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Volumn 70, Issue 3, 2014, Pages 701-711

Protective effect of resveratrol against doxorubicin-induced cardiac toxicity and fibrosis in male experimental rats

Author keywords

Antioxidants; Cardiac fibrosis; Cardiotoxicity; Doxorubicin; Resveratrol

Indexed keywords

ANTIOXIDANT; CARDIOTONIC AGENT; CASP3 PROTEIN, RAT; CASPASE 3; DOXORUBICIN; GLUTATHIONE; MESSENGER RNA; RESVERATROL; STILBENE DERIVATIVE; SUPEROXIDE DISMUTASE; TGFB1 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84933045942     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-014-0339-y     Document Type: Article
Times cited : (108)

References (51)
  • 1
    • 6944250259 scopus 로고    scopus 로고
    • Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies
    • PID: 15517885, COI: 1:CAS:528:DC%2BD2cXhtVSjsLrK
    • Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y (2004) Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24:2783–2840
    • (2004) Anticancer Res , vol.24 , pp. 2783-2840
    • Aggarwal, B.B.1    Bhardwaj, A.2    Aggarwal, R.S.3    Seeram, N.P.4    Shishodia, S.5    Takada, Y.6
  • 3
    • 84856221690 scopus 로고    scopus 로고
    • Davallialactone protects against adriamycin-induced cardiotoxicity in vitro and in vivo
    • PID: 21858697, COI: 1:CAS:528:DC%2BC3MXhsF2rt77K
    • Arunachalam S, Kim SY, Lee SH, Lee YH, Kim MS, Yun BS, Yi HK, Hwang PH (2012) Davallialactone protects against adriamycin-induced cardiotoxicity in vitro and in vivo. J Nat Med 66:149–157
    • (2012) J Nat Med , vol.66 , pp. 149-157
    • Arunachalam, S.1    Kim, S.Y.2    Lee, S.H.3    Lee, Y.H.4    Kim, M.S.5    Yun, B.S.6    Yi, H.K.7    Hwang, P.H.8
  • 4
    • 73649194769 scopus 로고
    • Improved method for the determination of blood glutathione
    • PID: 13967893, COI: 1:CAS:528:DyaF3sXksV2rsbo%3D
    • Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882–888
    • (1963) J Lab Clin Med , vol.61 , pp. 882-888
    • Beutler, E.1    Duron, O.2    Kelly, B.M.3
  • 5
    • 1942484416 scopus 로고    scopus 로고
    • Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury
    • PID: 15063153, COI: 1:CAS:528:DC%2BD2cXisl2rs7o%3D
    • Cao Z, Li Y (2004) Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury. Eur J Pharmacol 489(1–2):39–48
    • (2004) Eur J Pharmacol , vol.489 , Issue.1-2 , pp. 39-48
    • Cao, Z.1    Li, Y.2
  • 6
    • 79551655242 scopus 로고    scopus 로고
    • Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats
    • PID: 20874677, COI: 1:CAS:528:DC%2BC3MXkslahsr4%3D
    • Chan V, Fenning A, Iyer A, Hoey A, Brown L (2011) Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats. Curr Pharm Biotechnol 12:429–436
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 429-436
    • Chan, V.1    Fenning, A.2    Iyer, A.3    Hoey, A.4    Brown, L.5
  • 8
    • 67349234999 scopus 로고    scopus 로고
    • Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
    • PID: 19303434
    • Danz ED, Skramsted J, Henry N, Bennett JA, Keller RS (2009) Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway. Free Radic Biol Med 46:1589–1597
    • (2009) Free Radic Biol Med , vol.46 , pp. 1589-1597
    • Danz, E.D.1    Skramsted, J.2    Henry, N.3    Bennett, J.A.4    Keller, R.S.5
