Off-target mutations are rare in Cas9-modified mice

Nature Methods

Volumn 12, Issue 6, 2015, Pages 479-

  Iyer, Vivek ^a   Shen, Bin ^b   Zhang, Wensheng ^a,c   Hodgkins, Alex ^a   Keane, Thomas ^a   Huang, Xingxu ^b   Skarnes, William C ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b NANJING UNIVERSITY   (China)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

REPETITIVE DNA;

ALLELE; ANIMAL EXPERIMENT; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE SEQUENCE; GENETIC VARIABILITY; GENOME ANALYSIS; INDEL MUTATION; LETTER; MALE; MOUSE; NONHUMAN; OFF TARGET MUTATION; PRIORITY JOURNAL;

MUS;

EID: 84930153818     PISSN: 15487091     EISSN: 15487105     Source Type: Journal    
DOI: 10.1038/nmeth.3408     Document Type: Letter

References (6)

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3. Ran, F. A. et al. Cell 154, 1380-1389 (2013).
4. Smith, C. et al. Cell Stem Cell 15, 12-13 (2014).
5. Veres, A. et al. Cell Stem Cell 15, 27-30 (2014).
6. Suzuki, K. et al. Cell Stem Cell 15, 31-36 (2014).