메뉴 건너뛰기




Volumn 27, Issue 3, 2016, Pages 163-176

Lineage Reprogramming: A Promising Road for Pancreatic β Cell Regeneration

Author keywords

Cell replacement therapy; Cell reprogramming; Diabetes mellitus; Pancreatic cells; Transdifferentiation

Indexed keywords

TRANSCRIPTION FACTOR;

EID: 84958119853     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2016.01.002     Document Type: Review
Times cited : (33)

References (98)
  • 1
    • 33749070784 scopus 로고    scopus 로고
    • International trial of the Edmonton protocol for islet transplantation
    • Shapiro A.M., et al. International trial of the Edmonton protocol for islet transplantation. N. Engl. J. Med. 2006, 355:1318-1330.
    • (2006) N. Engl. J. Med. , vol.355 , pp. 1318-1330
    • Shapiro, A.M.1
  • 2
    • 33750846133 scopus 로고    scopus 로고
    • Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
    • D'Amour K.A., et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 2006, 24:1392-1401.
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1392-1401
    • D'Amour, K.A.1
  • 3
    • 84881527255 scopus 로고    scopus 로고
    • Insulin-producing cells derived from human embryonic stem cells: comparison of definitive endoderm- and nestin-positive progenitor-based differentiation strategies
    • Wei R., et al. Insulin-producing cells derived from human embryonic stem cells: comparison of definitive endoderm- and nestin-positive progenitor-based differentiation strategies. PLoS ONE 2013, 8:e72513.
    • (2013) PLoS ONE , vol.8 , pp. e72513
    • Wei, R.1
  • 4
    • 84910673362 scopus 로고    scopus 로고
    • Generation of functional human pancreatic beta cells in vitro
    • Pagliuca F.W., et al. Generation of functional human pancreatic beta cells in vitro. Cell 2014, 159:428-439.
    • (2014) Cell , vol.159 , pp. 428-439
    • Pagliuca, F.W.1
  • 5
    • 84983134468 scopus 로고    scopus 로고
    • Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
    • Rezania A., et al. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat. Biotechnol. 2014, 32:1121-1133.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 1121-1133
    • Rezania, A.1
  • 6
    • 84929657263 scopus 로고    scopus 로고
    • Switching roles: the functional plasticity of adult tissue stem cells
    • Wabik A., Jones P.H. Switching roles: the functional plasticity of adult tissue stem cells. EMBO J. 2015, 34:1164-1179.
    • (2015) EMBO J. , vol.34 , pp. 1164-1179
    • Wabik, A.1    Jones, P.H.2
  • 7
    • 38749108893 scopus 로고    scopus 로고
    • Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas
    • Xu X., et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 2008, 132:197-207.
    • (2008) Cell , vol.132 , pp. 197-207
    • Xu, X.1
  • 8
    • 84903385468 scopus 로고    scopus 로고
    • Generation of high-yield insulin producing cells from human bone marrow mesenchymal stem cells
    • Jafarian A., et al. Generation of high-yield insulin producing cells from human bone marrow mesenchymal stem cells. Mol. Biol. Rep. 2014, 41:4783-4794.
    • (2014) Mol. Biol. Rep. , vol.41 , pp. 4783-4794
    • Jafarian, A.1
  • 9
    • 84911436793 scopus 로고    scopus 로고
    • Pancreatic stem cells remain unresolved
    • Jiang F.X., Morahan G. Pancreatic stem cells remain unresolved. Stem Cells Dev. 2014, 23:2803-2812.
    • (2014) Stem Cells Dev. , vol.23 , pp. 2803-2812
    • Jiang, F.X.1    Morahan, G.2
  • 10
    • 79952277534 scopus 로고    scopus 로고
    • The quest for tissue stem cells in the pancreas and other organs, and their application in beta-cell replacement
    • Houbracken I., Bouwens L. The quest for tissue stem cells in the pancreas and other organs, and their application in beta-cell replacement. Rev. Diabet. Stud. 2010, 7:112-123.
    • (2010) Rev. Diabet. Stud. , vol.7 , pp. 112-123
    • Houbracken, I.1    Bouwens, L.2
  • 11
    • 84866389264 scopus 로고    scopus 로고
    • Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure
    • Talchai C., et al. Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell 2012, 150:1223-1234.