  • 9
    • 4444219725 scopus 로고    scopus 로고
    • Cardioprotection with resveratrol pretreatment: improved beneficial effects over standard treatment in rat hearts after global ischemia
    • PID: 15553937, COI: 1:CAS:528:DC%2BD2cXnvVCqt7g%3D
    • Dernek S, Ikizler M, Erkasap N, Ergun B, Koken T, Yilmaz K, Sevin B, Kaygisiz Z, Kural T (2004) Cardioprotection with resveratrol pretreatment: improved beneficial effects over standard treatment in rat hearts after global ischemia. Scand Cardiovasc J 38(4):245–254
    • (2004) Scand Cardiovasc J , vol.38 , Issue.4 , pp. 245-254
    • Dernek, S.1    Ikizler, M.2    Erkasap, N.3    Ergun, B.4    Koken, T.5    Yilmaz, K.6    Sevin, B.7    Kaygisiz, Z.8    Kural, T.9
  • 13
    • 84878688864 scopus 로고    scopus 로고
    • Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin-induced cardiac injury in rats
    • PID: 23112126
    • El Boghdady NA (2013) Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin-induced cardiac injury in rats. Cell Biochem Funct 31:344–351
    • (2013) Cell Biochem Funct , vol.31 , pp. 344-351
    • El Boghdady, N.A.1
  • 14
    • 0346099102 scopus 로고    scopus 로고
    • Overexpression of tumor necrosis factor-alpha diminishes pulmonary fibrosis induced by bleomycin or transforming growth factor-beta
    • Fujita M, Shannan JM, Morikawa O, Gauldie J, Hara N, Masan RJ (2003) Overexpression of tumor necrosis factor-alpha diminishes pulmonary fibrosis induced by bleomycin or transforming growth factor-beta. Am J Respir Cell Mol Biol 29:1–7
    • (2003) Am J Respir Cell Mol Biol , vol.29 , pp. 1-7
    • Fujita, M.1    Shannan, J.M.2    Morikawa, O.3    Gauldie, J.4    Hara, N.5    Masan, R.J.6
  • 15
    • 84870538675 scopus 로고    scopus 로고
    • Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in lymphoma nude mice by heme oxygenase-1 induction
    • PID: 22763982, COI: 1:CAS:528:DC%2BC38XhslWqs7fE
    • Gu J, Song ZP, Gui DM, Hu W, Chen YG, Zhang DD (2012) Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in lymphoma nude mice by heme oxygenase-1 induction. Cardiovasc Toxicol 12(4):341–349
    • (2012) Cardiovasc Toxicol , vol.12 , Issue.4 , pp. 341-349
    • Gu, J.1    Song, Z.P.2    Gui, D.M.3    Hu, W.4    Chen, Y.G.5    Zhang, D.D.6
  • 16
    • 84873151534 scopus 로고    scopus 로고
    • Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibition of the p38 MAPK pathway in H9c2 cells
    • PID: 23338126, COI: 1:CAS:528:DC%2BC3sXktVGqtbc%3D
    • Guo R, Lin J, Xu W, Shen N, Mo L, Zhang C, Feng J (2013) Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibition of the p38 MAPK pathway in H9c2 cells. Int J Mol Med 31:644–650
    • (2013) Int J Mol Med , vol.31 , pp. 644-650
    • Guo, R.1    Lin, J.2    Xu, W.3    Shen, N.4    Mo, L.5    Zhang, C.6    Feng, J.7
  • 18
    • 38549181533 scopus 로고    scopus 로고
    • Protective effects of naringenin-7-O-glucoside on doxorubicin-induced apoptosis in H9C2 cells
    • PID: 18154951, COI: 1:CAS:528:DC%2BD1cXhsVCmsb4%3D
    • Han X, Ren D, Fan P, Shen T, Lou H (2008) Protective effects of naringenin-7-O-glucoside on doxorubicin-induced apoptosis in H9C2 cells. Eur J Pharmacol 581:47–53
    • (2008) Eur J Pharmacol , vol.581 , pp. 47-53
