FoxO, autophagy, and cardiac remodeling

Journal of Cardiovascular Translational Research

Volumn 3, Issue 4, 2010, Pages 355-364

  Ferdous, Anwarul ^a   Battiprolu, Pavan K ^a   Ni, Yan G ^a   Rothermel, Beverly A ^a   Hill, Joseph A ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Autophagy; Cardiac Hypertrophy; Cardiac Remodeling; FoxO; Heart Failure

Indexed keywords

REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; TRANSCRIPTION FACTOR FOXO;

AUTOPHAGY; CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HEART DISEASE; HEART VENTRICLE REMODELING; HUMAN; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW;

AUTOPHAGY; CARDIAC OUTPUT; FORKHEAD TRANSCRIPTION FACTORS; HEART FAILURE; HUMANS; HYPERTROPHY, RIGHT VENTRICULAR; MYOCYTES, CARDIAC; PROTEASOME ENDOPEPTIDASE COMPLEX; RISK FACTORS; UBIQUITIN-PROTEIN LIGASES; VENTRICULAR REMODELING;

EID: 77955515497     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-010-9200-z     Document Type: Review

References (86)

1. D Lloyd-Jones RJ Adams TM Brown M Carnethon S Dai G De Simone, et al. 2010 Heart disease and stroke statistics-2010 update: a report from the American Heart Association Circulation 121 7 e46 e215 10.1161/CIRCULATIONAHA.109.192667 20019324
2. JA Hill EN Olson 2008 Cardiac plasticity The New England Journal of Medicine 358 13 1370 1380 10.1056/NEJMra072139 18367740 1:CAS:528: DC%2BD1cXjvFOnsb8%3D (Pubitemid 351468414)
3. KL Clark ED Halay E Lai SK Burley 1993 Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5 Nature 364 6436 412 420 10.1038/364412a0 8332212 1:CAS:528:DyaK3sXlsFehtLY%3D (Pubitemid 23263212)
4. P Carlsson M Mahlapuu 2002 Forkhead transcription factors: key players in development and metabolism Developmental Biology 250 1 1 23 10.1006/dbio.2002.0780 12297093 1:CAS:528:DC%2BD38XntVyms70%3D
5. KH Kaestner W Knochel DE Martinez 2000 Unified nomenclature for the winged helix/forkhead transcription factors Genes & Development 14 2 142 146 1:CAS:528:DC%2BD3cXhtVShtro%3D
6. PJ Wijchers JP Burbach MP Smidt 2006 In control of biology: of mice, men and Foxes The Biochemical Journal 397 2 233 246 10.1042/BJ20060387 16792526 1:CAS:528:DC%2BD28XntFeisL4%3D (Pubitemid 44076893)
7. GE Mercado FG Barr 2007 Fusions involving PAX and FOX genes in the molecular pathogenesis of alveolar rhabdomyosarcoma: recent advances Current Molecular Medicine 7 1 47 61 10.2174/156652407779940440 17311532 1:CAS:528:DC%2BD2sXht1egsLY%3D (Pubitemid 46322278)
8. A Borkhardt R Repp OA Haas T Leis J Harbott J Kreuder, et al. 1997 Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23) Oncogene 14 2 195 202 10.1038/sj.onc.1200814 9010221 1:CAS:528:DyaK2sXnsFCitA%3D%3D
9. BM Burgering GJ Kops 2002 Cell cycle and death control: long live Forkheads Trends in Biochemical Sciences 27 7 352 360 10.1016/S0968-0004(02) 02113-8 12114024 1:CAS:528:DC%2BD38XltFahsbk%3D (Pubitemid 34756518)
10. D Accili KC Arden 2004 FoxOs at the crossroads of cellular metabolism, differentiation, and transformation Cell 117 4 421 426 10.1016/S0092-8674(04) 00452-0 15137936 1:CAS:528:DC%2BD2cXktlCqtrw%3D (Pubitemid 38610228)
11. T Furuyama K Kitayama Y Shimoda M Ogawa K Sone K Yoshida-Araki, et al. 2004 Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice The Journal of Biological Chemistry 279 33 34741 34749 10.1074/jbc.M314214200 15184386 1:CAS:528:DC%2BD2cXmvFems7s%3D (Pubitemid 39318105)
