HMG-CoA reductase inhibition prior reperfusion improves reparative fibrosis post-myocardial infarction in a preclinical experimental model

International Journal of Cardiology

Volumn 175, Issue 3, 2014, Pages 528-538

  Vilahur, Gemma ^a   Casani, Laura ^a   Peña, Esther ^a   Juan Babot, Oriol ^a   Mendieta, Guiomar ^a   Crespo, Javier ^a   Badimon, Lina ^a,b  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Cardiac remodeling; HMG CoA reductase inhibition; Myocardial infarction; Swine

Indexed keywords

BETA HYDROXY ACID DERIVATIVE; CASPASE 3; CASPASE 8; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FAS ANTIGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE C EPSILON; PROTEIN P53; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG; CHOLESTEROL INTAKE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOTOXICITY; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; HEART ARRHYTHMIA; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HISTOPATHOLOGY; LIPOTOXICITY; LOADING DRUG DOSE; MITOCHONDRIAL MEMBRANE POTENTIAL; MUSCLE REGENERATION; MYOFIBROBLAST; NEUTROPHIL CHEMOTAXIS; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SWINE; ADVERSE EFFECTS; ANIMAL; CHOLESTEROL INTAKE; DISEASE MODEL; FIBROSIS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY;

ANIMALS; CHOLESTEROL, DIETARY; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; SWINE;

EID: 84905121778     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2014.06.040     Document Type: Article

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