    • Han, X.1    Ren, D.2    Fan, P.3    Shen, T.4    Lou, H.5
  • 19
    • 0032870898 scopus 로고    scopus 로고
    • Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo
    • PID: 10471354, COI: 1:CAS:528:DyaK1MXlsFyhtr4%3D
    • Holly TA, Drincic A, Byun Y, Nakamura S, Harris K, Klocke FJ, Cryns VL (1999) Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo. J Mol Cell Cardiol 31(9):1709–1715
    • (1999) J Mol Cell Cardiol , vol.31 , Issue.9 , pp. 1709-1715
    • Holly, T.A.1    Drincic, A.2    Byun, Y.3    Nakamura, S.4    Harris, K.5    Klocke, F.J.6    Cryns, V.L.7
  • 20
    • 0036170178 scopus 로고    scopus 로고
    • The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful
    • PID: 11823587, COI: 1:CAS:528:DC%2BD38XhtFGnsrw%3D
    • Juan ME, Vinardell MP, Planas JM (2002) The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful. J Nutr 132(2):257–260
    • (2002) J Nutr , vol.132 , Issue.2 , pp. 257-260
    • Juan, M.E.1    Vinardell, M.P.2    Planas, J.M.3
  • 21
    • 33846796318 scopus 로고    scopus 로고
    • Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver
    • PID: 17258234, COI: 1:CAS:528:DC%2BD2sXhs1Skur8%3D
    • Kasdallah-Grissa A, Mornagui B, Aouani E, Hammami M, El May M, Gharbi N, Kamoun A, El-Fazaâ S (2007) Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver. Life Sci 80(11):1033–1039
    • (2007) Life Sci , vol.80 , Issue.11 , pp. 1033-1039
    • Kasdallah-Grissa, A.1    Mornagui, B.2    Aouani, E.3    Hammami, M.4    El May, M.5    Gharbi, N.6    Kamoun, A.7    El-Fazaâ, S.8
  • 22
    • 84878628392 scopus 로고    scopus 로고
    • The effects of resveratrol on oxidant/antioxidant systems and their cofactors in rats
    • PID: 23709370
    • Kavas GO, Ayral PA, Elhan AH (2013) The effects of resveratrol on oxidant/antioxidant systems and their cofactors in rats. Adv Clin Exp Med 22(2):151–155
    • (2013) Adv Clin Exp Med , vol.22 , Issue.2 , pp. 151-155
    • Kavas, G.O.1    Ayral, P.A.2    Elhan, A.H.3
  • 24
    • 67650651227 scopus 로고    scopus 로고
    • Cardioprotective effect of lipistat against doxorubicin induced myocardial toxicity in albino rats
    • PID: 19317350, COI: 1:CAS:528:DC%2BD1MXmt1Crur0%3D
    • Koti BC, Vishwanathswamy AH, Wagawade J, Thippeswamy AH (2009) Cardioprotective effect of lipistat against doxorubicin induced myocardial toxicity in albino rats. Indian J Exp Biol 47:41–46
    • (2009) Indian J Exp Biol , vol.47 , pp. 41-46
    • Koti, B.C.1    Vishwanathswamy, A.H.2    Wagawade, J.3    Thippeswamy, A.H.4
  • 25
    • 0036645337 scopus 로고    scopus 로고
    • Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats
    • PID: 12093782, COI: 1:CAS:528:DC%2BD38XlvVWit7w%3D
    • Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K, Imaizumi T (2002) Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation 106(1):130–135
    • (2002) Circulation , vol.106 , Issue.1 , pp. 130-135
    • Kuwahara, F.1    Kai, H.2    Tokuda, K.3    Kai, M.4    Takeshita, A.5    Egashira, K.6    Imaizumi, T.7
  • 26
    • 80055109585 scopus 로고    scopus 로고
    • The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways
    • PID: 22019121