12. T Hosaka WH Biggs 3rd D Tieu AD Boyer NM Varki WK Cavenee, et al. 2004 Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification Proceedings of the National Academy of Sciences of the United States of America 101 9 2975 2980 10.1073/pnas.0400093101 14978268 1:CAS:528:DC%2BD2cXitlWhsbk%3D (Pubitemid 38327721)
13. DH Castrillon L Miao R Kollipara JW Horner RA DePinho 2003 Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a Science 301 5630 215 218 10.1126/science.1086336 12855809 1:CAS:528:DC%2BD3sXlsF2ns7g%3D (Pubitemid 36858475)
14. M Sandri C Sandri A Gilbert C Skurk E Calabria A Picard, et al. 2004 Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy Cell 117 3 399 412 10.1016/S0092-8674(04)00400-3 15109499 1:CAS:528:DC%2BD2cXjvFemtrs%3D (Pubitemid 38534545)
15. Y Kamei S Miura M Suzuki Y Kai J Mizukami T Taniguchi, et al. 2004 Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control The Journal of Biological Chemistry 279 39 41114 41123 10.1074/jbc.M400674200 15272020 1:CAS:528:DC%2BD2cXnslWmsrs%3D (Pubitemid 39287713)
16. J Zhao JJ Brault A Schild P Cao M Sandri S Schiaffino, et al. 2007 FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells Cell Metabolism 6 6 472 483 10.1016/j.cmet.2007.11.004 18054316 1:CAS:528:DC%2BD2sXhsVektb%2FI (Pubitemid 350163056)
17. PR Bois GC Grosveld 2003 FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts The EMBO Journal 22 5 1147 1157 10.1093/emboj/cdg116 12606579 1:CAS:528:DC%2BD3sXit1ylsL8%3D (Pubitemid 36313598)
18. ML Hribal J Nakae T Kitamura JR Shutter D Accili 2003 Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors The Journal of Cell Biology 162 4 535 541 10.1083/jcb.200212107 12925703 1:CAS:528:DC%2BD3sXms1Sqtr8%3D (Pubitemid 37022932)
19. J Nakae T Kitamura Y Kitamura WH Biggs 3rd KC Arden D Accili 2003 The forkhead transcription factor Foxo1 regulates adipocyte differentiation Developmental Cell 4 1 119 129 10.1016/S1534-5807(02)00401-X 12530968 1:CAS:528:DC%2BD3sXntVyqsw%3D%3D (Pubitemid 36105338)
20. WJ Bakker M Blazquez-Domingo A Kolbus J Besooyen P Steinlein H Beug, et al. 2004 FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1 The Journal of Cell Biology 164 2 175 184 10.1083/jcb.200307056 14734530 1:CAS:528:DC%2BD2cXmsV2jsQ%3D%3D (Pubitemid 38133938)
21. HJ Evans-Anderson CM Alfieri KE Yutzey 2008 Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors Circulation Research 102 6 686 694 10.1161/CIRCRESAHA.107.163428 18218983 1:CAS:528:DC%2BD1cXjs1Wmsbo%3D (Pubitemid 351457856)
22. DN Gross AP van den Heuvel MJ Birnbaum 2008 The role of FoxO in the regulation of metabolism Oncogene 27 16 2320 2336 10.1038/onc.2008.25 18391974 1:CAS:528:DC%2BD1cXktlOktrs%3D (Pubitemid 351501783)
23. YG Ni N Wang DJ Cao N Sachan DJ Morris RD Gerard, et al. 2007 FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases Proceedings of the National Academy of Sciences of the United States of America 104 51 20517 20522 10.1073/pnas.0610290104 18077353 1:CAS:528:DC%2BD1cXjsleltA%3D%3D
24. PK Vogt H Jiang M Aoki 2005 Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins Cell Cycle 4 7 908 913 15917664 1:CAS:528:DC%2BD28XhslCrurs%3D
25. WH Biggs 3rd J Meisenhelder T Hunter WK Cavenee KC Arden 1999 Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1 Proceedings of the National Academy of Sciences of the United States of America 96 13 7421 7426 10.1073/pnas.96.13.7421 10377430 1:CAS:528:DyaK1MXltVOqsrY%3D (Pubitemid 29299677)
26. A Brunet A Bonni MJ Zigmond MZ Lin P Juo LS Hu, et al. 1999 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Cell 96 6 857 868 10.1016/S0092-8674(00)80595-4 10102273 1:CAS:528: DyaK1MXitFGgsr0%3D
