메뉴 건너뛰기




Volumn 5, Issue , 2014, Pages

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH1 RECEPTOR; PROTEIN P53; GREEN FLUORESCENT PROTEIN; NOTCH1 PROTEIN, MOUSE; PRIMER DNA;

EID: 84922379425     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6005     Document Type: Article
Times cited : (111)

References (70)
  • 1
    • 33746851956 scopus 로고    scopus 로고
    • Tumor metastasis: Mechanistic insights and clinical challenges
    • Steeg, P. S. Tumor metastasis: mechanistic insights and clinical challenges. Nat. Med. 12, 895-904 (2006).
    • (2006) Nat. Med , vol.12 , pp. 895-904
    • Steeg, P.S.1
  • 2
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan, S. & Weinberg, R. A. Tumor metastasis: molecular insights and evolving paradigms. Cell 147, 275-292 (2011).
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 3
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri, R. & Weinberg, R. A. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 119, 1420-1428 (2009).
    • (2009) J. Clin. Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 4
    • 34249289041 scopus 로고    scopus 로고
    • Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype? Nat
    • Peinado, H., Olmeda, D. & Cano, A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 7, 415-428 (2007).
    • (2007) Rev. Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Snail, C.A.3
  • 5
    • 78651401992 scopus 로고    scopus 로고
    • Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis
    • Casas, E. et al. Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res. 71, 245-254 (2011).
    • (2011) Cancer Res , vol.71 , pp. 245-254
    • Casas, E.1
  • 6
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890 (2009).
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 7
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelialmesenchymal transitions
    • Thiery, J. P. & Sleeman, J. P. Complex networks orchestrate epithelialmesenchymal transitions. Nature reviews. Mol. Cell Biol. 7, 131-142 (2006).
    • (2006) Nature Reviews. Mol. Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 8
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang, J. et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117, 927-939 (2004).
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1
  • 9
    • 84863650416 scopus 로고    scopus 로고
    • EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice
    • Morel, A. P. et al. EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice. PLoS Genet. 8, e1002723 (2012).
    • (2012) PLoS Genet , vol.8 , pp. 1002723
    • Morel, A.P.1
  • 10
    • 80052712201 scopus 로고    scopus 로고
    • The ins and outs of the epithelial to mesenchymal transition in health and disease
    • Nieto, M. A. The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu. Rev. Cell Dev. Biol. 27, 347-376 (2011).
    • (2011) Annu. Rev. Cell Dev. Biol , vol.27 , pp. 347-376
    • Nieto, M.A.1
  • 11
    • 84883192492 scopus 로고    scopus 로고
    • Presence of Twist1-positive neoplastic cells in the stroma of chromosome-unstable colorectal tumors
    • Celesti, G. et al. Presence of Twist1-positive neoplastic cells in the stroma of chromosome-unstable colorectal tumors. Gastroenterology 145, 647-657, 615 (2013).
    • (2013) Gastroenterology , vol.145 , Issue.615 , pp. 647-657
    • Celesti, G.1
  • 12
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai, J. H., Donaher, J. L., Murphy, D. A., Chau, S. & Yang, J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22, 725-736 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 13
    • 33748101222 scopus 로고    scopus 로고
    • Towards a pan-European consensus on the treatment of patients with colorectal liver metastases
    • Van Cutsem, E. et al. Towards a pan-European consensus on the treatment of patients with colorectal liver metastases. Eur. J. Cancer 42, 2212-2221 (2006).
    • (2006) Eur. J. Cancer , vol.42 , pp. 2212-2221
    • Van Cutsem, E.1
  • 14
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • Rhim, A. D. et al. EMT and dissemination precede pancreatic tumor formation. Cell 148, 349-361 (2012).
    • (2012) Cell , vol.148 , pp. 349-361
    • Rhim, A.D.1
  • 15
    • 76549117990 scopus 로고    scopus 로고
    • Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment
    • Hung, K. E. et al. Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment. Proc. Natl Acad. Sci. USA 107, 1565-1570 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 1565-1570
    • Hung, K.E.1
  • 16
    • 65249153611 scopus 로고    scopus 로고
    • TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway
    • Trobridge, P. et al. TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. Gastroenterology 136, 1680-1688, 1687 (2009).
