Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

Acta Neuropathologica

Volumn 132, Issue 2, 2016, Pages 235-256

  Sadleir, Katherine R ^a   Kandalepas, Patty C ^a   Buggia Prévot, Virginie ^b,d   Nicholson, Daniel A ^c   Thinakaran, Gopal ^b   Vassar, Robert ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c RUSH MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

5XFAD mice; Alzheimer s disease; Amyloid; Axonal transport; A ; BACE1; Cathepsin D; Dystrophic neurite; Microtubule; Tubulin

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE 1; BETA TUBULIN; CATHEPSIN D; DYNEIN ADENOSINE TRIPHOSPHATASE; KINESIN; TUBULIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; SECRETASE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN TISSUE; COGNITION; CONTROLLED STUDY; DYSTROPHY; EMBRYO; FEMALE; IN VITRO STUDY; LIVE CELL IMAGING; LYSOSOME; MALE; MICROTUBULE; MOUSE; NERVE CELL CULTURE; NERVE FIBER TRANSPORT; NEURITE; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; AXON; C57BL MOUSE; DISEASE MODEL; GENETICS; METABOLISM; NERVE ENDING; PATHOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; AXONS; DISEASE MODELS, ANIMAL; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURITES; PLAQUE, AMYLOID; PRESYNAPTIC TERMINALS;

EID: 84961218816     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-016-1558-9     Document Type: Article

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