메뉴 건너뛰기




Volumn 15, Issue 1, 2016, Pages

Forkhead box transcription factor 1: Role in the pathogenesis of diabetic cardiomyopathy

Author keywords

Apoptosis; Diabetic cardiomyopathy; FOXO1; Inflammation; Metabolism; Oxidative stress

Indexed keywords

TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; AUTACOID; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN;

EID: 84960110612     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/s12933-016-0361-1     Document Type: Review
Times cited : (91)

References (134)
  • 1
    • 0031445908 scopus 로고    scopus 로고
    • The rising global burden of diabetes and its complications: estimates and projections to the year 2010
    • Amos AF, McCarty DJ, Zimmet P. The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet Med. 1997;14(Suppl 5):S1-85.
    • (1997) Diabet Med , vol.14 , pp. S1-S85
    • Amos, A.F.1    McCarty, D.J.2    Zimmet, P.3
  • 2
    • 10344255610 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: mechanisms, diagnosis and treatment
    • Hayat SA, Patel B, Khattar RS, Malik RA. Diabetic cardiomyopathy: mechanisms, diagnosis and treatment. Clin Sci. 2004;107(6):539-57.
    • (2004) Clin Sci , vol.107 , Issue.6 , pp. 539-557
    • Hayat, S.A.1    Patel, B.2    Khattar, R.S.3    Malik, R.A.4
  • 3
    • 0016251063 scopus 로고
    • Role of diabetes in congestive heart failure: the Framingham study
    • Kannel WB, Hjortland M, Castelli WP. Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol. 1974;34(1):29-34.
    • (1974) Am J Cardiol , vol.34 , Issue.1 , pp. 29-34
    • Kannel, W.B.1    Hjortland, M.2    Castelli, W.P.3
  • 4
    • 0018764335 scopus 로고
    • Diabetes and cardiovascular disease. The Framingham study
    • Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA. 1979;241(19):2035-8.
    • (1979) JAMA , vol.241 , Issue.19 , pp. 2035-2038
    • Kannel, W.B.1    McGee, D.L.2
  • 6
    • 84925023456 scopus 로고    scopus 로고
    • Activation of FOXO1 by insulin resistance promotes cardiac dysfunction and beta-myosin heavy chain gene expression
    • Qi Y, Zhu Q, Zhang K, Thomas C, Wu Y, Kumar R, Baker KM, Xu Z, Chen S, Guo S. Activation of FOXO1 by insulin resistance promotes cardiac dysfunction and beta-myosin heavy chain gene expression. Circ Heart Fail. 2015;8(1):198-208.
    • (2015) Circ Heart Fail , vol.8 , Issue.1 , pp. 198-208
    • Qi, Y.1    Zhu, Q.2    Zhang, K.3    Thomas, C.4    Wu, Y.5    Kumar, R.6    Baker, K.M.7    Xu, Z.8    Chen, S.9    Guo, S.10
  • 8
    • 0024973841 scopus 로고
    • The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo
    • Weigel D, Jurgens G, Kuttner F, Seifert E, Jackle H. The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo. Cell. 1989;57(4):645-58.
    • (1989) Cell , vol.57 , Issue.4 , pp. 645-658
    • Weigel, D.1    Jurgens, G.2    Kuttner, F.3    Seifert, E.4    Jackle, H.5
  • 9
    • 0025029381 scopus 로고
    • The fork head domain: a novel DNA binding motif of eukaryotic transcription factors?
    • Weigel D, Jackle H. The fork head domain: a novel DNA binding motif of eukaryotic transcription factors? Cell. 1990;63(3):455-6.
    • (1990) Cell , vol.63 , Issue.3 , pp. 455-456
    • Weigel, D.1    Jackle, H.2
  • 10
    • 62549108593 scopus 로고    scopus 로고
    • The evolution of Fox genes and their role in development and disease
    • Hannenhalli S, Kaestner KH. The evolution of Fox genes and their role in development and disease. Nat Rev Genet. 2009;10(4):233-40.
    • (2009) Nat Rev Genet , vol.10 , Issue.4 , pp. 233-240
    • Hannenhalli, S.1    Kaestner, K.H.2
  • 11
    • 80052968080 scopus 로고    scopus 로고
    • Regulation of FOXO transcription factors by acetylation and protein-protein interactions
    • Daitoku H, Sakamaki J, Fukamizu A. Regulation of FOXO transcription factors by acetylation and protein-protein interactions. Biochim Biophys Acta. 2011;1813(11):1954-60.
    • (2011) Biochim Biophys Acta , vol.1813 , Issue.11 , pp. 1954-1960
    • Daitoku, H.1    Sakamaki, J.2    Fukamizu, A.3
  • 12
    • 80052964810 scopus 로고    scopus 로고
    • Structural basis for DNA recognition by FOXO proteins
    • Obsil T, Obsilova V. Structural basis for DNA recognition by FOXO proteins. Biochim Biophys Acta. 2011;1813(11):1946-53.
    • (2011) Biochim Biophys Acta , vol.1813 , Issue.11 , pp. 1946-1953
    • Obsil, T.1    Obsilova, V.2
  • 13
    • 41849104205 scopus 로고    scopus 로고
    • Structure/function relationships underlying regulation of FOXO transcription factors
    • Obsil T, Obsilova V. Structure/function relationships underlying regulation of FOXO transcription factors. Oncogene. 2008;27(16):2263-75.
