobysheva I., et al. Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional beta1-blockade. J. Am. Coll. Cardiol. 2011, 57:601-611.
    • (2011) J. Am. Coll. Cardiol. , vol.57 , pp. 601-611
    • Sorrentino, S.A.1    Doerries, C.2    Manes, C.3    Speer, T.4    Dessy, C.5    Lobysheva, I.6
  • 160
    • 84905121778 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibition prior reperfusion improves reparative fibrosis post-myocardial infarction in a preclinical experimental model
    • Vilahur G., Casani L., Pena E., Juan-Babot O., Mendieta G., Crespo J., et al. HMG-CoA reductase inhibition prior reperfusion improves reparative fibrosis post-myocardial infarction in a preclinical experimental model. Int. J. Cardiol. 2014, 175:528-538.
    • (2014) Int. J. Cardiol. , vol.175 , pp. 528-538
    • Vilahur, G.1    Casani, L.2    Pena, E.3    Juan-Babot, O.4    Mendieta, G.5    Crespo, J.6
  • 161
    • 0035902491 scopus 로고    scopus 로고
    • Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy
    • Patel R., Nagueh S.F., Tsybouleva N., Abdellatif M., Lutucuta S., Kopelen H.A., et al. Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation 2001, 104:317-324.
    • (2001) Circulation , vol.104 , pp. 317-324
    • Patel, R.1    Nagueh, S.F.2    Tsybouleva, N.3    Abdellatif, M.4    Lutucuta, S.5    Kopelen, H.A.6
  • 162
    • 33845707278 scopus 로고    scopus 로고
    • Statins activate AMP-activated protein kinase in vitro and in vivo
    • Sun W., Lee T.S., Zhu M., Gu C., Wang Y., Zhu Y., et al. Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation 2006, 114:2655-2662.
    • (2006) Circulation , vol.114 , pp. 2655-2662
    • Sun, W.1    Lee, T.S.2    Zhu, M.3    Gu, C.4    Wang, Y.5    Zhu, Y.6
  • 163
    • 68349086952 scopus 로고    scopus 로고
    • Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase
    • Izumi Y., Shiota M., Kusakabe H., Hikita Y., Nakao T., Nakamura Y., et al. Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase. Hypertens. Res. 2009, 32:675-679.
    • (2009) Hypertens. Res. , vol.32 , pp. 675-679
    • Izumi, Y.1    Shiota, M.2    Kusakabe, H.3    Hikita, Y.4    Nakao, T.5    Nakamura, Y.6
  • 164
    • 0028967272 scopus 로고
    • Cell-type specificity of inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside. Lack of effect in rabbit cardiomyocytes and human erythrocytes, and inhibition in FTO-2B rat hepatoma cells
    • Javaux F., Vincent M.F., Wagner D.R., van den Berghe G. Cell-type specificity of inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside. Lack of effect in rabbit cardiomyocytes and human erythrocytes, and inhibition in FTO-2B rat hepatoma cells. Biochem. J. 1995, 305(Pt 3):913-919.
    • (1995) Biochem. J. , vol.305 , pp. 913-919
    • Javaux, F.1    Vincent, M.F.2    Wagner, D.R.3    van den Berghe, G.4
  • 165
    • 84906960371 scopus 로고    scopus 로고
    • The AMPK agonist AICAR inhibits TGF-beta1 induced activation of kidney myofibroblasts
    • Chen K.H., Hsu H.H., Lee C.C., Yen T.H., Ko Y.C., Yang C.W., et al. The AMPK agonist AICAR inhibits TGF-beta1 induced activation of kidney myofibroblasts. PLoS ONE 2014, 9.
    • (2014) PLoS ONE , vol.9
    • Chen, K.H.1    Hsu, H.H.2    Lee, C.C.3    Yen, T.H.4    Ko, Y.C.5    Yang, C.W.6
  • 166
    • 36348998521 scopus 로고    scopus 로고
    • Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
    • Goransson O., McBride A., Hawley S.A., Ross F.A., Shpiro N., Foretz M., et al. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J. Biol. Chem. 2007, 282:32549-32560.
