Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway

Journal of Biological Chemistry

Volumn 285, Issue 5, 2010, Pages 3133-3144

  Pillai, Vinodkumar B ^a   Sundaresan, Nagalingam R ^a   Kim, Gene ^a   Gupta, Madhu ^b   Rajamohan, Senthilkumar B ^a   Pillai, Jyothish B ^a   Samant, Sadhana ^a   Ravindra, P V ^a   Isbatan, Ayman ^a   Gupta, Mahesh P ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMP-ACTIVATED KINASE; CARDIAC HYPERTROPHIC RESPONSE; CARDIAC HYPERTROPHY; HEART FAILURE; IN-VITRO; IN-VIVO; INTRACELLULAR LEVELS; KNOCK OUTS; PROTEIN SYNTHESIS; STRESS RESPONSE; TRANSGENIC MICE;

ENZYME ACTIVITY; PATHOLOGY; PLANTS (BOTANY); SIGNALING;

HEART;

ADENYLATE KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN KINASE B; PROTEIN KINASE LKB1; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; SIRTUIN 3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN SERINE THREONINE KINASE; SIRT3 PROTEIN, MOUSE; STK11 PROTEIN, MOUSE; STK11 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART MUSCLE CELL; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; ANIMAL; CARDIOMEGALY; CHEMISTRY; HEART FAILURE; HYPERTROPHY; METABOLISM; PATHOLOGY; PROTEIN BINDING; RAT; TRANSGENIC MOUSE;

MUS MUSCULUS;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CARDIOMEGALY; HEART FAILURE; HYPERTROPHY; MICE; MICE, TRANSGENIC; NAD; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RATS; REACTIVE OXYGEN SPECIES; SIRTUIN 3;

EID: 77449120223     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.077271     Document Type: Article

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