    • (2008) Oncogene , vol.27 , Issue.16 , pp. 2263-2275
    • Obsil, T.1    Obsilova, V.2
  • 15
    • 0037237279 scopus 로고    scopus 로고
    • The forkhead transcription factor FOXO1 regulates adipocyte differentiation
    • Nakae J, Kitamura T, Kitamura Y, Biggs WH 3rd, Arden KC, Accili D. The forkhead transcription factor FOXO1 regulates adipocyte differentiation. Dev Cell. 2003;4(1):119-29.
    • (2003) Dev Cell , vol.4 , Issue.1 , pp. 119-129
    • Nakae, J.1    Kitamura, T.2    Kitamura, Y.3    Biggs, W.H.4    Arden, K.C.5    Accili, D.6
  • 16
    • 79251541212 scopus 로고    scopus 로고
    • The extending network of FOXO transcriptional target genes
    • van der Vos KE, Coffer PJ. The extending network of FOXO transcriptional target genes. Antioxid Redox Signal. 2011;14(4):579-92.
    • (2011) Antioxid Redox Signal , vol.14 , Issue.4 , pp. 579-592
    • Vos, K.E.1    Coffer, P.J.2
  • 17
    • 80052970809 scopus 로고    scopus 로고
    • FOXO transcription factors; regulation by AKT and 14-3-3 proteins
    • Tzivion G, Dobson M, Ramakrishnan G. FOXO transcription factors; regulation by AKT and 14-3-3 proteins. Biochim Biophys Acta. 2011;1813(11):1938-45.
    • (2011) Biochim Biophys Acta , vol.1813 , Issue.11 , pp. 1938-1945
    • Tzivion, G.1    Dobson, M.2    Ramakrishnan, G.3
  • 18
    • 70349689697 scopus 로고    scopus 로고
    • A fork in the path: developing therapeutic inroads with FOXO proteins
    • Maiese K, Hou J, Chong ZZ, Shang YC. A fork in the path: developing therapeutic inroads with FOXO proteins. Oxid Med Cell Longev. 2009;2(3):119-29.
    • (2009) Oxid Med Cell Longev , vol.2 , Issue.3 , pp. 119-129
    • Maiese, K.1    Hou, J.2    Chong, Z.Z.3    Shang, Y.C.4
  • 19
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: a play in three AKTS
    • Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three AKTS. Genes Dev. 1999;13(22):2905-27.
    • (1999) Genes Dev , vol.13 , Issue.22 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 20
    • 0032759047 scopus 로고    scopus 로고
    • Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling
    • Kops GJ, Burgering BM. Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling. J Mol Med (Berl). 1999;77(9):656-65.
    • (1999) J Mol Med (Berl) , vol.77 , Issue.9 , pp. 656-665
    • Kops, G.J.1    Burgering, B.M.2
  • 21
    • 0033522897 scopus 로고    scopus 로고
    • Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
    • Nakae J, Park BC, Accili D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem. 1999;274(23):15982-5.
    • (1999) J Biol Chem , vol.274 , Issue.23 , pp. 15982-15985
    • Nakae, J.1    Park, B.C.2    Accili, D.3
  • 22
    • 42449126643 scopus 로고    scopus 로고
    • Inhibition of FOXO1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis
    • Martinez SC, Tanabe K, Cras-Meneur C, Abumrad NA, Bernal-Mizrachi E, Permutt MA. Inhibition of FOXO1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes. 2008;57(4):846-59.
    • (2008) Diabetes , vol.57 , Issue.4 , pp. 846-859
    • Martinez, S.C.1    Tanabe, K.2    Cras-Meneur, C.3    Abumrad, N.A.4    Bernal-Mizrachi, E.5    Permutt, M.A.6
  • 24
    • 33750032892 scopus 로고    scopus 로고
    • CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage
    • Huang H, Regan KM, Lou Z, Chen J, Tindall DJ. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science. 2006;314(5797):294-7.
    • (2006) Science , vol.314 , Issue.5797 , pp. 294-297
    • Huang, H.1    Regan, K.M.2    Lou, Z.3    Chen, J.4    Tindall, D.J.5
  • 28
    • 27744518040 scopus 로고    scopus 로고
    • FOXO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    • Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, Gu W, Accili D. FOXO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab. 2005;2(3):153-63.
    • (2005) Cell Metab , vol.2 , Issue.3 , pp. 153-163
    • Kitamura, Y.I.1    Kitamura, T.2    Kruse, J.P.3    Raum, J.C.4    Stein, R.5    Gu, W.6    Accili, D.7
  • 31
    • 1542267804 scopus 로고    scopus 로고
    • Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
    • Hosaka T, Biggs WH, Tieu D, Boyer AD, Varki NM, Cavenee WK, Arden KC. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci USA. 2004;101(9):2975-80.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.9 , pp. 2975-2980
    • Hosaka, T.1    Biggs, W.H.2    Tieu, D.3    Boyer, A.D.4    Varki, N.M.5    Cavenee, W.K.6    Arden, K.C.7
  • 33
    • 41849093037 scopus 로고    scopus 로고
    • The role of FOXO in the regulation of metabolism
    • Gross DN, van den Heuvel AP, Birnbaum MJ. The role of FOXO in the regulation of metabolism. Oncogene. 2008;27(16):2320-36.
