Opposing activities of notch and wnt signaling regulate intestinal stem cells and gut homeostasis

Cell Reports

Volumn 11, Issue 1, 2015, Pages 33-42

  Tian, Hua ^a   Biehs, Brian ^b   Chiu, Cecilia ^b   Siebel, Christian W ^b   Wu, Yan ^b   Costa, Mike ^b   De Sauvage, Frederic J ^b   Klein, Ophir D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCKING ANTIBODY; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6 BLOCKING ANTIBODY; NOTCH RECEPTOR; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVITY; CELL DIFFERENTIATION; CELL FUNCTION; CELL HYPERPLASIA; CONTROLLED STUDY; CRYPT HOMEOSTASIS; GENE EXPRESSION; GENE MISEXPRESSION; HOMEOSTASIS; INTESTINAL STEM CELL; INTESTINE CRYPT; MOUSE; NONHUMAN; NOTCH SIGNALING; PANETH CELL; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; SECRETORY CELL; SIGNAL TRANSDUCTION; UPREGULATION; WNT SIGNALING PATHWAY; ANIMAL; CELL LINEAGE; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GENETICS; INTESTINE MUCOSA; METABOLISM; STEM CELL; WNT SIGNALING;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; GENE EXPRESSION REGULATION; HOMEOSTASIS; INTESTINAL MUCOSA; MICE; RECEPTORS, NOTCH; STEM CELLS; WNT SIGNALING PATHWAY;

EID: 84927696737     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.03.007     Document Type: Article

References (27)

1. Andreu P., Colnot S., Godard C., Gad S., Chafey P., Niwa-Kawakita M., Laurent-Puig P., Kahn A., Robine S., Perret C., Romagnolo B. Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine. Development 2005, 132:1443-1451.
2. Barker N., van Es J.H., Kuipers J., Kujala P., van den Born M., Cozijnsen M., Haegebarth A., Korving J., Begthel H., Peters P.J., Clevers H. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007, 449:1003-1007.
3. Blanpain C., Fuchs E. Epidermal stem cells of the skin. Annu. Rev. Cell Dev. Biol. 2006, 22:339-373.
4. Buczacki S.J., Zecchini H.I., Nicholson A.M., Russell R., Vermeulen L., Kemp R., Winton D.J. Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature 2013, 495:65-69.
5. de Lau W., Barker N., Low T.Y., Koo B.K., Li V.S., Teunissen H., Kujala P., Haegebarth A., Peters P.J., van de Wetering M., et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 2011, 476:293-297.
6. Farin H.F., Van Es J.H., Clevers H. Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology 2012, 143:1518-1529.e1517.
7. Fevr T., Robine S., Louvard D., Huelsken J. Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol. Cell. Biol. 2007, 27:7551-7559.
8. Fre S., Huyghe M., Mourikis P., Robine S., Louvard D., Artavanis-Tsakonas S. Notch signals control the fate of immature progenitor cells in the intestine. Nature 2005, 435:964-968.
9. Gregorieff A., Pinto D., Begthel H., Destrée O., Kielman M., Clevers H. Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology 2005, 129:626-638.
10. Ireland H., Houghton C., Howard L., Winton D.J. Cellular inheritance of a Cre-activated reporter gene to determine Paneth cell longevity in the murine small intestine. Dev. Dyn. 2005, 233:1332-1336.
11. Kazanjian A., Noah T., Brown D., Burkart J., Shroyer N.F. Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells. Gastroenterology 2010, 139:918-928. 928.e1-6.
12. Kim T.H., Shivdasani R.A. Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression. J.Biol. Chem. 2011, 286:11427-11433.
13. Kim K.A., Zhao J., Andarmani S., Kakitani M., Oshima T., Binnerts M.E., Abo A., Tomizuka K., Funk W.D. R-Spondin proteins: a novel link to beta-catenin activation. Cell Cycle 2006, 5:23-26.
14. Korinek V., Barker N., Moerer P., van Donselaar E., Huls G., Peters P.J., Clevers H. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 1998, 19:379-383.
15. Nicolas M., Wolfer A., Raj K., Kummer J.A., Mill P., van Noort M., Hui C.C., Clevers H., Dotto G.P., Radtke F. Notch1 functions as a tumor suppressor in mouse skin. Nat. Genet. 2003, 33:416-421.
16. Pinto D., Gregorieff A., Begthel H., Clevers H. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 2003, 17:1709-1713.
17. Ruffner H., Sprunger J., Charlat O., Leighton-Davies J., Grosshans B., Salathe A., Zietzling S., Beck V., Therier M., Isken A., et al. R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5. PLoS ONE 2012, 7:e40976.
18. Sato T., van Es J.H., Snippert H.J., Stange D.E., Vries R.G., van den Born M., Barker N., Shroyer N.F., van de Wetering M., Clevers H. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 2011, 469:415-418.
19. Shi F., Cheng Y.F., Wang X.L., Edge A.S. Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3' enhancer. J.Biol. Chem. 2010, 285:392-400.
20. van Es J.H., Jay P., Gregorieff A., van Gijn M.E., Jonkheer S., Hatzis P., Thiele A., van den Born M., Begthel H., Brabletz T., et al. Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat. Cell Biol. 2005, 7:381-386.
21. van Es J.H., van Gijn M.E., Riccio O., van den Born M., Vooijs M., Begthel H., Cozijnsen M., Robine S., Winton D.J., Radtke F., Clevers H. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005, 435:959-963.
22. van Es J.H., Haegebarth A., Kujala P., Itzkovitz S., Koo B.K., Boj S.F., Korving J., van den Born M., van Oudenaarden A., Robine S., Clevers H. A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. Mol. Cell. Biol. 2012, 32:1918-1927.
23. VanDussen K.L., Samuelson L.C. Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Dev. Biol. 2010, 346:215-223.
24. VanDussen K.L., Carulli A.J., Keeley T.M., Patel S.R., Puthoff B.J., Magness S.T., Tran I.T., Maillard I., Siebel C., Kolterud Å., et al. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development 2012, 139:488-497.
25. Wu Y., Cain-Hom C., Choy L., Hagenbeek T.J., de Leon G.P., Chen Y., Finkle D., Venook R., Wu X., Ridgway J., et al. Therapeutic antibody targeting of individual Notch receptors. Nature 2010, 464:1052-1057.
26. Yang Q., Bermingham N.A., Finegold M.J., Zoghbi H.Y. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 2001, 294:2155-2158.
27. Zhong Z., Baker J.J., Zylstra-Diegel C.R., Williams B.O. Lrp5 and Lrp6 play compensatory roles in mouse intestinal development. J.Cell. Biochem. 2012, 113:31-38.