Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus α-hemolysin - Mediated cellular injury

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 30, 2010, Pages 13473-13478

  Wilke, Georgia A ^a   Wardenburg, Juliane Bubeck ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Cellular receptor; Pore forming cytotoxin

Indexed keywords

ADAM10 ENDOPEPTIDASE; BACTERIAL TOXIN; DISINTEGRIN; STAPHYLOCOCCUS AUREUS ALPHA HEMOLYSIN; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; BACTERIAL PROTEIN; BETA1 INTEGRIN; HEMOLYSIN; MEMBRANE PROTEIN; PROTEIN BINDING; SECRETASE;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME LOCALIZATION; EUKARYOTIC CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; STAPHYLOCOCCUS AUREUS; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; EPITHELIUM CELL; ERYTHROCYTE; FOCAL ADHESION; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOBLOTTING; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; MUTATION; PATHOLOGY; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; RABBIT; RNA INTERFERENCE; TUMOR CELL LINE;

ADAM PROTEINS; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIGENS, CD29; BACTERIAL PROTEINS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITHELIAL CELLS; ERYTHROCYTES; FOCAL ADHESIONS; HEMOLYSIN PROTEINS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOBLOTTING; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; RABBITS; RNA INTERFERENCE; STAPHYLOCOCCUS AUREUS;

EID: 77955783248     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1001815107     Document Type: Article

References (31)

1. Lowy FD (1998) Staphylococcus aureus infections. N Engl J Med 339:520-532.
2. Klevens RM, et al.; Active Bacterial Core surveillance (ABCs) MRSA Investigators (2007) Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298:1763-1771.
3. Bhakdi S, Tranum-Jensen J (1991) Alpha-toxin of Staphylococcus aureus. Microbiol Rev 55:733-751.
4. Bubeck Wardenburg J, Schneewind O (2008) Vaccine protection against Staphylococcus aureus pneumonia. J Exp Med 205:287-294.
5. Menzies BE, Kernodle DS (1996) Passive immunization with antiserum to a nontoxic alpha-toxin mutant from Staphylococcus aureus is protective in a murine model. Infect Immun 64:1839-1841.
6. Kennedy AD, et al. (2010) Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infections in a mouse model. J Infect Dis, in press.
7. Husmann M, et al. (2006) Differential role of p38 mitogen activated protein kinase for cellular recovery from attack by pore-forming S. aureus alpha-toxin or streptolysin O. Biochem Biophys Res Commun 344:1128-1134.
8. Hildebrand A, Pohl M, Bhakdi S (1991) Staphylococcus aureus alpha-toxin. Dual mechanism of binding to target cells. J Biol Chem 266:17195-17200.
9. 125I-alpha-toxin (B) to erythrocytes. J Biol Chem 248:5545-5546.
10. 125I-labeled alpha-toxin to rabbit erythrocytes. Biochemistry 15:2348-2355.
11. Valeva A, et al. (2006) Evidence that clustered phosphocholine head groups serve as sites for binding and assembly of an oligomeric protein pore. J Biol Chem 281: 26014-26021.
12. Menzies BE, Kernodle DS (1994) Site-directed mutagenesis of the alpha-toxin gene of Staphylococcus aureus: Role of histidines in toxin activity in vitro and in a murine model. Infect Immun 62:1843-1847.
13. Vijayvargia R, Suresh CG, Krishnasastry MV (2004) Functional form of Caveolin-1 is necessary for the assembly of alpha-hemolysin. Biochem Biophys Res Commun 324: 1130-1136.
14. Pany S, Vijayvargia R, Krishnasastry MV (2004) Caveolin-1 binding motif of alpha-hemolysin: Its role in stability and pore formation. Biochem Biophys Res Commun 322: 29-36.
15. Reiss K, Saftig P (2009) The "a disintegrin and metalloprotease" (ADAM) family of sheddases: Physiological and cellular functions. Semin Cell Dev Biol 20:126-137.
16. White JM (2003) ADAMs: Modulators of cell-cell and cell-matrix interactions. Curr Opin Cell Biol 15:598-606.
17. Liang X, Ji Y (2007) Involvement of alpha5beta1-integrin and TNF-alpha in Staphylococcus aureus alpha-toxin-induced death of epithelial cells. Cell Microbiol 9: 1809-1821.
18. Streuli CH, Akhtar N (2009) Signal co-operation between integrins and other receptor systems. Biochem J 418:491-506.
19. Cary LA, Guan JL (1999) Focal adhesion kinase in integrin-mediated signaling. Front Biosci 4:D102-D113.
20. Nojima Y, et al. (1995) Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J Biol Chem 270:15398-15402.
21. Vuori K, Hirai H, Aizawa S, Ruoslahti E (1996) Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: A role for Src family kinases. Mol Cell Biol 16:2606-2613.
22. Persson C, Carballeira N, Wolf-Watz H, Fällman M (1997) The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions. EMBO J 16:2307-2318.
23. Kim H, Rhee SH, Pothoulakis C, LaMont JT (2009) Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin. Exp Cell Res 315:3336-3344.
24. Song L, et al. (1996) Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. Science 274:1859-1866.
25. Janes PW, et al. (2005) Adam meets Eph: An ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Cell 123:291-304.
26. Takeda S, Igarashi T, Mori H, Araki S (2006) Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold. EMBO J 25:2388-2396.
27. Brosnahan AJ, Mantz MJ, Squier CA, Peterson ML, Schlievert PM (2009) Cytolysins augment superantigen penetration of stratified mucosa. J Immunol 182:2364-2373.
28. Hartmann D, et al. (2002) The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet 11: 2615-2624.
29. Berger KL, et al. (2009) Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. Proc Natl Acad Sci USA 106:7577-7582.
30. Ragle BE, Bubeck Wardenburg J (2009) Anti-alpha-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia. Infect Immun 77: 2712-2718.
31. Gogarten W, Emala CW, Lindeman KS, Hirshman CA (2001) Oxytocin and lysophosphatidic acid induce stress fiber formation in human myometrial cells via a pathway involving Rhokinase. Biol Reprod 65:401-406.