    • (2007) J. Biol. Chem. , vol.282 , pp. 32549-32560
    • Goransson, O.1    McBride, A.2    Hawley, S.A.3    Ross, F.A.4    Shpiro, N.5    Foretz, M.6
  • 169
    • 84888203586 scopus 로고    scopus 로고
    • Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice
    • Li Y.Y., Yu L.F., Zhang L.N., Qiu B.Y., Su M.B., Wu F., et al. Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol. Appl. Pharmacol. 2013, 273:325-334.
    • (2013) Toxicol. Appl. Pharmacol. , vol.273 , pp. 325-334
    • Li, Y.Y.1    Yu, L.F.2    Zhang, L.N.3    Qiu, B.Y.4    Su, M.B.5    Wu, F.6
  • 170
    • 19944369735 scopus 로고    scopus 로고
    • Adiponectin-mediated modulation of hypertrophic signals in the heart
    • Shibata R., Ouchi N., Ito M., Kihara S., Shiojima I., Pimentel D.R., et al. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat. Med. 2004, 10:1384-1389.
    • (2004) Nat. Med. , vol.10 , pp. 1384-1389
    • Shibata, R.1    Ouchi, N.2    Ito, M.3    Kihara, S.4    Shiojima, I.5    Pimentel, D.R.6
  • 171
    • 84892912997 scopus 로고    scopus 로고
    • Adiponectin mediated APPL1-AMPK signaling induces cell migration, MMP activation, and collagen remodeling in cardiac fibroblasts
    • Dadson K., Chasiotis H., Wannaiampikul S., Tungtrongchitr R., Xu A., Sweeney G. Adiponectin mediated APPL1-AMPK signaling induces cell migration, MMP activation, and collagen remodeling in cardiac fibroblasts. J. Cell. Biochem. 2014, 115:785-793.
    • (2014) J. Cell. Biochem. , vol.115 , pp. 785-793
    • Dadson, K.1    Chasiotis, H.2    Wannaiampikul, S.3    Tungtrongchitr, R.4    Xu, A.5    Sweeney, G.6
  • 172
    • 77953691004 scopus 로고    scopus 로고
    • Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response
    • Shimano M., Ouchi N., Shibata R., Ohashi K., Pimentel D.R., Murohara T., et al. Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response. J. Mol. Cell. Cardiol. 2010, 49:210-220.
    • (2010) J. Mol. Cell. Cardiol. , vol.49 , pp. 210-220
    • Shimano, M.1    Ouchi, N.2    Shibata, R.3    Ohashi, K.4    Pimentel, D.R.5    Murohara, T.6
  • 173
    • 78751554136 scopus 로고    scopus 로고
    • Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation
    • Konishi M., Haraguchi G., Ohigashi H., Ishihara T., Saito K., Nakano Y., et al. Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation. Cardiovasc. Res. 2011, 89:309-319.
    • (2011) Cardiovasc. Res. , vol.89 , pp. 309-319
    • Konishi, M.1    Haraguchi, G.2    Ohigashi, H.3    Ishihara, T.4    Saito, K.5    Nakano, Y.6
  • 174
    • 84940024469 scopus 로고    scopus 로고
    • Deficiency in adiponectin exaggerates cigarette smoking exposure-induced cardiac contractile dysfunction: role of autophagy
    • Hu N., Yang L., Dong M., Ren J., Zhang Y. Deficiency in adiponectin exaggerates cigarette smoking exposure-induced cardiac contractile dysfunction: role of autophagy. Pharmacol. Res. 2015, 100:175-189.
    • (2015) Pharmacol. Res. , vol.100 , pp. 175-189
    • Hu, N.1    Yang, L.2    Dong, M.3    Ren, J.4    Zhang, Y.5
  • 175
    • 84938559650 scopus 로고    scopus 로고
    • AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings
    • Zhang Y., Zhao J., Li R., Lau W.B., Yuan Y.X., Liang B., et al. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am. J. Physiol. Endocrinol. Metab. 2015, 309:E275-E282.