    • (2012) Cell , vol.150 , pp. 1223-1234
    • Talchai, C.1
  • 12
    • 84900330718 scopus 로고    scopus 로고
    • Pancreatic beta cell dedifferentiation in diabetes and redifferentiation following insulin therapy
    • Wang Z., et al. Pancreatic beta cell dedifferentiation in diabetes and redifferentiation following insulin therapy. Cell Metab. 2014, 19:872-882.
    • (2014) Cell Metab. , vol.19 , pp. 872-882
    • Wang, Z.1
  • 13
    • 33847358768 scopus 로고    scopus 로고
    • Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing beta-cells
    • Kayali A.G., et al. Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing beta-cells. Diabetes 2007, 56:703-708.
    • (2007) Diabetes , vol.56 , pp. 703-708
    • Kayali, A.G.1
  • 14
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 15
    • 84883396879 scopus 로고    scopus 로고
    • Reprogramming adult human dermal fibroblasts to islet-like cells by epigenetic modification coupled to transcription factor modulation
    • Katz L.S., et al. Reprogramming adult human dermal fibroblasts to islet-like cells by epigenetic modification coupled to transcription factor modulation. Stem Cells Dev. 2013, 22:2551-2560.
    • (2013) Stem Cells Dev. , vol.22 , pp. 2551-2560
    • Katz, L.S.1
  • 16
    • 84878432544 scopus 로고    scopus 로고
    • Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells
    • Pennarossa G., et al. Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:8948-8953.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 8948-8953
    • Pennarossa, G.1
  • 17
    • 84893777704 scopus 로고    scopus 로고
    • Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages
    • Li K., et al. Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell 2014, 14:228-236.
    • (2014) Cell Stem Cell , vol.14 , pp. 228-236
    • Li, K.1
  • 18
    • 84877253665 scopus 로고    scopus 로고
    • A small molecule swertisin from Enicostemma littorale differentiates NIH3T3 cells into islet-like clusters and restores normoglycemia upon transplantation in diabetic Balb/c mice
    • Dadheech N., et al. A small molecule swertisin from Enicostemma littorale differentiates NIH3T3 cells into islet-like clusters and restores normoglycemia upon transplantation in diabetic Balb/c mice. Evid. Based Complement. Alternat. Med. 2013, 2013:280392.
    • (2013) Evid. Based Complement. Alternat. Med. , vol.2013 , pp. 280392
    • Dadheech, N.1
  • 19
    • 80054756679 scopus 로고    scopus 로고
    • Ectopic PDX-1 expression directly reprograms human keratinocytes along pancreatic insulin-producing cells fate
    • Mauda-Havakuk M., et al. Ectopic PDX-1 expression directly reprograms human keratinocytes along pancreatic insulin-producing cells fate. PLoS ONE 2011, 6:e26298.
    • (2011) PLoS ONE , vol.6 , pp. e26298
    • Mauda-Havakuk, M.1
  • 20
    • 84894590087 scopus 로고    scopus 로고
    • Regulation of miRNA during direct reprogramming of dental pulp cells to insulin-producing cells
    • Nozaki T., Ohura K. Regulation of miRNA during direct reprogramming of dental pulp cells to insulin-producing cells. Biochem. Biophys. Res. Commun. 2014, 444:195-198.
    • (2014) Biochem. Biophys. Res. Commun. , vol.444 , pp. 195-198
    • Nozaki, T.1    Ohura, K.2
  • 21
    • 0035917850 scopus 로고    scopus 로고
    • Gene therapy for streptozotocin-induced diabetic mice by electroporational transfer of naked human insulin precursor DNA into skeletal muscle in vivo
    • Yin D., Tang J.G. Gene therapy for streptozotocin-induced diabetic mice by electroporational transfer of naked human insulin precursor DNA into skeletal muscle in vivo. FEBS Lett. 2001, 495:16-20.
    • (2001) FEBS Lett. , vol.495 , pp. 16-20
    • Yin, D.1    Tang, J.G.2
  • 22
    • 33748289497 scopus 로고    scopus 로고
    • Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle
    • Mas A., et al. Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle. Diabetes 2006, 55:1546-1553.
