Adiponectin-mediated modulation of hypertrophic signals in the heart

Nature Medicine

Volumn 10, Issue 12, 2004, Pages 1384-1389

  Shibata, Rei ^a   Ouchi, Noriyuki ^a   Ito, Masahiro ^b   Kihara, Shinji ^c   Shiojima, Ichiro ^a   Pimentel, David R ^b   Kumada, Masahiro ^c   Sato, Kaori ^a   Schiekofer, Stephan ^a   Ohashi, Koji ^c   Funahashi, Tohru ^c   Colucci, Wilson S ^b   Walsh, Kenneth ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ADIPONECTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; GENE TRANSFER; HEART HYPERTROPHY; HEART MUSCLE CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ADIPONECTIN; ANIMALS; BLOOD PRESSURE; BLOTTING, WESTERN; CARDIOMEGALY; ECHOCARDIOGRAPHY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE TRANSFER TECHNIQUES; HEART RATE; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIENZYME COMPLEXES; MYOCARDIUM; MYOCYTES, CARDIAC; OBESITY; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

ADENOVIRIDAE; ANIMALIA;

EID: 19944369735     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1137     Document Type: Article

References (24)

1. Reilly, M.P. & Rader, D.J. The metabolic syndrome: more than the sum of its parts? Circulation 108, 1546-1551 (2003).
2. Ouchi, N., Kihara, S., Funahashi, T., Matsuzawa, Y. & Walsh, K. Obesity, adiponectin and vascular inflammatory disease. Curr. Opin. Lipidol. 14, 561-566 (2003).
3. Ilercil, A. et al. Relationship of impaired glucose tolerance to left ventricular structure and function: The Strong Heart Study. Am. Heart J. 141, 992-998 (2001).
4. Rutter, M.K. et al. Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study. Circulation 107, 448-454 (2003).
5. Schannwell, C.M., Schneppenheim, M., Perings, S., Plehn, G. & Strauer, B.E. Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy. Cardiology 98, 33-39 (2002).
6. Kahn, B.B. & Flier, J.S. Obesity and insulin resistance. J. Clin. Invest. 106, 473-481 (2000).
7. Scherer, P.E., Williams, S., Fogliano, M., Baldini, G. & Lodish, H.F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270, 26746-26749 (1995).
8. Maeda, N. et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat. Med. 8, 731-737 (2002).
9. Kubota, N. et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J. Biol. Chem. 277, 25863-25866 (2002).
10. Shibata, R. et al. Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J. Biol. Chem. 279, 28670-28674 (2004).
11. Xiao, L. et al. MEK1/2-ERK1/2 mediates alpha 1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes. J. Mol. Cell. Cardiol. 33, 779-787 (2001).
12. Esposito, G. et al. Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload. Circulation 103, 1453-1458 (2001).
13. Kobayashi, H. et al. Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ. Res. 94, e27-e31 (2004).
14. Tomas, E. et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc. Natl. Acad. Sci. USA 99, 16309-16313 (2002).
15. Yamauchi, T. et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8, 1288-1295 (2002).
16. Wu, X. et al. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 52, 1355-1363 (2003).
17. Ouchi, N. et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J. Biol. Chem. 279, 1304-1309 (2004).
18. Chan, A.Y., Soltys, C.L., Young, M.E., Proud, C.G. & Dyck, J.R. Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. J. Biol. Chem., 279, 32771-32179 (2004).
19. Nagata, D., Mogi, M. & Walsh, K. AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress. J. Biol. Chem. 278, 31000-31006 (2003).
20. Mu, J., Brozinick, J.T., Jr, Valladares, O., Bucan, M. & Birnbaum, M.J. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol. Cell 7, 1085-1094 (2001).
21. Kudo, N., Barr, A.J., Barr, R.L., Desai, S. & Lopaschuk, G.D. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. J. Biol. Chem. 270, 17513-17520 (1995).
22. Tian, R., Musi, N., D'Agostino, J., Hirshman, M.F. & Goodyear, L.J. Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy. Circulation 104, 1664-1669 (2001).
23. Pimentel, D.R. et al. Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circ. Res. 89, 453-460 (2001).
24. Rogers, J.H. et al. RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload. J. Clin. Invest. 104, 567-576 (1999).