    • Li Y, Liu Y, Fu Y, Wei T, Le Guyader L, Gao G, Liu RS, Chang YZ, Chen C (2012) The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. Biomaterials 33:402–411
    • (2012) Biomaterials , vol.33 , pp. 402-411
    • Li, Y.1    Liu, Y.2    Fu, Y.3    Wei, T.4    Le Guyader, L.5    Gao, G.6    Liu, R.S.7    Chang, Y.Z.8    Chen, C.9
  • 27
    • 71849104860 scopus 로고
    • Protein measurement with the folin phenol reagent
    • PID: 14907713, COI: 1:CAS:528:DyaG38XhsVyrsw%3D%3D
    • Lowry OH, Rosebrough N, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265–275
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, O.H.1    Rosebrough, N.2    Farr, A.L.3    Randall, R.J.4
  • 29
    • 3042595700 scopus 로고    scopus 로고
    • Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4
    • PID: 15231041, COI: 1:CAS:528:DC%2BD2cXmtFSksL8%3D
    • Mohamed HE, Asker ME, Ali SI, El-Fattah TM (2004) Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4. J Pharm Pharmacol 56:757–768
    • (2004) J Pharm Pharmacol , vol.56 , pp. 757-768
    • Mohamed, H.E.1    Asker, M.E.2    Ali, S.I.3    El-Fattah, T.M.4
  • 30
    • 0015530358 scopus 로고
    • The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen
    • COI: 1:CAS:528:DyaE38Xps1Wisw%3D%3D
    • Nishikimi M, Roa NA, Yogi K (1972) The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Bioph Res Common 46:849–854
    • (1972) Biochem Bioph Res Common , vol.46 , pp. 849-854
    • Nishikimi, M.1    Roa, N.A.2    Yogi, K.3
  • 31
    • 84860523994 scopus 로고    scopus 로고
    • Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies
    • PID: 22465037, COI: 1:CAS:528:DC%2BC38Xlt1Kkt7w%3D
    • Octavia Y, Tocchetti CG, Gabrielson KL, Janssens S, Crijns HJ, Moens AL (2012) Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. J Mol Cell Cardiol 52:1213–1225
    • (2012) J Mol Cell Cardiol , vol.52 , pp. 1213-1225
    • Octavia, Y.1    Tocchetti, C.G.2    Gabrielson, K.L.3    Janssens, S.4    Crijns, H.J.5    Moens, A.L.6
  • 32
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • PID: 36810, COI: 1:CAS:528:DyaE1MXksFaisbk%3D
    • Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 33
    • 84860475045 scopus 로고    scopus 로고
    • Resveratrol attenuates doxorubicin-induced cellular damage by modulating nitric oxide and apoptosis
    • PID: 21144718, COI: 1:CAS:528:DC%2BC38XmsVGksb4%3D
    • Oktem G, Uysal A, Oral O, Sezer ED, Olukman M, Erol A, Akgur SA, Bilir A (2012) Resveratrol attenuates doxorubicin-induced cellular damage by modulating nitric oxide and apoptosis. Exp Toxicol Pathol 64(5):471–479
    • (2012) Exp Toxicol Pathol , vol.64 , Issue.5 , pp. 471-479
    • Oktem, G.1    Uysal, A.2    Oral, O.3    Sezer, E.D.4    Olukman, M.5    Erol, A.6    Akgur, S.A.7    Bilir, A.8
  • 36
    • 33646111188 scopus 로고    scopus 로고
    • Use of resveratrol to improve the effectiveness of cisplatin and doxorubicin: study in human gynecologic cancer cell lines and in rodent heart
    • Rezk YA, Balulad SS, Keller RS, Bennett JA (2006) Use of resveratrol to improve the effectiveness of cisplatin and doxorubicin: study in human gynecologic cancer cell lines and in rodent heart. Am J Obstet Gynecol 194:23–26
    • (2006) Am J Obstet Gynecol , vol.194 , pp. 23-26
    • Rezk, Y.A.1    Balulad, S.S.2    Keller, R.S.3    Bennett, J.A.4