    • (2006) Diabetes , vol.55 , pp. 1546-1553
    • Mas, A.1
  • 23
    • 84944441860 scopus 로고    scopus 로고
    • Successful generation of human induced pluripotent stem cell lines from blood samples held at room temperature for up to 48 hr
    • Agu C.A., et al. Successful generation of human induced pluripotent stem cell lines from blood samples held at room temperature for up to 48 hr. Stem Cell Rep. 2015, 5:660-671.
    • (2015) Stem Cell Rep. , vol.5 , pp. 660-671
    • Agu, C.A.1
  • 24
    • 84902709238 scopus 로고    scopus 로고
    • Skeletal myogenic differentiation of human urine-derived cells as a potential source for skeletal muscle regeneration
    • Published online June 19, 2014
    • Chen W., et al. Skeletal myogenic differentiation of human urine-derived cells as a potential source for skeletal muscle regeneration. J. Tissue Eng. Regen. Med. 2014, Published online June 19, 2014. 10.1002/term.1914.
    • (2014) J. Tissue Eng. Regen. Med.
    • Chen, W.1
  • 25
    • 57349112286 scopus 로고    scopus 로고
    • Generation and regeneration of cells of the liver and pancreas
    • Zaret K.S., Grompe M. Generation and regeneration of cells of the liver and pancreas. Science 2008, 322:1490-1494.
    • (2008) Science , vol.322 , pp. 1490-1494
    • Zaret, K.S.1    Grompe, M.2
  • 26
    • 34548782660 scopus 로고    scopus 로고
    • Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein beta
    • Meivar-Levy I., et al. Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein beta. Hepatology 2007, 46:898-905.
    • (2007) Hepatology , vol.46 , pp. 898-905
    • Meivar-Levy, I.1
  • 27
    • 84896718466 scopus 로고    scopus 로고
    • Reprogramming of various cell types to a beta-like state by Pdx1, Ngn3 and MafA
    • Akinci E., et al. Reprogramming of various cell types to a beta-like state by Pdx1, Ngn3 and MafA. PLoS ONE 2013, 8:e82424.
    • (2013) PLoS ONE , vol.8 , pp. e82424
    • Akinci, E.1
  • 28
    • 33846924386 scopus 로고    scopus 로고
    • Fibronectin and laminin induce expression of islet cell markers in hepatic oval cells in culture
    • Leite A.R., et al. Fibronectin and laminin induce expression of islet cell markers in hepatic oval cells in culture. Cell Tissue Res. 2007, 327:529-537.
    • (2007) Cell Tissue Res. , vol.327 , pp. 529-537
    • Leite, A.R.1
  • 29
    • 84860305756 scopus 로고    scopus 로고
    • Transdifferentiation of hepatic oval cells into pancreatic islet beta-cells
    • Li Y., et al. Transdifferentiation of hepatic oval cells into pancreatic islet beta-cells. Front. Biosci. (Landmark Ed.) 2012, 17:2391-2395.
    • (2012) Front. Biosci. (Landmark Ed.) , vol.17 , pp. 2391-2395
    • Li, Y.1
  • 30
    • 84873656615 scopus 로고    scopus 로고
    • Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules
    • Liu J., et al. Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules. Sci. Rep. 2013, 3:1185.
    • (2013) Sci. Rep. , vol.3 , pp. 1185
    • Liu, J.1
  • 31
    • 0041856137 scopus 로고    scopus 로고
    • Functional, persistent, and extended liver to pancreas transdifferentiation
    • Ber I., et al. Functional, persistent, and extended liver to pancreas transdifferentiation. J. Biol. Chem. 2003, 278:31950-31957.
    • (2003) J. Biol. Chem. , vol.278 , pp. 31950-31957
    • Ber, I.1
  • 32
    • 84875777960 scopus 로고    scopus 로고
    • Genetically reprogrammed, liver-derived insulin-producing cells are glucose-responsive, but susceptible to autoimmune destruction in settings of murine model of type 1 diabetes
    • Tang D.Q., et al. Genetically reprogrammed, liver-derived insulin-producing cells are glucose-responsive, but susceptible to autoimmune destruction in settings of murine model of type 1 diabetes. Am. J. Transl. Res. 2013, 5:184-199.
