메뉴 건너뛰기




Volumn 22, Issue 3, 2012, Pages 304-317

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(26)  Ardito, Christine M a   Grüner, Barbara M b   Takeuchi, Kenneth K c   Lubeseder Martellato, Clara b   Teichmann, Nicole b   Mazur, Pawel K d   DelGiorno, Kathleen E a,c   Carpenter, Eileen S a   Halbrook, Christopher J a,c   Hall, Jason C a,c   Pal, Debjani a   Briel, Thomas b   Herner, Alexander b   Trajkovic Arsic, Marija b   Sipos, Bence e   Liou, Geou Yarh c   Storz, Peter c   Murray, Nicole R c   Threadgill, David W f   Sibilia, Maria g   more..


Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BAY 86 9766; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEMCITABINE; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

EID: 84866007085     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccr.2012.07.024     Document Type: Article
Times cited : (425)

References (52)
  • 3
    • 0027996869 scopus 로고
    • Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor
    • Basu T., Warne P.H., Downward J. Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor. Oncogene 1994, 9:3483-3491.
    • (1994) Oncogene , vol.9 , pp. 3483-3491
    • Basu, T.1    Warne, P.H.2    Downward, J.3
  • 4
    • 64049085356 scopus 로고    scopus 로고
    • Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras
    • Carrière C., Young A.L., Gunn J.R., Longnecker D.S., Korc M. Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras. Biochem. Biophys. Res. Commun. 2009, 382:561-565.
    • (2009) Biochem. Biophys. Res. Commun. , vol.382 , pp. 561-565
    • Carrière, C.1    Young, A.L.2    Gunn, J.R.3    Longnecker, D.S.4    Korc, M.5
  • 5
    • 27744583596 scopus 로고    scopus 로고
    • Measuring Ras-family GTP levels in vivo-running hot and cold
    • Castro A.F., Rebhun J.F., Quilliam L.A. Measuring Ras-family GTP levels in vivo-running hot and cold. Methods 2005, 37:190-196.
    • (2005) Methods , vol.37 , pp. 190-196
    • Castro, A.F.1    Rebhun, J.F.2    Quilliam, L.A.3
  • 7
    • 0025161919 scopus 로고
    • Pancreatic acinar cells in culture: expression of acinar and ductal antigens in a growth-related manner
    • De Lisle R.C., Logsdon C.D. Pancreatic acinar cells in culture: expression of acinar and ductal antigens in a growth-related manner. Eur. J. Cell Biol. 1990, 51:64-75.
    • (1990) Eur. J. Cell Biol. , vol.51 , pp. 64-75
    • De Lisle, R.C.1    Logsdon, C.D.2
  • 8
    • 0030755457 scopus 로고    scopus 로고
    • Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras
    • Dlugosz A.A., Hansen L., Cheng C., Alexander N., Denning M.F., Threadgill D.W., Magnuson T., Coffey R.J., Yuspa S.H. Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras. Cancer Res. 1997, 57:3180-3188.
    • (1997) Cancer Res. , vol.57 , pp. 3180-3188
    • Dlugosz, A.A.1    Hansen, L.2    Cheng, C.3    Alexander, N.4    Denning, M.F.5    Threadgill, D.W.6    Magnuson, T.7    Coffey, R.J.8    Yuspa, S.H.9
  • 9
    • 0037389850 scopus 로고    scopus 로고
    • Expression of molecular targets for tyrosine kinase receptor antagonists in malignant endocrine pancreatic tumors
    • Fjällskog M.L., Lejonklou M.H., Oberg K.E., Eriksson B.K., Janson E.T. Expression of molecular targets for tyrosine kinase receptor antagonists in malignant endocrine pancreatic tumors. Clin. Cancer Res. 2003, 9:1469-1473.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1469-1473
    • Fjällskog, M.L.1    Lejonklou, M.H.2    Oberg, K.E.3    Eriksson, B.K.4    Janson, E.T.5
  • 10
    • 0030024411 scopus 로고    scopus 로고
    • Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors
    • Friess H., Berberat P., Schilling M., Kunz J., Korc M., Büchler M.W. Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors. J. Mol. Med. 1996, 74:35-42.
    • (1996) J. Mol. Med. , vol.74 , pp. 35-42
    • Friess, H.1    Berberat, P.2    Schilling, M.3    Kunz, J.4    Korc, M.5    Büchler, M.W.6
  • 11
    • 0027229556 scopus 로고
    • Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
    • Gale N.W., Kaplan S., Lowenstein E.J., Schlessinger J., Bar-Sagi D. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature 1993, 363:88-92.
    • (1993) Nature , vol.363 , pp. 88-92