    • (2009) Gastroenterology , vol.136 , Issue.1687 , pp. 1680-1688
    • Trobridge, P.1
  • 17
    • 84898596713 scopus 로고    scopus 로고
    • PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine
    • Davies, E. J., Marsh Durban, V., Meniel, V., Williams, G. T. & Clarke, A. R. PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine. J. Pathol. 233, 27-38 (2013).
    • (2013) J. Pathol , vol.233 , pp. 27-38
    • Davies, E.J.1    Marsh Durban, V.2    Meniel, V.3    Williams, G.T.4    Clarke, A.R.5
  • 18
    • 80052285316 scopus 로고    scopus 로고
    • Zeb1 is required for TrkB-induced epithelialmesenchymal transition, anoikis resistance and metastasis
    • Smit, M. A. & Peeper, D. S. Zeb1 is required for TrkB-induced epithelialmesenchymal transition, anoikis resistance and metastasis. Oncogene 30, 3735-3744 (2011).
    • (2011) Oncogene , vol.30 , pp. 3735-3744
    • Smit, M.A.1    Peeper, D.S.2
  • 19
    • 77954030498 scopus 로고    scopus 로고
    • NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells
    • Maier, H. J. et al. NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Cancer Lett. 295, 214-228 (2010).
    • (2010) Cancer Lett , vol.295 , pp. 214-228
    • Maier, H.J.1
  • 20
    • 84855865135 scopus 로고    scopus 로고
    • An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription
    • Knouf, E. C. et al. An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription. Nucleic Acids Res. 40, 499-510 (2012).
    • (2012) Nucleic Acids Res , vol.40 , pp. 499-510
    • Knouf, E.C.1
  • 21
    • 84859720222 scopus 로고    scopus 로고
    • A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition
    • Moes, M. et al. A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition. PLoS ONE 7, e35440 (2012).
    • (2012) PLoS ONE , vol.7 , pp. 35440
    • Moes, M.1
  • 22
    • 84055184850 scopus 로고    scopus 로고
    • MiR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    • Siemens, H. et al. miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 10, 4256-4271 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 4256-4271
    • Siemens, H.1
  • 23
    • 78349273712 scopus 로고    scopus 로고
    • Slug inhibits proliferation of human prostate cancer cells via downregulation of cyclin D1 expression
    • Liu, J. et al. Slug inhibits proliferation of human prostate cancer cells via downregulation of cyclin D1 expression. Prostate 70, 1768-1777 (2010).
    • (2010) Prostate , vol.70 , pp. 1768-1777
    • Liu, J.1
  • 24
    • 79351468712 scopus 로고    scopus 로고
    • Activation of beta-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters
    • Li, J. & Zhou, B. P. Activation of beta-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters. BMC Cancer 11, 49 (2011).
    • (2011) BMC Cancer , vol.11 , pp. 49
    • Li, J.1    Zhou, B.P.2
  • 25
    • 78651098156 scopus 로고    scopus 로고
    • Complex interplay between beta-catenin signalling and Notch effectors in intestinal tumorigenesis
    • Peignon, G. et al. Complex interplay between beta-catenin signalling and Notch effectors in intestinal tumorigenesis. Gut 60, 166-176 (2011).
    • (2011) Gut , vol.60 , pp. 166-176
    • Peignon, G.1
  • 26
    • 0035734285 scopus 로고    scopus 로고
    • Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
    • Jonkers, J. et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat. Genet. 29, 418-425 (2001).