    • (2013) Am. J. Transl. Res. , vol.5 , pp. 184-199
    • Tang, D.Q.1
  • 33
    • 0038413922 scopus 로고    scopus 로고
    • NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
    • Kojima H., et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat. Med. 2003, 9:596-603.
    • (2003) Nat. Med. , vol.9 , pp. 596-603
    • Kojima, H.1
  • 34
    • 20344394437 scopus 로고    scopus 로고
    • Cell-replacement therapy for diabetes: generating functional insulin-producing tissue from adult human liver cells
    • Sapir T., et al. Cell-replacement therapy for diabetes: generating functional insulin-producing tissue from adult human liver cells. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:7964-7969.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 7964-7969
    • Sapir, T.1
  • 35
    • 59749087109 scopus 로고    scopus 로고
    • Reprogramming of liver to pancreas
    • Thowfeequ S., et al. Reprogramming of liver to pancreas. Methods Mol. Biol. 2009, 482:407-418.
    • (2009) Methods Mol. Biol. , vol.482 , pp. 407-418
    • Thowfeequ, S.1
  • 36
    • 70450235041 scopus 로고    scopus 로고
    • Exendin-4 promotes liver cell proliferation and enhances the PDX-1-induced liver to pancreas transdifferentiation process
    • Aviv V., et al. Exendin-4 promotes liver cell proliferation and enhances the PDX-1-induced liver to pancreas transdifferentiation process. J. Biol. Chem. 2009, 284:33509-33520.
    • (2009) J. Biol. Chem. , vol.284 , pp. 33509-33520
    • Aviv, V.1
  • 37
    • 84890860572 scopus 로고    scopus 로고
    • A small-molecule inducer of PDX1 expression identified by high-throughput screening
    • Yuan Y., et al. A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chem. Biol. 2013, 20:1513-1522.
    • (2013) Chem. Biol. , vol.20 , pp. 1513-1522
    • Yuan, Y.1
  • 38
    • 0141534119 scopus 로고    scopus 로고
    • Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis
    • Miyatsuka T., et al. Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem. Biophys. Res. Commun. 2003, 310:1017-1025.
    • (2003) Biochem. Biophys. Res. Commun. , vol.310 , pp. 1017-1025
    • Miyatsuka, T.1
  • 39
    • 61749094740 scopus 로고    scopus 로고
    • Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes
    • Yechoor V., et al. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev. Cell 2009, 16:358-373.
    • (2009) Dev. Cell , vol.16 , pp. 358-373
    • Yechoor, V.1
  • 40
    • 33846964532 scopus 로고    scopus 로고
    • Beta cells occur naturally in extrahepatic bile ducts of mice
    • Dutton J.R., et al. Beta cells occur naturally in extrahepatic bile ducts of mice. J. Cell Sci. 2007, 120:239-245.
    • (2007) J. Cell Sci. , vol.120 , pp. 239-245
    • Dutton, J.R.1
  • 41
    • 67651062586 scopus 로고    scopus 로고
    • Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells
    • Nagaya M., et al. Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells. J. Endocrinol. 2009, 201:37-47.
    • (2009) J. Endocrinol. , vol.201 , pp. 37-47
    • Nagaya, M.1
  • 42
    • 84866550121 scopus 로고    scopus 로고
    • + cells in the liver to insulin-secreting ducts
    • + cells in the liver to insulin-secreting ducts. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:15336-15341.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 15336-15341
    • Banga, A.1
  • 43
    • 84891735789 scopus 로고    scopus 로고
    • Stable insulin-secreting ducts formed by reprogramming of cells in the liver using a three-gene cocktail and a PPAR agonist
    • Banga A., et al. Stable insulin-secreting ducts formed by reprogramming of cells in the liver using a three-gene cocktail and a PPAR agonist. Gene Ther. 2014, 21:19-27.
    • (2014) Gene Ther. , vol.21 , pp. 19-27
    • Banga, A.1
  • 44
    • 84875820870 scopus 로고    scopus 로고
    • Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming
    • Hickey R.D., et al. Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Res. 2013, 11:503-515.
    • (2013) Stem Cell Res. , vol.11 , pp. 503-515
    • Hickey, R.D.1
  • 45
    • 0035029838 scopus 로고    scopus 로고
    • Regulation of the pancreatic pro-endocrine gene neurogenin3
    • Lee J.C., et al. Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes 2001, 50:928-936.
