SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway

European Heart Journal

Volumn 33, Issue 9, 2012, Pages 1067-1075

  Kumarswamy, Regalla ^a   Lyon, Alexander R ^b,c   Volkmann, Ingo ^a   Mills, Adam M ^b   Bretthauer, Julia ^a   Pahuja, Aanchal ^a   Geers Knrr, Cornelia ^a   Kraft, Theresia ^a   Hajjar, Roger J ^d   MacLeod, Kenneth T ^b   Harding, Sian E ^b   Thum, Thomas ^a,e  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c ROYAL BROMPTON HOSPITAL   (United Kingdom)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

FoxO3A; Gene therapy; Heart failure; MicroRNA 1; NCX1; SERCA2a

Indexed keywords

MICRORNA; PROTEIN KINASE B; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL NUCLEUS; CONTROLLED STUDY; DEREGULATION; GENE SILENCING; HEART FAILURE; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; TISSUE REGENERATION; VALIDATION STUDY;

ANIMALS; CELLS, CULTURED; CORONARY VESSELS; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; GENE THERAPY; HEART FAILURE; LACTONES; LIGATION; MALE; MICRORNAS; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SESQUITERPENES; SIGNAL TRANSDUCTION; SODIUM-CALCIUM EXCHANGER;

EID: 84860623522     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehs043     Document Type: Article

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