27. GJ Kops BM Burgering 1999 Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling Journal of Molecular Medicine 77 9 656 665 10.1007/s001099900050 10569203 1:CAS:528:DyaK1MXns1SqurY%3D (Pubitemid 29500958)
28. J Nakae BC Park D Accili 1999 Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway The Journal of Biological Chemistry 274 23 15982 15985 10.1074/jbc.274.23.15982 10347145 1:CAS:528:DyaK1MXjs1Ogurg%3D (Pubitemid 29269297)
29. G Rena S Guo SC Cichy TG Unterman P Cohen 1999 Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B The Journal of Biological Chemistry 274 24 17179 17183 10.1074/jbc.274.24.17179 10358075 1:CAS:528:DyaK1MXjvVGku7o%3D (Pubitemid 29275181)
30. A Brunet J Park H Tran LS Hu BA Hemmings ME Greenberg 2001 Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a) Molecular and Cellular Biology 21 3 952 965 10.1128/MCB.21.3.952-965.2001 11154281 1:CAS:528:DC%2BD3MXmtVOrtQ%3D%3D (Pubitemid 32104742)
31. ED Tang G Nunez FG Barr KL Guan 1999 Negative regulation of the forkhead transcription factor FKHR by Akt The Journal of Biological Chemistry 274 24 16741 16746 10.1074/jbc.274.24.16741 10358014 1:CAS:528:DyaK1MXjvVGksb0%3D (Pubitemid 29275120)
32. Z Tothova DG Gilliland 2007 FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system Cell Stem Cell 1 2 140 152 10.1016/j.stem.2007.07.017 18371346 1:CAS:528:DC%2BD2sXhtVSnsrvI (Pubitemid 47215597)
33. G Rena YL Woods AR Prescott M Peggie TG Unterman MR Williams, et al. 2002 Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion The EMBO Journal 21 9 2263 2271 10.1093/emboj/21.9.2263 11980723 1:CAS:528:DC%2BD38XktFWjurk%3D (Pubitemid 34516785)
34. YL Woods G Rena N Morrice A Barthel W Becker S Guo, et al. 2001 The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site The Biochemical Journal 355 Pt 3 597 607 11311120 1:STN:280:DC%2BD3M3itFyhsw%3D%3D
35. JY Yang CS Zong W Xia H Yamaguchi Q Ding X Xie, et al. 2008 ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation Nature Cell Biology 10 2 138 148 10.1038/ncb1676 18204439 1:CAS:528:DC%2BD1cXhs1Kiu74%3D (Pubitemid 351194043)
36. MC Hu DF Lee W Xia LS Golfman F Ou-Yang JY Yang, et al. 2004 IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a Cell 117 2 225 237 10.1016/S0092-8674(04)00302-2 15084260 1:CAS:528:DC%2BD2cXjsFyru74%3D (Pubitemid 38496242)
37. EL Greer A Brunet 2005 FOXO transcription factors at the interface between longevity and tumor suppression Oncogene 24 50 7410 7425 10.1038/sj.onc.1209086 16288288 1:CAS:528:DC%2BD2MXht1Wis7vP (Pubitemid 41637981)
38. H Takaishi H Konishi H Matsuzaki Y Ono Y Shirai N Saito, et al. 1999 Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B Proceedings of the National Academy of Sciences of the United States of America 96 21 11836 11841 10.1073/pnas.96.21.11836 10518537 1:CAS:528:DyaK1MXmvVGjsr4%3D (Pubitemid 29502819)
39. A Brunet F Kanai J Stehn J Xu D Sarbassova JV Frangioni, et al. 2002 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport The Journal of Cell Biology 156 5 817 828 10.1083/jcb.200112059 11864996 1:CAS:528:DC%2BD38XitVGmsbY%3D (Pubitemid 34839865)
40. G Rena AR Prescott S Guo P Cohen TG Unterman 2001 Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting The Biochemical Journal 354 Pt 3 605 612 10.1042/0264-6021:3540605 11237865 1:CAS:528:DC%2BD3MXisFaksLc%3D (Pubitemid 32269724)
41. AM Brownawell GJ Kops IG Macara BM Burgering 2001 Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX Molecular and Cellular Biology 21 10 3534 3546 10.1128/MCB.21.10.3534-3546.2001 11313479 1:CAS:528: DC%2BD3MXjtF2jtr0%3D (Pubitemid 32381789)