    • (2008) Oncogene , vol.27 , Issue.16 , pp. 2320-2336
    • Gross, D.N.1    Heuvel, A.P.2    Birnbaum, M.J.3
  • 34
    • 1642332084 scopus 로고    scopus 로고
    • Integration of smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • Seoane J, Le H-V, Shen L, Anderson SA, Massagué J. Integration of smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell. 2004;117(2):211-23.
    • (2004) Cell , vol.117 , Issue.2 , pp. 211-223
    • Seoane, J.1    Le, H.-V.2    Shen, L.3    Anderson, S.A.4    Massagué, J.5
  • 35
    • 33748208668 scopus 로고    scopus 로고
    • C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells
    • Gomis RR, Alarcon C, Nadal C, Van Poznak C, Massague J. C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell. 2006;10(3):203-14.
    • (2006) Cancer Cell , vol.10 , Issue.3 , pp. 203-214
    • Gomis, R.R.1    Alarcon, C.2    Nadal, C.3    Poznak, C.4    Massague, J.5
  • 37
  • 38
    • 34848861463 scopus 로고    scopus 로고
    • The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
    • Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, Brunet A. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem. 2007;282(41):30107-19.
    • (2007) J Biol Chem , vol.282 , Issue.41 , pp. 30107-30119
    • Greer, E.L.1    Oskoui, P.R.2    Banko, M.R.3    Maniar, J.M.4    Gygi, M.P.5    Gygi, S.P.6    Brunet, A.7
  • 39
    • 37349025432 scopus 로고    scopus 로고
    • FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2
    • Bakker WJ, Harris IS, Mak TW. FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2. Mol Cell. 2007;28(6):941-53.
    • (2007) Mol Cell , vol.28 , Issue.6 , pp. 941-953
    • Bakker, W.J.1    Harris, I.S.2    Mak, T.W.3
  • 40
    • 34848868499 scopus 로고    scopus 로고
    • The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling
    • Shaw WM, Luo S, Landis J, Ashraf J, Murphy CT. The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol. 2007;17(19):1635-45.
    • (2007) Curr Biol , vol.17 , Issue.19 , pp. 1635-1645
    • Shaw, W.M.1    Luo, S.2    Landis, J.3    Ashraf, J.4    Murphy, C.T.5
  • 41
    • 37349099564 scopus 로고    scopus 로고
    • Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathways
    • Siegenthaler JA, Miller MW. Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathways. Dev Biol. 2008;313(1):35-46.
    • (2008) Dev Biol , vol.313 , Issue.1 , pp. 35-46
    • Siegenthaler, J.A.1    Miller, M.W.2
  • 42
    • 0034680839 scopus 로고    scopus 로고
    • Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity
    • Schmoll D, Walker KS, Alessi DR, Grempler R, Burchell A, Guo S, Walther R, Unterman TG. Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity. J Biol Chem. 2000;275(46):36324-33.
    • (2000) J Biol Chem , vol.275 , Issue.46 , pp. 36324-36333
    • Schmoll, D.1    Walker, K.S.2    Alessi, D.R.3    Grempler, R.4    Burchell, A.5    Guo, S.6    Walther, R.7    Unterman, T.G.8
  • 43
    • 0034730660 scopus 로고    scopus 로고
    • Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins
    • Hall RK, Yamasaki T, Kucera T, Waltner-Law M, O'Brien R, Granner DK. Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins. J Biol Chem. 2000;275(39):30169-75.
    • (2000) J Biol Chem , vol.275 , Issue.39 , pp. 30169-30175
    • Hall, R.K.1    Yamasaki, T.2    Kucera, T.3    Waltner-Law, M.4    O'Brien, R.5    Granner, D.K.6
  • 45
    • 23844470550 scopus 로고    scopus 로고
    • Cloning of the rat pyruvate dehydrogenase kinase 4 gene promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor gamma coactivator
    • Ma K, Zhang Y, Elam MB, Cook GA, Park EA. Cloning of the rat pyruvate dehydrogenase kinase 4 gene promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor gamma coactivator. J Biol Chem. 2005;280(33):29525-32.
    • (2005) J Biol Chem , vol.280 , Issue.33 , pp. 29525-29532
    • Ma, K.1    Zhang, Y.2    Elam, M.B.3    Cook, G.A.4    Park, E.A.5
  • 47
    • 62949147248 scopus 로고    scopus 로고
    • Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells
    • Li X, Rong Y, Zhang M, Wang XL, LeMaire SA, Coselli JS, Zhang Y, Shen YH. Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells. Biochem Biophys Res Commun. 2009;381(4):660-5.
    • (2009) Biochem Biophys Res Commun , vol.381 , Issue.4 , pp. 660-665
    • Li, X.1    Rong, Y.2    Zhang, M.3    Wang, X.L.4    LeMaire, S.A.5    Coselli, J.S.6    Zhang, Y.7    Shen, Y.H.8
  • 48
    • 84871797076 scopus 로고    scopus 로고
    • FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Kruppel-like factor 2
    • Lee HY, Youn SW, Cho HJ, Kwon YW, Lee SW, Kim SJ, Park YB, Oh BH, Kim HS. FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Kruppel-like factor 2. Cardiovasc Res. 2013;97(1):143-52.
