-
1
-
-
33749070784
-
International trial of the Edmonton protocol for islet transplantation
-
Shapiro A.M., et al. International trial of the Edmonton protocol for islet transplantation. N. Engl. J. Med. 2006, 355:1318-1330.
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 1318-1330
-
-
Shapiro, A.M.1
-
2
-
-
33750846133
-
Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
-
D'Amour K.A., et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 2006, 24:1392-1401.
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 1392-1401
-
-
D'Amour, K.A.1
-
3
-
-
84881527255
-
Insulin-producing cells derived from human embryonic stem cells: comparison of definitive endoderm- and nestin-positive progenitor-based differentiation strategies
-
Wei R., et al. Insulin-producing cells derived from human embryonic stem cells: comparison of definitive endoderm- and nestin-positive progenitor-based differentiation strategies. PLoS ONE 2013, 8:e72513.
-
(2013)
PLoS ONE
, vol.8
, pp. e72513
-
-
Wei, R.1
-
4
-
-
84910673362
-
Generation of functional human pancreatic beta cells in vitro
-
Pagliuca F.W., et al. Generation of functional human pancreatic beta cells in vitro. Cell 2014, 159:428-439.
-
(2014)
Cell
, vol.159
, pp. 428-439
-
-
Pagliuca, F.W.1
-
5
-
-
84983134468
-
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
-
Rezania A., et al. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat. Biotechnol. 2014, 32:1121-1133.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 1121-1133
-
-
Rezania, A.1
-
6
-
-
84929657263
-
Switching roles: the functional plasticity of adult tissue stem cells
-
Wabik A., Jones P.H. Switching roles: the functional plasticity of adult tissue stem cells. EMBO J. 2015, 34:1164-1179.
-
(2015)
EMBO J.
, vol.34
, pp. 1164-1179
-
-
Wabik, A.1
Jones, P.H.2
-
7
-
-
38749108893
-
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas
-
Xu X., et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 2008, 132:197-207.
-
(2008)
Cell
, vol.132
, pp. 197-207
-
-
Xu, X.1
-
8
-
-
84903385468
-
Generation of high-yield insulin producing cells from human bone marrow mesenchymal stem cells
-
Jafarian A., et al. Generation of high-yield insulin producing cells from human bone marrow mesenchymal stem cells. Mol. Biol. Rep. 2014, 41:4783-4794.
-
(2014)
Mol. Biol. Rep.
, vol.41
, pp. 4783-4794
-
-
Jafarian, A.1
-
9
-
-
84911436793
-
Pancreatic stem cells remain unresolved
-
Jiang F.X., Morahan G. Pancreatic stem cells remain unresolved. Stem Cells Dev. 2014, 23:2803-2812.
-
(2014)
Stem Cells Dev.
, vol.23
, pp. 2803-2812
-
-
Jiang, F.X.1
Morahan, G.2
-
10
-
-
79952277534
-
The quest for tissue stem cells in the pancreas and other organs, and their application in beta-cell replacement
-
Houbracken I., Bouwens L. The quest for tissue stem cells in the pancreas and other organs, and their application in beta-cell replacement. Rev. Diabet. Stud. 2010, 7:112-123.
-
(2010)
Rev. Diabet. Stud.
, vol.7
, pp. 112-123
-
-
Houbracken, I.1
Bouwens, L.2
-
11
-
-
84866389264
-
Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure
-
Talchai C., et al. Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell 2012, 150:1223-1234.
-
(2012)
Cell
, vol.150
, pp. 1223-1234
-
-
Talchai, C.1
-
12
-
-
84900330718
-
Pancreatic beta cell dedifferentiation in diabetes and redifferentiation following insulin therapy
-
Wang Z., et al. Pancreatic beta cell dedifferentiation in diabetes and redifferentiation following insulin therapy. Cell Metab. 2014, 19:872-882.
-
(2014)
Cell Metab.
, vol.19
, pp. 872-882
-
-
Wang, Z.1
-
13
-
-
33847358768
-
Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing beta-cells
-
Kayali A.G., et al. Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing beta-cells. Diabetes 2007, 56:703-708.
-
(2007)
Diabetes
, vol.56
, pp. 703-708
-
-
Kayali, A.G.1
-
14
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
15
-
-
84883396879
-
Reprogramming adult human dermal fibroblasts to islet-like cells by epigenetic modification coupled to transcription factor modulation
-
Katz L.S., et al. Reprogramming adult human dermal fibroblasts to islet-like cells by epigenetic modification coupled to transcription factor modulation. Stem Cells Dev. 2013, 22:2551-2560.
