AMP-activated protein kinase inhibits transforming growth factor-β-induced Smad3-dependent transcription and myofibroblast transdifferentiation

Journal of Biological Chemistry

Volumn 283, Issue 16, 2008, Pages 10461-10469

  Mishra, Rangnath ^a   Cool, Barbara L ^b   Laderoute, Keith R ^c   Foretz, Marc ^d,e   Viollet, Benoit ^d,e   Simonson, Michael S ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ABBOTT LABORATORIES   (United States)

^c SRI INTERNATIONAL   (United States)

^d INSTITUT COCHIN   (France)

^e INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; CELL CULTURE; CHEMICAL REACTIONS; COLLAGEN; ENZYME INHIBITION; GROWTH (MATERIALS); MOLECULAR INTERACTIONS; MUSCLE; PEPTIDES; PHOSPHORYLATION; PORT TERMINALS; PROTEINS; TISSUE; TRANSCRIPTION;

ACTIVATED PROTEIN KINASES; COLLAGEN I; CONSTITUTIVELY ACTIVES; DOMINANT NEGATIVES; EXTRACELLULAR MATRIXES; IN CELLS; IN VITRO; INDUCED TRANSCRIPTIONS; MOLECULAR MECHANISMS; MYOFIBROBLAST; NUCLEAR TRANSLOCATIONS; SMOOTH MUSCLE ACTINS; SPLICE VARIANTS; TRANSCRIPTIONAL REGULATIONS; TRANSDIFFERENTIATION; TRANSFORMING GROWTH FACTORS;

ENZYME ACTIVITY;

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; AMP ACTIVATED PROTEIN KINASES; AMP-ACTIVATED PROTEIN KINASES; COLLAGEN; FIBRONECTIN; MULTIENZYME COMPLEX; PROTEIN SERINE THREONINE KINASE; SMAD3 PROTEIN, HUMAN;

ADENOVIRUS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ACTIVE TRANSPORT; BIOLOGICAL MODEL; CELL NUCLEUS; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FIBROBLAST; GENETIC TRANSCRIPTION; METABOLISM; PHENOTYPE; PHYSIOLOGY;

ADENOVIRIDAE;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOVIRIDAE; CELL NUCLEUS; COLLAGEN; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FIBROBLASTS; FIBRONECTINS; HUMANS; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; SMAD3 PROTEIN; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 44849096242     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800902200     Document Type: Article

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