  • 37
    • 84867101055 scopus 로고    scopus 로고
    • Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer
    • PID: 22595400, COI: 1:CAS:528:DC%2BC38XotVWisLg%3D
    • Scoditti E, Calabriso N, Massaro M, Pellegrino M, Storelli C, Martines G, De Caterina R, Carluccio MA (2012) Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch Biochem Biophys 527:81–89
    • (2012) Arch Biochem Biophys , vol.527 , pp. 81-89
    • Scoditti, E.1    Calabriso, N.2    Massaro, M.3    Pellegrino, M.4    Storelli, C.5    Martines, G.6    De Caterina, R.7    Carluccio, M.A.8
  • 38
    • 84871430037 scopus 로고    scopus 로고
    • Resveratrol attenuates ischemia/reperfusion injury in neonatal cardiomyocytes and its underlying mechanism
    • PID: 23284668, COI: 1:CAS:528:DC%2BC3sXksVyktw%3D%3D
    • Shen M, Wu RX, Zhao L, Li J, Guo HT, Fan R, Cui Y, Wang YM, Yue SQ, Pei JM (2012) Resveratrol attenuates ischemia/reperfusion injury in neonatal cardiomyocytes and its underlying mechanism. PLoS One 7(12):e51223
    • (2012) PLoS One , vol.7 , Issue.12 , pp. e51223
    • Shen, M.1    Wu, R.X.2    Zhao, L.3    Li, J.4    Guo, H.T.5    Fan, R.6    Cui, Y.7    Wang, Y.M.8    Yue, S.Q.9    Pei, J.M.10
  • 39
    • 34047121135 scopus 로고    scopus 로고
    • Metallothionein protects against doxorubicin-induced cardiomyopathy through inhibition of superoxide generation and related nitrosative impairment
    • PID: 17382496, COI: 1:CAS:528:DC%2BD2sXjslGktb0%3D
    • Shuai YI, Guo IB, Peng S-G, Li-Shi Z, Guo J, Han G, Shen Dong Y (2007) Metallothionein protects against doxorubicin-induced cardiomyopathy through inhibition of superoxide generation and related nitrosative impairment. Toxicol Lett 170:66–74
    • (2007) Toxicol Lett , vol.170 , pp. 66-74
    • Shuai, Y.I.1    Guo, I.B.2    Peng, S.-G.3    Li-Shi, Z.4    Guo, J.5    Han, G.6    Shen Dong, Y.7
  • 40
    • 79961047423 scopus 로고    scopus 로고
    • Resveratrol and health—a comprehensive review of human clinical trials
    • PID: 21688389, COI: 1:CAS:528:DC%2BC3MXps1Sltrk%3D
    • Smoliga JM, Baur JA, Hausenblas HA (2011) Resveratrol and health—a comprehensive review of human clinical trials. Mol Nutr Food Res 55:1129–1141
    • (2011) Mol Nutr Food Res , vol.55 , pp. 1129-1141
    • Smoliga, J.M.1    Baur, J.A.2    Hausenblas, H.A.3
  • 43
    • 33745312299 scopus 로고    scopus 로고
    • Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo
    • PID: 16766856, COI: 1:CAS:528:DC%2BD28XmslWrsbs%3D
    • Ueno M, Kakinuma Y, Yuhki K, Murakoshi N, Iemitsu M, Miyauchi T, Yamaguchi I (2006) Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo. J Pharmacol Sci 101:151–158
    • (2006) J Pharmacol Sci , vol.101 , pp. 151-158
    • Ueno, M.1    Kakinuma, Y.2    Yuhki, K.3    Murakoshi, N.4    Iemitsu, M.5    Miyauchi, T.6    Yamaguchi, I.7
  • 45
    • 79960995848 scopus 로고    scopus 로고
    • Resveratrol suppresses apoptosis in intact human cardiac tissue—in vitro model simulating extracorporeal circulation
    • COI: 1:STN:280:DC%2BC3Mrhs1Kjtw%3D%3D
    • Usta E, Mustafi M, Walker T, Ziemer G (2011) Resveratrol suppresses apoptosis in intact human cardiac tissue—in vitro model simulating extracorporeal circulation. J Cardiovasc Surg (Torino) 52:399–409
