메뉴 건너뛰기




Volumn 78, Issue , 2016, Pages 243-276

ADAM Proteases and Gastrointestinal Function

Author keywords

ADAM10; ADAM17; EGFR; Intestinal stem cells; Notch; TNF

Indexed keywords

ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; ADAM17 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; MEMBRANE PROTEIN;

EID: 84958652284     PISSN: 00664278     EISSN: 15451585     Source Type: Book Series    
DOI: 10.1146/annurev-physiol-021014-071720     Document Type: Review
Times cited : (61)

References (154)
  • 1
    • 84866487100 scopus 로고    scopus 로고
    • Ectodomain shedding and ADAMs in development
    • Weber S, Saftig P. 2012. Ectodomain shedding and ADAMs in development. Development 139:3693-709
    • (2012) Development , vol.139 , pp. 3693-3709
    • Weber, S.1    Saftig, P.2
  • 3
    • 84862850617 scopus 로고    scopus 로고
    • Regulation of α-secretase ADAM10 expression and activity
    • Endres K, Fahrenholz F. 2012. Regulation of α-secretase ADAM10 expression and activity. Exp. Brain Res. 217:343-52
    • (2012) Exp. Brain Res , vol.217 , pp. 343-352
    • Endres, K.1    Fahrenholz, F.2
  • 4
    • 63649141727 scopus 로고    scopus 로고
    • The "A disintegrin and metalloprotease" (ADAM) family of sheddases: Physiological and cellular functions
    • Reiss K, Saftig P. 2009. The "A disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions. Semin. Cell Dev. Biol. 20:126-37
    • (2009) Semin. Cell Dev. Biol , vol.20 , pp. 126-137
    • Reiss, K.1    Saftig, P.2
  • 5
    • 79960923986 scopus 로고    scopus 로고
    • ADAM17: A molecular switch to control inflammation and tissue regeneration
    • Scheller J, Chalaris A, Garbers C, Rose-John S. 2011. ADAM17: a molecular switch to control inflammation and tissue regeneration. Trends Immunol. 32:380-87
    • (2011) Trends Immunol , vol.32 , pp. 380-387
    • Scheller, J.1    Chalaris, A.2    Garbers, C.3    Rose-John, S.4
  • 6
    • 84883143934 scopus 로고    scopus 로고
    • Metalloproteinases and their natural inhibitors in inflammation and immunity
    • Khokha R, Murthy A, Weiss A. 2013. Metalloproteinases and their natural inhibitors in inflammation and immunity. Nat. Rev. Immunol. 13:649-65
    • (2013) Nat. Rev. Immunol , vol.13 , pp. 649-665
    • Khokha, R.1    Murthy, A.2    Weiss, A.3
  • 7
    • 84867572642 scopus 로고    scopus 로고
    • Testicular and epididymal ADAMs: Expression and function during fertilization
    • Cho C. 2012. Testicular and epididymal ADAMs: expression and function during fertilization. Nat. Rev. Urol. 9:550-60
    • (2012) Nat. Rev. Urol , vol.9 , pp. 550-560
    • Cho, C.1
  • 8
    • 84855822415 scopus 로고    scopus 로고
    • Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE
    • Adrain C, Zettl M, Christova Y, Taylor N, Freeman M. 2012. Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE. Science 335:225-28
    • (2012) Science , vol.335 , pp. 225-228
    • Adrain, C.1    Zettl, M.2    Christova, Y.3    Taylor, N.4    Freeman, M.5
  • 9
    • 84862909285 scopus 로고    scopus 로고
    • IRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS
    • McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, et al. 2012. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science 335:229-32
    • (2012) Science , vol.335 , pp. 229-232
    • McIlwain, D.R.1    Lang, P.A.2    Maretzky, T.3    Hamada, K.4    Ohishi, K.5
  • 10
    • 84885320661 scopus 로고    scopus 로고
    • Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation
    • Christova Y, Adrain C, Bambrough P, Ibrahim A, Freeman M. 2013. Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation. EMBO Rep. 14:884-90
    • (2013) EMBO Rep , vol.14 , pp. 884-890
    • Christova, Y.1    Adrain, C.2    Bambrough, P.3    Ibrahim, A.4    Freeman, M.5
  • 11
    • 84879929720 scopus 로고    scopus 로고
    • IRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding
    • Maretzky T, McIlwain DR, Issuree PD, Li X, Malapeira J, et al. 2013. iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding. PNAS 110:11433-38
    • (2013) PNAS , vol.110 , pp. 11433-11438
    • Maretzky, T.1    McIlwain, D.R.2    Issuree, P.D.3    Li, X.4    Malapeira, J.5
  • 12
    • 84929224114 scopus 로고    scopus 로고
    • IRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling
    • Li X, Maretzky T, Weskamp G, Monette S, Qing X, et al. 2015. iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling. PNAS 112:6080-85
    • (2015) PNAS , vol.112 , pp. 6080-6085
    • Li, X.1    Maretzky, T.2    Weskamp, G.3    Monette, S.4    Qing, X.5
  • 13
    • 84869121252 scopus 로고    scopus 로고
    • TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals
    • Dornier E, Coumailleau F, Ottavi JF, Moretti J, Boucheix C, et al. 2012. TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. J. Cell Biol. 199:481-96
    • (2012) J. Cell Biol , vol.199 , pp. 481-496
    • Dornier, E.1    Coumailleau, F.2    Ottavi, J.F.3    Moretti, J.4    Boucheix, C.5
  • 14
    • 84869211737 scopus 로고    scopus 로고
    • The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression
    • Haining EJ, Yang J, Bailey RL, Khan K, Collier R, et al. 2012. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. J. Biol. Chem. 287:39753-65
    • (2012) J. Biol. Chem , vol.287 , pp. 39753-39765
    • Haining, E.J.1    Yang, J.2    Bailey, R.L.3    Khan, K.4    Collier, R.5
  • 15
    • 84864991638 scopus 로고    scopus 로고
    • Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10
    • Prox J, Willenbrock M, Weber S, Lehmann T, Schmidt-Arras D, et al. 2012. Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10. Cell Mol. Life Sci. 69:2919-32
    • (2012) Cell Mol. Life Sci , vol.69 , pp. 2919-2932
    • Prox, J.1    Willenbrock, M.2    Weber, S.3    Lehmann, T.4    Schmidt-Arras, D.5
  • 16
    • 84924560120 scopus 로고    scopus 로고
    • The IL-6/gp130/STAT3 signaling axis: Recent advances towards specific inhibition
    • Garbers C, Aparicio-Siegmund S, Rose-John S. 2015. The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition. Curr. Opin Immunol. 34C:75-82
    • (2015) Curr. Opin Immunol , vol.34 C , pp. 75-82
    • Garbers, C.1    Aparicio-Siegmund, S.2    Rose-John, S.3
  • 17
    • 26844448800 scopus 로고    scopus 로고
    • Adam meets Eph: An ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans
    • Janes PW, Saha N, Barton WA, Kolev MV, Wimmer-Kleikamp SH, et al. 2005. Adam meets Eph: An ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Cell 123:291-304
    • (2005) Cell , vol.123 , pp. 291-304
    • Janes, P.W.1    Saha, N.2    Barton, W.A.3    Kolev, M.V.4    Wimmer-Kleikamp, S.H.5
  • 19
    • 31544437691 scopus 로고    scopus 로고
    • A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44
    • Stoeck A, Keller S, Riedle S, Sanderson MP, Runz S, et al. 2006. A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem. J. 393:609-18
    • (2006) Biochem. J , vol.393 , pp. 609-618