    • (2015) Am. J. Physiol. Endocrinol. Metab. , vol.309 , pp. E275-E282
    • Zhang, Y.1    Zhao, J.2    Li, R.3    Lau, W.B.4    Yuan, Y.X.5    Liang, B.6
  • 176
    • 84937809888 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol in heart failure
    • Sung M.M., Dyck J.R. Therapeutic potential of resveratrol in heart failure. Ann. N. Y. Acad. Sci. 2015, 1348:32-45.
    • (2015) Ann. N. Y. Acad. Sci. , vol.1348 , pp. 32-45
    • Sung, M.M.1    Dyck, J.R.2
  • 178
    • 84902330009 scopus 로고    scopus 로고
    • Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart
    • Sin T.K., Yu A.P., Yung B.Y., Yip S.P., Chan L.W., Wong C.S., et al. Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart. J. Physiol. 2014, 592:2535-2548.
    • (2014) J. Physiol. , vol.592 , pp. 2535-2548
    • Sin, T.K.1    Yu, A.P.2    Yung, B.Y.3    Yip, S.P.4    Chan, L.W.5    Wong, C.S.6
  • 179
    • 84928635872 scopus 로고    scopus 로고
    • Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-beta/Smad3 pathway
    • Chen T., Li J., Liu J., Li N., Wang S., Liu H., et al. Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-beta/Smad3 pathway. Am. J. Physiol. Heart Circ. Physiol. 2015, 308:H424-H434.
    • (2015) Am. J. Physiol. Heart Circ. Physiol. , vol.308 , pp. H424-H434
    • Chen, T.1    Li, J.2    Liu, J.3    Li, N.4    Wang, S.5    Liu, H.6
  • 180
    • 84860477354 scopus 로고    scopus 로고
    • SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
    • Price N.L., Gomes A.P., Ling A.J., Duarte F.V., Martin-Montalvo A., North B.J., et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 2012, 15:675-690.
    • (2012) Cell Metab. , vol.15 , pp. 675-690
    • Price, N.L.1    Gomes, A.P.2    Ling, A.J.3    Duarte, F.V.4    Martin-Montalvo, A.5    North, B.J.6
  • 181
    • 77449120223 scopus 로고    scopus 로고
    • Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway
    • Pillai V.B., Sundaresan N.R., Kim G., Gupta M., Rajamohan S.B., Pillai J.B., et al. Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. J. Biol. Chem. 2010, 285:3133-3144.
    • (2010) J. Biol. Chem. , vol.285 , pp. 3133-3144
    • Pillai, V.B.1    Sundaresan, N.R.2    Kim, G.3    Gupta, M.4    Rajamohan, S.B.5    Pillai, J.B.6
  • 182
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444:337-342.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3    Jamieson, H.A.4    Lerin, C.5    Kalra, A.6
  • 183
    • 77950348878 scopus 로고    scopus 로고
    • AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
    • Um J.H., Park S.J., Kang H., Yang S., Foretz M., McBurney M.W., et al. AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 2010, 59:554-563.
    • (2010) Diabetes , vol.59 , pp. 554-563
    • Um, J.H.1    Park, S.J.2    Kang, H.3    Yang, S.4    Foretz, M.5    McBurney, M.W.6
  • 184
    • 84933045942 scopus 로고    scopus 로고
    • Protective effect of resveratrol against doxorubicin-induced cardiac toxicity and fibrosis in male experimental rats
    • Arafa M.H., Mohammad N.S., Atteia H.H., Abd-Elaziz H.R. Protective effect of resveratrol against doxorubicin-induced cardiac toxicity and fibrosis in male experimental rats. J. Physiol. Biochem. 2014, 70:701-711.
    • (2014) J. Physiol. Biochem. , vol.70 , pp. 701-711
    • Arafa, M.H.1    Mohammad, N.S.2    Atteia, H.H.3    Abd-Elaziz, H.R.4
  • 185
    • 84907443927 scopus 로고    scopus 로고
    • Protective effect of resveratrol against pressure overload-induced heart failure
    • Gupta P.K., DiPette D.J., Supowit S.C. Protective effect of resveratrol against pressure overload-induced heart failure. Food Sci. Nutri. 2014, 2:218-229.