    • Gale, N.W.1    Kaplan, S.2    Lowenstein, E.J.3    Schlessinger, J.4    Bar-Sagi, D.5
  • 12
    • 0030762433 scopus 로고    scopus 로고
    • A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells
    • Gangarosa L.M., Sizemore N., Graves-Deal R., Oldham S.M., Der C.J., Coffey R.J. A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells. J. Biol. Chem. 1997, 272:18926-18931.
    • (1997) J. Biol. Chem. , vol.272 , pp. 18926-18931
    • Gangarosa, L.M.1    Sizemore, N.2    Graves-Deal, R.3    Oldham, S.M.4    Der, C.J.5    Coffey, R.J.6
  • 16
    • 0034235628 scopus 로고    scopus 로고
    • The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors
    • Hansen L.A., Woodson R.L., Holbus S., Strain K., Lo Y.C., Yuspa S.H. The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors. Cancer Res. 2000, 60:3328-3332.
    • (2000) Cancer Res. , vol.60 , pp. 3328-3332
    • Hansen, L.A.1    Woodson, R.L.2    Holbus, S.3    Strain, K.4    Lo, Y.C.5    Yuspa, S.H.6
  • 20
    • 77951030170 scopus 로고    scopus 로고
    • Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and activator of transcription 3 and epidermal growth factor receptor or Src
    • Jaganathan S., Yue P., Turkson J. Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and activator of transcription 3 and epidermal growth factor receptor or Src. J. Pharmacol. Exp. Ther. 2010, 333:373-381.
    • (2010) J. Pharmacol. Exp. Ther. , vol.333 , pp. 373-381
    • Jaganathan, S.1    Yue, P.2    Turkson, J.3
  • 23
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    • Kawaguchi Y., Cooper B., Gannon M., Ray M., MacDonald R.J., Wright C.V. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat. Genet. 2002, 32:128-134.
    • (2002) Nat. Genet. , vol.32 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3    Ray, M.4    MacDonald, R.J.5    Wright, C.V.6
  • 25
    • 0028102597 scopus 로고
    • Chronic pancreatitis is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor alpha, and phospholipase C gamma
    • Korc M., Friess H., Yamanaka Y., Kobrin M.S., Buchler M., Beger H.G. Chronic pancreatitis is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor alpha, and phospholipase C gamma. Gut 1994, 35:1468-1473.
    • (1994) Gut , vol.35 , pp. 1468-1473
    • Korc, M.1    Friess, H.2    Yamanaka, Y.3    Kobrin, M.S.4    Buchler, M.5    Beger, H.G.6
  • 27
    • 78249289929 scopus 로고    scopus 로고
    • Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
    • Lee K.E., Bar-Sagi D. Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell 2010, 18:448-458.
    • (2010) Cancer Cell , vol.18 , pp. 448-458
    • Lee, K.E.1    Bar-Sagi, D.2
  • 28
    • 65449175676 scopus 로고    scopus 로고
    • Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor
    • Lee T.C., Threadgill D.W. Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor. Genesis 2009, 47:85-92.
    • (2009) Genesis , vol.47 , pp. 85-92
    • Lee, T.C.1    Threadgill, D.W.2
  • 30
    • 0034656212 scopus 로고    scopus 로고
    • Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
    • Marino S., Vooijs M., van Der Gulden H., Jonkers J., Berns A. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 2000, 14:994-1004.
    • (2000) Genes Dev. , vol.14 , pp. 994-1004
    • Marino, S.1    Vooijs, M.2    van Der Gulden, H.3    Jonkers, J.4    Berns, A.5
  • 35
    • 12544255563 scopus 로고    scopus 로고
    • Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis
    • Monick M.M., Cameron K., Staber J., Powers L.S., Yarovinsky T.O., Koland J.G., Hunninghake G.W. Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis. J. Biol. Chem. 2005, 280:2147-2158.
    • (2005) J. Biol. Chem. , vol.280 , pp. 2147-2158
    • Monick, M.M.1    Cameron, K.2    Staber, J.3    Powers, L.S.4    Yarovinsky, T.O.5    Koland, J.G.6    Hunninghake, G.W.7
  • 36
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • National Cancer Institute of Canada Clinical Trials Group
    • Moore M.J., Goldstein D., Hamm J., Figer A., Hecht J.R., Gallinger S., Au H.J., Murawa P., Walde D., Wolff R.A., et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 2007, 25:1960-1966. National Cancer Institute of Canada Clinical Trials Group.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.R.5    Gallinger, S.6    Au, H.J.7    Murawa, P.8    Walde, D.9    Wolff, R.A.10