    • Stoeck, A.1    Keller, S.2    Riedle, S.3    Sanderson, M.P.4    Runz, S.5
  • 20
    • 84906899235 scopus 로고    scopus 로고
    • Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state
    • Shimoda M, Principe S, Jackson HW, Luga V, Fang H, et al. 2014. Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state. Nat. Cell Biol. 16:889-901
    • (2014) Nat. Cell Biol , vol.16 , pp. 889-901
    • Shimoda, M.1    Principe, S.2    Jackson, H.W.3    Luga, V.4    Fang, H.5
  • 21
    • 84890403593 scopus 로고    scopus 로고
    • Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-αshedding
    • Folgosa L, Zellner HB, El Shikh ME, Conrad DH. 2013. Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-αshedding. J. Immunol. 191:5951-58
    • (2013) J. Immunol , vol.191 , pp. 5951-5958
    • Folgosa, L.1    Zellner, H.B.2    El Shikh, M.E.3    Conrad, D.H.4
  • 23
    • 77049113770 scopus 로고    scopus 로고
    • The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity
    • Brew K, Nagase H. 2010. The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. Biochim. Biophys. Acta 1803:55-71
    • (2010) Biochim. Biophys. Acta , vol.1803 , pp. 55-71
    • Brew, K.1    Nagase, H.2
  • 24
    • 76849107016 scopus 로고    scopus 로고
    • Direct activation of TACE-mediated ectodomain shedding by p38MAP kinase regulates EGF receptor-dependent cell proliferation
    • Xu P, Derynck R. 2010. Direct activation of TACE-mediated ectodomain shedding by p38MAP kinase regulates EGF receptor-dependent cell proliferation. Mol. Cell 37:551-66
    • (2010) Mol. Cell , vol.37 , pp. 551-566
    • Xu, P.1    Derynck, R.2
  • 25
    • 84860714018 scopus 로고    scopus 로고
    • TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association
    • Xu P, Liu J, Sakaki-Yumoto M, Derynck R. 2012. TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. Sci. Signal 5:ra34
    • (2012) Sci. Signal , vol.5 , pp. ra34
    • Xu, P.1    Liu, J.2    Sakaki-Yumoto, M.3    Derynck, R.4
  • 26
    • 37249079599 scopus 로고    scopus 로고
    • The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events
    • Moss ML, Bomar M, Liu Q, Sage H, Dempsey P, et al. 2007. The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events. J. Biol. Chem. 282:35712-21
    • (2007) J. Biol. Chem , vol.282 , pp. 35712-35721
    • Moss, M.L.1    Bomar, M.2    Liu, Q.3    Sage, H.4    Dempsey, P.5
  • 27
    • 34250167944 scopus 로고    scopus 로고
    • Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer
    • Fridman JS, Caulder E, Hansbury M, Liu X, Yang G, et al. 2007. Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer. Clin. Cancer Res. 13:1892-902
    • (2007) Clin. Cancer Res , vol.13 , pp. 1892-1902
    • Fridman, J.S.1    Caulder, E.2    Hansbury, M.3    Liu, X.4    Yang, G.5
  • 28
    • 33745791118 scopus 로고    scopus 로고
    • Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer
    • Zhou BB, Peyton M, He B, Liu C, Girard L, et al. 2006. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell 10:39-50
    • (2006) Cancer Cell , vol.10 , pp. 39-50
    • Zhou, B.B.1    Peyton, M.2    He, B.3    Liu, C.4    Girard, L.5
  • 31
    • 84875602708 scopus 로고    scopus 로고
    • Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function
    • Atapattu L, Saha N, Llerena C, Vail ME, Scott AM, et al. 2012. Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function. J. Cell Sci. 125:6084-93
    • (2012) J. Cell Sci , vol.125 , pp. 6084-6093
    • Atapattu, L.1    Saha, N.2    Llerena, C.3    Vail, M.E.4    Scott, A.M.5
  • 32
    • 84927696737 scopus 로고    scopus 로고
    • Opposing activities ofNotch andWnt signaling regulate intestinal stem cells and gut homeostasis
    • Tian H, Biehs B, Chiu C, Siebel CW,WuY, et al. 2015. Opposing activities ofNotch andWnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep. 11:33-42
    • (2015) Cell Rep , vol.11 , pp. 33-42
    • Tian, H.1    Biehs, B.2    Chiu, C.3    Siebel, C.W.4    Wu, Y.5
  • 33
    • 84875837518 scopus 로고    scopus 로고
    • Blockade of individual Notch ligands and receptors controls graft-versus-host disease
    • Tran IT, Sandy AR, Carulli AJ, Ebens C, Chung J, et al. 2013. Blockade of individual Notch ligands and receptors controls graft-versus-host disease. J. Clin. Investig. 123:1590-604
    • (2013) J. Clin. Investig , vol.123 , pp. 1590-1604
    • Tran, I.T.1    Sandy, A.R.2    Carulli, A.J.3    Ebens, C.4    Chung, J.5
  • 34
    • 84855419201 scopus 로고    scopus 로고
    • Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells
    • VanDussen KL, Carulli AJ, Keeley TM, Patel SR, Puthoff BJ, et al. 2012. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development 139:488-97
    • (2012) Development , vol.139 , pp. 488-497
    • VanDussen, K.L.1    Carulli, A.J.2    Keeley, T.M.3    Patel, S.R.4    Puthoff, B.J.5
  • 35
    • 84923395423 scopus 로고    scopus 로고
    • Differential effects of targeting Notch receptors in a mouse model of liver cancer
    • Huntzicker EG, Hotzel K, Choy L, Che L, Ross J, et al. 2015. Differential effects of targeting Notch receptors in a mouse model of liver cancer. Hepatology 61:942-52
    • (2015) Hepatology , vol.61 , pp. 942-952
    • Huntzicker, E.G.1    Hotzel, K.2    Choy, L.3    Che, L.4    Ross, J.5
  • 36
    • 79951664674 scopus 로고    scopus 로고
    • Vertebrate intestinal endoderm development
    • Spence JR, Lauf R, Shroyer NF. 2011. Vertebrate intestinal endoderm development. Dev. Dyn. 240:501-20
    • (2011) Dev. Dyn , vol.240 , pp. 501-520
    • Spence, J.R.1    Lauf, R.2    Shroyer, N.F.3
  • 37
    • 70350225535 scopus 로고    scopus 로고
    • Vertebrate endoderm development and organ formation
    • Zorn AM, Wells JM. 2009. Vertebrate endoderm development and organ formation. Annu. Rev. Cell Dev. Biol. 25:221-51
    • (2009) Annu. Rev. Cell Dev. Biol , vol.25 , pp. 221-251
    • Zorn, A.M.1    Wells, J.M.2
  • 38
    • 84891007206 scopus 로고    scopus 로고
    • Adult intestinal stem cells: Critical drivers of epithelial homeostasis and regeneration
    • Barker N. 2014. Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat. Rev. Mol. Cell Biol. 15:19-33
    • (2014) Nat. Rev. Mol. Cell Biol , vol.15 , pp. 19-33
    • Barker, N.1
  • 39
    • 84880548336 scopus 로고    scopus 로고
    • The intestinal crypt, a prototype stem cell compartment
    • Clevers H. 2013. The intestinal crypt, a prototype stem cell compartment. Cell 154:274-84
    • (2013) Cell , vol.154 , pp. 274-284
    • Clevers, H.1
  • 40
    • 84873672050 scopus 로고    scopus 로고
    • Paneth cells: Maestros of the small intestinal crypts
    • Clevers HC, Bevins CL. 2013. Paneth cells: maestros of the small intestinal crypts. Annu. Rev. Physiol. 75:289-311
    • (2013) Annu. Rev. Physiol , vol.75 , pp. 289-311
    • Clevers, H.C.1    Bevins, C.L.2
  • 41
    • 84928926944 scopus 로고    scopus 로고
    • Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease
    • Sancho R, Cremona CA, Behrens A. 2015. Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease. EMBO Rep. 16:571-81
    • (2015) EMBO Rep , vol.16 , pp. 571-581
    • Sancho, R.1    Cremona, C.A.2    Behrens, A.3
  • 43
    • 33847422295 scopus 로고    scopus 로고
    • Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE
    • Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, et al. 2007. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development 134:535-44
    • (2007) Development , vol.134 , pp. 535-544
    • Vooijs, M.1    Ong, C.T.2    Hadland, B.3    Huppert, S.4    Liu, Z.5
  • 44
    • 78751515624 scopus 로고    scopus 로고
    • Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas
    • Kopinke D, Brailsford M, Shea JE, Leavitt R, Scaife CL, Murtaugh LC. 2011. Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas. Development 138:431-41
    • (2011) Development , vol.138 , pp. 431-441
    • Kopinke, D.1    Brailsford, M.2    Shea, J.E.3    Leavitt, R.4    Scaife, C.L.5    Murtaugh, L.C.6
  • 46
    • 48749089743 scopus 로고    scopus 로고
    • Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2
    • Riccio O, van Gijn ME, Bezdek AC, Pellegrinet L, van Es JH, et al. 2008. Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep. 9:377-83
    • (2008) EMBO Rep , vol.9 , pp. 377-383
    • Riccio, O.1    Van Gijn, M.E.2    Bezdek, A.C.3    Pellegrinet, L.4    Van Es, J.H.5
  • 47
    • 65549086537 scopus 로고    scopus 로고
    • Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine
    • Fre S, Pallavi SK, Huyghe M, Lae M, Janssen KP, et al. 2009. Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. PNAS 106:6309-14
    • (2009) PNAS , vol.106 , pp. 6309-6314
    • Fre, S.1    Pallavi, S.K.2    Huyghe, M.3    Lae, M.4    Janssen, K.P.5
  • 48
    • 79953204955 scopus 로고    scopus 로고
    • Dll1-and Dll4-mediated Notch signaling are required for homeostasis of intestinal stem cells
    • Pellegrinet L, Rodilla V, Liu Z, Chen S, Koch U, et al. 2011. Dll1-and Dll4-mediated Notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology 140:1230-40.e7
    • (2011) Gastroenterology , vol.140 , pp. 1230e7-1240e7
    • Pellegrinet, L.1    Rodilla, V.2    Liu, Z.3    Chen, S.4    Koch, U.5
  • 49
    • 84896691636 scopus 로고    scopus 로고
    • Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity
    • Kim TH, Li F, Ferreiro-Neira I, Ho LL, Luyten A, et al. 2014. Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity. Nature 506:511-15
    • (2014) Nature , vol.506 , pp. 511-515
    • Kim, T.H.1    Li, F.2    Ferreiro-Neira, I.3    Ho, L.L.4    Luyten, A.5
  • 51
    • 0036796421 scopus 로고    scopus 로고
    • The disintegrin/ metalloprotease ADAM 10 is essential forNotch signalling but not for α-secretase activity in fibroblasts
    • Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, et al. 2002. The disintegrin/ metalloprotease ADAM 10 is essential forNotch signalling but not for α-secretase activity in fibroblasts. Hum. Mol. Genet. 11:2615-24
    • (2002) Hum. Mol. Genet , vol.11 , pp. 2615-2624
    • Hartmann, D.1    De Strooper, B.2    Serneels, L.3    Craessaerts, K.4    Herreman, A.5
  • 52
    • 84904353983 scopus 로고    scopus 로고
    • Regulated proteolysis ofNOTCH2 and NOTCH3 receptors by ADAM10 and presenilins
    • Groot AJ, Habets R, Yahyanejad S, Hodin CM, Reiss K, et al. 2014. Regulated proteolysis ofNOTCH2 and NOTCH3 receptors by ADAM10 and presenilins. Mol. Cell. Biol. 34:2822-32
    • (2014) Mol. Cell. Biol , vol.34 , pp. 2822-2832
    • Groot, A.J.1    Habets, R.2    Yahyanejad, S.3    Hodin, C.M.4    Reiss, K.5
  • 54
    • 78751520783 scopus 로고    scopus 로고
    • The disintegrin/ metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling
    • Weber S, Niessen MT, Prox J, Lullmann-Rauch R, Schmitz A, et al. 2011. The disintegrin/ metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Development 138:495-505
    • (2011) Development , vol.138 , pp. 495-505
    • Weber, S.1    Niessen, M.T.2    Prox, J.3    Lullmann-Rauch, R.4    Schmitz, A.5
  • 55
    • 80053446182 scopus 로고    scopus 로고
    • Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice
    • Fre S, Hannezo E, Sale S, Huyghe M, Lafkas D, et al. 2011. Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLOS ONE 6:e25785
    • (2011) PLOS ONE , vol.6 , pp. e25785
    • Fre, S.1    Hannezo, E.2    Sale, S.3    Huyghe, M.4    Lafkas, D.5
  • 57
    • 78651067425 scopus 로고    scopus 로고
    • Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells
    • Montgomery RK, Carlone DL, Richmond CA, Farilla L, KranendonkME, et al. 2011. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. PNAS 108:179-84
    • (2011) PNAS , vol.108 , pp. 179-184
    • Montgomery, R.K.1    Carlone, D.L.2    Richmond, C.A.3    Farilla, L.4    Kranendonk, M.E.5
  • 58
    • 80054041585 scopus 로고    scopus 로고
    • A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
    • Tian H, Biehs B,Warming S, Leong KG, Rangell L, et al. 2011. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478:255-59
    • (2011) Nature , vol.478 , pp. 255-259
    • Tian, H.1    Biehs, B.2    Warming, S.3    Leong, K.G.4    Rangell, L.5
  • 60
    • 46249128798 scopus 로고    scopus 로고
    • Bmi1 is expressed in vivo in intestinal stem cells
    • Sangiorgi E, CapecchiMR. 2008. Bmi1 is expressed in vivo in intestinal stem cells. Nat. Genet. 40:915-20
    • (2008) Nat. Genet , vol.40 , pp. 915-920
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 61
    • 21544467772 scopus 로고    scopus 로고
    • ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion,migration, and β-catenin translocation
    • Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, et al. 2005. ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion,migration, and β-catenin translocation. PNAS 102:9182-87
    • (2005) PNAS , vol.102 , pp. 9182-9187
    • Maretzky, T.1    Reiss, K.2    Ludwig, A.3    Buchholz, J.4    Scholz, F.5
  • 62
    • 45349091378 scopus 로고    scopus 로고
    • ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis
    • Maretzky T, Scholz F, Koten B, Proksch E, Saftig P, Reiss K. 2008. ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis. J. Investig. Dermatol. 128:1737-46
    • (2008) J. Investig. Dermatol , vol.128 , pp. 1737-1746
    • Maretzky, T.1    Scholz, F.2    Koten, B.3    Proksch, E.4    Saftig, P.5    Reiss, K.6
  • 63
    • 80052499952 scopus 로고    scopus 로고
    • Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling
    • Solanas G, Cortina C, Sevillano M, Batlle E. 2011. Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling. Nat. Cell Biol. 13:1100-7
    • (2011) Nat. Cell Biol , vol.13 , pp. 1100-1107
    • Solanas, G.1    Cortina, C.2    Sevillano, M.3    Batlle, E.4
  • 64
    • 39749085844 scopus 로고    scopus 로고
    • TACE/ADAM-17: A component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer
    • Merchant NB, Voskresensky I, Rogers CM, Lafleur B, Dempsey PJ, et al. 2008. TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Clin. Cancer Res. 14:1182-91
    • (2008) Clin. Cancer Res , vol.14 , pp. 1182-1191
    • Merchant, N.B.1    Voskresensky, I.2    Rogers, C.M.3    Lafleur, B.4    Dempsey, P.J.5
  • 65
    • 8044250278 scopus 로고    scopus 로고
    • Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α
    • Moss ML, Jin SL, Milla ME, Bickett DM, Burkhart W, et al. 1997. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α. Nature 385:733-36
    • (1997) Nature , vol.385 , pp. 733-736
    • Moss, M.L.1    Jin, S.L.2    Milla, M.E.3    Bickett, D.M.4    Burkhart, W.5
  • 66
    • 0031985413 scopus 로고    scopus 로고
    • TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
    • Peschon JJ, Torrance DS, Stocking KL, Glaccum MB, Otten C, et al. 1998. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J. Immunol. 160:943-52
    • (1998) J. Immunol , vol.160 , pp. 943-952
    • Peschon, J.J.1    Torrance, D.S.2    Stocking, K.L.3    Glaccum, M.B.4    Otten, C.5
  • 68
    • 84899117057 scopus 로고    scopus 로고
    • Cellular sources of pathogenic and protective TNF and experimental strategies based on utilization of TNF humanized mice
    • Winsauer C, Kruglov AA, Chashchina AA, Drutskaya MS, Nedospasov SA. 2014. Cellular sources of pathogenic and protective TNF and experimental strategies based on utilization of TNF humanized mice. Cytokine Growth Factor Rev. 25:115-23
    • (2014) Cytokine Growth Factor Rev , vol.25 , pp. 115-123
    • Winsauer, C.1    Kruglov, A.A.2    Chashchina, A.A.3    Drutskaya, M.S.4    Nedospasov, S.A.5
  • 69
    • 0029045856 scopus 로고
    • Strain-dependent epithelial defects in mice lacking the EGF receptor
    • Sibilia M, Wagner EF. 1995. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234-38
    • (1995) Science , vol.269 , pp. 234-238
    • Sibilia, M.1    Wagner, E.F.2
  • 70
    • 0029064203 scopus 로고
    • Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype
    • Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, et al. 1995. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269:230-34
    • (1995) Science , vol.269 , pp. 230-234
    • Threadgill, D.W.1    Dlugosz, A.A.2    Hansen, L.A.3    Tennenbaum, T.4    Lichti, U.5
  • 71
    • 0029074587 scopus 로고
    • Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
    • Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, et al. 1995. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376:337-41
    • (1995) Nature , vol.376 , pp. 337-341
    • Miettinen, P.J.1    Berger, J.E.2    Meneses, J.3    Phung, Y.4    Pedersen, R.A.5
  • 72
    • 62649171270 scopus 로고    scopus 로고
    • The role of protease activity in ErbB biology
    • Blobel CP, Carpenter G, Freeman M. 2009. The role of protease activity in ErbB biology. Exp. Cell Res. 315:671-82
    • (2009) Exp. Cell Res , vol.315 , pp. 671-682
    • Blobel, C.P.1    Carpenter, G.2    Freeman, M.3
  • 73
    • 0037066757 scopus 로고    scopus 로고
    • Tumor necrosis factor-α converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability
    • Sunnarborg SW, Hinkle CL, StevensonM, Russell WE, Raska CS, et al. 2002. Tumor necrosis factor-α converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J. Biol. Chem. 277:12838-45
    • (2002) J. Biol. Chem , vol.277 , pp. 12838-12845
    • Sunnarborg, S.W.1    Hinkle, C.L.2    Stevenson, M.3    Russell, W.E.4    Raska, C.S.5
  • 74
    • 2942715388 scopus 로고    scopus 로고
    • Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned
    • Strunk KE, Amann V, Threadgill DW. 2004. Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned. Genetics 167:1821-32
    • (2004) Genetics , vol.167 , pp. 1821-1832
    • Strunk, K.E.1    Amann, V.2    Threadgill, D.W.3
  • 75
    • 57349182490 scopus 로고    scopus 로고
    • Deficiency of TNFαconverting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype inmice
    • Gelling RW, Yan W, Al-Noori S, Pardini A, Morton GJ, et al. 2008. Deficiency of TNFαconverting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype inmice. Endocrinology 149:6053-64
    • (2008) Endocrinology , vol.149 , pp. 6053-6064
    • Gelling, R.W.1    Yan, W.2    Al-Noori, S.3    Pardini, A.4    Morton, G.J.5
  • 76
    • 33947629847 scopus 로고    scopus 로고
    • Non-cell autonomous expression of TNF-α-converting enzyme ADAM17 is required for normal lymphocyte development
    • Li N, Boyd K, Dempsey PJ, Vignali DA. 2007. Non-cell autonomous expression of TNF-α-converting enzyme ADAM17 is required for normal lymphocyte development. J. Immunol. 178:4214-21
    • (2007) J. Immunol , vol.178 , pp. 4214-4221
    • Li, N.1    Boyd, K.2    Dempsey, P.J.3    Vignali, D.A.4
  • 78
    • 84864317357 scopus 로고    scopus 로고
    • Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation
    • Franzke CW, Cobzaru C, Triantafyllopoulou A, Loffek S, Horiuchi K, et al. 2012. Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. J. Exp. Med. 209:1105-19
    • (2012) J. Exp. Med , vol.209 , pp. 1105-1119
    • Franzke, C.W.1    Cobzaru, C.2    Triantafyllopoulou, A.3    Loffek, S.4    Horiuchi, K.5
  • 79
    • 78650548872 scopus 로고    scopus 로고
    • MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
    • Brandl K, Sun L, Neppl C, Siggs OM, Le Gall SM, et al. 2010. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. PNAS 107:19967-72
    • (2010) PNAS , vol.107 , pp. 19967-19972
    • Brandl, K.1    Sun, L.2    Neppl, C.3    Siggs, O.M.4    Le Gall, S.M.5
  • 80
    • 77955348535 scopus 로고    scopus 로고
    • Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
    • Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, et al. 2010. Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J. Exp. Med. 207:1617-24
    • (2010) J. Exp. Med , vol.207 , pp. 1617-1624
    • Chalaris, A.1    Adam, N.2    Sina, C.3    Rosenstiel, P.4    Lehmann-Koch, J.5
  • 81
    • 84886909059 scopus 로고    scopus 로고
    • A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor
    • Yan F, Liu L, Dempsey PJ, Tsai YH, Raines EW, et al. 2013. A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. J. Biol. Chem. 288:30742-51
    • (2013) J. Biol. Chem , vol.288 , pp. 30742-30751
    • Yan, F.1    Liu, L.2    Dempsey, P.J.3    Tsai, Y.H.4    Raines, E.W.5
  • 82
    • 84944615587 scopus 로고    scopus 로고
    • Loss of ADAM17-mediatedTNFαsignaling in intestinal cells attenuates mucosal atrophy in a mouse model of parenteral nutrition
    • Feng Y, Tsai YH,Xiao W, RallsMW,Stoeck A, et al. 2015. Loss of ADAM17-mediatedTNFαsignaling in intestinal cells attenuates mucosal atrophy in a mouse model of parenteral nutrition. Mol. Cell. Biol. 35:3604-21
    • (2015) Mol. Cell. Biol , vol.35 , pp. 3604-3621
    • Feng, Y.1    Tsai, Y.H.2    Xiao, W.3    Ralls, M.W.4    Stoeck, A.5
  • 83