42. MC Wang D Bohmann H Jasper 2005 JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling Cell 121 1 115 125 10.1016/j.cell.2005.02.030 15820683 1:CAS:528:DC%2BD2MXjsVaksLw%3D
43. A Brunet LB Sweeney JF Sturgill KF Chua PL Greer Y Lin, et al. 2004 Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase Science 303 5666 2011 2015 10.1126/science.1094637 14976264 1:CAS:528:DC%2BD2cXisVGlt70%3D (Pubitemid 38393275)
44. MK Lehtinen Z Yuan PR Boag Y Yang J Villen EB Becker, et al. 2006 A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span Cell 125 5 987 1001 10.1016/j.cell.2006.03.046 16751106 1:CAS:528:DC%2BD28Xls1Shtrk%3D (Pubitemid 43795191)
45. EL Greer PR Oskoui MR Banko JM Maniar MP Gygi SP Gygi, et al. 2007 The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor The Journal of Biological Chemistry 282 41 30107 30119 10.1074/jbc.M705325200 17711846 1:CAS:528:DC%2BD2sXhtFagtbnK (Pubitemid 350035296)
46. A Sunters PA Madureira KM Pomeranz M Aubert JJ Brosens SJ Cook, et al. 2006 Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt Cancer Research 66 1 212 220 10.1158/0008-5472.CAN-05-1997 16397234 1:CAS:528:DC%2BD28XhsFWhuw%3D%3D (Pubitemid 43166027)
47. JY Yang MC Hung 2009 A new fork for clinical application: targeting forkhead transcription factors in cancer Clinical Cancer Research 15 3 752 757 10.1158/1078-0432.CCR-08-0124 19188143 1:CAS:528:DC%2BD1MXht1Ons7g%3D
48. FM Jacobs LP van der Heide PJ Wijchers JP Burbach MF Hoekman MP Smidt 2003 FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics The Journal of Biological Chemistry 278 38 35959 35967 10.1074/jbc.M302804200 12857750 1:CAS:528:DC%2BD3sXnt1aqtb4%3D (Pubitemid 37139914)
49. LP van der Heide FM Jacobs JP Burbach MF Hoekman MP Smidt 2005 FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling The Biochemical Journal 391 Pt 3 623 629 15987244
50. M Fukuoka H Daitoku M Hatta H Matsuzaki S Umemura A Fukamizu 2003 Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation International Journal of Molecular Medicine 12 4 503 508 12964026 1:CAS:528:DC%2BD3sXovFGgsb0%3D
51. A van der Horst LG Tertoolen LM de Vries-Smits RA Frye RH Medema BM Burgering 2004 FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1) The Journal of Biological Chemistry 279 28 28873 28879 10.1074/jbc.M401138200 15126506 1:CAS:528:DC%2BD2cXlsVCnsbo%3D (Pubitemid 38915754)
52. MC Motta N Divecha M Lemieux C Kamel D Chen W Gu, et al. 2004 Mammalian SIRT1 represses forkhead transcription factors Cell 116 4 551 563 10.1016/S0092-8674(04)00126-6 14980222 1:CAS:528:DC%2BD2cXhvVKru7s%3D (Pubitemid 38264432)
53. H Daitoku M Hatta H Matsuzaki S Aratani T Ohshima M Miyagishi, et al. 2004 Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity Proceedings of the National Academy of Sciences of the United States of America 101 27 10042 10047 10.1073/pnas.0400593101 15220471 1:CAS:528:DC%2BD2cXlvFOhsr0%3D (Pubitemid 38891191)
54. Y Yang H Hou EM Haller SV Nicosia W Bai 2005 Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation The EMBO Journal 24 5 1021 1032 10.1038/sj.emboj.7600570 15692560 1:CAS:528:DC%2BD2MXitV2isb0%3D (Pubitemid 40470150)
55. D Frescas L Valenti D Accili 2005 Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes The Journal of Biological Chemistry 280 21 20589 20595 10.1074/jbc.M412357200 15788402 1:CAS:528:DC%2BD2MXktlCls7g%3D (Pubitemid 40776761)