    • (2013) Cardiovasc Res , vol.97 , Issue.1 , pp. 143-152
    • Lee, H.Y.1    Youn, S.W.2    Cho, H.J.3    Kwon, Y.W.4    Lee, S.W.5    Kim, S.J.6    Park, Y.B.7    Oh, B.H.8    Kim, H.S.9
  • 50
    • 33846005165 scopus 로고    scopus 로고
    • A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression
    • Abid MR, Shih SC, Otu HH, Spokes KC, Okada Y, Curiel DT, Minami T, Aird WC. A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression. J Biol Chem. 2006;281(46):35544-53.
    • (2006) J Biol Chem , vol.281 , Issue.46 , pp. 35544-35553
    • Abid, M.R.1    Shih, S.C.2    Otu, H.H.3    Spokes, K.C.4    Okada, Y.5    Curiel, D.T.6    Minami, T.7    Aird, W.C.8
  • 52
    • 76949106391 scopus 로고    scopus 로고
    • Hydrogen peroxide stress stimulates phosphorylation of FOXO1 in rat aortic endothelial cells
    • Wang YY, Chen SM, Li H. Hydrogen peroxide stress stimulates phosphorylation of FOXO1 in rat aortic endothelial cells. Acta Pharmacol Sin. 2010;31(2):160-4.
    • (2010) Acta Pharmacol Sin , vol.31 , Issue.2 , pp. 160-164
    • Wang, Y.Y.1    Chen, S.M.2    Li, H.3
  • 53
    • 57049104503 scopus 로고    scopus 로고
    • FOXO1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alpha-treated adipocytes
    • Ito Y, Daitoku H, Fukamizu A. FOXO1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alpha-treated adipocytes. Biochem Biophys Res Commun. 2009;378(2):290-5.
    • (2009) Biochem Biophys Res Commun , vol.378 , Issue.2 , pp. 290-295
    • Ito, Y.1    Daitoku, H.2    Fukamizu, A.3
  • 56
  • 57
    • 24944572210 scopus 로고    scopus 로고
    • Regulation of the proapoptotic factor FOXO1 (FKHR) in cardiomyocytes by growth factors and alpha1-adrenergic agonists
    • Morris JB, Kenney B, Huynh H, Woodcock EA. Regulation of the proapoptotic factor FOXO1 (FKHR) in cardiomyocytes by growth factors and alpha1-adrenergic agonists. Endocrinology. 2005;146(10):4370-6.
    • (2005) Endocrinology , vol.146 , Issue.10 , pp. 4370-4376
    • Morris, J.B.1    Kenney, B.2    Huynh, H.3    Woodcock, E.A.4
  • 61
    • 77951924231 scopus 로고    scopus 로고
    • The FOXO family in cardiac function and dysfunction
    • Ronnebaum SM, Patterson C. The FOXO family in cardiac function and dysfunction. Annu Rev Physiol. 2010;72:81-94.
    • (2010) Annu Rev Physiol , vol.72 , pp. 81-94
    • Ronnebaum, S.M.1    Patterson, C.2
  • 64
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema RH, Kops GJ, Bos JL, Burgering BM. AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature. 2000;404(6779):782-7.
    • (2000) Nature , vol.404 , Issue.6779 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 65
    • 0037094096 scopus 로고    scopus 로고
    • The forkhead transcription factor FOXO regulates transcription of p27Kip1 and Bim in response to IL-2
    • Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, Burgering BM, Medema RH. The forkhead transcription factor FOXO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol. 2002;168(10):5024-31.
    • (2002) J Immunol , vol.168 , Issue.10 , pp. 5024-5031
    • Stahl, M.1    Dijkers, P.F.2    Kops, G.J.3    Lens, S.M.4    Coffer, P.J.5    Burgering, B.M.6    Medema, R.H.7
  • 67
    • 41449088342 scopus 로고    scopus 로고
    • Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors
    • Evans-Anderson HJ, Alfieri CM, Yutzey KE. Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors. Circ Res. 2008;102(6):686-94.
    • (2008) Circ Res , vol.102 , Issue.6 , pp. 686-694
    • Evans-Anderson, H.J.1    Alfieri, C.M.2    Yutzey, K.E.3
  • 68
    • 32944466267 scopus 로고    scopus 로고
    • High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of FOXO3A transcription factor independent of lipotoxicity and apoptosis
    • Relling DP, Esberg LB, Fang CX, Johnson WT, Murphy EJ, Carlson EC, Saari JT, Ren J. High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of FOXO3A transcription factor independent of lipotoxicity and apoptosis. J Hypertens. 2006;24(3):549-61.
    • (2006) J Hypertens , vol.24 , Issue.3 , pp. 549-561
    • Relling, D.P.1    Esberg, L.B.2    Fang, C.X.3    Johnson, W.T.4    Murphy, E.J.5    Carlson, E.C.6    Saari, J.T.7    Ren, J.8
  • 69
    • 43049150679 scopus 로고    scopus 로고
    • Oligonucleotide microarray analysis of genes regulating apoptosis in chronically ischemic and postinfarction myocardium
    • Dabek J, Owczarek A, Gasior Z, Ulczok R, Skowerski M, Kulach A, Mazurek U, Bochenek A. Oligonucleotide microarray analysis of genes regulating apoptosis in chronically ischemic and postinfarction myocardium. Biochem Genet. 2008;46(5-6):241-7.
