메뉴 건너뛰기




Volumn 9, Issue 4, 2013, Pages 459-462

Biomarker evidence for uncoupling of amyloid build-up and toxicity in Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid; Biomarkers; Brain amyloidosis; Longitudinal studies; Tau; Toxicity

Indexed keywords

AMYLOID BETA PROTEIN;

EID: 84882455578     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2012.07.002     Document Type: Note
Times cited : (13)

References (41)
  • 2
    • 0013859362 scopus 로고
    • Correlation between scores for dementia and counts of "senile plaques" in cerebral grey matter of elderly subjects
    • Roth M, Tomlinson BE, Blessed G. Correlation between scores for dementia and counts of "senile plaques" in cerebral grey matter of elderly subjects. Nature 1966;209:109-10.
    • (1966) Nature , vol.209 , pp. 109-110
    • Roth, M.1    Tomlinson, B.E.2    Blessed, G.3
  • 3
    • 0014313861 scopus 로고
    • The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects
    • Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 1968;114:797-811.
    • (1968) Br J Psychiatry , vol.114 , pp. 797-811
    • Blessed, G.1    Tomlinson, B.E.2    Roth, M.3
  • 4
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner GG, Wong CW. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984;120:885-90.
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 6
    • 0023132387 scopus 로고
    • Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
    • Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 1987;235:877-80.
    • (1987) Science , vol.235 , pp. 877-880
    • Goldgaber, D.1    Lerman, M.I.2    McBride, O.W.3    Saffiotti, U.4    Gajdusek, D.C.5
  • 7
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987;325: 733-6.
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1    Lemaire, H.G.2    Unterbeck, A.3    Salbaum, J.M.4    Masters, C.L.5    Grzeschik, K.H.6
  • 8
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991;349:704-6.
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.C.2    Mullan, M.3    Brown, J.4    Crawford, F.5    Fidani, L.6
  • 9
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ. Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 2001;81:741-66.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 10
    • 77957927865 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease: Back to the future
    • Bertram L, Lill CM, Tanzi RE. The genetics of Alzheimer disease: Back to the future. Neuron 2010;68:270-81.
    • (2010) Neuron , vol.68 , pp. 270-281
    • Bertram, L.1    Lill, C.M.2    Tanzi, R.E.3
  • 11
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 1991; 12:383-8.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 12
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe DJ. The molecular pathology of Alzheimer's disease. Neuron 1991;6:487-98.
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 13
    • 84863750982 scopus 로고    scopus 로고
    • Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease
    • Blennow K, Zetterberg H, Rinne JO, Salloway S,Wei J, Black R, et al. Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease. Arch Neurol 2012;69:1002-10.
    • (2012) Arch Neurol , vol.69 , pp. 1002-1010
    • Blennow, K.1    Zetterberg, H.2    Rinne, J.O.3    Salloway, S.4    Wei, J.5    Black, R.6
  • 14
    • 84863224067 scopus 로고    scopus 로고
    • Development of biomarkers to chart all Alzheimer's disease stages: The royal road to cutting the therapeutic Gordian Knot
    • Hampel H, Lista S, Khachaturian ZS. Development of biomarkers to chart all Alzheimer's disease stages: The royal road to cutting the therapeutic Gordian Knot. Alzheimers Dement 2012;8:312-36.
    • (2012) Alzheimers Dement , vol.8 , pp. 312-336
    • Hampel, H.1    Lista, S.2    Khachaturian, Z.S.3
  • 16
    • 77949423619 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    • Blennow K, Hampel H, Weiner M, Zetterberg H. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol 2010; 6:131-44.