-
(2013)
Stem Cells Dev.
, vol.22
, pp. 2551-2560
-
-
Katz, L.S.1
-
16
-
-
84878432544
-
Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells
-
Pennarossa G., et al. Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:8948-8953.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 8948-8953
-
-
Pennarossa, G.1
-
17
-
-
84893777704
-
Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages
-
Li K., et al. Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell 2014, 14:228-236.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 228-236
-
-
Li, K.1
-
18
-
-
84877253665
-
A small molecule swertisin from Enicostemma littorale differentiates NIH3T3 cells into islet-like clusters and restores normoglycemia upon transplantation in diabetic Balb/c mice
-
Dadheech N., et al. A small molecule swertisin from Enicostemma littorale differentiates NIH3T3 cells into islet-like clusters and restores normoglycemia upon transplantation in diabetic Balb/c mice. Evid. Based Complement. Alternat. Med. 2013, 2013:280392.
-
(2013)
Evid. Based Complement. Alternat. Med.
, vol.2013
, pp. 280392
-
-
Dadheech, N.1
-
19
-
-
80054756679
-
Ectopic PDX-1 expression directly reprograms human keratinocytes along pancreatic insulin-producing cells fate
-
Mauda-Havakuk M., et al. Ectopic PDX-1 expression directly reprograms human keratinocytes along pancreatic insulin-producing cells fate. PLoS ONE 2011, 6:e26298.
-
(2011)
PLoS ONE
, vol.6
, pp. e26298
-
-
Mauda-Havakuk, M.1
-
20
-
-
84894590087
-
Regulation of miRNA during direct reprogramming of dental pulp cells to insulin-producing cells
-
Nozaki T., Ohura K. Regulation of miRNA during direct reprogramming of dental pulp cells to insulin-producing cells. Biochem. Biophys. Res. Commun. 2014, 444:195-198.
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.444
, pp. 195-198
-
-
Nozaki, T.1
Ohura, K.2
-
21
-
-
0035917850
-
Gene therapy for streptozotocin-induced diabetic mice by electroporational transfer of naked human insulin precursor DNA into skeletal muscle in vivo
-
Yin D., Tang J.G. Gene therapy for streptozotocin-induced diabetic mice by electroporational transfer of naked human insulin precursor DNA into skeletal muscle in vivo. FEBS Lett. 2001, 495:16-20.
-
(2001)
FEBS Lett.
, vol.495
, pp. 16-20
-
-
Yin, D.1
Tang, J.G.2
-
22
-
-
33748289497
-
Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle
-
Mas A., et al. Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle. Diabetes 2006, 55:1546-1553.
-
(2006)
Diabetes
, vol.55
, pp. 1546-1553
-
-
Mas, A.1
-
23
-
-
84944441860
-
Successful generation of human induced pluripotent stem cell lines from blood samples held at room temperature for up to 48 hr
-
Agu C.A., et al. Successful generation of human induced pluripotent stem cell lines from blood samples held at room temperature for up to 48 hr. Stem Cell Rep. 2015, 5:660-671.
-
(2015)
Stem Cell Rep.
, vol.5
, pp. 660-671
-
-
Agu, C.A.1
-
24
-
-
84902709238
-
Skeletal myogenic differentiation of human urine-derived cells as a potential source for skeletal muscle regeneration
-
Published online June 19, 2014
-
Chen W., et al. Skeletal myogenic differentiation of human urine-derived cells as a potential source for skeletal muscle regeneration. J. Tissue Eng. Regen. Med. 2014, Published online June 19, 2014. 10.1002/term.1914.
-
(2014)
J. Tissue Eng. Regen. Med.
-
-
Chen, W.1
-
25
-
-
57349112286
-
Generation and regeneration of cells of the liver and pancreas
-
Zaret K.S., Grompe M. Generation and regeneration of cells of the liver and pancreas. Science 2008, 322:1490-1494.
-
(2008)
Science
, vol.322
, pp. 1490-1494
-
-
Zaret, K.S.1
Grompe, M.2
-
26
-
-
34548782660
-
Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein beta
-
Meivar-Levy I., et al. Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein beta. Hepatology 2007, 46:898-905.
