Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial- mesenchymal transition

Journal of the American College of Cardiology

Volumn 63, Issue 24, 2014, Pages 2734-2741

  Murdoch, Colin E ^a   Chaubey, Sanjay ^a   Zeng, Lingfang ^a   Yu, Bin ^a   Ivetic, Aleksander ^a   Walker, Simon J ^a   Vanhoutte, Davy ^b   Heymans, Stephane ^b   Grieve, David J ^a   Cave, Alison C ^a   Brewer, Alison C ^a   Zhang, Min ^a   Shah, Ajay M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

angiotensin II; diastolic dysfunction; endothelial mesenchymal transition; endothelium; NADPH (nicotinamide adenine dinucleotide phosphate) oxidase

Indexed keywords

ACETYLCYSTEINE; ANGIOTENSIN II; MESSENGER RNA; PROCOLLAGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; VASCULAR CELL ADHESION MOLECULE 1; ALPHA SMOOTH MUSCLE ACTIN; BETA GALACTOSIDASE; CALVASCULIN; CD31 ANTIGEN; CD45 ANTIGEN; CONNECTIVE TISSUE GROWTH FACTOR; OSTEOPONTIN; PROCOLLAGEN I; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARDITIS; CELL ADHESION; CELL INFILTRATION; CELL TRANSFORMATION; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL MESENCHYMAL TRANSITION; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; HEART EJECTION FRACTION; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART MUSCLE FIBROSIS; HEART OUTPUT; HEART STROKE VOLUME; HEART VENTRICLE HYPERTROPHY; INFLAMMATORY CELL; LEFT VENTRICULAR DIASTOLIC DYSFUNCTION; LEUKOCYTE; LEUKOCYTE ADHERENCE; MALE; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NONHUMAN; PARACRINE SIGNALING; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SYSTOLIC HYPERTENSION; ANIMAL MODEL; ANIMAL TISSUE; CARDIOVASCULAR PARAMETERS; CELL INTERACTION; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDOTHELIUM CELL; HEART LEFT VENTRICLE END SYSTOLIC ELASTANCE; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PATHOGENESIS; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRANSGENIC MOUSE; WILD TYPE;

ANGIOTENSIN II; DIASTOLIC DYSFUNCTION; ENDOTHELIAL-MESENCHYMAL TRANSITION; ENDOTHELIUM; NADPH (NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE) OXIDASE;

ANIMALS; CARDIOMEGALY; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FIBROSIS; HEART FAILURE, DIASTOLIC; HUMANS; INFLAMMATION MEDIATORS; MALE; MEMBRANE GLYCOPROTEINS; MESENCHYMAL STROMAL CELLS; MICE; MICE, TRANSGENIC; NADPH OXIDASE; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84899129310     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2014.02.572     Document Type: Article

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