56. H Matsuzaki H Daitoku M Hatta H Aoyama K Yoshimochi A Fukamizu 2005 Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation Proceedings of the National Academy of Sciences of the United States of America 102 32 11278 11283 10.1073/pnas.0502738102 16076959 1:CAS:528:DC%2BD2MXoslKit74%3D (Pubitemid 41153811)
57. A van der Horst BM Burgering 2007 Stressing the role of FoxO proteins in lifespan and disease Nature Reviews. Molecular Cell Biology 8 6 440 450 10.1038/nrm2190 17522590 1:CAS:528:DC%2BD2sXlsFOhsbg%3D (Pubitemid 46809159)
58. H Matsuzaki H Daitoku M Hatta K Tanaka A Fukamizu 2003 Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation Proceedings of the National Academy of Sciences of the United States of America 100 20 11285 11290 10.1073/pnas.1934283100 13679577 1:CAS:528:DC%2BD3sXotFKmsr4%3D (Pubitemid 37205927)
59. DR Plas CB Thompson 2003 Akt activation promotes degradation of tuberin and FOXO3a via the proteasome The Journal of Biological Chemistry 278 14 12361 12366 10.1074/jbc.M213069200 12517744 1:CAS:528:DC%2BD3sXisVOnt7Y%3D (Pubitemid 36800220)
60. H Huang KM Regan F Wang D Wang DI Smith JM van Deursen, et al. 2005 Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation Proceedings of the National Academy of Sciences of the United States of America 102 5 1649 1654 10.1073/pnas.0406789102 15668399 1:CAS:528:DC%2BD2MXhs1Kltbc%3D (Pubitemid 40209222)
61. A van der Horst AM de Vries-Smits AB Brenkman MH van Triest N van den Broek F Colland, et al. 2006 FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP Nature Cell Biology 8 10 1064 1073 10.1038/ncb1469 16964248 1:CAS:528:DC%2BD28XhtVWqsLbM (Pubitemid 44473601)
62. RL Deter C De Duve 1967 Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes The Journal of Cell Biology 33 2 437 449 10.1083/jcb.33.2.437 4292315 1:CAS:528: DyaF2sXhtFamurw%3D
63. DJ Klionsky SD Emr 2000 Autophagy as a regulated pathway of cellular degradation Science 290 5497 1717 1721 10.1126/science.290.5497.1717 11099404 1:CAS:528:DC%2BD3cXovVOitbw%3D (Pubitemid 32004796)
64. AM Cuervo 2004 Autophagy: in sickness and in health Trends in Cell Biology 14 2 70 77 10.1016/j.tcb.2003.12.002 15102438 1:CAS:528: DC%2BD2cXhtVOrtL4%3D (Pubitemid 38186640)
65. K Suzuki Y Ohsumi 2007 Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae FEBS Letters 581 11 2156 2161 10.1016/j.febslet.2007.01.096 17382324 1:CAS:528:DC%2BD2sXlt1Chs7k%3D (Pubitemid 46709906)
66. B Levine G Kroemer 2008 Autophagy in the pathogenesis of disease Cell 132 1 27 42 10.1016/j.cell.2007.12.018 18191218 1:CAS:528:DC%2BD1cXhtFehtb8%3D
67. I Vergne E Roberts RA Elmaoued V Tosch MA Delgado T Proikas-Cezanne, et al. 2009 Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy The EMBO Journal 28 15 2244 2258 10.1038/emboj.2009.159 19590496 1:CAS:528:DC%2BD1MXotVSnsLs%3D
68. C Mammucari G Milan V Romanello E Masiero R Rudolf P Del Piccolo, et al. 2007 FoxO3 controls autophagy in skeletal muscle in vivo Cell Metabolism 6 6 458 471 10.1016/j.cmet.2007.11.001 18054315 1:CAS:528:DC%2BD2sXhsVektb%2FN (Pubitemid 350163055)
69. A Sengupta JD Molkentin KE Yutzey 2009 FoxO transcription factors promote autophagy in cardiomyocytes The Journal of Biological Chemistry 284 41 28319 28331 10.1074/jbc.M109.024406 19696026 1:CAS:528:DC%2BD1MXht1SqsbvP
70. A Terman H Dalen JW Eaton J Neuzil UT Brunk 2003 Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis Experimental Gerontology 38 8 863 876 10.1016/S0531-5565(03)00114-1 12915208 1:CAS:528:DC%2BD3sXmt1Kjtr4%3D (Pubitemid 36952668)