-
(2007)
Hepatology
, vol.46
, pp. 898-905
-
-
Meivar-Levy, I.1
-
27
-
-
84896718466
-
Reprogramming of various cell types to a beta-like state by Pdx1, Ngn3 and MafA
-
Akinci E., et al. Reprogramming of various cell types to a beta-like state by Pdx1, Ngn3 and MafA. PLoS ONE 2013, 8:e82424.
-
(2013)
PLoS ONE
, vol.8
, pp. e82424
-
-
Akinci, E.1
-
28
-
-
33846924386
-
Fibronectin and laminin induce expression of islet cell markers in hepatic oval cells in culture
-
Leite A.R., et al. Fibronectin and laminin induce expression of islet cell markers in hepatic oval cells in culture. Cell Tissue Res. 2007, 327:529-537.
-
(2007)
Cell Tissue Res.
, vol.327
, pp. 529-537
-
-
Leite, A.R.1
-
29
-
-
84860305756
-
Transdifferentiation of hepatic oval cells into pancreatic islet beta-cells
-
Li Y., et al. Transdifferentiation of hepatic oval cells into pancreatic islet beta-cells. Front. Biosci. (Landmark Ed.) 2012, 17:2391-2395.
-
(2012)
Front. Biosci. (Landmark Ed.)
, vol.17
, pp. 2391-2395
-
-
Li, Y.1
-
30
-
-
84873656615
-
Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules
-
Liu J., et al. Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules. Sci. Rep. 2013, 3:1185.
-
(2013)
Sci. Rep.
, vol.3
, pp. 1185
-
-
Liu, J.1
-
31
-
-
0041856137
-
Functional, persistent, and extended liver to pancreas transdifferentiation
-
Ber I., et al. Functional, persistent, and extended liver to pancreas transdifferentiation. J. Biol. Chem. 2003, 278:31950-31957.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 31950-31957
-
-
Ber, I.1
-
32
-
-
84875777960
-
Genetically reprogrammed, liver-derived insulin-producing cells are glucose-responsive, but susceptible to autoimmune destruction in settings of murine model of type 1 diabetes
-
Tang D.Q., et al. Genetically reprogrammed, liver-derived insulin-producing cells are glucose-responsive, but susceptible to autoimmune destruction in settings of murine model of type 1 diabetes. Am. J. Transl. Res. 2013, 5:184-199.
-
(2013)
Am. J. Transl. Res.
, vol.5
, pp. 184-199
-
-
Tang, D.Q.1
-
33
-
-
0038413922
-
NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
-
Kojima H., et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat. Med. 2003, 9:596-603.
-
(2003)
Nat. Med.
, vol.9
, pp. 596-603
-
-
Kojima, H.1
-
34
-
-
20344394437
-
Cell-replacement therapy for diabetes: generating functional insulin-producing tissue from adult human liver cells
-
Sapir T., et al. Cell-replacement therapy for diabetes: generating functional insulin-producing tissue from adult human liver cells. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:7964-7969.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 7964-7969
-
-
Sapir, T.1
-
35
-
-
59749087109
-
Reprogramming of liver to pancreas
-
Thowfeequ S., et al. Reprogramming of liver to pancreas. Methods Mol. Biol. 2009, 482:407-418.
-
(2009)
Methods Mol. Biol.
, vol.482
, pp. 407-418
-
-
Thowfeequ, S.1
-
36
-
-
70450235041
-
Exendin-4 promotes liver cell proliferation and enhances the PDX-1-induced liver to pancreas transdifferentiation process
-
Aviv V., et al. Exendin-4 promotes liver cell proliferation and enhances the PDX-1-induced liver to pancreas transdifferentiation process. J. Biol. Chem. 2009, 284:33509-33520.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 33509-33520
-
-
Aviv, V.1
-
37
-
-
84890860572
-
A small-molecule inducer of PDX1 expression identified by high-throughput screening
-
Yuan Y., et al. A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chem. Biol. 2013, 20:1513-1522.
-
(2013)
Chem. Biol.
, vol.20
, pp. 1513-1522
-
-
Yuan, Y.1
-
38
-
-
0141534119
-
Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis
-
Miyatsuka T., et al. Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem. Biophys. Res. Commun. 2003, 310:1017-1025.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.310
, pp. 1017-1025
-
-
Miyatsuka, T.1
-
39
-
-
61749094740
-
Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes
-
Yechoor V., et al. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev. Cell 2009, 16:358-373.
