Pioglitazone improves left ventricular diastolic function and decreases collagen accumulation in prediabetic stage of a type II diabetic rat

Journal of Cardiovascular Pharmacology

Volumn 38, Issue 6, 2001, Pages 868-874

  Tsuji, Teppei ^a   Mizushige, Katsufumi ^a   Noma, Takahisa ^a   Murakami, Kazushi ^a   Ohmori, Koji ^a   Miyatake, Akira ^a   Kohno, Masakazu ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

Collagen; Diabetes; Left ventricular diastolic function; Oxidative stress; Pioglitazone

Indexed keywords

COLLAGEN; GLUCOSE; LIPID; MALONALDEHYDE; PIOGLITAZONE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIASTOLE; DOPPLER ECHOCARDIOGRAPHY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE METABOLISM; HEART LEFT VENTRICLE; HISTOPATHOLOGY; LIPID METABOLISM; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD GLUCOSE; COLLAGEN; DIABETES MELLITUS, TYPE 2; DIASTOLE; ECHOCARDIOGRAPHY, DOPPLER; HEMODYNAMIC PROCESSES; HYPOGLYCEMIC AGENTS; INSULIN; KINETICS; LIPIDS; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; PREDIABETIC STATE; RATS; RATS, INBRED OLETF; RATS, LONG-EVANS; THIAZOLES; THIAZOLIDINEDIONES; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0035199792     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200112000-00008     Document Type: Article

References (22)

1. Role of oxidative stress in development of complications in diabetes
2. Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model
3. Dietary troglitazone decreases oxidative stress in early stage type II diabetic rats
4. Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects
5. Thiazolidinediones in the treatment of insulin resistance and type II diabetes
6. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
7. Pioglitazone increases insulin sensitivity by activating insulin receptor kinase
8. Troglitazone has a scavenging effect on reactive oxygen species
9. Two cases of severe clinical and histologic hepatotoxicity associated with troglitazone
10. Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes
11. Spontaneous long-term hyperglycemic rat with diabetic complications Otsuka Long-Evans Tokushima Fatty (OLETF) strain
12. Characteristics of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long-Evans Tokushima Fatty rats
13. Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: Effect of lazaroid therapy
14. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
15. The diabetic heart: Metabolic causes for the development of a cardiomyopathy
16. Diabetic cardiomyopathy
17. Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy
18. Early abnormalities of cardiac function in non-insulin-dependent diabetes mellitus and impaired glucose tolerance
19. Transforming growth factor-β1 expression and phenotypic modulation in the kidney of hypertensive rats
20. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
21. Evaluation of diastolic filling of left ventricle in health and disease: Doppler echocardiography is the Clinician's Rosetta stone
22. Utility of preload alteration in assessment of left ventricular filling pressure by Doppler echocardiography: A simultaneous catheterization and Doppler echocardiographic study