    • (2011) J Cardiovasc Surg (Torino) , vol.52 , pp. 399-409
    • Usta, E.1    Mustafi, M.2    Walker, T.3    Ziemer, G.4
  • 46
    • 63849183966 scopus 로고    scopus 로고
    • Dietary trans-resveratrol bioavailability and effect on CCl4-induced liver lipid peroxidation
    • PID: 18823437, COI: 1:CAS:528:DC%2BD1MXltlyhtL4%3D
    • Vitaglione P, Ottanelli B, Milani S, Morisco F, Caporaso N, Fogliano V (2009) Dietary trans-resveratrol bioavailability and effect on CCl4-induced liver lipid peroxidation. J Gastroenterol Hepatol 24(4):618–622
    • (2009) J Gastroenterol Hepatol , vol.24 , Issue.4 , pp. 618-622
    • Vitaglione, P.1    Ottanelli, B.2    Milani, S.3    Morisco, F.4    Caporaso, N.5    Fogliano, V.6
  • 47
    • 0036087649 scopus 로고    scopus 로고
    • Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart
    • PID: 11959632, COI: 1:CAS:528:DC%2BD38XjslWmtr4%3D
    • Wang B, Hao J, Jones SC, Yee MS, Roth JC, Dixon IM (2002) Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart. Am J Physiol Heart Circ Physiol 282:H1685–H1696
    • (2002) Am J Physiol Heart Circ Physiol , vol.282 , pp. H1685-H1696
    • Wang, B.1    Hao, J.2    Jones, S.C.3    Yee, M.S.4    Roth, J.C.5    Dixon, I.M.6
  • 48
    • 34548487798 scopus 로고    scopus 로고
    • Effect of resveratrol on heart function of rats with adriamycin-induced heart failure
    • PID: 17972590, COI: 1:CAS:528:DC%2BD1cXhvVynsr4%3D
    • Wang GY, Wang YM, Zhang LN, Li Q, Yue H, Song CM, Feng JK, Wang N (2007) Effect of resveratrol on heart function of rats with adriamycin-induced heart failure. Zhongguo Zhong Yao Za Zhi 32(15):1563–1565
    • (2007) Zhongguo Zhong Yao Za Zhi , vol.32 , Issue.15 , pp. 1563-1565
    • Wang, G.Y.1    Wang, Y.M.2    Zhang, L.N.3    Li, Q.4    Yue, H.5    Song, C.M.6    Feng, J.K.7    Wang, N.8
  • 49
    • 84863387579 scopus 로고    scopus 로고
    • Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy
    • PID: 22209892, COI: 1:CAS:528:DC%2BC38XltVagsb0%3D
    • Xu X, Chen K, Kobayashi S, Timm D, Liang Q (2012) Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy. J Pharmacol Exp Ther 341(1):183–195
    • (2012) J Pharmacol Exp Ther , vol.341 , Issue.1 , pp. 183-195
    • Xu, X.1    Chen, K.2    Kobayashi, S.3    Timm, D.4    Liang, Q.5
  • 50
    • 84863267798 scopus 로고    scopus 로고
    • Cellular and molecular effects of resveratrol in health and disease
    • PID: 22065601, COI: 1:CAS:528:DC%2BC38XpvVOktA%3D%3D
    • Yu W, Fu YC, Wang W (2012) Cellular and molecular effects of resveratrol in health and disease. J Cell Biochem 113:752–759
    • (2012) J Cell Biochem , vol.113 , pp. 752-759
    • Yu, W.1    Fu, Y.C.2    Wang, W.3
  • 51
    • 84863250768 scopus 로고    scopus 로고
    • Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-κB signaling pathway
    • PID: 22246136, COI: 1:CAS:528:DC%2BC38XmtFWns7s%3D
    • Zhang C, Lin G, Wan W, Li X, Zeng B, Yang B, Huang C (2012) Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-κB signaling pathway. Int J Mol Med 29:557–563
    • (2012) Int J Mol Med , vol.29 , pp. 557-563
    • Zhang, C.1    Lin, G.2    Wan, W.3    Li, X.4    Zeng, B.5    Yang, B.6    Huang, C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.