-
(2009)
Dev. Cell
, vol.16
, pp. 358-373
-
-
Yechoor, V.1
-
40
-
-
33846964532
-
Beta cells occur naturally in extrahepatic bile ducts of mice
-
Dutton J.R., et al. Beta cells occur naturally in extrahepatic bile ducts of mice. J. Cell Sci. 2007, 120:239-245.
-
(2007)
J. Cell Sci.
, vol.120
, pp. 239-245
-
-
Dutton, J.R.1
-
41
-
-
67651062586
-
Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells
-
Nagaya M., et al. Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells. J. Endocrinol. 2009, 201:37-47.
-
(2009)
J. Endocrinol.
, vol.201
, pp. 37-47
-
-
Nagaya, M.1
-
42
-
-
84866550121
-
+ cells in the liver to insulin-secreting ducts
-
+ cells in the liver to insulin-secreting ducts. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:15336-15341.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 15336-15341
-
-
Banga, A.1
-
43
-
-
84891735789
-
Stable insulin-secreting ducts formed by reprogramming of cells in the liver using a three-gene cocktail and a PPAR agonist
-
Banga A., et al. Stable insulin-secreting ducts formed by reprogramming of cells in the liver using a three-gene cocktail and a PPAR agonist. Gene Ther. 2014, 21:19-27.
-
(2014)
Gene Ther.
, vol.21
, pp. 19-27
-
-
Banga, A.1
-
44
-
-
84875820870
-
Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming
-
Hickey R.D., et al. Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Res. 2013, 11:503-515.
-
(2013)
Stem Cell Res.
, vol.11
, pp. 503-515
-
-
Hickey, R.D.1
-
45
-
-
0035029838
-
Regulation of the pancreatic pro-endocrine gene neurogenin3
-
Lee J.C., et al. Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes 2001, 50:928-936.
-
(2001)
Diabetes
, vol.50
, pp. 928-936
-
-
Lee, J.C.1
-
46
-
-
0346727348
-
Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
-
Sumazaki R., et al. Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat. Genet. 2004, 36:83-87.
-
(2004)
Nat. Genet.
, vol.36
, pp. 83-87
-
-
Sumazaki, R.1
-
47
-
-
74549196559
-
Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness
-
Coad R.A., et al. Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness. Biochem. Cell Biol. 2009, 87:975-987.
-
(2009)
Biochem. Cell Biol.
, vol.87
, pp. 975-987
-
-
Coad, R.A.1
-
48
-
-
18844429273
-
Release of transgenic human insulin from gastric G cells: a novel approach for the amelioration of diabetes
-
Lu Y.C., et al. Release of transgenic human insulin from gastric G cells: a novel approach for the amelioration of diabetes. Endocrinology 2005, 146:2610-2619.
-
(2005)
Endocrinology
, vol.146
, pp. 2610-2619
-
-
Lu, Y.C.1
-
49
-
-
0034623757
-
Glucose-dependent insulin release from genetically engineered K cells
-
Cheung A.T., et al. Glucose-dependent insulin release from genetically engineered K cells. Science 2000, 290:1959-1962.
-
(2000)
Science
, vol.290
, pp. 1959-1962
-
-
Cheung, A.T.1
-
50
-
-
84866272024
-
Evaluation of insulin expression and secretion in genetically engineered gut K and L-cells
-
Ahmad Z., et al. Evaluation of insulin expression and secretion in genetically engineered gut K and L-cells. BMC Biotechnol. 2012, 12:64.
-
(2012)
BMC Biotechnol.
, vol.12
, pp. 64
-
-
Ahmad, Z.1
-
51
-
-
80155201439
-
Engineering an L-cell line that expresses insulin under the control of the glucagon-like peptide-1 promoter for diabetes treatment
-
Rasouli M., et al. Engineering an L-cell line that expresses insulin under the control of the glucagon-like peptide-1 promoter for diabetes treatment. BMC Biotechnol. 2011, 11:99.
-
(2011)
BMC Biotechnol.
, vol.11
, pp. 99
-
-
Rasouli, M.1
-
52
-
-
84888082418
-
Insulin secreted from genetically engineered intestinal cells reduces blood glucose levels in diabetic mice
-
Rasouli M., et al. Insulin secreted from genetically engineered intestinal cells reduces blood glucose levels in diabetic mice. Curr. Gene Ther. 2013, 13:229-239.
-
(2013)
Curr. Gene Ther.
