Aβ1-42 reduces synapse number and inhibits neurite outgrowth in primary cortical and hippocampal neurons: A quantitative analysis

Journal of Neuroscience Methods

Volumn 175, Issue 1, 2008, Pages 96-103

  Evans, Nicholas A ^a   Facci, Laura ^a   Owen, Davina E ^a   Soden, Peter E ^a   Burbidge, Stephen A ^a   Prinjha, Rab K ^a   Richardson, Jill C ^a   Skaper, Stephen D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

A 1 42; Primary neurons; Quantitative synapse assay; Synaptogenesis

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; ASPARTYLLYSYLLEUCYLVALYLPHENYLALANYLPHENYLALANYLALANINAMIDE; PROTEIN INHIBITOR; SYNAPSIN I; SYNAPSIN II; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT; SYNAPSIN;

ANIMAL CELL; ARTICLE; BRAIN CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; FETUS; HIPPOCAMPUS; NERVE FIBER GROWTH; NEUROTOXICITY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL EMBRYO; BRAIN CORTEX; CELL COUNT; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; METABOLISM; NERVE CELL; NEURITE; SYNAPSE; TIME;

AMYLOID BETA-PROTEIN; ANALYSIS OF VARIANCE; ANIMALS; CELL COUNT; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; HIPPOCAMPUS; NEURITES; NEURONS; PEPTIDE FRAGMENTS; RATS; SYNAPSES; SYNAPSINS; TIME FACTORS;

EID: 52049088941     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2008.08.001     Document Type: Article

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