    • (2008) Biochem Genet , vol.46 , Issue.5-6 , pp. 241-247
    • Dabek, J.1    Owczarek, A.2    Gasior, Z.3    Ulczok, R.4    Skowerski, M.5    Kulach, A.6    Mazurek, U.7    Bochenek, A.8
  • 70
    • 84904750812 scopus 로고    scopus 로고
    • Deletion of FOXO1 leads to shortening of QRS by increasing Na(+) channel activity through enhanced expression of both cardiac NaV1.5 and beta3 subunit
    • Cai B, Wang N, Mao W, You T, Lu Y, Li X, Ye B, Li F, Xu H. Deletion of FOXO1 leads to shortening of QRS by increasing Na(+) channel activity through enhanced expression of both cardiac NaV1.5 and beta3 subunit. J Mol Cell Cardiol. 2014;74:297-306.
    • (2014) J Mol Cell Cardiol , vol.74 , pp. 297-306
    • Cai, B.1    Wang, N.2    Mao, W.3    You, T.4    Lu, Y.5    Li, X.6    Ye, B.7    Li, F.8    Xu, H.9
  • 71
    • 79953186624 scopus 로고    scopus 로고
    • FOXO transcription factors promote cardiomyocyte survival upon induction of oxidative stress
    • Sengupta A, Molkentin JD, Paik JH, DePinho RA, Yutzey KE. FOXO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem. 2011;286(9):7468-78.
    • (2011) J Biol Chem , vol.286 , Issue.9 , pp. 7468-7478
    • Sengupta, A.1    Molkentin, J.D.2    Paik, J.H.3    DePinho, R.A.4    Yutzey, K.E.5
  • 72
    • 85026973146 scopus 로고    scopus 로고
    • Role of forkhead transcription factors in myocardial ischemic reperfusion injury in diabetes
    • Li H, Micheael GI, Mingzhe T, Yalan L, Liangqing Z, Xia Z. Role of forkhead transcription factors in myocardial ischemic reperfusion injury in diabetes. J Diabetes Metab. 2013;4:247.
    • (2013) J Diabetes Metab , vol.4 , pp. 247
    • Li, H.1    Micheael, G.I.2    Mingzhe, T.3    Yalan, L.4    Liangqing, Z.5    Xia, Z.6
  • 73
    • 54049155806 scopus 로고    scopus 로고
    • Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription
    • Fang CX, Dong F, Thomas DP, Ma H, He L, Ren J. Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription. Am J Physiol Heart Circ Physiol. 2008;295(3):H1206-15.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295 , Issue.3 , pp. H1206-H1215
    • Fang, C.X.1    Dong, F.2    Thomas, D.P.3    Ma, H.4    He, L.5    Ren, J.6
  • 74
    • 0043025552 scopus 로고    scopus 로고
    • Heart failure: the frequent, forgotten, and often fatal complication of diabetes
    • Bell DS. Heart failure: the frequent, forgotten, and often fatal complication of diabetes. Diabetes Care. 2003;26(8):2433-41.
    • (2003) Diabetes Care , vol.26 , Issue.8 , pp. 2433-2441
    • Bell, D.S.1
  • 75
  • 76
    • 0031051579 scopus 로고    scopus 로고
    • Mechanisms determining course and outcome of diabetic patients who have had acute myocardial infarction
    • Aronson D, Rayfield EJ, Chesebro JH. Mechanisms determining course and outcome of diabetic patients who have had acute myocardial infarction. Ann Intern Med. 1997;126(4):296-306.
    • (1997) Ann Intern Med , vol.126 , Issue.4 , pp. 296-306
    • Aronson, D.1    Rayfield, E.J.2    Chesebro, J.H.3
  • 78
    • 33644548673 scopus 로고    scopus 로고
    • Diabetic heart disease
    • Marwick TH. Diabetic heart disease. Heart. 2006;92(3):296-300.
    • (2006) Heart , vol.92 , Issue.3 , pp. 296-300
    • Marwick, T.H.1
  • 81
    • 34347352169 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy revisited
    • Boudina S, Abel ED. Diabetic cardiomyopathy revisited. Circulation. 2007;115(25):3213-23.
    • (2007) Circulation , vol.115 , Issue.25 , pp. 3213-3223
    • Boudina, S.1    Abel, E.D.2
  • 82
    • 33645280925 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: the search for a unifying hypothesis
    • Poornima IG, Parikh P, Shannon RP. Diabetic cardiomyopathy: the search for a unifying hypothesis. Circ Res. 2006;98(5):596-605.
    • (2006) Circ Res , vol.98 , Issue.5 , pp. 596-605
    • Poornima, I.G.1    Parikh, P.2    Shannon, R.P.3
  • 83
    • 77953164614 scopus 로고    scopus 로고
    • The increase in cardiac pyruvate dehydrogenase kinase-4 after short-term dexamethasone is controlled by an Akt-p38-forkhead box other factor-1 signaling axis
    • Puthanveetil P, Wang Y, Wang F, Kim MS, Abrahani A, Rodrigues B. The increase in cardiac pyruvate dehydrogenase kinase-4 after short-term dexamethasone is controlled by an Akt-p38-forkhead box other factor-1 signaling axis. Endocrinology. 2010;151(5):2306-18.
