Off-target effects in CRISPR/Cas9-mediated genome engineering

Molecular Therapy Nucleic Acids

Volumn 4, Issue 11, 2015, Pages e264-

  Zhang, Xiao Hui ^a,b   Tee, Louis Y ^c   Wang, Xiao Gang ^d   Huang, Qun Shan ^a   Yang, Shi Hua ^a  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^b KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d JINAN UNIVERSITY   (China)

Author keywords

CRISPR Cas9; Off target

Indexed keywords

DNA FRAGMENT; GENOMIC DNA; GUIDE RNA; PAM RNA; RNA; SGRNA; UNCLASSIFIED DRUG;

BACTERIAL GENOME; CHROMATIN IMMUNOPRECIPITATION; CONFORMATIONAL TRANSITION; CRISPR CAS SYSTEM; DNA CLEAVAGE; DNA END JOINING REPAIR; DNA SEQUENCE; GENE MUTATION; GENE TARGETING; GENETIC ENGINEERING; GENOMIC INSTABILITY; GENOMICS; GENOTYPE PHENOTYPE CORRELATION; HUMAN; MUTAGENESIS; NEXT GENERATION SEQUENCING; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; SEQUENCE ALIGNMENT; TRANSGENIC ORGANISM; WILD TYPE;

EID: 84959354962     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2015.37     Document Type: Review

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