, vol.13
, pp. 229-239
-
-
Rasouli, M.1
-
53
-
-
84859350525
-
Generation of functional insulin-producing cells in the gut by Foxo1 ablation
-
Talchai C., et al. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat. Genet. 2012, 44:406-412.
-
(2012)
Nat. Genet.
, vol.44
, pp. 406-412
-
-
Talchai, C.1
-
54
-
-
84897030116
-
De novo formation of insulin-producing "neo-beta cell islets" from intestinal crypts
-
Chen Y.J., et al. De novo formation of insulin-producing "neo-beta cell islets" from intestinal crypts. Cell Rep. 2014, 6:1046-1058.
-
(2014)
Cell Rep.
, vol.6
, pp. 1046-1058
-
-
Chen, Y.J.1
-
55
-
-
0037628628
-
Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells
-
Suzuki A., et al. Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:5034-5039.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 5034-5039
-
-
Suzuki, A.1
-
56
-
-
0030681247
-
Notochord to endoderm signaling is required for pancreas development
-
Kim S.K., et al. Notochord to endoderm signaling is required for pancreas development. Development 1997, 124:4243-4252.
-
(1997)
Development
, vol.124
, pp. 4243-4252
-
-
Kim, S.K.1
-
57
-
-
38049117732
-
The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis
-
Wang S., et al. The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:19873-19878.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 19873-19878
-
-
Wang, S.1
-
58
-
-
7844226615
-
Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2) and glucokinase genes: insulin secretion in response to physiological concentrations of glucose
-
Motoyoshi S., et al. Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2) and glucokinase genes: insulin secretion in response to physiological concentrations of glucose. Diabetologia 1998, 41:1492-1501.
-
(1998)
Diabetologia
, vol.41
, pp. 1492-1501
-
-
Motoyoshi, S.1
-
59
-
-
0029738626
-
Insulin-secreting non-islet cells are resistant to autoimmune destruction
-
Lipes M.A., et al. Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:8595-8600.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 8595-8600
-
-
Lipes, M.A.1
-
60
-
-
0037191099
-
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3
-
Heremans Y., et al. Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J. Cell Biol. 2002, 159:303-312.
-
(2002)
J. Cell Biol.
, vol.159
, pp. 303-312
-
-
Heremans, Y.1
-
61
-
-
84902149899
-
Engineered insulin secretion from neuroendocrine cells isolated from human thyroid
-
Thule P.M., et al. Engineered insulin secretion from neuroendocrine cells isolated from human thyroid. World J. Surg. 2014, 38:1251-1261.
-
(2014)
World J. Surg.
, vol.38
, pp. 1251-1261
-
-
Thule, P.M.1
-
62
-
-
2342510386
-
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
-
Dor Y., et al. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004, 429:41-46.
-
(2004)
Nature
, vol.429
, pp. 41-46
-
-
Dor, Y.1
-
63
-
-
84876579681
-
β-Cells are not generated in pancreatic duct ligation-induced injury in adult mice
-
Rankin M.M., et al. β-Cells are not generated in pancreatic duct ligation-induced injury in adult mice. Diabetes 2013, 62:1634-1645.
-
(2013)
Diabetes
, vol.62
, pp. 1634-1645
-
-
Rankin, M.M.1
-
64
-
-
79951539242
-
+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
-
+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 2011, 138:653-665.
-
(2011)
Development
, vol.138
, pp. 653-665
-
-
Kopp, J.L.1
-
65
-
-
58149378342
-
Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
-
Inada A., et al. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:19915-19919.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 19915-19919
-
-
Inada, A.1
-
66
-
-
84905815332
-
Loss of Fbw7 reprograms adult pancreatic ductal cells into alpha, delta, and beta cells
-
Sancho R., et al. Loss of Fbw7 reprograms adult pancreatic ductal cells into alpha, delta, and beta cells. Cell Stem Cell 2014, 15:139-153.
-
(2014)
Cell Stem Cell
, vol.15
, pp. 139-153
-
-
Sancho, R.1
-
67
-
-
84860994977
-
Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming
-
Swales N., et al. Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming. PLoS ONE 2012, 7:e37055.
-
(2012)
PLoS ONE
, vol.7
, pp. e37055
-
-
Swales, N.1
-
68
-
-
0035084164
-
Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells
-
Hui H., et al. Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. Diabetes 2001, 50:785-796.
