Calcium/calmodulin-dependent protein kinase II couples wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy

Hypertension

Volumn 65, Issue 2, 2015, Pages 335-344

  Zhang, Min ^a,b   Hagenmueller, Marco ^a,c   Riffel, Johannes H ^a,c   Kreusser, Michael M ^a,c   Bernhold, Elmar ^a   Fan, Jingjing ^a   Katus, Hugo A ^a,c   Backs, Johannes ^a,c   Hardt, Stefan E ^a,c,d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^d Center for Cardiac and Circulatory Diseases   (Germany)

Author keywords

calcium calmodulin dependent protein kinase type 2; cardiomyopathies; dishevelled proteins; histone deacetylase 4; Wnt signaling pathway

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BETA CATENIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II DELTA; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II GAMMA; DISHEVELLED 1; HISTONE DEACETYLASE 4; ISOPRENALINE; MYOSIN ENHANCER FACTOR 2; PROTEIN; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; BENZYLAMINE DERIVATIVE; DISHEVELLED PROTEINS; HDAC5 PROTEIN, MOUSE; HISTONE DEACETYLASE; MEF2A PROTEIN, MOUSE; MEF2B PROTEIN, MOUSE; MYOCYTE ENHANCER FACTOR 2; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SULFONAMIDE; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE INACTIVATION; GENE OVEREXPRESSION; HEART EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE FIBROSIS; HEART SIZE; HEART VENTRICLE HYPERTROPHY; HEMODYNAMIC PARAMETERS; MOUSE; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TIBIA LENGTH RATIO; TRANSTHORACIC ECHOCARDIOGRAPHY; WESTERN BLOTTING; WILD TYPE; WNT SIGNALING PATHWAY; ANIMAL; ANTAGONISTS AND INHIBITORS; DEFICIENCY; ECHOGRAPHY; ENZYMOLOGY; FIBROSIS; GENETICS; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE; HEART VENTRICLE REMODELING; KNOCKOUT MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; BENZYLAMINES; BETA CATENIN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; FIBROSIS; HEART FAILURE; HISTONE DEACETYLASES; HYPERTROPHY, LEFT VENTRICULAR; MAP KINASE SIGNALING SYSTEM; MEF2 TRANSCRIPTION FACTORS; MICE; MICE, KNOCKOUT; MYOCARDIUM; PHENOTYPE; PHOSPHOPROTEINS; PROTEIN KINASE C; SULFONAMIDES; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84921539288     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.04467     Document Type: Article

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