    • (2010) Endocrinology , vol.151 , Issue.5 , pp. 2306-2318
    • Puthanveetil, P.1    Wang, Y.2    Wang, F.3    Kim, M.S.4    Abrahani, A.5    Rodrigues, B.6
  • 84
    • 0032192401 scopus 로고    scopus 로고
    • Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects
    • Majer M, Popov KM, Harris RA, Bogardus C, Prochazka M. Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects. Mol Genet Metab. 1998;65(2):181-6.
    • (1998) Mol Genet Metab , vol.65 , Issue.2 , pp. 181-186
    • Majer, M.1    Popov, K.M.2    Harris, R.A.3    Bogardus, C.4    Prochazka, M.5
  • 85
    • 84860545805 scopus 로고    scopus 로고
    • The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes
    • Constantin-Teodosiu D, Constantin D, Stephens F, Laithwaite D, Greenhaff PL. The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes. Diabetes. 2012;61(5):1017-24.
    • (2012) Diabetes , vol.61 , Issue.5 , pp. 1017-1024
    • Constantin-Teodosiu, D.1    Constantin, D.2    Stephens, F.3    Laithwaite, D.4    Greenhaff, P.L.5
  • 86
    • 39749171700 scopus 로고    scopus 로고
    • O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene
    • Kuo M, Zilberfarb V, Gangneux N, Christeff N, Issad T. O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene. FEBS Lett. 2008;582(5):829-34.
    • (2008) FEBS Lett , vol.582 , Issue.5 , pp. 829-834
    • Kuo, M.1    Zilberfarb, V.2    Gangneux, N.3    Christeff, N.4    Issad, T.5
  • 87
  • 88
    • 64649104157 scopus 로고    scopus 로고
    • FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats
    • Behl Y, Krothapalli P, Desta T, Roy S, Graves DT. FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats. Diabetes. 2009;58(4):917-25.
    • (2009) Diabetes , vol.58 , Issue.4 , pp. 917-925
    • Behl, Y.1    Krothapalli, P.2    Desta, T.3    Roy, S.4    Graves, D.T.5
  • 89
    • 66649115077 scopus 로고    scopus 로고
    • FOXO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue
    • Kim JJ, Li P, Huntley J, Chang JP, Arden KC, Olefsky JM. FOXO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue. Diabetes. 2009;58(6):1275-82.
    • (2009) Diabetes , vol.58 , Issue.6 , pp. 1275-1282
    • Kim, J.J.1    Li, P.2    Huntley, J.3    Chang, J.P.4    Arden, K.C.5    Olefsky, J.M.6
  • 90
    • 77950861884 scopus 로고    scopus 로고
    • Functional recovery of diabetic mouse hearts by glutaredoxin-1 gene therapy: role of Akt-FOXO-signaling network
    • Lekli I, Mukherjee S, Ray D, Gurusamy N, Kim YH, Tosaki A, Engelman RM, Ho YS, Das DK. Functional recovery of diabetic mouse hearts by glutaredoxin-1 gene therapy: role of Akt-FOXO-signaling network. Gene Ther. 2010;17(4):478-85.
    • (2010) Gene Ther , vol.17 , Issue.4 , pp. 478-485
    • Lekli, I.1    Mukherjee, S.2    Ray, D.3    Gurusamy, N.4    Kim, Y.H.5    Tosaki, A.6    Engelman, R.M.7    Ho, Y.S.8    Das, D.K.9
  • 91
    • 34547185623 scopus 로고    scopus 로고
    • Oxidative stress and redox signalling in cardiac hypertrophy and heart failure
    • Seddon M, Looi YH, Shah AM. Oxidative stress and redox signalling in cardiac hypertrophy and heart failure. Heart. 2007;93(8):903-7.
    • (2007) Heart , vol.93 , Issue.8 , pp. 903-907
    • Seddon, M.1    Looi, Y.H.2    Shah, A.M.3
  • 92
    • 84905965749 scopus 로고    scopus 로고
    • Fatty acid-binding protein 4, a point of convergence for angiogenic and metabolic signaling pathways in endothelial cells
    • Harjes U, Bridges E, McIntyre A, Fielding BA, Harris AL. Fatty acid-binding protein 4, a point of convergence for angiogenic and metabolic signaling pathways in endothelial cells. J Biol Chem. 2014;289(33):23168-76.
    • (2014) J Biol Chem , vol.289 , Issue.33 , pp. 23168-23176
    • Harjes, U.1    Bridges, E.2    McIntyre, A.3    Fielding, B.A.4    Harris, A.L.5
  • 93
    • 0036787607 scopus 로고    scopus 로고
    • Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor FOXO1
    • Nakae J, Biggs WH 3rd, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor FOXO1. Nat Genet. 2002;32(2):245-53.
    • (2002) Nat Genet , vol.32 , Issue.2 , pp. 245-253
    • Nakae, J.1    Biggs, W.H.2    Kitamura, T.3    Cavenee, W.K.4    Wright, C.V.5    Arden, K.C.6    Accili, D.7
  • 95
    • 84923376645 scopus 로고    scopus 로고
    • Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
    • Song YM, Lee YH, Kim JW, Ham DS, Kang ES, Cha BS, Lee HC, Lee BW. Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway. Autophagy. 2015;11(1):46-59.
