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Volumn 61, Issue 5, 2012, Pages 1017-1024

The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; FAT; FORKHEAD TRANSCRIPTION FACTOR; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVATE DEHYDROGENASE KINASE 2; PYRUVATE DEHYDROGENASE KINASE 4; TRANSCRIPTION FACTOR FKHR;

EID: 84860545805     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0799     Document Type: Article
Times cited : (53)

References (49)
  • 1
    • 0019948577 scopus 로고
    • Effect of diet on the utilization of blood-borne and intramuscular substrates during exercise in man
    • Jansson E, Kaijser L. Effect of diet on the utilization of blood-borne and intramuscular substrates during exercise in man. Acta Physiol Scand 1982; 115:19-30 (Pubitemid 12073440)
    • (1982) Acta Physiologica Scandinavica , vol.115 , Issue.1 , pp. 19-30
    • Jansson, E.1    Kaijser, L.2
  • 2
    • 0027422164 scopus 로고
    • Pyruvate dehydrogenase activity and acetyl group accumulation during exercise after different diets
    • Putman CT, Spriet LL, Hultman E, et al. Pyruvate dehydrogenase activity and acetyl group accumulation during exercise after different diets. Am J Physiol 1993;265:E752-E760
    • (1993) Am J Physiol , vol.265
    • Putman, C.T.1    Spriet, L.L.2    Hultman, E.3
  • 4
    • 1842716810 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome in patients with coronary heart disease, cerebrovascular disease, peripheral arterial disease or abdominal aortic aneurysm
    • DOI 10.1016/j.atherosclerosis.2003.12.033, PII S0021915004000292
    • Gorter PM, Olijhoek JK, van der Graaf Y, Algra A, Rabelink TJ, Visseren FL; SMART Study Group. Prevalence of the metabolic syndrome in patients with coronary heart disease, cerebrovascular disease, peripheral arterial disease or abdominal aortic aneurysm. Atherosclerosis 2004;173:363-369 (Pubitemid 38469808)
    • (2004) Atherosclerosis , vol.173 , Issue.2 , pp. 363-369
    • Gorter, P.M.1    Olijhoek, J.K.2    Van Der, G.Y.3    Algra, A.4    Rabelink, T.J.5    Visseren, F.L.J.6
  • 5
    • 0020697189 scopus 로고
    • The mammalian pyruvate dehydrogenase complex: Structure and regulation
    • Wieland OH. The mammalian pyruvate dehydrogenase complex: structure and regulation. Rev Physiol Biochem Pharmacol 1983;96:123-170
    • (1983) Rev Physiol Biochem Pharmacol , vol.96 , pp. 123-170
    • Wieland, O.H.1
  • 6
    • 0027068240 scopus 로고
    • PDC activity and acetyl group accumulation in skeletal muscle during prolonged exercise
    • Constantin-Teodosiu D, Cederblad G, Hultman E. PDC activity and acetyl group accumulation in skeletal muscle during prolonged exercise. J Appl Physiol 1992;73:2403-2407 (Pubitemid 23019646)
    • (1992) Journal of Applied Physiology , vol.73 , Issue.6 , pp. 2403-2407
    • Constantin-Teodosiu, D.1    Cederblad, G.2    Hultman, E.3
  • 7
    • 0031972736 scopus 로고    scopus 로고
    • Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex
    • Bowker-Kinley MM, Davis WI, Wu P, Harris RA, Popov KM. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J 1998;329:191-196 (Pubitemid 28022308)
    • (1998) Biochemical Journal , vol.329 , Issue.1 , pp. 191-196
    • Bowker-Kinley, M.M.1    Davis, W.I.2    Wu, P.3    Harris, R.A.4    Popov, K.M.5
  • 8
    • 0032504147 scopus 로고    scopus 로고
    • Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation
    • DOI 10.1074/jbc.273.28.17680
    • Huang B, Gudi R, Wu P, Harris RA, Hamilton J, Popov KM. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. J Biol Chem 1998;273:17680-17688 (Pubitemid 28355107)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.28 , pp. 17680-17688
    • Huang, B.1    Gudi, R.2    Wu, P.3    Harris, R.A.4    Hamilton, J.5    Popov, K.M.6
  • 9
    • 0036066319 scopus 로고    scopus 로고
    • Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin
    • Huang B, Wu P, Bowker-Kinley MM, Harris RA. Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin. Diabetes 2002;51:276-283 (Pubitemid 34764781)