    • 70349199083 scopus 로고    scopus 로고
    • Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium
    • Lee D, Yu M, Lee E, Kim H, Yang Y, et al. 2009. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. J. Clin. Investig. 119:2702-13
    • (2009) J. Clin. Investig , vol.119 , pp. 2702-2713
    • Lee, D.1    Yu, M.2    Lee, E.3    Kim, H.4    Yang, Y.5
  • 84
    • 84866234496 scopus 로고    scopus 로고
    • Enterocyte expression of epidermal growth factor receptor is not required for intestinal adaptation in response to massive small bowel resection
    • Rowland KJ, McMellen ME, Wakeman D, Wandu WS, Erwin CR, Warner BW. 2012. Enterocyte expression of epidermal growth factor receptor is not required for intestinal adaptation in response to massive small bowel resection. J. Pediatr. Surg. 47:1748-53
    • (2012) J. Pediatr. Surg , vol.47 , pp. 1748-1753
    • Rowland, K.J.1    McMellen, M.E.2    Wakeman, D.3    Wandu, W.S.4    Erwin, C.R.5    Warner, B.W.6
  • 85
    • 79957907960 scopus 로고    scopus 로고
    • Colon-specific delivery of a probioticderived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism
    • Yan F, Cao H, Cover TL, Washington MK, Shi Y, et al. 2011. Colon-specific delivery of a probioticderived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J. Clin. Investig. 121:2242-53
    • (2011) J. Clin. Investig , vol.121 , pp. 2242-2253
    • Yan, F.1    Cao, H.2    Cover, T.L.3    Washington, M.K.4    Shi, Y.5
  • 86
    • 84863248698 scopus 로고    scopus 로고
    • ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival
    • Zhang Y, Dube PE,WashingtonMK, Yan F, Polk DB. 2012. ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival. Lab. Investig. 92:437-50
    • (2012) Lab. Investig , vol.92 , pp. 437-450
    • Zhang, Y.1    Dube, P.E.2    Washington, M.K.3    Yan, F.4    Polk, D.B.5
  • 87
    • 84900400868 scopus 로고    scopus 로고
    • ErbB receptors and their growth factor ligands in pediatric intestinal inflammation
    • Frey MR, Polk DB. 2014. ErbB receptors and their growth factor ligands in pediatric intestinal inflammation. Pediatr. Res. 75:127-32
    • (2014) Pediatr. Res , vol.75 , pp. 127-132
    • Frey, M.R.1    Polk, D.B.2
  • 88
    • 84859196824 scopus 로고    scopus 로고
    • The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor
    • Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, et al. 2012. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell 149:146-58
    • (2012) Cell , vol.149 , pp. 146-158
    • Powell, A.E.1    Wang, Y.2    Li, Y.3    Poulin, E.J.4    Means, A.L.5
  • 89
    • 84859430024 scopus 로고    scopus 로고
    • Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling
    • Wong VW, Stange DE, Page ME, Buczacki S,Wabik A, et al. 2012. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat. Cell Biol. 14:401-8
    • (2012) Nat. Cell Biol , vol.14 , pp. 401-408
    • Wong, V.W.1    Stange, D.E.2    Page, M.E.3    Buczacki, S.4    Wabik, A.5
  • 90
    • 38449086094 scopus 로고    scopus 로고
    • Cutting edge:TNF-α-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock
    • Horiuchi K, KimuraT,MiyamotoT,Takaishi H, OkadaY, et al. 2007. Cutting edge:TNF-α-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J. Immunol. 179:2686-89
    • (2007) J. Immunol , vol.179 , pp. 2686-2689
    • Horiuchi, K.1    Kimura, T.2    Miyamoto, T.3    Takaishi, H.4    Okada, Y.5
  • 91
    • 77953910301 scopus 로고    scopus 로고
    • Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase αsubunit
    • Saha A, Backert S,Hammond CE,Gooz M, Smolka AJ. 2010. Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase αsubunit. Gastroenterology 139:239-48
    • (2010) Gastroenterology , vol.139 , pp. 239-248
    • Saha, A.1    Backert, S.2    Hammond, C.E.3    Gooz, M.4    Smolka, A.J.5
  • 92
    • 80053971276 scopus 로고    scopus 로고
    • A Staphylococcus aureus poreforming toxin subverts the activity of ADAM10 to cause lethal infection in mice
    • Inoshima I, Inoshima N, Wilke GA, Powers ME, Frank KM, et al. 2011. A Staphylococcus aureus poreforming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat. Med. 17:1310-14
    • (2011) Nat. Med , vol.17 , pp. 1310-1314
    • Inoshima, I.1    Inoshima, N.2    Wilke, G.A.3    Powers, M.E.4    Frank, K.M.5
  • 93
    • 77955783248 scopus 로고    scopus 로고
    • Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus α-hemolysin-mediated cellular injury
    • Wilke GA, Wardenburg JB. 2010. Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus α-hemolysin-mediated cellular injury. PNAS 107:13473-78
    • (2010) PNAS , vol.107 , pp. 13473-13478
    • Wilke, G.A.1    Wardenburg, J.B.2
  • 94
    • 84907487930 scopus 로고    scopus 로고
    • Bacteroides fragilis subverts mucosal biology: From symbiont to colon carcinogenesis
    • Sears CL, Geis AL, Housseau F. 2014. Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis. J. Clin. Investig. 124:4166-72
    • (2014) J. Clin. Investig , vol.124 , pp. 4166-4172
    • Sears, C.L.1    Geis, A.L.2    Housseau, F.3
  • 95
    • 77953893605 scopus 로고    scopus 로고
    • Listeria monocytogenes internalin and E-cadherin: From bench to bedside
    • Bonazzi M, Lecuit M, Cossart P. 2009. Listeria monocytogenes internalin and E-cadherin: from bench to bedside. Cold Spring Harb. Perspect. Biol. 1:a003087
    • (2009) Cold Spring Harb. Perspect. Biol , vol.1 , pp. a003087
    • Bonazzi, M.1    Lecuit, M.2    Cossart, P.3
  • 96
    • 0026747170 scopus 로고
    • Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor
    • Naglich JG, Metherall JE, RussellDW,Eidels L. 1992. Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell 69:1051-61
    • (1992) Cell , vol.69 , pp. 1051-1061
    • Naglich, J.G.1    Metherall, J.E.2    Russell, D.W.3    Eidels, L.4
  • 97
    • 84964693347 scopus 로고    scopus 로고
    • Redeeming an old foe: Protective as well as pathophysiological roles for tumor necrosis factor in inflammatory bowel disease
    • Dube P, Punit S, PolkDB. 2014. Redeeming an old foe: protective as well as pathophysiological roles for tumor necrosis factor in inflammatory bowel disease. Am. J. Physiol. Gastrointest. Liver Physiol. 308:G161-70
    • (2014) Am. J. Physiol. Gastrointest. Liver Physiol , vol.308 , pp. G161-G170
    • Dube, P.1    Punit, S.2    Polk, D.B.3
  • 98
    • 84904119437 scopus 로고    scopus 로고
    • Pleiotropic functions of TNF-αin the regulation of the intestinal epithelial response to inflammation
    • Leppkes M, Roulis M, Neurath MF, Kollias G, Becker C. 2014. Pleiotropic functions of TNF-αin the regulation of the intestinal epithelial response to inflammation. Int. Immunol. 26:509-15
    • (2014) Int. Immunol , vol.26 , pp. 509-515
    • Leppkes, M.1    Roulis, M.2    Neurath, M.F.3    Kollias, G.4    Becker, C.5
  • 99
    • 0036288520 scopus 로고    scopus 로고
    • Tumour necrosis factor α converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease
    • Brynskov J, Foegh P, Pedersen G, Ellervik C, Kirkegaard T, et al. 2002. Tumour necrosis factor α converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease. Gut 51:37-43
    • (2002) Gut , vol.51 , pp. 37-43
    • Brynskov, J.1    Foegh, P.2    Pedersen, G.3    Ellervik, C.4    Kirkegaard, T.5
  • 101
    • 0035931044 scopus 로고    scopus 로고
    • Implication of TNF-α convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis
    • Colon AL, Menchen LA, Hurtado O, De Cristobal J, Lizasoain I, et al. 2001. Implication of TNF-α convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis. Cytokine 16:220-26
    • (2001) Cytokine , vol.16 , pp. 220-226
    • Colon, A.L.1    Menchen, L.A.2    Hurtado, O.3    De Cristobal, J.4    Lizasoain, I.5
  • 102
    • 33947363664 scopus 로고    scopus 로고
    • Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling
    • Forsyth CB, Banan A, Farhadi A, Fields JZ, Tang Y, et al. 2007. Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling. J. Pharmacol. Exp. Ther. 321:84-97
    • (2007) J. Pharmacol. Exp. Ther , vol.321 , pp. 84-97
    • Forsyth, C.B.1    Banan, A.2    Farhadi, A.3    Fields, J.Z.4    Tang, Y.5
  • 103
    • 0346057808 scopus 로고    scopus 로고
    • Tumour necrosis factor-αconverting enzyme (TACE) activity in human colonic epithelial cells
    • KirkegaardT, PedersenG, SaermarkT, Brynskov J. 2004. Tumour necrosis factor-αconverting enzyme (TACE) activity in human colonic epithelial cells. Clin. Exp. Immunol. 135:146-53
    • (2004) Clin. Exp. Immunol , vol.135 , pp. 146-153
    • Kirkegaard, T.1    Pedersen, G.2    Saermark, T.3    Brynskov, J.4
  • 104
    • 84876368553 scopus 로고    scopus 로고
    • High expression of the "A Disintegrin and Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases
    • Franze E, Caruso R, Stolfi C, Sarra M, Cupi ML, et al. 2013. High expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases. Inflamm. Bowel Dis. 19:501-11
    • (2013) Inflamm. Bowel Dis , vol.19 , pp. 501-511
    • Franze, E.1    Caruso, R.2    Stolfi, C.3    Sarra, M.4    Cupi, M.L.5
  • 105
    • 0030752587 scopus 로고    scopus 로고
    • Mice lacking transforming growth factor α have an increased susceptibility to dextran sulfate-induced colitis
    • Egger B, Procaccino F, Lakshmanan J, ReinshagenM,Hoffmann P, et al. 1997. Mice lacking transforming growth factor α have an increased susceptibility to dextran sulfate-induced colitis. Gastroenterology 113:825-32
    • (1997) Gastroenterology , vol.113 , pp. 825-832
    • Egger, B.1    Procaccino, F.2    Lakshmanan, J.3    Reinshagen, M.4    Hoffmann, P.5
  • 106
    • 0034508756 scopus 로고    scopus 로고
    • Efficacy and safety of weight-adapted nadroparin calcium versus heparin sodium in prevention of clinically evident thromboembolic complications in 1,190 general surgical patients
    • Egger B, Schmid SW, Naef M, Wildi S, Buchler MW. 2000. Efficacy and safety of weight-adapted nadroparin calcium versus heparin sodium in prevention of clinically evident thromboembolic complications in 1,190 general surgical patients. Dig. Surg. 17:602-9
    • (2000) Dig. Surg , vol.17 , pp. 602-609
    • Egger, B.1    Schmid, S.W.2    Naef, M.3    Wildi, S.4    Buchler, M.W.5
  • 107
    • 59849113041 scopus 로고    scopus 로고
    • The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF
    • Frey MR, Edelblum KL, Mullane MT, Liang D, Polk DB. 2009. The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF. Gastroenterology 136:217-26
    • (2009) Gastroenterology , vol.136 , pp. 217-226
    • Frey, M.R.1    Edelblum, K.L.2    Mullane, M.T.3    Liang, D.4    Polk, D.B.5
  • 108
    • 1442358746 scopus 로고    scopus 로고
    • Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
    • Sahin U,Weskamp G, Kelly K, Zhou HM, Higashiyama S, et al. 2004. Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J. Cell Biol. 164:769-79
    • (2004) J. Cell Biol , vol.164 , pp. 769-779
    • Sahin, U.1    Weskamp, G.2    Kelly, K.3    Zhou, H.M.4    Higashiyama, S.5
  • 109
    • 84893358098 scopus 로고    scopus 로고
    • Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis
    • Lu N, Wang L, Cao H, Liu L, Van Kaer L, et al. 2014. Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis. J. Immunol. 192:1013-23
    • (2014) J. Immunol , vol.192 , pp. 1013-1023
    • Lu, N.1    Wang, L.2    Cao, H.3    Liu, L.4    Van Kaer, L.5
  • 110
    • 84875820266 scopus 로고    scopus 로고
    • Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK
    • NeufertC, BeckerC,TureciO,WaldnerMJ, Backert I, et al. 2013. Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK. J. Clin. Investig. 123:1428-43
    • (2013) J. Clin. Investig , vol.123 , pp. 1428-1443
    • Neufert, C.1    Becker, C.2    Tureci, O.3    Waldner, M.J.4    Backert, I.5
  • 112
    • 0034616385 scopus 로고    scopus 로고
    • Tumornecrosis factor-α-converting enzyme is required for cleavage of erbB4/HER4
    • RioC,Buxbaum JD, Peschon JJ, Corfas G. 2000.Tumornecrosis factor-α-converting enzyme is required for cleavage of erbB4/HER4. J. Biol. Chem. 275:10379-87
    • (2000) J. Biol. Chem , vol.275 , pp. 10379-10387
    • Rio, C.1    Buxbaum, J.D.2    Peschon, J.J.3    Corfas, G.4
  • 113
    • 0032493646 scopus 로고    scopus 로고
    • Tyrosine phosphorylation and proteolysis: Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin
    • VecchiM, Rudolph-Owen LA, Brown CL, Dempsey PJ, Carpenter G. 1998. Tyrosine phosphorylation and proteolysis: pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin. J. Biol. Chem. 273:20589-95
    • (1998) J. Biol. Chem , vol.273 , pp. 20589-20595
    • Vecchi, M.1    Rudolph-Owen, L.A.2    Brown, C.L.3    Dempsey, P.J.4    Carpenter, G.5
  • 114
    • 85030566169 scopus 로고    scopus 로고
    • Intestinal cell responses in different injury/regeneration models are differentially dependent on ADAM17
    • Tsai Y-H, Feng Y, Wade AW, Teitelbaum DH, Dempsey PJ. 2012. Intestinal cell responses in different injury/regeneration models are differentially dependent on ADAM17. Gastroenterology 142:S61
    • (2012) Gastroenterology , vol.142 , pp. S61
    • Tsai, Y.-H.1    Feng, Y.2    Wade, A.W.3    Teitelbaum, D.H.4    Dempsey, P.J.5
  • 115
    • 84897919842 scopus 로고    scopus 로고
    • Intestinal epithelial cell apoptosis and loss of barrier function in the setting of altered microbiota with enteral nutrient deprivation
    • Demehri FR, Barrett M, Ralls MW, Miyasaka EA, Feng Y, Teitelbaum DH. 2013. Intestinal epithelial cell apoptosis and loss of barrier function in the setting of altered microbiota with enteral nutrient deprivation. Front. Cell Infect. Microbiol. 3:105
    • (2013) Front. Cell Infect. Microbiol , vol.3 , pp. 105
    • Demehri, F.R.1    Barrett, M.2    Ralls, M.W.3    Miyasaka, E.A.4    Feng, Y.5    Teitelbaum, D.H.6
  • 116
    • 84855304103 scopus 로고    scopus 로고