    • (2015) Autophagy , vol.11 , Issue.1 , pp. 46-59
    • Song, Y.M.1    Lee, Y.H.2    Kim, J.W.3    Ham, D.S.4    Kang, E.S.5    Cha, B.S.6    Lee, H.C.7    Lee, B.W.8
  • 96
    • 84942114489 scopus 로고    scopus 로고
    • FOXO transcription factors and regenerative pathways in diabetes mellitus
    • Maiese K. FOXO transcription factors and regenerative pathways in diabetes mellitus. Curr Neurovasc Res. 2015;12(4):404-13.
    • (2015) Curr Neurovasc Res , vol.12 , Issue.4 , pp. 404-413
    • Maiese, K.1
  • 99
    • 78650691023 scopus 로고    scopus 로고
    • Deacetylation of FOXO by sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes
    • Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J. Deacetylation of FOXO by sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes. Circ Res. 2010;107(12):1470-82.
    • (2010) Circ Res , vol.107 , Issue.12 , pp. 1470-1482
    • Hariharan, N.1    Maejima, Y.2    Nakae, J.3    Paik, J.4    Depinho, R.A.5    Sadoshima, J.6
  • 100
    • 70350500068 scopus 로고    scopus 로고
    • FOXO transcription factors promote autophagy in cardiomyocytes
    • Sengupta A, Molkentin JD, Yutzey KE. FOXO transcription factors promote autophagy in cardiomyocytes. J Biol Chem. 2009;284(41):28319-31.
    • (2009) J Biol Chem , vol.284 , Issue.41 , pp. 28319-28331
    • Sengupta, A.1    Molkentin, J.D.2    Yutzey, K.E.3
  • 101
    • 77955891625 scopus 로고    scopus 로고
    • Hyperglycaemia-induced cardiomyocyte death is mediated via MCP-1 production and induction of a novel zinc-finger protein MCPIP
    • Younce CW, Wang K, Kolattukudy PE. Hyperglycaemia-induced cardiomyocyte death is mediated via MCP-1 production and induction of a novel zinc-finger protein MCPIP. Cardiovasc Res. 2010;87(4):665-74.
    • (2010) Cardiovasc Res , vol.87 , Issue.4 , pp. 665-674
    • Younce, C.W.1    Wang, K.2    Kolattukudy, P.E.3
  • 103
    • 79251548626 scopus 로고    scopus 로고
    • Forkhead homeobox type O transcription factors in the responses to oxidative stress
    • Storz P. Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal. 2011;14(4):593-605.
    • (2011) Antioxid Redox Signal , vol.14 , Issue.4 , pp. 593-605
    • Storz, P.1
  • 106
    • 84858322507 scopus 로고    scopus 로고
    • Role of forkhead transcription factors in diabetes-induced oxidative stress
    • Ponugoti B, Dong G, Graves DT. Role of forkhead transcription factors in diabetes-induced oxidative stress. Exp Diabetes Res. 2012;2012:7.
    • (2012) Exp Diabetes Res , vol.2012 , pp. 7
    • Ponugoti, B.1    Dong, G.2    Graves, D.T.3
  • 107
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    • Nemoto S, Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science. 2002;295(5564):2450-2.
    • (2002) Science , vol.295 , Issue.5564 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 108
    • 35148877285 scopus 로고    scopus 로고
    • Regulation of pancreatic beta-cell function by the forkhead protein FOXO1
    • Buteau J, Accili D. Regulation of pancreatic beta-cell function by the forkhead protein FOXO1. Diabetes Obes Metab. 2007;9(Suppl 2):140-6.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 140-146
    • Buteau, J.1    Accili, D.2
  • 109
    • 0027381832 scopus 로고
    • Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus
    • Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creager MA. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation. 1993;88(6):2510-6.
    • (1993) Circulation , vol.88 , Issue.6 , pp. 2510-2516
    • Johnstone, M.T.1    Creager, S.J.2    Scales, K.M.3    Cusco, J.A.4    Lee, B.K.5    Creager, M.A.6
  • 110
    • 0034681949 scopus 로고    scopus 로고
    • Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance
    • Balletshofer BM, Rittig K, Enderle MD, Volk A, Maerker E, Jacob S, Matthaei S, Rett K, Häring HU. Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance. Circulation. 2000;101(15):1780-4.
    • (2000) Circulation , vol.101 , Issue.15 , pp. 1780-1784
    • Balletshofer, B.M.1    Rittig, K.2    Enderle, M.D.3    Volk, A.4    Maerker, E.5    Jacob, S.6    Matthaei, S.7    Rett, K.8    Häring, H.U.9
  • 114
    • 84859986058 scopus 로고    scopus 로고
    • Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of FOXO1 gene
    • Qiang L, Tsuchiya K, Kim-Muller JY, Lin HV, Welch C, Accili D. Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of FOXO1 gene. J Biol Chem. 2012;287(17):13944-51.
    • (2012) J Biol Chem , vol.287 , Issue.17 , pp. 13944-13951
    • Qiang, L.1    Tsuchiya, K.2    Kim-Muller, J.Y.3    Lin, H.V.4    Welch, C.5    Accili, D.6
  • 117
    • 16844370417 scopus 로고    scopus 로고
    • FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis
    • Alikhani M, Alikhani Z, Graves DT. FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis. J Biol Chem. 2005;280(13):12096-102.