  • 37
    • 76649105065 scopus 로고    scopus 로고
    • Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
    • Morris J.P., Cano D.A., Sekine S., Wang S.C., Hebrok M. Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J. Clin. Invest. 2010, 120:508-520.
    • (2010) J. Clin. Invest. , vol.120 , pp. 508-520
    • Morris, J.P.1    Cano, D.A.2    Sekine, S.3    Wang, S.C.4    Hebrok, M.5
  • 38
    • 36048973747 scopus 로고    scopus 로고
    • The EGF receptor is required for efficient liver regeneration
    • Natarajan A., Wagner B., Sibilia M. The EGF receptor is required for efficient liver regeneration. Proc. Natl. Acad. Sci. USA 2007, 104:17081-17086.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 17081-17086
    • Natarajan, A.1    Wagner, B.2    Sibilia, M.3
  • 40
    • 33645748963 scopus 로고    scopus 로고
    • Transforming growth factor alpha expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (Iressa) in human pancreatic cancer cell lines
    • Pino M.S., Shrader M., Baker C.H., Cognetti F., Xiong H.Q., Abbruzzese J.L., McConkey D.J. Transforming growth factor alpha expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (Iressa) in human pancreatic cancer cell lines. Cancer Res. 2006, 66:3802-3812.
    • (2006) Cancer Res. , vol.66 , pp. 3802-3812
    • Pino, M.S.1    Shrader, M.2    Baker, C.H.3    Cognetti, F.4    Xiong, H.Q.5    Abbruzzese, J.L.6    McConkey, D.J.7
  • 41
    • 33749489415 scopus 로고    scopus 로고
    • Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma
    • Ringel J., Jesnowski R., Moniaux N., Lüttges J., Ringel J., Choudhury A., Batra S.K., Klöppel G., Löhr M. Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma. Cancer Res. 2006, 66:9045-9053.
    • (2006) Cancer Res. , vol.66 , pp. 9045-9053
    • Ringel, J.1    Jesnowski, R.2    Moniaux, N.3    Lüttges, J.4    Ringel, J.5    Choudhury, A.6    Batra, S.K.7    Klöppel, G.8    Löhr, M.9
  • 43
    • 0025297086 scopus 로고
    • Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
    • Sandgren E.P., Luetteke N.C., Palmiter R.D., Brinster R.L., Lee D.C. Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell 1990, 61:1121-1135.
    • (1990) Cell , vol.61 , pp. 1121-1135
    • Sandgren, E.P.1    Luetteke, N.C.2    Palmiter, R.D.3    Brinster, R.L.4    Lee, D.C.5
  • 46
    • 22144431886 scopus 로고    scopus 로고
    • Autocrine, paracrine and juxtacrine signaling by EGFR ligands
    • Singh A.B., Harris R.C. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cell. Signal. 2005, 17:1183-1193.
    • (2005) Cell. Signal. , vol.17 , pp. 1183-1193
    • Singh, A.B.1    Harris, R.C.2
  • 47
    • 34548205213 scopus 로고    scopus 로고
    • Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN
    • Siveke J.T., Einwächter H., Sipos B., Lubeseder-Martellato C., Klöppel G., Schmid R.M. Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. Cancer Cell 2007, 12:266-279.
    • (2007) Cancer Cell , vol.12 , pp. 266-279
    • Siveke, J.T.1    Einwächter, H.2    Sipos, B.3    Lubeseder-Martellato, C.4    Klöppel, G.5    Schmid, R.M.6
  • 49
    • 79960663856 scopus 로고    scopus 로고
    • Adam17-dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites
    • Tang J., Zarbock A., Gomez I., Wilson C.L., Lefort C.T., Stadtmann A., Bell B., Huang L.C., Ley K., Raines E.W. Adam17-dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites. Blood 2011, 118:786-794.
    • (2011) Blood , vol.118 , pp. 786-794
    • Tang, J.1    Zarbock, A.2    Gomez, I.3    Wilson, C.L.4    Lefort, C.T.5    Stadtmann, A.6    Bell, B.7    Huang, L.C.8    Ley, K.9    Raines, E.W.10
  • 51
    • 77956642350 scopus 로고    scopus 로고
    • Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells
    • Zhao S., Wang Y., Cao L., Ouellette M.M., Freeman J.W. Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells. Int. J. Cancer 2010, 127:2076-2087.
    • (2010) Int. J. Cancer , vol.127 , pp. 2076-2087
    • Zhao, S.1    Wang, Y.2    Cao, L.3    Ouellette, M.M.4    Freeman, J.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.