    • (2001) Diabetes , vol.50 , pp. 928-936
    • Lee, J.C.1
  • 46
    • 0346727348 scopus 로고    scopus 로고
    • Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
    • Sumazaki R., et al. Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat. Genet. 2004, 36:83-87.
    • (2004) Nat. Genet. , vol.36 , pp. 83-87
    • Sumazaki, R.1
  • 47
    • 74549196559 scopus 로고    scopus 로고
    • Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness
    • Coad R.A., et al. Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness. Biochem. Cell Biol. 2009, 87:975-987.
    • (2009) Biochem. Cell Biol. , vol.87 , pp. 975-987
    • Coad, R.A.1
  • 48
    • 18844429273 scopus 로고    scopus 로고
    • Release of transgenic human insulin from gastric G cells: a novel approach for the amelioration of diabetes
    • Lu Y.C., et al. Release of transgenic human insulin from gastric G cells: a novel approach for the amelioration of diabetes. Endocrinology 2005, 146:2610-2619.
    • (2005) Endocrinology , vol.146 , pp. 2610-2619
    • Lu, Y.C.1
  • 49
    • 0034623757 scopus 로고    scopus 로고
    • Glucose-dependent insulin release from genetically engineered K cells
    • Cheung A.T., et al. Glucose-dependent insulin release from genetically engineered K cells. Science 2000, 290:1959-1962.
    • (2000) Science , vol.290 , pp. 1959-1962
    • Cheung, A.T.1
  • 50
    • 84866272024 scopus 로고    scopus 로고
    • Evaluation of insulin expression and secretion in genetically engineered gut K and L-cells
    • Ahmad Z., et al. Evaluation of insulin expression and secretion in genetically engineered gut K and L-cells. BMC Biotechnol. 2012, 12:64.
    • (2012) BMC Biotechnol. , vol.12 , pp. 64
    • Ahmad, Z.1
  • 51
    • 80155201439 scopus 로고    scopus 로고
    • Engineering an L-cell line that expresses insulin under the control of the glucagon-like peptide-1 promoter for diabetes treatment
    • Rasouli M., et al. Engineering an L-cell line that expresses insulin under the control of the glucagon-like peptide-1 promoter for diabetes treatment. BMC Biotechnol. 2011, 11:99.
    • (2011) BMC Biotechnol. , vol.11 , pp. 99
    • Rasouli, M.1
  • 52
    • 84888082418 scopus 로고    scopus 로고
    • Insulin secreted from genetically engineered intestinal cells reduces blood glucose levels in diabetic mice
    • Rasouli M., et al. Insulin secreted from genetically engineered intestinal cells reduces blood glucose levels in diabetic mice. Curr. Gene Ther. 2013, 13:229-239.
    • (2013) Curr. Gene Ther. , vol.13 , pp. 229-239
    • Rasouli, M.1
  • 53
    • 84859350525 scopus 로고    scopus 로고
    • Generation of functional insulin-producing cells in the gut by Foxo1 ablation
    • Talchai C., et al. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat. Genet. 2012, 44:406-412.
    • (2012) Nat. Genet. , vol.44 , pp. 406-412
    • Talchai, C.1
  • 54
    • 84897030116 scopus 로고    scopus 로고
    • De novo formation of insulin-producing "neo-beta cell islets" from intestinal crypts
    • Chen Y.J., et al. De novo formation of insulin-producing "neo-beta cell islets" from intestinal crypts. Cell Rep. 2014, 6:1046-1058.
    • (2014) Cell Rep. , vol.6 , pp. 1046-1058
    • Chen, Y.J.1
  • 55
    • 0037628628 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells
    • Suzuki A., et al. Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:5034-5039.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 5034-5039
    • Suzuki, A.1
  • 56
    • 0030681247 scopus 로고    scopus 로고
    • Notochord to endoderm signaling is required for pancreas development
    • Kim S.K., et al. Notochord to endoderm signaling is required for pancreas development. Development 1997, 124:4243-4252.