    • (2005) J Biol Chem , vol.280 , Issue.13 , pp. 12096-12102
    • Alikhani, M.1    Alikhani, Z.2    Graves, D.T.3
  • 118
    • 77952312505 scopus 로고    scopus 로고
    • FOXO1 plays an essential role in apoptosis of retinal pericytes
    • Alikhani M, Roy S, Graves DT. FOXO1 plays an essential role in apoptosis of retinal pericytes. Mol Vis. 2010;16:408-15.
    • (2010) Mol Vis , vol.16 , pp. 408-415
    • Alikhani, M.1    Roy, S.2    Graves, D.T.3
  • 119
    • 18844434370 scopus 로고    scopus 로고
    • Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease
    • Chong ZZ, Li F, Maiese K. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol. 2005;75(3):207-46.
    • (2005) Prog Neurobiol , vol.75 , Issue.3 , pp. 207-246
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 120
    • 77954234752 scopus 로고    scopus 로고
    • Cytosolic FOXO1: alive and killing
    • Medema RH, Jaattela M. Cytosolic FOXO1: alive and killing. Nat Cell Biol. 2010;12(7):642-3.
    • (2010) Nat Cell Biol , vol.12 , Issue.7 , pp. 642-643
    • Medema, R.H.1    Jaattela, M.2
  • 122
    • 54949132875 scopus 로고    scopus 로고
    • Bcl-2 family proteins and cancer
    • Yip KW, Reed JC. Bcl-2 family proteins and cancer. Oncogene. 2008;27(50):6398-406.
    • (2008) Oncogene , vol.27 , Issue.50 , pp. 6398-6406
    • Yip, K.W.1    Reed, J.C.2
  • 123
    • 34948882797 scopus 로고    scopus 로고
    • Autophagic or necrotic cell death in the absence of caspase and bcl-2 family members
    • Lam D, Levraud JP, Luciani MF, Golstein P. Autophagic or necrotic cell death in the absence of caspase and bcl-2 family members. Biochem Biophys Res Commun. 2007;363(3):536-41.
    • (2007) Biochem Biophys Res Commun , vol.363 , Issue.3 , pp. 536-541
    • Lam, D.1    Levraud, J.P.2    Luciani, M.F.3    Golstein, P.4
  • 125
  • 126
    • 77949460107 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: signaling defects and therapeutic approaches
    • Dobrin JS, Lebeche D. Diabetic cardiomyopathy: signaling defects and therapeutic approaches. Expert Rev Cardiovasc Ther. 2010;8(3):373-91.
    • (2010) Expert Rev Cardiovasc Ther , vol.8 , Issue.3 , pp. 373-391
    • Dobrin, J.S.1    Lebeche, D.2
  • 127
    • 9444224416 scopus 로고    scopus 로고
    • Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heart
    • Belke DD, Swanson EA, Dillmann WH. Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heart. Diabetes. 2004;53(12):3201-8.
    • (2004) Diabetes , vol.53 , Issue.12 , pp. 3201-3208
    • Belke, D.D.1    Swanson, E.A.2    Dillmann, W.H.3
  • 128
    • 0033837124 scopus 로고    scopus 로고
    • Diminished function and expression of the cardiac Na + -Ca2 + exchanger in diabetic rats: implication in Ca2 + overload
    • Hattori Y, Matsuda N, Kimura J, Ishitani T, Tamada A, Gando S, Kemmotsu O, Kanno M. Diminished function and expression of the cardiac Na + -Ca2 + exchanger in diabetic rats: implication in Ca2 + overload. J Physiol. 2000;527(Pt 1):85-94.
    • (2000) J Physiol , vol.527 , Issue.PART. 1 , pp. 85-94
    • Hattori, Y.1    Matsuda, N.2    Kimura, J.3    Ishitani, T.4    Tamada, A.5    Gando, S.6    Kemmotsu, O.7    Kanno, M.8
  • 131
    • 84922809316 scopus 로고    scopus 로고
    • QKI deficiency promotes FOXO1 mediated nitrosative stress and endoplasmic reticulum stress contributing to increased vulnerability to ischemic injury in diabetic heart
    • Guo W, Jiang T, Lian C, Wang H, Zheng Q, Ma H. QKI deficiency promotes FOXO1 mediated nitrosative stress and endoplasmic reticulum stress contributing to increased vulnerability to ischemic injury in diabetic heart. J Mol Cell Cardiol. 2014;75:131-40.
    • (2014) J Mol Cell Cardiol , vol.75 , pp. 131-140
    • Guo, W.1    Jiang, T.2    Lian, C.3    Wang, H.4    Zheng, Q.5    Ma, H.6
  • 132
    • 84942244247 scopus 로고    scopus 로고
    • Circulating interleukin-1beta promotes endoplasmic reticulum stress-induced myocytes apoptosis in diabetic cardiomyopathy via interleukin-1 receptor-associated kinase-2
    • Liu Z, Zhao N, Zhu H, Zhu S, Pan S, Xu J, Zhang X, Zhang Y, Wang J. Circulating interleukin-1beta promotes endoplasmic reticulum stress-induced myocytes apoptosis in diabetic cardiomyopathy via interleukin-1 receptor-associated kinase-2. Cardiovasc Diabetol. 2015;14(1):125.
    • (2015) Cardiovasc Diabetol , vol.14 , Issue.1 , pp. 125
    • Liu, Z.1    Zhao, N.2    Zhu, H.3    Zhu, S.4    Pan, S.5    Xu, J.6    Zhang, X.7    Zhang, Y.8    Wang, J.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.