Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism

Journal of Clinical Investigation

Volumn 121, Issue 6, 2011, Pages 2242-2253

  Yan, Fang ^a   Cao, Hanwei ^a   Cover, Timothy L ^b,c   Washington, M Kay ^b   Shi, Yan ^d   Liu, LinShu ^e   Chaturvedi, Rupesh ^b,c   Peek Jr , Richard M ^b   Wilson, Keith T ^b,c   Polk, D Brent ^a,b,f  

^a MONROE CARELL JR CHILDREN S HOSPITAL AT VANDERBILT   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d XIAMEN UNIVERSITY   (China)

^e EASTERN REGIONAL RESEARCH CENTER   (United States)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 1ALPHA; INTERLEUKIN 4; INTERLEUKIN 5; OXAZOLONE; PECTIN; PROBIOTIC AGENT; PROTEIN BAX; PROTEIN KINASE B; PROTEIN P40; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR; ZEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; COLITIS; COLON MUCOSA; COMPETITIVE INHIBITION; CONTROLLED STUDY; DESCENDING COLON; DOWN REGULATION; DRUG DELIVERY SYSTEM; ENZYME ACTIVATION; EX VIVO STUDY; HUMAN; HUMAN CELL; HYDROGEL; IN VITRO STUDY; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; LACTOBACILLUS RHAMNOSUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ADMINISTRATION, RECTAL; ANIMALS; APOPTOSIS; BACTERIAL PROTEINS; COLITIS; DEXTRAN SULFATE; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; EPITHELIAL CELLS; HYDROGELS; INTESTINAL MUCOSA; LACTOBACILLUS RHAMNOSUS; MICE; MICE, INBRED C57BL; MICROSPHERES; OXAZOLONE; PERMEABILITY; PROBIOTICS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TYRPHOSTINS;

EID: 79957907960     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI44031     Document Type: Article

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