71. K Lin JB Dorman A Rodan C Kenyon 1997 daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans Science 278 5341 1319 1322 10.1126/science.278.5341.1319 9360933 1:CAS:528:DyaK2sXntlOltrs%3D (Pubitemid 27495748)
72. S Ogg S Paradis S Gottlieb GI Patterson L Lee HA Tissenbaum, et al. 1997 The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans Nature 389 6654 994 999 10.1038/40194 9353126 1:CAS:528:DyaK2sXntVartrs%3D (Pubitemid 27485694)
73. ME Giannakou M Goss MA Junger E Hafen SJ Leevers L Partridge 2004 Long-lived Drosophila with overexpressed dFOXO in adult fat body Science 305 5682 361 10.1126/science.1098219 15192154 1:CAS:528:DC%2BD2cXlslyntr0%3D (Pubitemid 38938145)
74. DA Salih A Brunet 2008 FoxO transcription factors in the maintenance of cellular homeostasis during aging Current Opinion in Cell Biology 20 2 126 136 10.1016/j.ceb.2008.02.005 18394876 1:CAS:528:DC%2BD1cXks1Gnurw%3D
75. A Simonsen RC Cumming A Brech P Isakson DR Schubert KD Finley 2008 Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila Autophagy 4 2 176 184 18059160 1:CAS:528:DC%2BD1cXksFGrtbg%3D
76. A Salminen K Kaarniranta 2009 SIRT1: regulation of longevity via autophagy Cellular Signalling 21 9 1356 1360 10.1016/j.cellsig.2009.02.014 19249351 1:CAS:528:DC%2BD1MXnt1enuro%3D
77. H Zhu P Tannous JL Johnstone Y Kong JM Shelton JA Richardson, et al. 2007 Cardiac autophagy is a maladaptive response to hemodynamic stress Journal of Clinical Investigation 117 7 1782 1793 10.1172/JCI27523 17607355 1:CAS:528:DC%2BD2sXnvVagur4%3D (Pubitemid 47036312)
78. RS Decker K Wildenthal 1980 Lysosomal alterations in hypoxic and reoxygenated hearts. I. Ultrastructural and cytochemical changes American Journal of Pathology 98 2 425 444 7355988 1:STN:280:DyaL3c7islKgsw%3D%3D
79. DJ Cao TG Gillette JA Hill 2009 Cardiomyocyte autophagy: remodeling, repairing, and reconstructing the heart Current Hypertension Reports 11 6 406 411 10.1007/s11906-009-0070-1 19895751
80. S Hein E Arnon S Kostin M Schonburg A Elsasser V Polyakova, et al. 2003 Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms Circulation 107 7 984 991 10.1161/01.CIR.0000051865.66123.B7 12600911 (Pubitemid 36258721)
81. S Kostin L Pool A Elsasser S Hein HC Drexler E Arnon, et al. 2003 Myocytes die by multiple mechanisms in failing human hearts Circulation Research 92 7 715 724 10.1161/01.RES.0000067471.95890.5C 12649263 1:CAS:528: DC%2BD3sXislCguro%3D (Pubitemid 36457635)
82. BA Rothermel JA Hill 2008 Autophagy in load-induced heart disease Circulation Research 103 12 1363 1369 10.1161/CIRCRESAHA.108.186551 19059838 1:CAS:528:DC%2BD1cXhsVWrtrvL
83. A Nakai O Yamaguchi T Takeda Y Higuchi S Hikoso M Taniike, et al. 2007 The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress Natural Medicines 13 5 619 624 10.1038/nm1574 1:CAS:528:DC%2BD2sXkvVOgsr4%3D (Pubitemid 46828485)
84. C He DJ Klionsky 2009 Regulation mechanisms and signaling pathways of autophagy Annual Review of Genetics 43 67 93 10.1146/annurev-genet-102808-114910 19653858 1:CAS:528:DC%2BD1MXhsF2qtrjK
85. YG Ni K Berenji N Wang M Oh N Sachan A Dey, et al. 2006 Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling Circulation 114 11 1159 1168 10.1161/CIRCULATIONAHA.106.637124 16952979 1:CAS:528:DC%2BD28XptVOrtr4%3D (Pubitemid 44386480)
86. Kong, D. K., Georgescu, S. P., Cano, C., Aronovitz, M. J., Iovanna, J. L., Patten, R. D., et al. (2010). Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. Molecular Biology of the Cell, 21(8), 1335-1349.