Foxo1 increases pro-inflammatory gene expression by inducing C/EBPβ in TNF-α-treated adipocytes

Biochemical and Biophysical Research Communications

Volumn 378, Issue 2, 2009, Pages 290-295

  Ito, Yu ^a   Daitoku, Hiroaki ^a   Fukamizu, Akiyoshi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

3T3 L1 adipocytes; C EBP ; Foxo1; IL 6; MCP 1

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR FKHR; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; INSULIN RESISTANCE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CHEMOKINE CCL2; CHROMATIN IMMUNOPRECIPITATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; INFLAMMATION; INTERLEUKIN-6; MICE; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 57049104503     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.11.043     Document Type: Article

References (23)

1. Bastard J.P., Maachi M., Lagathu C., Kim M.J., Caron M., Vidal H., Capeau J., and Feve B. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur. Cytokine Netw. 17 (2006) 4-12
2. Shoelson S.E., Lee J., and Goldfine A.B. Inflammation and insulin resistance. J. Clin. Invest. 116 (2006) 1793-1801
3. Hotamisligil G.S., Shargill N.S., and Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 (1993) 87-91
4. Schreyer S.A., Chua Jr. S.C., and LeBoeuf R.C. Obesity and diabetes in TNF-alpha receptor-deficient mice. J. Clin. Invest. 102 (1998) 402-411
5. Uysal K.T., Wiesbrock S.M., Marino M.W., and Hotamisligil G.S. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389 (1997) 610-614
6. Guo D., and Donner D.B. Tumor necrosis factor promotes phosphorylation and binding of insulin receptor substrate 1 to phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J. Biol. Chem. 271 (1996) 615-618
7. Hotamisligil G.S., Peraldi P., Budavari A., Ellis R., White M.F., and Spiegelman B.M. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 271 (1996) 665-668
8. Bastard J.P., Maachi M., Van Nhieu J.T., Jardel C., Bruckert E., Grimaldi A., Robert J.J., Capeau J., and Hainque B. Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J. Clin. Endocrinol. Metab. 87 (2002) 2084-2089
9. Rotter V., Nagaev I., and Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J. Biol. Chem. 278 (2003) 45777-45784
10. Sartipy P., and Loskutoff D.J. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc. Natl. Acad. Sci. USA 100 (2003) 7265-7270
11. Kanda H., Tateya S., Tamori Y., Kotani K., Hiasa K., Kitazawa R., Kitazawa S., Miyachi H., Maeda S., Egashira K., and Kasuga M. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 116 (2006) 1494-1505
12. Wellen K.E., and Hotamisligil G.S. Inflammation, stress, and diabetes. J. Clin. Invest. 115 (2005) 1111-1119
13. Salih D.A., and Brunet A. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr. Opin. Cell Biol. 20 (2008) 126-136
14. Nakae J., Kitamura T., Kitamura Y., Biggs III W.H., Arden K.C., and Accili D. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell 4 (2003) 119-129
15. Nakae J., Cao Y., Oki M., Orba Y., Sawa H., Kiyonari H., Iskandar K., Suga K., Lombes M., and Hayashi Y. Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure. Diabetes 57 (2008) 563-576
16. Daitoku H., Yamagata K., Matsuzaki H., Hatta M., and Fukamizu A. Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes 52 (2003) 642-649
17. Rubin C.S., Hirsch A., Fung C., and Rosen O.M. Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. J. Biol. Chem. 253 (1978) 7570-7578
18. Ramji D.P., and Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem. J. 365 (2002) 561-575
19. Bretz J.D., Williams S.C., Baer M., Johnson P.F., and Schwartz R.C. C/EBP-related protein 2 confers lipopolysaccharide-inducible expression of interleukin 6 and monocyte chemoattractant protein 1 to a lymphoblastic cell line. Proc. Natl. Acad. Sci. USA 91 (1994) 7306-7310
20. Fasshauer M., Klein J., Lossner U., and Paschke R. Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes. Horm. Metab. Res. 35 (2003) 147-152
21. Alikhani M., Alikhani Z., and Graves D.T. FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis. J. Biol. Chem. 280 (2005) 12096-12102
22. Houstis N., Rosen E.D., and Lander E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440 (2006) 944-948
23. Daitoku H., and Fukamizu A. FOXO transcription factors in the regulatory networks of longevity. J. Biochem. 141 (2007) 769-774