    • (2002) Diabetes , vol.51 , Issue.2 , pp. 276-283
    • Huang, B.1    Wu, P.2    Bowker-Kinley, M.M.3    Harris, R.A.4
  • 10
    • 0032792498 scopus 로고    scopus 로고
    • Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes
    • DOI 10.2337/diabetes.48.8.1593
    • Wu P, Inskeep K, Bowker-Kinley MM, Popov KM, Harris RA. Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes. Diabetes 1999;48:1593-1599 (Pubitemid 29356868)
    • (1999) Diabetes , vol.48 , Issue.8 , pp. 1593-1599
    • Wu, P.1    Inskeep, K.2    Bowker-Kinley, M.M.3    Popov, K.M.4    Harris, R.A.5
  • 11
    • 0034653968 scopus 로고    scopus 로고
    • Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression
    • DOI 10.1042/0264-6021:3460651
    • Sugden MC, Kraus A, Harris RA, Holness MJ. Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression. Biochem J 2000;346:651-657 (Pubitemid 30171025)
    • (2000) Biochemical Journal , vol.346 , Issue.3 , pp. 651-657
    • Sugden, M.C.1    Kraus, A.2    Harris, R.A.3    Holness, M.J.4
  • 12
    • 0346245917 scopus 로고    scopus 로고
    • AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats
    • Mayers RM, Butlin RJ, Kilgour E, et al. AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats. Biochem Soc Trans 2003;31:1165-1167 (Pubitemid 38030931)
    • (2003) Biochemical Society Transactions , vol.31 , Issue.6 , pp. 1165-1167
    • Mayers, R.M.1    Butlin, R.J.2    Kilgour, E.3    Leighton, B.4    Martin, D.5    Myatt, J.6    Orme, J.P.7    Holloway, B.R.8
  • 13
    • 0035998737 scopus 로고    scopus 로고
    • Physiological and therapeutic roles of peroxisome proliferator-activated receptors
    • Berger J, Wagner JA. Physiological and therapeutic roles of peroxisome proliferator-activated receptors. Diabetes Technol Ther 2002;4:163-174 (Pubitemid 34663479)
    • (2002) Diabetes Technology and Therapeutics , vol.4 , Issue.2 , pp. 163-174
    • Berger, J.1    Wagner, J.A.2
  • 14
    • 0035929170 scopus 로고    scopus 로고
    • Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha
    • DOI 10.1006/bbrc.2001.5608
    • Wu P, Peters JM, Harris RA. Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha. Biochem Biophys Res Commun 2001;287:391-396 (Pubitemid 32917610)
    • (2001) Biochemical and Biophysical Research Communications , vol.287 , Issue.2 , pp. 391-396
    • Wu, P.1    Peters, J.M.2    Harris, R.A.3
  • 15
    • 21344434775 scopus 로고    scopus 로고
    • Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells
    • DOI 10.1111/j.1742-4658.2005.04713.x
    • Abbot EL, McCormack JG, Reynet C, Hassall DG, Buchan KW, Yeaman SJ. Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells. FEBS J 2005;272:3004-3014 (Pubitemid 40904688)
    • (2005) FEBS Journal , vol.272 , Issue.12 , pp. 3004-3014
    • Abbot, E.L.1    McCormack, J.G.2    Reynet, C.3    Hassall, D.G.4    Buchan, K.W.5    Yeaman, S.J.6
  • 17
    • 34547865385 scopus 로고    scopus 로고
    • PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle
    • DOI 10.1113/jphysiol.2007.135459
    • Constantin D, Constantin-Teodosiu D, Layfield R, Tsintzas K, Bennett AJ, Greenhaff PL. PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle. J Physiol 2007;583:381-390 (Pubitemid 47248448)
    • (2007) Journal of Physiology , vol.583 , Issue.1 , pp. 381-390
    • Constantin, D.1    Constantin-teodosiu, D.2    Layfield, R.3    Tsintzas, K.4    Bennett, A.J.5    Greenhaff, P.L.6
  • 18
    • 0037013201 scopus 로고    scopus 로고
    • Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands
    • DOI 10.1074/jbc.M110158200
    • Sato O, Kuriki C, Fukui Y, Motojima K. Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands. J Biol Chem 2002;277:15703-15711 (Pubitemid 34967844)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.18 , pp. 15703-15711
    • Sato, O.1    Kuriki, C.2    Fukui, Y.3    Motojima, K.4
  • 20
    • 0142200472 scopus 로고    scopus 로고