    • (1997) Development , vol.124 , pp. 4243-4252
    • Kim, S.K.1
  • 57
    • 38049117732 scopus 로고    scopus 로고
    • The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis
    • Wang S., et al. The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:19873-19878.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 19873-19878
    • Wang, S.1
  • 58
    • 7844226615 scopus 로고    scopus 로고
    • Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2) and glucokinase genes: insulin secretion in response to physiological concentrations of glucose
    • Motoyoshi S., et al. Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2) and glucokinase genes: insulin secretion in response to physiological concentrations of glucose. Diabetologia 1998, 41:1492-1501.
    • (1998) Diabetologia , vol.41 , pp. 1492-1501
    • Motoyoshi, S.1
  • 59
    • 0029738626 scopus 로고    scopus 로고
    • Insulin-secreting non-islet cells are resistant to autoimmune destruction
    • Lipes M.A., et al. Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:8595-8600.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 8595-8600
    • Lipes, M.A.1
  • 60
    • 0037191099 scopus 로고    scopus 로고
    • Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3
    • Heremans Y., et al. Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J. Cell Biol. 2002, 159:303-312.
    • (2002) J. Cell Biol. , vol.159 , pp. 303-312
    • Heremans, Y.1
  • 61
    • 84902149899 scopus 로고    scopus 로고
    • Engineered insulin secretion from neuroendocrine cells isolated from human thyroid
    • Thule P.M., et al. Engineered insulin secretion from neuroendocrine cells isolated from human thyroid. World J. Surg. 2014, 38:1251-1261.
    • (2014) World J. Surg. , vol.38 , pp. 1251-1261
    • Thule, P.M.1
  • 62
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y., et al. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004, 429:41-46.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1
  • 63
    • 84876579681 scopus 로고    scopus 로고
    • β-Cells are not generated in pancreatic duct ligation-induced injury in adult mice
    • Rankin M.M., et al. β-Cells are not generated in pancreatic duct ligation-induced injury in adult mice. Diabetes 2013, 62:1634-1645.
    • (2013) Diabetes , vol.62 , pp. 1634-1645
    • Rankin, M.M.1
  • 64
    • 79951539242 scopus 로고    scopus 로고
    • + ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    • + ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 2011, 138:653-665.
    • (2011) Development , vol.138 , pp. 653-665
    • Kopp, J.L.1
  • 65
    • 58149378342 scopus 로고    scopus 로고
    • Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
    • Inada A., et al. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:19915-19919.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 19915-19919
    • Inada, A.1
  • 66
    • 84905815332 scopus 로고    scopus 로고
    • Loss of Fbw7 reprograms adult pancreatic ductal cells into alpha, delta, and beta cells
    • Sancho R., et al. Loss of Fbw7 reprograms adult pancreatic ductal cells into alpha, delta, and beta cells. Cell Stem Cell 2014, 15:139-153.
    • (2014) Cell Stem Cell , vol.15 , pp. 139-153
    • Sancho, R.1
  • 67
    • 84860994977 scopus 로고    scopus 로고
    • Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming
    • Swales N., et al. Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming. PLoS ONE 2012, 7:e37055.
    • (2012) PLoS ONE , vol.7 , pp. e37055
    • Swales, N.1
  • 68
    • 0035084164 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells
    • Hui H., et al. Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. Diabetes 2001, 50:785-796.
    • (2001) Diabetes , vol.50 , pp. 785-796
    • Hui, H.1
  • 69
    • 72949124420 scopus 로고    scopus 로고
    • 5'-AZA induces Ngn3 expression and endocrine differentiation in the PANC-1 human ductal cell line
    • Lefebvre B., et al. 5'-AZA induces Ngn3 expression and endocrine differentiation in the PANC-1 human ductal cell line. Biochem. Biophys. Res. Commun. 2010, 391:305-309.
    • (2010) Biochem. Biophys. Res. Commun. , vol.391 , pp. 305-309
    • Lefebvre, B.1
  • 70
    • 84873111871 scopus 로고    scopus 로고
    • Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration
    • Pan F.C., et al. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development 2013, 140:751-764.
    • (2013) Development , vol.140 , pp. 751-764
    • Pan, F.C.1
  • 71
    • 65249128642 scopus 로고    scopus 로고
    • Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro
    • Baeyens L., et al. Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro. Gastroenterology 2009, 136:1750-1760.