    • (2014) Food Sci. Nutri. , vol.2 , pp. 218-229
    • Gupta, P.K.1    DiPette, D.J.2    Supowit, S.C.3
  • 186
    • 84988624805 scopus 로고    scopus 로고
    • Resveratrol ameliorates cardiac dysfunction induced by pressure overload in rats via structural protection and modulation of Ca(2+) cycling proteins
    • Dong Q., Wu Z., Li X., Yan J., Zhao L., Yang C., et al. Resveratrol ameliorates cardiac dysfunction induced by pressure overload in rats via structural protection and modulation of Ca(2+) cycling proteins. J. Transl. Med. 2014, 12:323.
    • (2014) J. Transl. Med. , vol.12 , pp. 323
    • Dong, Q.1    Wu, Z.2    Li, X.3    Yan, J.4    Zhao, L.5    Yang, C.6
  • 187
    • 84930959190 scopus 로고    scopus 로고
    • C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation
    • Lei H., Wu D., Wang J.Y., Li L., Zhang C.L., Feng H., et al. C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation. Basic Res. Cardiol. 2015, 110:35.
    • (2015) Basic Res. Cardiol. , vol.110 , pp. 35
    • Lei, H.1    Wu, D.2    Wang, J.Y.3    Li, L.4    Zhang, C.L.5    Feng, H.6
  • 188
    • 84883825935 scopus 로고    scopus 로고
    • C1q/tumor necrosis factor-related protein-9, a novel adipocyte-derived cytokine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation
    • Sun Y., Yi W., Yuan Y., Lau W.B., Yi D., Wang X., et al. C1q/tumor necrosis factor-related protein-9, a novel adipocyte-derived cytokine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation. Circulation 2013, 128:S113-S120.
    • (2013) Circulation , vol.128 , pp. S113-S120
    • Sun, Y.1    Yi, W.2    Yuan, Y.3    Lau, W.B.4    Yi, D.5    Wang, X.6
  • 189
    • 84883397824 scopus 로고    scopus 로고
    • Indole-3-carbinol protects against pressure overload induced cardiac remodeling via activating AMPK-alpha
    • Deng W., Zong J., Bian Z., Zhou H., Yuan Y., Zhang R., et al. Indole-3-carbinol protects against pressure overload induced cardiac remodeling via activating AMPK-alpha. Mol. Nutr. Food Res. 2013, 57:1680-1687.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 1680-1687
    • Deng, W.1    Zong, J.2    Bian, Z.3    Zhou, H.4    Yuan, Y.5    Zhang, R.6
  • 191
    • 84864535254 scopus 로고    scopus 로고
    • Intake of fermented beverages protect against acute myocardial injury: target organ cardiac effects and vasculoprotective effects
    • Vilahur G., Casani L., Guerra J.M., Badimon L. Intake of fermented beverages protect against acute myocardial injury: target organ cardiac effects and vasculoprotective effects. Basic Res. Cardiol. 2012, 107:291.
    • (2012) Basic Res. Cardiol. , vol.107 , pp. 291
    • Vilahur, G.1    Casani, L.2    Guerra, J.M.3    Badimon, L.4
  • 193
    • 84900427186 scopus 로고    scopus 로고
    • Ablation of cereblon attenuates myocardial ischemia-reperfusion injury
    • Kim J., Lee K.M., Park C.S., Park W.J. Ablation of cereblon attenuates myocardial ischemia-reperfusion injury. Biochem. Biophys. Res. Commun. 2014, 447:649-654.