    • (2001) Nat. Genet , vol.29 , pp. 418-425
    • Jonkers, J.1
  • 27
    • 84880020762 scopus 로고    scopus 로고
    • A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention
    • Rad, R. et al. A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. Cancer Cell 24, 15-29 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 15-29
    • Rad, R.1
  • 28
    • 20544447734 scopus 로고    scopus 로고
    • Notch signals control the fate of immature progenitor cells in the intestine
    • Fre, S. et al. Notch signals control the fate of immature progenitor cells in the intestine. Nature 435, 964-968 (2005).
    • (2005) Nature , vol.435 , pp. 964-968
    • Fre, S.1
  • 29
    • 65549086537 scopus 로고    scopus 로고
    • Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine
    • Fre, S. et al. Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc. Natl Acad. Sci. USA 106, 6309-6314 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 6309-6314
    • Fre, S.1
  • 30
    • 0028567875 scopus 로고
    • A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors
    • Fodde, R. et al. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc. Natl Acad. Sci. USA 91, 8969-8973 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 8969-8973
    • Fodde, R.1
  • 31
    • 67749093259 scopus 로고    scopus 로고
    • Crosstalk of Notch with p53 and p63 in cancer growth control
    • Dotto, G. P. Crosstalk of Notch with p53 and p63 in cancer growth control. Nat. Rev. Cancer 9, 587-595 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 587-595
    • Dotto, G.P.1
  • 32
    • 4043059169 scopus 로고    scopus 로고
    • Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
    • el Marjou, F. et al. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39, 186-193 (2004).
    • (2004) Genesis , vol.39 , pp. 186-193
    • El Marjou, F.1
  • 33
    • 0344736673 scopus 로고    scopus 로고
    • Notch signaling controls multiple steps of pancreatic differentiation
    • Murtaugh, L. C., Stanger, B. Z., Kwan, K. M. & Melton, D. A. Notch signaling controls multiple steps of pancreatic differentiation. Proc. Natl Acad. Sci. USA 100, 14920-14925 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 14920-14925
    • Murtaugh, L.C.1    Stanger, B.Z.2    Kwan, K.M.3    Melton, D.A.4
  • 34
    • 12644253829 scopus 로고    scopus 로고
    • Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas
    • Fazeli, A. et al. Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas. Proc. Natl Acad. Sci. USA 94, 10199-10204 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 10199-10204
    • Fazeli, A.1
  • 35
    • 0034724315 scopus 로고    scopus 로고
    • Tumorigenesis in the multiple intestinal neoplasia mouse: Redundancy of negative regulators and specificity of modifiers
    • Halberg, R. B. et al. Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc. Natl Acad. Sci. USA 97, 3461-3466 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 3461-3466
    • Halberg, R.B.1
  • 36
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159-170 (1996).
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 37
    • 34547101481 scopus 로고    scopus 로고
    • Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer
    • Vignjevic, D. et al. Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res. 67, 6844-6853 (2007).
    • (2007) Cancer Res , vol.67 , pp. 6844-6853
    • Vignjevic, D.1
  • 38
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin, P. J. et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275, 1787-1790 (1997).
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1
  • 39
    • 33749320834 scopus 로고    scopus 로고
    • APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression
    • Janssen, K. P. et al. APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology 131, 1096-1109 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 1096-1109
    • Janssen, K.P.1
  • 41
    • 36549010842 scopus 로고    scopus 로고
    • Jagged1-mediated Notch activation induces epithelial-tomesenchymal transition through Slug-induced repression of E-cadherin
    • Leong, K. G. et al. Jagged1-mediated Notch activation induces epithelial-tomesenchymal transition through Slug-induced repression of E-cadherin. J. Exp. Med. 204, 2935-2948 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 2935-2948
    • Leong, K.G.1
  • 42
    • 79951813950 scopus 로고    scopus 로고
    • The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells
    • Brabletz, S. et al. The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J. 30, 770-782 (2011).
    • (2011) EMBO J , vol.30 , pp. 770-782
    • Brabletz, S.1
  • 43
    • 79951810835 scopus 로고    scopus 로고
    • Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells
    • Vallejo, D. M., Caparros, E. & Dominguez, M. Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. EMBO J. 30, 756-769 (2011).