    • Epidermal growth factor/TNF-α transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition
    • Feng Y, Teitelbaum DH. 2012. Epidermal growth factor/TNF-α transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition. Am. J. Physiol. Gastrointest. Liver Physiol. 302:G236-49
    • (2012) Am. J. Physiol. Gastrointest. Liver Physiol , vol.302 , pp. G236-G249
    • Feng, Y.1    Teitelbaum, D.H.2
  • 117
    • 85030566169 scopus 로고    scopus 로고
    • Intestinal epithelial cell responses to total parenteral nutrition (TPN) are under complex regulation by ADAM17
    • Feng Y, Tsai YH, Teitelbaum DH, Dempsey PJ. 2012. Intestinal epithelial cell responses to total parenteral nutrition (TPN) are under complex regulation by ADAM17. Gastroenterology 142:S167-68
    • (2012) Gastroenterology , vol.142 , pp. S167-S168
    • Feng, Y.1    Tsai, Y.H.2    Teitelbaum, D.H.3    Dempsey, P.J.4
  • 118
    • 84880986819 scopus 로고    scopus 로고
    • Tumour necrosis factor-α-induced loss of intestinal barrier function requires TNFR1 and TNFR2 signalling in a mouse model of total parenteral nutrition
    • Feng Y, Teitelbaum DH. 2013. Tumour necrosis factor-α-induced loss of intestinal barrier function requires TNFR1 and TNFR2 signalling in a mouse model of total parenteral nutrition. J. Physiol. 591:3709-23
    • (2013) J. Physiol , vol.591 , pp. 3709-3723
    • Feng, Y.1    Teitelbaum, D.H.2
  • 119
    • 79955113861 scopus 로고    scopus 로고
    • Intestinal epithelial cells as producers but not targets of chronicTNFsuffice to cause murine Crohn-like pathology
    • Roulis M, Armaka M, Manoloukos M, Apostolaki M, Kollias G. 2011. Intestinal epithelial cells as producers but not targets of chronicTNFsuffice to cause murine Crohn-like pathology.PNAS108:5396-401
    • (2011) PNAS , vol.108 , pp. 5396-5401
    • Roulis, M.1    Armaka, M.2    Manoloukos, M.3    Apostolaki, M.4    Kollias, G.5
  • 120
    • 0036303112 scopus 로고    scopus 로고
    • Intestinal epithelial cells as a source of inflammatory cytokines and chemokines
    • Stadnyk AW. 2002. Intestinal epithelial cells as a source of inflammatory cytokines and chemokines. Can. J. Gastroenterol. 16:241-46
    • (2002) Can. J. Gastroenterol , vol.16 , pp. 241-246
    • Stadnyk, A.W.1
  • 121
    • 84884390272 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice
    • Xue X, Ramakrishnan S, Anderson E,TaylorM, Zimmermann EM, et al. 2013. Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice. Gastroenterology 145:831-41
    • (2013) Gastroenterology , vol.145 , pp. 831-841
    • Xue, X.1    Ramakrishnan, S.2    Anderson, E.3    Taylor, M.4    Zimmermann, E.M.5
  • 122
    • 84879561482 scopus 로고    scopus 로고
    • A disintegrin andmetalloproteinase 17 regulates TNF and TNFR1 levels in inflammation and liver regeneration in mice
    • McMahan RS, Riehle KJ, FaustoN, Campbell JS. 2013. A disintegrin andmetalloproteinase 17 regulates TNF and TNFR1 levels in inflammation and liver regeneration in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 305:G25-34
    • (2013) Am. J. Physiol. Gastrointest. Liver Physiol , vol.305 , pp. G25-34
    • McMahan, R.S.1    Riehle, K.J.2    Fausto, N.3    Campbell, J.S.4
  • 123
    • 12544257436 scopus 로고    scopus 로고
    • ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx
    • Sanderson MP, Erickson SN, Gough PJ, Garton KJ, Wille PT, et al. 2005. ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx. J. Biol. Chem. 280:1826-37
    • (2005) J. Biol. Chem , vol.280 , pp. 1826-1837
    • Sanderson, M.P.1    Erickson, S.N.2    Gough, P.J.3    Garton, K.J.4    Wille, P.T.5
  • 124
    • 77952634453 scopus 로고    scopus 로고
    • NADPHoxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon
    • CoantN, Ben Mkaddem S, Pedruzzi E, Guichard C,Treton X, et al. 2010.NADPHoxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon. Mol. Cell. Biol. 30:2636-50
    • (2010) Mol. Cell. Biol , vol.30 , pp. 2636-2650
    • Coant, N.1    Ben, M.S.2    Pedruzzi, E.3    Guichard, C.4    Treton, X.5
  • 125
    • 79956306866 scopus 로고    scopus 로고
    • Suppression of hath1 gene expression directly regulated by hes1 viaNotch signaling is associated with goblet cell depletion in ulcerative colitis
    • Zheng X, Tsuchiya K,Okamoto R, IwasakiM, Kano Y, et al. 2011. Suppression of hath1 gene expression directly regulated by hes1 viaNotch signaling is associated with goblet cell depletion in ulcerative colitis. Inflamm. Bowel. Dis. 17:2251-60
    • (2011) Inflamm. Bowel. Dis , vol.17 , pp. 2251-2260
    • Zheng, X.1    Tsuchiya, K.2    Okamoto, R.3    Iwasaki, M.4    Kano, Y.5
  • 126
    • 80051507729 scopus 로고    scopus 로고
    • From intestinal stem cells to inflammatory bowel diseases
    • GersemannM, Stange EF, Wehkamp J. 2011. From intestinal stem cells to inflammatory bowel diseases. World J. Gastroenterol. 17:3198-203
    • (2011) World J. Gastroenterol , vol.17 , pp. 3198-3203
    • Gersemann, M.1    Stange, E.F.2    Wehkamp, J.3
  • 128
    • 84862591151 scopus 로고    scopus 로고
    • Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization
    • Xu H, Zhu J, Smith S, Foldi J, Zhao B, et al. 2012. Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat. Immunol. 13:642-50
    • (2012) Nat. Immunol , vol.13 , pp. 642-650
    • Xu, H.1    Zhu, J.2    Smith, S.3    Foldi, J.4    Zhao, B.5
  • 129
    • 84976232357 scopus 로고    scopus 로고
    • Myeloid-specific deletion of ADAM10 dramatically increases susceptibility to DSS-induced colitis
    • Tsai YH, Rakshit R, Chung J, Maillard I, Dempsey PJ. 2013. Myeloid-specific deletion of ADAM10 dramatically increases susceptibility to DSS-induced colitis. Gastroenterology 144:S308
    • (2013) Gastroenterology , vol.144 , pp. S308
    • Tsai, Y.H.1    Rakshit, R.2    Chung, J.3    Maillard, I.4    Dempsey, P.J.5
  • 131
    • 56749133149 scopus 로고    scopus 로고
    • The ADAMs: Signalling scissors in the tumour microenvironment
    • Murphy G. 2008. The ADAMs: signalling scissors in the tumour microenvironment. Nat. Rev. Cancer 8:929-41
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 929-941
    • Murphy, G.1
  • 132
    • 84873637033 scopus 로고    scopus 로고
    • Notch in the intestine: Regulation of homeostasis and pathogenesis
    • Noah TK, Shroyer NF. 2013. Notch in the intestine: regulation of homeostasis and pathogenesis. Annu. Rev. Physiol. 75:263-88
    • (2013) Annu. Rev. Physiol , vol.75 , pp. 263-288
    • Noah, T.K.1    Shroyer, N.F.2
  • 133
    • 20544460148 scopus 로고    scopus 로고
    • Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
    • van Es JH, van GijnME, Riccio O, van den Born M, Vooijs M, et al. 2005. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435:959-63
    • (2005) Nature , vol.435 , pp. 959-963
    • Van Es, J.H.1    Van Gijn, M.E.2    Riccio, O.3    Van Den Born, M.4    Vooijs, M.5
  • 134
    • 78651098156 scopus 로고    scopus 로고