    • (2014) Biochem. Biophys. Res. Commun. , vol.447 , pp. 649-654
    • Kim, J.1    Lee, K.M.2    Park, C.S.3    Park, W.J.4
  • 194
    • 84901199526 scopus 로고    scopus 로고
    • Treatment with brain natriuretic peptide prevents the development of cardiac dysfunction in obese diabetic db/db mice
    • Plante E., Menaouar A., Danalache B.A., Broderick T.L., Jankowski M., Gutkowska J. Treatment with brain natriuretic peptide prevents the development of cardiac dysfunction in obese diabetic db/db mice. Diabetologia 2014, 57:1257-1267.
    • (2014) Diabetologia , vol.57 , pp. 1257-1267
    • Plante, E.1    Menaouar, A.2    Danalache, B.A.3    Broderick, T.L.4    Jankowski, M.5    Gutkowska, J.6
  • 195
    • 84924297804 scopus 로고    scopus 로고
    • Protective effects of desacyl ghrelin on diabetic cardiomyopathy
    • Pei X.M., Yung B.Y., Yip S.P., Chan L.W., Wong C.S., Ying M., et al. Protective effects of desacyl ghrelin on diabetic cardiomyopathy. Acta Diabetol. 2015, 52:293-306.
    • (2015) Acta Diabetol. , vol.52 , pp. 293-306
    • Pei, X.M.1    Yung, B.Y.2    Yip, S.P.3    Chan, L.W.4    Wong, C.S.5    Ying, M.6
  • 196
    • 84908376463 scopus 로고    scopus 로고
    • Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway
    • Zhang Z., Wang S., Zhou S., Yan X., Wang Y., Chen J., et al. Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway. J. Mol. Cell. Cardiol. 2014, 77:42-52.
    • (2014) J. Mol. Cell. Cardiol. , vol.77 , pp. 42-52
    • Zhang, Z.1    Wang, S.2    Zhou, S.3    Yan, X.4    Wang, Y.5    Chen, J.6
  • 198
    • 84883673564 scopus 로고    scopus 로고
    • A novel mechanism by which SDF-1beta protects cardiac cells from palmitate-induced endoplasmic reticulum stress and apoptosis via CXCR7 and AMPK/p38 MAPK-mediated interleukin-6 generation
    • Zhao Y., Tan Y., Xi S., Li Y., Li C., Cui J., et al. A novel mechanism by which SDF-1beta protects cardiac cells from palmitate-induced endoplasmic reticulum stress and apoptosis via CXCR7 and AMPK/p38 MAPK-mediated interleukin-6 generation. Diabetes 2013, 62:2545-2558.
    • (2013) Diabetes , vol.62 , pp. 2545-2558
    • Zhao, Y.1    Tan, Y.2    Xi, S.3    Li, Y.4    Li, C.5    Cui, J.6
  • 199
  • 200
    • 84894466528 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor deletion exacerbates pressure overload-induced cardiac hypertrophy through mitigating autophagy
    • Xu X., Hua Y., Nair S., Bucala R., Ren J. Macrophage migration inhibitory factor deletion exacerbates pressure overload-induced cardiac hypertrophy through mitigating autophagy. Hypertension 2014, 63:490-499.
    • (2014) Hypertension , vol.63 , pp. 490-499
    • Xu, X.1    Hua, Y.2    Nair, S.3    Bucala, R.4    Ren, J.5
  • 201
    • 84869837353 scopus 로고    scopus 로고
    • Direct AMP-activated protein kinase activators: a review of evidence from the patent literature
    • Giordanetto F., Karis D. Direct AMP-activated protein kinase activators: a review of evidence from the patent literature. Expert Opin. Ther. Pat. 2012, 22:1467-1477.
    • (2012) Expert Opin. Ther. Pat. , vol.22 , pp. 1467-1477
    • Giordanetto, F.1    Karis, D.2
  • 202
    • 84876220612 scopus 로고    scopus 로고
    • Regulation of interplay between autophagy and apoptosis in the diabetic heart: new role of AMPK
    • Zou M.H., Xie Z. Regulation of interplay between autophagy and apoptosis in the diabetic heart: new role of AMPK. Autophagy 2013, 9:624-625.
    • (2013) Autophagy , vol.9 , pp. 624-625
    • Zou, M.H.1    Xie, Z.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.