    • (2011) EMBO J , vol.30 , pp. 756-769
    • Vallejo, D.M.1    Caparros, E.2    Dominguez, M.3
  • 44
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • Wellner, U. et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat. Cell. Biol. 11, 1487-1495 (2009).
    • (2009) Nat. Cell. Biol , vol.11 , pp. 1487-1495
    • Wellner, U.1
  • 45
    • 2442705493 scopus 로고    scopus 로고
    • Snail blocks the cell cycle and confers resistance to cell death
    • Vega, S. et al. Snail blocks the cell cycle and confers resistance to cell death. Genes Dev. 18, 1131-1143 (2004).
    • (2004) Genes Dev , vol.18 , pp. 1131-1143
    • Vega, S.1
  • 46
    • 33748116186 scopus 로고    scopus 로고
    • A transient EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer
    • Spaderna, S. et al. A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology 131, 830-840 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 830-840
    • Spaderna, S.1
  • 47
    • 84863133508 scopus 로고    scopus 로고
    • Axin pathway activity regulates in vivo pY654-beta-catenin accumulation and pulmonary fibrosis
    • Ulsamer, A. et al. Axin pathway activity regulates in vivo pY654-beta-catenin accumulation and pulmonary fibrosis. J. Biol. Chem. 287, 5164-5172 (2012).
    • (2012) J. Biol. Chem , vol.287 , pp. 5164-5172
    • Ulsamer, A.1
  • 48
    • 80053568372 scopus 로고    scopus 로고
    • Notch post-translationally regulates beta-catenin protein in stem and progenitor cells
    • Kwon, C. et al. Notch post-translationally regulates beta-catenin protein in stem and progenitor cells. Nat. Cell. Biol. 13, 1244-1251 (2011).
    • (2011) Nat. Cell. Biol , vol.13 , pp. 1244-1251
    • Kwon, C.1
  • 49
    • 78651446926 scopus 로고    scopus 로고
    • Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling
    • Sonoshita, M. et al. Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling. Cancer Cell 19, 125-137 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 125-137
    • Sonoshita, M.1
  • 50
    • 84877263242 scopus 로고    scopus 로고
    • A microRNA miR-34a-regulated bimodal switch targets notch in colon cancer stem cells
    • Bu, P. et al. A microRNA miR-34a-regulated bimodal switch targets notch in colon cancer stem cells. Cell Stem Cell 12, 602-615 (2013).
    • (2013) Cell Stem Cell , vol.12 , pp. 602-615
    • Bu, P.1
  • 51
    • 67649417877 scopus 로고    scopus 로고
    • Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB
    • Katoh, M. Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB. Int. J. Oncol. 34, 1737-1742 (2009).
    • (2009) Int. J. Oncol , vol.34 , pp. 1737-1742
    • Katoh, M.1
  • 52
    • 84855729906 scopus 로고    scopus 로고
    • A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
    • Kim, N. H. et al. A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J. Cell. Biol. 195, 417-433 (2011).
    • (2011) J. Cell. Biol , vol.195 , pp. 417-433
    • Kim, N.H.1
  • 53
    • 84869021181 scopus 로고    scopus 로고
    • Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation
    • Calon, A. et al. Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation. Cancer Cell 22, 571-584 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 571-584
    • Calon, A.1
  • 54
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis, J. & Pollard, J. W. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124, 263-266 (2006).
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 55
    • 84873728505 scopus 로고    scopus 로고
    • Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1
    • Lu, J. et al. Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell 23, 171-185 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 171-185
    • Lu, J.1
  • 57
    • 78049308800 scopus 로고    scopus 로고
    • Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
    • Prat, A. et al. Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res. 12, R68 (2010).
    • (2010) Breast Cancer Res , vol.12 , pp. 68
    • Prat, A.1
  • 58
    • 70449526719 scopus 로고    scopus 로고
    • Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility
    • Giampieri, S. et al. Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat. Cell. Biol. 11, 1287-1296 (2009).