    • Complex interplay between β-Catenin signalling and Notch effectors in intestinal tumorigenesis
    • Peignon G, Durand A, Cacheux W, Ayrault O, Terris B, et al. 2011. Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis. Gut 60:166-76
    • (2011) Gut , vol.60 , pp. 166-176
    • Peignon, G.1    Durand, A.2    Cacheux, W.3    Ayrault, O.4    Terris, B.5
  • 135
    • 84976235518 scopus 로고    scopus 로고
    • Cell-autonomous ADAM10 signaling is required for adenoma initiation after APC mutation
    • Tsai YH, Feng Y, Rakshit R, Fearon ER, Dempsey PJ. 2013. Cell-autonomous ADAM10 signaling is required for adenoma initiation after APC mutation. Gastroenterology 144:S51-52
    • (2013) Gastroenterology , vol.144 , pp. S51-52
    • Tsai, Y.H.1    Feng, Y.2    Rakshit, R.3    Fearon, E.R.4    Dempsey, P.J.5
  • 136
    • 84922379425 scopus 로고    scopus 로고
    • ConcomitantNotch activation and p53 deletion trigger epithelial-to-mesenchymal transition andmetastasis inmouse gut
    • Chanrion M, Kuperstein I, BarriereC, ElMarjou F,Cohen D, et al. 2014. ConcomitantNotch activation and p53 deletion trigger epithelial-to-mesenchymal transition andmetastasis inmouse gut. Nat.Commun. 5:5005
    • (2014) Nat. Commun , vol.5 , pp. 5005
    • Chanrion, M.1    Kuperstein, I.2    Barriere, C.3    ElMarjou, F.4    Cohen, D.5
  • 137
    • 84922369531 scopus 로고    scopus 로고
    • Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO
    • Sonoshita M, Itatani Y, Kakizaki F, Sakimura K, Terashima T, et al. 2015. Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO. Cancer Discov. 5:198-211
    • (2015) Cancer Discov , vol.5 , pp. 198-211
    • Sonoshita, M.1    Itatani, Y.2    Kakizaki, F.3    Sakimura, K.4    Terashima, T.5
  • 138
    • 84873728505 scopus 로고    scopus 로고
    • Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1
    • Lu J, Ye X, Fan F, Xia L, Bhattacharya R, et al. 2013. Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell 23:171-85
    • (2013) Cancer Cell , vol.23 , pp. 171-185
    • Lu, J.1    Ye, X.2    Fan, F.3    Xia, L.4    Bhattacharya, R.5
  • 139
    • 62649146531 scopus 로고    scopus 로고
    • ERBBs in the gastrointestinal tract: Recent progress and new perspectives
    • FiskeWH, Threadgill D, Coffey RJ. 2009. ERBBs in the gastrointestinal tract: recent progress and new perspectives. Exp. Cell Res. 315:583-601
    • (2009) Exp. Cell Res , vol.315 , pp. 583-601
    • Fiske, W.H.1    Threadgill, D.2    Coffey, R.J.3
  • 140
    • 0032991651 scopus 로고    scopus 로고
    • Metalloproteasemediated ligand release regulates autocrine signaling through the epidermal growth factor receptor
    • Dong J, Opresko LK, Dempsey PJ, Lauffenburger DA, Coffey RJ, Wiley HS. 1999. Metalloproteasemediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. PNAS 96:6235-40
    • (1999) PNAS , vol.96 , pp. 6235-6240
    • Dong, J.1    Opresko, L.K.2    Dempsey, P.J.3    Lauffenburger, D.A.4    Coffey, R.J.5    Wiley, H.S.6
  • 142
    • 84903441759 scopus 로고    scopus 로고
    • ADAM17-dependent c-MET-STAT3 signalingmediates resistance toMEKinhibitors in KRAS mutant colorectal cancer
    • Van Schaeybroeck S, Kalimutho M, Dunne PD, Carson R, Allen W, et al. 2014. ADAM17-dependent c-MET-STAT3 signalingmediates resistance toMEKinhibitors in KRAS mutant colorectal cancer. Cell Rep. 7:1940-55
    • (2014) Cell Rep , vol.7 , pp. 1940-1955
    • Van Schaeybroeck, S.1    Kalimutho, M.2    Dunne, P.D.3    Carson, R.4    Allen, W.5
  • 143
    • 84896495700 scopus 로고    scopus 로고
    • Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development
    • Waldner MJ, Neurath MF. 2014. Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development. Semin. Immunol. 26:75-79
    • (2014) Semin. Immunol , vol.26 , pp. 75-79
    • Waldner, M.J.1    Neurath, M.F.2
  • 144
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
    • Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, et al. 2000. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat. Med. 6:583-88
    • (2000) Nat. Med , vol.6 , pp. 583-588
    • Atreya, R.1    Mudter, J.2    Finotto, S.3    Mullberg, J.4    Jostock, T.5
  • 145
    • 5644252874 scopus 로고    scopus 로고
    • TGF-βsuppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    • Becker C, FantiniMC, SchrammC,LehrHA, Wirtz S, et al. 2004. TGF-βsuppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 21:491-501
    • (2004) Immunity , vol.21 , pp. 491-501
    • Becker, C.1    Fantini, M.C.2    Schramm, C.3    Lehr, H.A.4    Wirtz, S.5
  • 146
    • 77949326158 scopus 로고    scopus 로고
    • Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
    • Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, et al. 2010. Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. J. Immunol. 184:1543-51
    • (2010) J. Immunol , vol.184 , pp. 1543-1551
    • Matsumoto, S.1    Hara, T.2    Mitsuyama, K.3    Yamamoto, M.4    Tsuruta, O.5
  • 147
    • 33747774200 scopus 로고    scopus 로고
    • STAT3activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice
    • MitsuyamaK,Matsumoto S, Rose-John S, SuzukiA,HaraT, et al. 2006.STAT3activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. Gut 55:1263-69
    • (2006) Gut , vol.55 , pp. 1263-1269
    • Mitsuyama, K.1    Matsumoto, S.2    Rose-John, S.3    Suzuki, A.4    Hara, T.5
  • 149
    • 84878760040 scopus 로고    scopus 로고
    • Growing self-organizingmini-guts from a single intestinal stem cell: Mechanism and applications
    • Sato T, CleversH. 2013. Growing self-organizingmini-guts from a single intestinal stem cell: mechanism and applications. Science 340:1190-94
    • (2013) Science , vol.340 , pp. 1190-1194
    • Sato, T.1    Clevers, H.2
  • 150
  • 151
    • 84255160975 scopus 로고    scopus 로고
    • Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis
    • Yoda M, Kimura T, Tohmonda T, Uchikawa S, Koba T, et al. 2011. Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis. Blood 118:6939-42
    • (2011) Blood , vol.118 , pp. 6939-6942
    • Yoda, M.1    Kimura, T.2    Tohmonda, T.3    Uchikawa, S.4    Koba, T.5
  • 153
    • 77949528417 scopus 로고    scopus 로고
    • ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo
    • Gibb DR, El Shikh M, Kang DJ, Rowe WJ, El Sayed R, et al. 2010. ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. J. Exp. Med. 207:623-35
    • (2010) J. Exp. Med , vol.207 , pp. 623-635
    • Gibb, D.R.1    El Shikh, M.2    Kang, D.J.3    Rowe, W.J.4    El Sayed, R.5
  • 154
    • 81455154973 scopus 로고    scopus 로고
    • A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture
    • Chaimowitz NS, Martin RK, Cichy J, Gibb DR, Patil P, et al. 2011. A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture. J. Immunol. 187:5114-22
    • (2011) J. Immunol , vol.187 , pp. 5114-5122
    • Chaimowitz, N.S.1    Martin, R.K.2    Cichy, J.3    Gibb, D.R.4    Patil, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.