-
(2001)
Diabetes
, vol.50
, pp. 785-796
-
-
Hui, H.1
-
69
-
-
72949124420
-
5'-AZA induces Ngn3 expression and endocrine differentiation in the PANC-1 human ductal cell line
-
Lefebvre B., et al. 5'-AZA induces Ngn3 expression and endocrine differentiation in the PANC-1 human ductal cell line. Biochem. Biophys. Res. Commun. 2010, 391:305-309.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.391
, pp. 305-309
-
-
Lefebvre, B.1
-
70
-
-
84873111871
-
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration
-
Pan F.C., et al. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development 2013, 140:751-764.
-
(2013)
Development
, vol.140
, pp. 751-764
-
-
Pan, F.C.1
-
71
-
-
65249128642
-
Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro
-
Baeyens L., et al. Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro. Gastroenterology 2009, 136:1750-1760.
-
(2009)
Gastroenterology
, vol.136
, pp. 1750-1760
-
-
Baeyens, L.1
-
72
-
-
79955430577
-
Suppression of Ptf1a activity induces acinar-to-endocrine conversion
-
Hesselson D., et al. Suppression of Ptf1a activity induces acinar-to-endocrine conversion. Curr. Biol. 2011, 21:712-717.
-
(2011)
Curr. Biol.
, vol.21
, pp. 712-717
-
-
Hesselson, D.1
-
73
-
-
53349178722
-
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
-
Zhou Q., et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008, 455:627-632.
-
(2008)
Nature
, vol.455
, pp. 627-632
-
-
Zhou, Q.1
-
74
-
-
84863410743
-
Functional role of an islet transcription factor, INSM1/IA-1, on pancreatic acinar cell trans-differentiation
-
Zhang T., et al. Functional role of an islet transcription factor, INSM1/IA-1, on pancreatic acinar cell trans-differentiation. J. Cell Physiol. 2012, 227:2470-2479.
-
(2012)
J. Cell Physiol.
, vol.227
, pp. 2470-2479
-
-
Zhang, T.1
-
75
-
-
84891668969
-
Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing beta-like cells
-
Lima M.J., et al. Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing beta-like cells. Diabetes 2013, 62:2821-2833.
-
(2013)
Diabetes
, vol.62
, pp. 2821-2833
-
-
Lima, M.J.1
-
76
-
-
1542284736
-
Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan
-
Rooman I., Bouwens L. Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan. Diabetologia 2004, 47:259-265.
-
(2004)
Diabetologia
, vol.47
, pp. 259-265
-
-
Rooman, I.1
Bouwens, L.2
-
77
-
-
12944327377
-
In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells
-
Baeyens L., et al. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 2005, 48:49-57.
-
(2005)
Diabetologia
, vol.48
, pp. 49-57
-
-
Baeyens, L.1
-
78
-
-
84892173922
-
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice
-
Baeyens L., et al. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat. Biotechnol. 2014, 32:76-83.
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 76-83
-
-
Baeyens, L.1
-
79
-
-
84874626174
-
Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming
-
Bramswig N.C., et al. Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming. J. Clin. Invest. 2013, 123:1275-1284.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 1275-1284
-
-
Bramswig, N.C.1
-
80
-
-
52049105359
-
K(ATP)-channels and glucose-regulated glucagon secretion
-
Rorsman P., et al. K(ATP)-channels and glucose-regulated glucagon secretion. Trends Endocrinol. Metab. 2008, 19:277-284.
-
(2008)
Trends Endocrinol. Metab.
, vol.19
, pp. 277-284
-
-
Rorsman, P.1
-
81
-
-
77951853210
-
Unique arrangement of alpha- and beta-cells in human islets of Langerhans
-
Bosco D., et al. Unique arrangement of alpha- and beta-cells in human islets of Langerhans. Diabetes 2010, 59:1202-1210.
-
(2010)
Diabetes
, vol.59
, pp. 1202-1210
-
-
Bosco, D.1
-
82
-
-
84864401274
-
α-Cell role in β-cell generation and regeneration
-
Habener J.F., Stanojevic V. α-Cell role in β-cell generation and regeneration. Islets 2012, 4:188-198.
-
(2012)
Islets
, vol.4
, pp. 188-198
-
-
Habener, J.F.1
Stanojevic, V.2
-
83
-
-
84860410786
-
Context-specific alpha- to-beta-cell reprogramming by forced Pdx1 expression
-
Yang Y.P., et al. Context-specific alpha- to-beta-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011, 25:1680-1685.