    • (2009) Gastroenterology , vol.136 , pp. 1750-1760
    • Baeyens, L.1
  • 72
    • 79955430577 scopus 로고    scopus 로고
    • Suppression of Ptf1a activity induces acinar-to-endocrine conversion
    • Hesselson D., et al. Suppression of Ptf1a activity induces acinar-to-endocrine conversion. Curr. Biol. 2011, 21:712-717.
    • (2011) Curr. Biol. , vol.21 , pp. 712-717
    • Hesselson, D.1
  • 73
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • Zhou Q., et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008, 455:627-632.
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1
  • 74
    • 84863410743 scopus 로고    scopus 로고
    • Functional role of an islet transcription factor, INSM1/IA-1, on pancreatic acinar cell trans-differentiation
    • Zhang T., et al. Functional role of an islet transcription factor, INSM1/IA-1, on pancreatic acinar cell trans-differentiation. J. Cell Physiol. 2012, 227:2470-2479.
    • (2012) J. Cell Physiol. , vol.227 , pp. 2470-2479
    • Zhang, T.1
  • 75
    • 84891668969 scopus 로고    scopus 로고
    • Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing beta-like cells
    • Lima M.J., et al. Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing beta-like cells. Diabetes 2013, 62:2821-2833.
    • (2013) Diabetes , vol.62 , pp. 2821-2833
    • Lima, M.J.1
  • 76
    • 1542284736 scopus 로고    scopus 로고
    • Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan
    • Rooman I., Bouwens L. Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan. Diabetologia 2004, 47:259-265.
    • (2004) Diabetologia , vol.47 , pp. 259-265
    • Rooman, I.1    Bouwens, L.2
  • 77
    • 12944327377 scopus 로고    scopus 로고
    • In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells
    • Baeyens L., et al. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 2005, 48:49-57.
    • (2005) Diabetologia , vol.48 , pp. 49-57
    • Baeyens, L.1
  • 78
    • 84892173922 scopus 로고    scopus 로고
    • Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice
    • Baeyens L., et al. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat. Biotechnol. 2014, 32:76-83.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 76-83
    • Baeyens, L.1
  • 79
    • 84874626174 scopus 로고    scopus 로고
    • Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming
    • Bramswig N.C., et al. Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming. J. Clin. Invest. 2013, 123:1275-1284.
    • (2013) J. Clin. Invest. , vol.123 , pp. 1275-1284
    • Bramswig, N.C.1
  • 80
    • 52049105359 scopus 로고    scopus 로고
    • K(ATP)-channels and glucose-regulated glucagon secretion
    • Rorsman P., et al. K(ATP)-channels and glucose-regulated glucagon secretion. Trends Endocrinol. Metab. 2008, 19:277-284.
    • (2008) Trends Endocrinol. Metab. , vol.19 , pp. 277-284
    • Rorsman, P.1
  • 81
    • 77951853210 scopus 로고    scopus 로고
    • Unique arrangement of alpha- and beta-cells in human islets of Langerhans
    • Bosco D., et al. Unique arrangement of alpha- and beta-cells in human islets of Langerhans. Diabetes 2010, 59:1202-1210.
    • (2010) Diabetes , vol.59 , pp. 1202-1210
    • Bosco, D.1
  • 82
    • 84864401274 scopus 로고    scopus 로고
    • α-Cell role in β-cell generation and regeneration
    • Habener J.F., Stanojevic V. α-Cell role in β-cell generation and regeneration. Islets 2012, 4:188-198.
    • (2012) Islets , vol.4 , pp. 188-198
    • Habener, J.F.1    Stanojevic, V.2
  • 83
    • 84860410786 scopus 로고    scopus 로고
    • Context-specific alpha- to-beta-cell reprogramming by forced Pdx1 expression
    • Yang Y.P., et al. Context-specific alpha- to-beta-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011, 25:1680-1685.
    • (2011) Genes Dev. , vol.25 , pp. 1680-1685
    • Yang, Y.P.1
  • 84
    • 68149162957 scopus 로고    scopus 로고
    • The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    • Collombat P., et al. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 2009, 138:449-462.
