C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation

Basic Research in Cardiology

Volumn 110, Issue 4, 2015, Pages

  Lei, Hong ^a   Wu, Dan ^a   Wang, Jin Yu ^a   Li, Li ^a   Zhang, Cheng Lin ^a   Feng, Han ^a   Fu, Feng Ying ^a   Wu, Li Ling ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

C1q tumor necrosis factor related protein 6; Cardiac fibrosis; Myocardial infarction; Myocardin related transcription factor A; Myofibroblast differentiation; RhoA

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANTIFIBROTIC AGENT; C1Q TUMOR NECROSIS FACTOR RELATED PROTEIN 6; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COMPLEMENT COMPONENT C1Q; CONNECTIVE TISSUE GROWTH FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MYOCARDIN RELATED TRANSCRIPTION FACTOR A; PROTEIN KINASE B; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSGELIN; UNCLASSIFIED DRUG; C1QTNF6 PROTEIN, HUMAN; COLLAGEN; MKL1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; GROWTH INHIBITION; HEART INFARCTION; HEART MUSCLE FIBROSIS; IN VITRO STUDY; MALE; MOLECULAR PATHOLOGY; MYOFIBROBLAST; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CELL CULTURE; CYTOLOGY; FIBROSIS; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN; FIBROSIS; HUMANS; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; MYOFIBROBLASTS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84930959190     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-015-0492-7     Document Type: Article

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