Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 28, 2015, Pages E3699-E3708

  Gowrishankar, Swetha ^a   Yuan, Peng ^a   Wu, Yumei ^a   Schrag, Matthew ^a   Paradise, Summer ^a   Grutzendler, Jaime ^a   De Camilli, Pietro ^a   Ferguson, Shawn M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's; Axonal transport; Cathepsin; Lysosome; Progranulin

Indexed keywords

AMPHIPHYSIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; DYNAMIN I; GLIAL FIBRILLARY ACIDIC PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ENZYME; MICROTUBULE ASSOCIATED PROTEIN 2; PRESENILIN 1; PROTEINASE; SOMATOMEDIN B RECEPTOR; SORTILIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; MEMBRANE PROTEIN; SECRETASE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGOSOME; CELL MATURATION; CELL POPULATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOSOME; GOLGI COMPLEX; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; LYSOSOME; LYSOSOME MEMBRANE; MITOCHONDRION; MOUSE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; RETROGRADE NERVE FIBER TRANSPORT; ANIMAL; AXON; DISEASE MODEL; ENZYMOLOGY; METABOLISM;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; AXONS; DISEASE MODELS, ANIMAL; LYSOSOMES; MEMBRANE PROTEINS; MICE; PLAQUE, AMYLOID;

EID: 84937132776     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1510329112     Document Type: Article

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