    • Forkhead transcription factor F0X01 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation
    • DOI 10.1042/BJ20030022
    • Furuyama T, Kitayama K, Yamashita H, Mori N. Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation. Biochem J 2003;375:365-371 (Pubitemid 37315444)
    • (2003) Biochemical Journal , vol.375 , Issue.2 , pp. 365-371
    • Furuyama, T.1    Kitayama, K.2    Yamashita, H.3    Mori, N.4
  • 22
    • 10644294794 scopus 로고    scopus 로고
    • Muscle pyruvate availability can limit the flux, but not activation, of the pyruvate dehydrogenase complex during submaximal exercise in humans
    • DOI 10.1113/jphysiol.2004.073411
    • Constantin-Teodosiu D, Peirce NS, Fox J, Greenhaff PL. Muscle pyruvate availability can limit the flux, but not activation, of the pyruvate dehydrogenase complex during submaximal exercise in humans. J Physiol 2004;561:647-655 (Pubitemid 39646550)
    • (2004) Journal of Physiology , vol.561 , Issue.2 , pp. 647-655
    • Constantin-Teodosiu, D.1    Peirce, N.S.2    Fox, J.3    Greenhaff, P.L.4
  • 23
    • 0025836738 scopus 로고
    • Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise
    • Constantin-Teodosiu D, Carlin JI, Cederblad G, Harris RC, Hultman E. Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise. Acta Physiol Scand 1991;143:367-372
    • (1991) Acta Physiol Scand , vol.143 , pp. 367-372
    • Constantin-Teodosiu, D.1    Carlin, J.I.2    Cederblad, G.3    Harris, R.C.4    Hultman, E.5
  • 26
    • 0031951706 scopus 로고    scopus 로고
    • Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise
    • Timmons JA, Gustafsson T, Sundberg CJ, Jansson E, Greenhaff PL. Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise. Am J Physiol 1998;274:E377-E380
    • (1998) Am J Physiol , vol.274
    • Timmons, J.A.1    Gustafsson, T.2    Sundberg, C.J.3    Jansson, E.4    Greenhaff, P.L.5
  • 27
    • 0001213072 scopus 로고
    • Muscle electrolytes in man determined by neutron activation analysis on needle biopsy specimens. A study on normal subjects, kidney patients, and patients with chronic diarrhoea
    • Bergstrom J. Muscle electrolytes in man determined by neutron activation analysis on needle biopsy specimens. A study on normal subjects, kidney patients, and patients with chronic diarrhoea. Scand J Clin Lab Invest 1962;14(Suppl. 68):1-110
    • (1962) Scand J Clin Lab Invest , vol.14 , Issue.SUPPL. 68 , pp. 1-110
    • Bergstrom, J.1
  • 28
    • 0016199722 scopus 로고
    • Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values
    • Harris RC, Hultman E, Nordesjö LO. Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values. Scand J Clin Lab Invest 1974;33:109-120
    • (1974) Scand J Clin Lab Invest , vol.33 , pp. 109-120
    • Harris, R.C.1    Hultman, E.2    Nordesjö, L.O.3
  • 29
  • 30
    • 0025936701 scopus 로고
    • A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue
    • Constantin-Teodosiu D, Cederblad G, Hultman E. A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue. Anal Biochem 1991;198:347-351
    • (1991) Anal Biochem , vol.198 , pp. 347-351
    • Constantin-Teodosiu, D.1    Cederblad, G.2    Hultman, E.3
  • 33
    • 0036713906 scopus 로고    scopus 로고
    • Long-term fat diet adaptation effects on performance, training capacity, and fat utilization
    • Helge JW. Long-term fat diet adaptation effects on performance, training capacity, and fat utilization. Med Sci Sports Exerc 2002;34:1499-1504 (Pubitemid 35006824)
    • (2002) Medicine and Science in Sports and Exercise , vol.34 , Issue.9 , pp. 1499-1504
    • Helge, J.W.1
  • 36
  • 37
    • 52749093466 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase kinase 4: Regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue
    • Cadoudal T, Distel E, Durant S, et al. Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue. Diabetes 2008;57:2272-2279
    • (2008) Diabetes , vol.57 , pp. 2272-2279
    • Cadoudal, T.1    Distel, E.2    Durant, S.3