    • (2009) Cell , vol.138 , pp. 449-462
    • Collombat, P.1
  • 85
    • 84880506680 scopus 로고    scopus 로고
    • Adult duct-lining cells can reprogram into beta-like cells able to counter repeated cycles of toxin-induced diabetes
    • Al-Hasani K., et al. Adult duct-lining cells can reprogram into beta-like cells able to counter repeated cycles of toxin-induced diabetes. Dev. Cell 2013, 26:86-100.
    • (2013) Dev. Cell , vol.26 , pp. 86-100
    • Al-Hasani, K.1
  • 86
    • 84887311096 scopus 로고    scopus 로고
    • The inactivation of Arx in pancreatic alpha-cells triggers their neogenesis and conversion into functional beta-like cells
    • Courtney M., et al. The inactivation of Arx in pancreatic alpha-cells triggers their neogenesis and conversion into functional beta-like cells. PLoS Genet. 2013, 9:e1003934.
    • (2013) PLoS Genet. , vol.9 , pp. e1003934
    • Courtney, M.1
  • 87
    • 77957009475 scopus 로고    scopus 로고
    • Small-molecule inducers of insulin expression in pancreatic alpha-cells
    • Fomina-Yadlin D., et al. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:15099-15104.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 15099-15104
    • Fomina-Yadlin, D.1
  • 88
    • 84855361818 scopus 로고    scopus 로고
    • GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity
    • Fomina-Yadlin D., et al. GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. PLoS ONE 2012, 7:e28808.
    • (2012) PLoS ONE , vol.7 , pp. e28808
    • Fomina-Yadlin, D.1
  • 89
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    • Thorel F., et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 2010, 464:1149-1154.
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1
  • 90
    • 77958099053 scopus 로고    scopus 로고
    • Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells
    • Chung C.H., et al. Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells. Stem Cells 2010, 28:1630-1638.
    • (2010) Stem Cells , vol.28 , pp. 1630-1638
    • Chung, C.H.1
  • 91
    • 84920744392 scopus 로고    scopus 로고
    • Diabetes recovery by age-dependent conversion of pancreatic delta-cells into insulin producers
    • Chera S., et al. Diabetes recovery by age-dependent conversion of pancreatic delta-cells into insulin producers. Nature 2014, 514:503-507.
    • (2014) Nature , vol.514 , pp. 503-507
    • Chera, S.1
  • 92
    • 84856394012 scopus 로고    scopus 로고
    • Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture
    • Negi S., et al. Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture. PLoS ONE 2012, 7:e30415.
    • (2012) PLoS ONE , vol.7 , pp. e30415
    • Negi, S.1
  • 93
    • 80053608936 scopus 로고    scopus 로고
    • Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro
    • Russ H.A., et al. Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS ONE 2011, 6:e25566.
    • (2011) PLoS ONE , vol.6 , pp. e25566
    • Russ, H.A.1
  • 94
    • 84861216975 scopus 로고    scopus 로고
    • Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway
    • Bar Y., et al. Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway. J. Biol. Chem. 2012, 287:17269-17280.
    • (2012) J. Biol. Chem. , vol.287 , pp. 17269-17280
    • Bar, Y.1
  • 95
    • 80054743186 scopus 로고    scopus 로고
    • Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice
    • Landsman L., et al. Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:17010-17015.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 17010-17015
    • Landsman, L.1
  • 96
    • 84874669151 scopus 로고    scopus 로고
    • Small molecules, big roles - the chemical manipulation of stem cell fate and somatic cell reprogramming
    • Zhang Y., et al. Small molecules, big roles - the chemical manipulation of stem cell fate and somatic cell reprogramming. J. Cell Sci. 2012, 125:5609-5620.
    • (2012) J. Cell Sci. , vol.125 , pp. 5609-5620
    • Zhang, Y.1
  • 97
    • 79953881831 scopus 로고    scopus 로고
    • Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency
    • Anokye-Danso F., et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 2011, 8:376-388.
    • (2011) Cell Stem Cell , vol.8 , pp. 376-388
    • Anokye-Danso, F.1
  • 98
    • 84950238996 scopus 로고    scopus 로고
    • A XEN-like state bridges somatic cells to pluripotency during chemical reprogramming
    • Zhao Y., et al. A XEN-like state bridges somatic cells to pluripotency during chemical reprogramming. Cell 2015, 163:1678-1691.
    • (2015) Cell , vol.163 , pp. 1678-1691
    • Zhao, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.