-
(2011)
Genes Dev.
, vol.25
, pp. 1680-1685
-
-
Yang, Y.P.1
-
84
-
-
68149162957
-
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
-
Collombat P., et al. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 2009, 138:449-462.
-
(2009)
Cell
, vol.138
, pp. 449-462
-
-
Collombat, P.1
-
85
-
-
84880506680
-
Adult duct-lining cells can reprogram into beta-like cells able to counter repeated cycles of toxin-induced diabetes
-
Al-Hasani K., et al. Adult duct-lining cells can reprogram into beta-like cells able to counter repeated cycles of toxin-induced diabetes. Dev. Cell 2013, 26:86-100.
-
(2013)
Dev. Cell
, vol.26
, pp. 86-100
-
-
Al-Hasani, K.1
-
86
-
-
84887311096
-
The inactivation of Arx in pancreatic alpha-cells triggers their neogenesis and conversion into functional beta-like cells
-
Courtney M., et al. The inactivation of Arx in pancreatic alpha-cells triggers their neogenesis and conversion into functional beta-like cells. PLoS Genet. 2013, 9:e1003934.
-
(2013)
PLoS Genet.
, vol.9
, pp. e1003934
-
-
Courtney, M.1
-
87
-
-
77957009475
-
Small-molecule inducers of insulin expression in pancreatic alpha-cells
-
Fomina-Yadlin D., et al. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:15099-15104.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 15099-15104
-
-
Fomina-Yadlin, D.1
-
88
-
-
84855361818
-
GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity
-
Fomina-Yadlin D., et al. GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. PLoS ONE 2012, 7:e28808.
-
(2012)
PLoS ONE
, vol.7
, pp. e28808
-
-
Fomina-Yadlin, D.1
-
89
-
-
77951611220
-
Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
-
Thorel F., et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 2010, 464:1149-1154.
-
(2010)
Nature
, vol.464
, pp. 1149-1154
-
-
Thorel, F.1
-
90
-
-
77958099053
-
Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells
-
Chung C.H., et al. Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells. Stem Cells 2010, 28:1630-1638.
-
(2010)
Stem Cells
, vol.28
, pp. 1630-1638
-
-
Chung, C.H.1
-
91
-
-
84920744392
-
Diabetes recovery by age-dependent conversion of pancreatic delta-cells into insulin producers
-
Chera S., et al. Diabetes recovery by age-dependent conversion of pancreatic delta-cells into insulin producers. Nature 2014, 514:503-507.
-
(2014)
Nature
, vol.514
, pp. 503-507
-
-
Chera, S.1
-
92
-
-
84856394012
-
Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture
-
Negi S., et al. Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture. PLoS ONE 2012, 7:e30415.
-
(2012)
PLoS ONE
, vol.7
, pp. e30415
-
-
Negi, S.1
-
93
-
-
80053608936
-
Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro
-
Russ H.A., et al. Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS ONE 2011, 6:e25566.
-
(2011)
PLoS ONE
, vol.6
, pp. e25566
-
-
Russ, H.A.1
-
94
-
-
84861216975
-
Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway
-
Bar Y., et al. Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway. J. Biol. Chem. 2012, 287:17269-17280.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 17269-17280
-
-
Bar, Y.1
-
95
-
-
80054743186
-
Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice
-
Landsman L., et al. Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:17010-17015.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 17010-17015
-
-
Landsman, L.1
-
96
-
-
84874669151
-
Small molecules, big roles - the chemical manipulation of stem cell fate and somatic cell reprogramming
-
Zhang Y., et al. Small molecules, big roles - the chemical manipulation of stem cell fate and somatic cell reprogramming. J. Cell Sci. 2012, 125:5609-5620.
-
(2012)
J. Cell Sci.
, vol.125
, pp. 5609-5620
-
-
Zhang, Y.1
-
97
-
-
79953881831
-
Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency
-
Anokye-Danso F., et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 2011, 8:376-388.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 376-388
-
-
Anokye-Danso, F.1
-
98
-
-
84950238996
-
A XEN-like state bridges somatic cells to pluripotency during chemical reprogramming
-
Zhao Y., et al. A XEN-like state bridges somatic cells to pluripotency during chemical reprogramming. Cell 2015, 163:1678-1691.
-
(2015)
Cell
, vol.163
, pp. 1678-1691
-
-
Zhao, Y.1
|