  • 38
    • 0038363836 scopus 로고    scopus 로고
    • Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16
    • DOI 10.1677/jme.0.0300253
    • Imae M, Fu Z, Yoshida A, Noguchi T, Kato H. Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16. J Mol Endocrinol 2003;30:253-262 (Pubitemid 36592517)
    • (2003) Journal of Molecular Endocrinology , vol.30 , Issue.2 , pp. 253-262
    • Imae, M.1    Fu, Z.2    Yoshida, A.3    Noguchi, T.4    Kato, H.5
  • 41
    • 0037900979 scopus 로고    scopus 로고
    • Minireview: Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors
    • DOI 10.1210/en.2003-0288
    • Lee CH, Olson P, Evans RM. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 2003;144:2201-2207 (Pubitemid 36629867)
    • (2003) Endocrinology , vol.144 , Issue.6 , pp. 2201-2207
    • Lee, C.-H.1    Olson, P.2    Evans, R.M.3
  • 43
    • 0035868368 scopus 로고    scopus 로고
    • Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting
    • DOI 10.1042/0264-6021:3540605
    • Rena G, Prescott AR, Guo S, Cohen P, Unterman TG. Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. Biochem J 2001;354:605-612 (Pubitemid 32269724)
    • (2001) Biochemical Journal , vol.354 , Issue.3 , pp. 605-612
    • Rena, G.1    Prescott, A.R.2    Guo, S.3    Cohen, P.4    Unterman, T.G.5
  • 44
    • 53149125147 scopus 로고    scopus 로고
    • Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle
    • Greenhaff PL, Karagounis LG, Peirce N, et al. Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle. Am J Physiol Endocrinol Metab 2008; 295:E595-E604
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Greenhaff, P.L.1    Karagounis, L.G.2    Peirce, N.3
  • 45
    • 33749338109 scopus 로고    scopus 로고
    • Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states
    • DOI 10.2337/db05-1606
    • Kim YI, Lee FN, Choi WS, Lee S, Youn JH. Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states. Diabetes 2006;55:2311-2317 (Pubitemid 44743629)
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2311-2317
    • Kim, Y.I.1    Lee, F.N.2    Choi, W.S.3    Lee, S.4    Youn, J.H.5
  • 46
    • 1842475551 scopus 로고    scopus 로고
    • Protein Kinase B-alpha Inhibits Human Pyruvate Dehydrogenase Kinase-4 Gene Induction by Dexamethasone Through Inactivation of FOXO Transcription Factors
    • DOI 10.2337/diabetes.53.4.899
    • Kwon HS, Huang B, Unterman TG, Harris RA. Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors. Diabetes 2004;53:899-910 (Pubitemid 38436601)
    • (2004) Diabetes , vol.53 , Issue.4 , pp. 899-910
    • Kwon, H.-S.1    Huang, B.2    Unterman, T.G.3    Harris, R.A.4
  • 47
    • 0015789942 scopus 로고
    • Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo
    • McAllister A, Allison SP, Randle PJ. Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo. Biochem J 1973; 134:1067-1081
    • (1973) Biochem J , vol.134 , pp. 1067-1081
    • McAllister, A.1    Allison, S.P.2    Randle, P.J.3
  • 48
    • 0023107554 scopus 로고
    • Dichloroacetate inhibits glycolysis and augments insulin-stimulated glycogen synthesis in rat muscle
    • Clark AS, Mitch WE, Goodman MN, Fagan JM, Goheer MA, Curnow RT. Dichloroacetate inhibits glycolysis and augments insulin-stimulated glycogen synthesis in rat muscle. J Clin Invest 1987;79:588-594 (Pubitemid 17009697)
    • (1987) Journal of Clinical Investigation , vol.79 , Issue.2 , pp. 588-594
    • Clark, A.S.1    Mitch, W.E.2    Goodman, M.N.3
  • 49
    • 0031923040 scopus 로고    scopus 로고
    • Hepatic pyruvate dehydrogenase activity in humans: Effect of cirrhosis, transplantation, and dichloroacetate
    • Shangraw RE, Rabkin JM, Lopaschuk GD. Hepatic pyruvate dehydrogenase activity in humans: effect of cirrhosis, transplantation, and dichloroacetate. Am J Physiol 1998;274:G569-G577
    • (1998) Am J Physiol , vol.274
    • Shangraw, R.E.1    Rabkin, J.M.2    Lopaschuk, G.D.3


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