    • (2009) Nat. Cell. Biol , vol.11 , pp. 1287-1296
    • Giampieri, S.1
  • 59
    • 84863137323 scopus 로고    scopus 로고
    • Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signalregulated kinase 1/2-mediated nuclear factor kappaB activation
    • Zhang, Q. et al. Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signalregulated kinase 1/2-mediated nuclear factor kappaB activation. J. Biol. Chem. 287, 6208-6217 (2012).
    • (2012) J. Biol. Chem , vol.287 , pp. 6208-6217
    • Zhang, Q.1
  • 60
    • 23444439817 scopus 로고    scopus 로고
    • Using process diagrams for the graphical representation of biological networks
    • Kitano, H., Funahashi, A., Matsuoka, Y. & Oda, K. Using process diagrams for the graphical representation of biological networks. Nat. Biotechnol. 23, 961-966 (2005).
    • (2005) Nat. Biotechnol , vol.23 , pp. 961-966
    • Kitano, H.1    Funahashi, A.2    Matsuoka, Y.3    Oda, K.4
  • 61
    • 68449103579 scopus 로고    scopus 로고
    • The Systems Biology Graphical Notation
    • Le Novere, N. et al. The Systems Biology Graphical Notation. Nat. Biotechnol. 27, 735-741 (2009).
    • (2009) Nat. Biotechnol , vol.27 , pp. 735-741
    • Le Novere, N.1
  • 62
    • 0037342537 scopus 로고    scopus 로고
    • The systems biology markup language (SBML): A medium for representation and exchange of biochemical network models
    • Hucka, M. et al. The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19, 524-531 (2003).
    • (2003) Bioinformatics , vol.19 , pp. 524-531
    • Hucka, M.1
  • 63
    • 84885007150 scopus 로고    scopus 로고
    • NaviCell: A web-based environment for navigation, curation and maintenance of large molecular interaction maps
    • Kuperstein, I. et al. NaviCell: a web-based environment for navigation, curation and maintenance of large molecular interaction maps. BMC Syst. Biol. 7, 100 (2013).
    • (2013) BMC Syst. Biol , vol.7 , pp. 100
    • Kuperstein, I.1
  • 64
    • 40749087306 scopus 로고    scopus 로고
    • BiNoM:a Cytoscape plugin for manipulating and analyzing biological networks
    • Zinovyev, A., Viara, E., Calzone, L. & Barillot, E. BiNoM: a Cytoscape plugin for manipulating and analyzing biological networks. Bioinformatics 24, 876-877 (2008).
    • (2008) Bioinformatics , vol.24 , pp. 876-877
    • Zinovyev, A.1    Viara, E.2    Calzone, L.3    Barillot, E.4
  • 65
    • 84863229597 scopus 로고    scopus 로고
    • VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing
    • Koboldt, D. C. et al. VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. Genome Res. 22, 568-576 (2012).
    • (2012) Genome Res , vol.22 , pp. 568-576
    • Koboldt, D.C.1
  • 66
    • 77956534324 scopus 로고    scopus 로고
    • ANNOVAR: Functional annotation of genetic variants from high-throughput sequencing data
    • Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).
    • (2010) Nucleic Acids Res , vol.38 , pp. 164
    • Wang, K.1    Li, M.2    Hakonarson, H.3
  • 67
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Muzny, D. M. et al. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012).
    • (2012) Nature , vol.487 , pp. 330-337
    • Muzny, D.M.1
  • 68
    • 31144459985 scopus 로고    scopus 로고
    • Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    • Bild, A. H. et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439, 353-357 (2006).
    • (2006) Nature , vol.439 , pp. 353-357
    • Bild, A.H.1
  • 69
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 70
    • 0035953394 scopus 로고    scopus 로고
    • DNA microarrays identification of primary and secondary target genes regulated by p53
    • Kannan, K. et al. DNA microarrays identification of primary and secondary target genes regulated by p53. Oncogene 20, 2225-2234 (2001).
    • (2001) Oncogene , vol.20 , pp. 2225-2234
    • Kannan, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.