    • (2010) Nat Rev Neurol , vol.6 , pp. 131-144
    • Blennow, K.1    Hampel, H.2    Weiner, M.3    Zetterberg, H.4
  • 17
    • 33947223454 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau/beta-amyloid (42) ratio as a prediction of cognitive decline in nondemented older adults
    • Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Arch Neurol 2007; 64:343-9.
    • (2007) Arch Neurol , vol.64 , pp. 343-349
    • Fagan, A.M.1    Roe, C.M.2    Xiong, C.3    Mintun, M.A.4    Morris, J.C.5    Holtzman, D.M.6
  • 18
    • 84858141828 scopus 로고    scopus 로고
    • Accelerated cortical atrophy in cognitively normal elderly with high beta-amyloid deposition
    • Chetelat G, Villemagne VL, Villain N, Jones G, Ellis KA, Ames D, et al. Accelerated cortical atrophy in cognitively normal elderly with high beta-amyloid deposition. Neurology 2012;78:477-84.
    • (2012) Neurology , vol.78 , pp. 477-484
    • Chetelat, G.1    Villemagne, V.L.2    Villain, N.3    Jones, G.4    Ellis, K.A.5    Ames, D.6
  • 19
    • 73549092137 scopus 로고    scopus 로고
    • Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease
    • Morris JC, Roe CM, Grant EA, Head D, Storandt M, Goate AM, et al. Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease. Arch Neurol 2009;66:1469-75.
    • (2009) Arch Neurol , vol.66 , pp. 1469-1475
    • Morris, J.C.1    Roe, C.M.2    Grant, E.A.3    Head, D.4    Storandt, M.5    Goate, A.M.6
  • 21
    • 34447634667 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly
    • Stomrud E, Hansson O, Blennow K, Minthon L, Londos E. Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly. Dement Geriatr Cogn Disord 2007; 24:118-24.
    • (2007) Dement Geriatr Cogn Disord , vol.24 , pp. 118-124
    • Stomrud, E.1    Hansson, O.2    Blennow, K.3    Minthon, L.4    Londos, E.5
  • 24
    • 84855304100 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of beta-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia
    • Buchhave P, Minthon L, Zetterberg H, Wallin AK, Blennow K, Hansson O. Cerebrospinal fluid levels of beta-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia. Arch Gen Psychiatry 2012;69:98-106.
    • (2012) Arch Gen Psychiatry , vol.69 , pp. 98-106
    • Buchhave, P.1    Minthon, L.2    Zetterberg, H.3    Wallin, A.K.4    Blennow, K.5    Hansson, O.6
  • 26
    • 34248190279 scopus 로고    scopus 로고
    • A beta oligomers: A decade of discovery
    • Walsh DM, Selkoe DJ. A beta oligomers: A decade of discovery. J Neurochem 2007;101:1172-84.
    • (2007) J Neurochem , vol.101 , pp. 1172-1184
    • Walsh, D.M.1    Selkoe, D.J.2
  • 27
    • 80054024011 scopus 로고    scopus 로고
    • Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders
    • Jucker M, Walker LC. Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol 2011; 70:532-40.
    • (2011) Ann Neurol , vol.70 , pp. 532-540
    • Jucker, M.1    Walker, L.C.2
  • 28
    • 73949089674 scopus 로고    scopus 로고
    • Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide
    • Hu X, Crick SL, Bu G, Frieden C, Pappu RV, Lee JM. Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc Natl Acad Sci USA 2009;106:20324-9.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20324-20329
    • Hu, X.1    Crick, S.L.2    Bu, G.3    Frieden, C.4    Pappu, R.V.5    Lee, J.M.6
  • 29
    • 79952167224 scopus 로고    scopus 로고
    • Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
    • Sandberg MK, Al-Doujaily H, Sharps B, Clarke AR, Collinge J. Prion propagation and toxicity in vivo occur in two distinct mechanistic phases. Nature 2011;470:540-2.
    • (2011) Nature , vol.470 , pp. 540-542
    • Sandberg, M.K.1    Al-Doujaily, H.2    Sharps, B.3    Clarke, A.R.4    Collinge, J.5
  • 31
    • 62649174753 scopus 로고    scopus 로고
    • Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
    • Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, et al. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci USA 2009;106:4012-7.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 4012-4017
    • Koffie, R.M.1    Meyer-Luehmann, M.2    Hashimoto, T.3    Adams, K.W.4    Mielke, M.L.5    Garcia-Alloza, M.6
  • 32
    • 13644249900 scopus 로고    scopus 로고
    • Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice
    • Boncristiano S, Calhoun ME, Howard V, Bondolfi L, Kaeser SA, Wiederhold KH, et al. Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice. Neurobiol Aging 2005;26:607-13.
    • (2005) Neurobiol Aging , vol.26 , pp. 607-613
    • Boncristiano, S.1    Calhoun, M.E.2    Howard, V.3    Bondolfi, L.4    Kaeser, S.A.5    Wiederhold, K.H.6
  • 33
    • 47749153411 scopus 로고    scopus 로고
    • Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation
    • Hartley DM, Zhao C, Speier AC,Woodard GA, Li S, Li Z, et al. Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation. J Biol Chem 2008;283:16790-800.
    • (2008) J Biol Chem , vol.283 , pp. 16790-16800
    • Hartley, D.M.1    Zhao, C.2    Speier, A.C.3    Woodard, G.A.4    Li, S.5    Li, Z.6
  • 34
    • 33744956272 scopus 로고    scopus 로고
    • Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge
    • Smith DP, Smith DG, Curtain CC, Boas JF, Pilbrow JR, Ciccotosto GD, et al. Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge. J Biol Chem 2006; 281:15145-54.
    • (2006) J Biol Chem , vol.281 , pp. 15145-15154
    • Smith, D.P.1    Smith, D.G.2    Curtain, C.C.3    Boas, J.F.4    Pilbrow, J.R.5    Ciccotosto, G.D.6
  • 35
    • 0033045848 scopus 로고    scopus 로고
    • In vitro peroxidase oxidation induces stable dimers of beta-amyloid (1-42) through dityrosine bridge formation
    • Galeazzi L, Ronchi P, Franceschi C, Giunta S. In vitro peroxidase oxidation induces stable dimers of beta-amyloid (1-42) through dityrosine bridge formation. Amyloid 1999;6:7-13.
    • (1999) Amyloid , vol.6 , pp. 7-13
    • Galeazzi, L.1    Ronchi, P.2    Franceschi, C.3    Giunta, S.4
  • 36
    • 1842504323 scopus 로고    scopus 로고
    • Redox-active metals, oxidative stress, and Alzheimer's disease pathology
    • Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT. Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann NY Acad Sci 2004;1012:153-63.
    • (2004) Ann NY Acad Sci , vol.1012 , pp. 153-163
    • Huang, X.1    Moir, R.D.2    Tanzi, R.E.3    Bush, A.I.4    Rogers, J.T.5
  • 37
    • 84859298550 scopus 로고    scopus 로고
    • The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: An update
    • Bales KR. The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: An update. Expert Opin Drug Discov 2012;7:281-97.
    • (2012) Expert Opin Drug Discov , vol.7 , pp. 281-297
    • Bales, K.R.1
  • 39
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 2008; 14:837-42.
    • (2008) Nat Med , vol.14 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3    Garcia-Munoz, A.4    Shepardson, N.E.5    Smith, I.6
  • 40
    • 79955044494 scopus 로고    scopus 로고
    • Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration
    • Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci USA 2011;108:5819-24.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 5819-5824
    • Jin, M.1    Shepardson, N.2    Yang, T.3    Chen, G.4    Walsh, D.5    Selkoe, D.J.6
  • 41
    • 70450257636 scopus 로고    scopus 로고
    • Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains
    • Noguchi A, Matsumura S, Dezawa M, Tada M, Yanazawa M, Ito A, et al. Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains. J Biol Chem 2009;284:32895-905.
    • (2009) J Biol Chem , vol.284 , pp. 32895-32905
    • Noguchi, A.1    Matsumura, S.2    Dezawa, M.3    Tada, M.4    Yanazawa, M.5    Ito, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.