miR-29c regulates BACE1 protein expression

Brain Research

Volumn 1395, Issue , 2011, Pages 108-115

  Zong, Yuanyuan ^a   Wang, Hailin ^a   Dong, Wei ^a   Quan, Xiongzhi ^a   Zhu, Hua ^a   Xu, Yanfeng ^a   Huang, Lan ^a   Ma, Chunmei ^a   Qin, Chuan ^a  

^a INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

Author keywords

Alzheimer's disease; APPswe PS E9 mouse; BACE1 protein; MicroRNAs; miR 29c

Indexed keywords

BETA SECRETASE 1; MESSENGER RNA; MICRORNA; MICRORNA 29C; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; VALIDATION PROCESS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICRORNAS; MUTATION; TRANSGENES;

MUS; MUS MUSCULUS;

EID: 79957907210     PISSN: 00068993     EISSN: 00068993     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.04.035     Document Type: Article

References (22)

1. Bartel, D.P., 2004. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
2. Boissonneault, V., Plante, I., Rivest, S., Provost, P., 2009. MicroRNA-298, and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J. Biol. Chem. 284, 1971-1981.
3. Carrington, J.C., Ambros, V., 2003. Role of microRNAs in plant and animal development. Science 301, 336-338. (Pubitemid 36877060)
4. Fabbri, M., Garzon, R., Cimmino, A., Liu, Z., Zanesi, N., Callegari, 2007. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl. Acad. Sci. U. S. A. 104, 15805-15810.
5. Farh, K.K., Grimson, A., Jan, C., Lewis, B.P., Johnston, W.K., Lim, L. P., Burge, C.B., Bartel, D.P., 2005. The widespread impact of mammalian microRNAs on mRNA repression and evolution. Science 310, 1817-1821. (Pubitemid 41814382)
6. Hébert, S.S., De Strooper, B., 2009. Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci. 32, 199-206.
7. Hébert, S.S., Horré, K., Nicolaï, L., Papadopoulou, A.S., Mandemakers, W., Silahtaroglu, A.N., Kauppinen, S., Delacourte, A., De Strooper, B., 2008. Loss of microRNA clustermiR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc. Natl. Acad. Sci. U. S. A. 105, 6415-6420.
8. Johnson-Wood, K., Lee, M., Motter, R., Hu, K., Gordon, G., Barbour, R., Khan, K., Gordon, M., Tan, H., Games, D., Lieberburg, I., Schenk, D., Seubert, P., McConlogue, L., 1997. Amyloid precursor protein processing and Aâ42 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 94, 1550-1555.
9. Juan, F., Wei, D., Xiongzhi, Q., Ran, D., Chunmei, M., Lan, H., Chuan, Q., Lianfeng, Z., 2008. The changes of the cardiac structure and function in cTnTR141W transgenic mice. Int. J. Cardiol. 128, 83-90.
10. Krek, A., Grun, D., Poy, M.N., Wolf, R., Rosenberg, L., Epstein, E.J., MacMenamin, P., da Piedade, I., Gunsalus, K.C., Stoffel, M., Rajewsky, N., 2005. Combinatorial microRNA target predictions. Nat. Genet. 37, 495-500.
11. Lewis, B.P., Burge, C.B., Barte, l D.P., 2005. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15-20. (Pubitemid 40094598)
12. Luo, Y., Bolon, B., Kahn, S., Bennett, B.D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., Martin, L., Louis, J.C., Yan, Q., Richards, W.G., Citron, M., Vassar, R., 2001. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat. Neurosci. 4, 231-232.
13. Mott, J.L., Kobayashi, S., Bronk, S.F., Gores, G.J., 2007. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 26, 6133-6140. (Pubitemid 47414372)
14. Roberds, S.L., Anderson, J., Basi, G., Bienkowski, M.J., Branstetter, D.G., Chen, K.S., Freedman, S.B., Frigon, N.L., Games, D., Hu, K., Johnson-Wood, K., Kappenman, K.E., Kawabe, T.T., Kola, I., Kuehn, R., Lee, M., Liu, W., Motter, R., Nichols, N.F., Power, M., Robertson, D.W., Schenk, D., Schoor, M., Shopp, G.M., Shuck, M.E., Sinha, S., Svensson, K.A., Tatsuno, G., Tintrup, H., Wijsman, J., Wright, S., McConlogue, L., 2001. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum. Mol. Genet. 10, 1317-1324.
15. Sengupta, S., den Boon, J.A., Chen, I.H., Newton, M.A., Stanhope, S.A., Cheng, Y.J., Chen, C.J., Hildesheim, A., Sugden, B., Ahlquist, P., 2008. MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Proc. Natl. Acad. Sci. U. S. A. 105, 5874-5878.
16. Shioya, M., Obayashi, S., Tabunoki, H., Arima, K., Saitoh, Y., Ishida, T., Satoh, J., 2010. Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neuron navigator 3. Neuropathol. Appl. Neurobiol. 36, 320-330.
17. Stamatopoulos, B., Meuleman, N., Haibe-Kains, B., Saussoy, P., Van den Neste, E., Michaux, L., Heimann, P., Martiat, P., Bron, D., Lagneaux, L., 2009. MicroRNA-29c and microRNA-223 downregulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification. Blood 113, 5237-5245.
18. Wang, W.X., Rajeev, B.W., Stromberg, A.J., Ren, N., Tang, G., Huang, Q., Rigoutsos, I., Nelson, P.T., 2008. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J. Neurosci. 28, 1213-1223. (Pubitemid 351186356)
19. Wang, X., Liu, P., Zhu, H., Xu, Y., Ma, C., Dai, X., Huang, L., Liu, Y., Zhang, L., Qin, C., 2009. miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res. Bull. 80, 268-273.
20. Wang, H., Liu, J., Zong, Y., Xu, Y., Deng, W., Zhu, H., Liu, Y., Ma, C., Huang, L., Zhang, L., Qin, C., 2010. miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor. Brain Res. 1357, 166-174.
21. Yang, L.B., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X.L., Beach, T., Sue, L., Wong, P., Price, D., Li, R., Shen, Y., 2003. Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat. Med. 9, 3-4.
22. Zhao, J., Fu, Y., Yasvoina, M., Shao, P., Hitt, B., O'Connor, T., Logan, S., Maus, E., Citron, M., Berry, R., Binder, L., Vassar, R., 2007. Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. J. Neurosci. 27, 3639-3649. (Pubitemid 46557686)