메뉴 건너뛰기




Volumn 41, Issue 12, 1998, Pages 1492-1501

Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2) and glucokinase genes: Insulin secretion in response to physiological concentrations of glucose

Author keywords

AtT20 Cell; Glucokinase; Glucose metabolism; Glucose transporter type 2 (GLUT2); Human insulin gene; Insulin secretion

Indexed keywords

ANTIBIOTIC G 418; CALCIUM CHANNEL; CORTICOTROPIN RELEASING FACTOR RECEPTOR; DEOXYGLUCOSE; DIAZOXIDE; GLUCOKINASE; NIFEDIPINE; SULFONYLUREA;

EID: 7844226615     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051096     Document Type: Article
Times cited : (24)

References (47)
  • 1
    • 0026572747 scopus 로고
    • Pathogenesis of Type2 (non-insulin dependent) diabetes mellitus: A balanced overview
    • DeFronzo RA (1992) Pathogenesis of Type2 (non-insulin dependent) diabetes mellitus: a balanced overview. Diabetologia 35: 389-397
    • (1992) Diabetologia , vol.35 , pp. 389-397
    • DeFronzo, R.A.1
  • 2
    • 0024287123 scopus 로고
    • The biochemistry of diabetes
    • Taylor R, Agius L (1988) The biochemistry of diabetes. Biochem J 250: 625-640
    • (1988) Biochem J , vol.250 , pp. 625-640
    • Taylor, R.1    Agius, L.2
  • 3
    • 0026468362 scopus 로고
    • What if Minkowski had been ageusic? An alternative angle on diabetes
    • McGarry JD (1992) What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258: 766-770
    • (1992) Science , vol.258 , pp. 766-770
    • McGarry, J.D.1
  • 4
    • 0023692118 scopus 로고
    • Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells
    • Thorens B, Sarkar HK, Kaback HR, Lodish HF (1988) Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells. Cell 55: 281-290
    • (1988) Cell , vol.55 , pp. 281-290
    • Thorens, B.1    Sarkar, H.K.2    Kaback, H.R.3    Lodish, H.F.4
  • 5
    • 0025107006 scopus 로고
    • Glucokinase and glucose transporter expression in liver and islets: Implications for control of glucose homeostasis
    • Newgard CB, Quaade C, Hughes SD, Milburn JL (1990) Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homeostasis. Biochem Soc Trans 18: 851-853
    • (1990) Biochem Soc Trans , vol.18 , pp. 851-853
    • Newgard, C.B.1    Quaade, C.2    Hughes, S.D.3    Milburn, J.L.4
  • 6
    • 0030038249 scopus 로고    scopus 로고
    • Annotated questions and answers about glucose metabolism and insulin secretion of β-cells
    • Matschinsky FM, Sweet IR (1996) Annotated questions and answers about glucose metabolism and insulin secretion of β-cells. Diabetes Rev 4: 130-144
    • (1996) Diabetes Rev , vol.4 , pp. 130-144
    • Matschinsky, F.M.1    Sweet, I.R.2
  • 7
    • 0030894850 scopus 로고    scopus 로고
    • The pancreatic beta-cell as a fuel sensor: An electrophysiologist's viewpoint
    • Rorsman P (1997) The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint. Diabetologia 40: 487-495
    • (1997) Diabetologia , vol.40 , pp. 487-495
    • Rorsman, P.1
  • 8
    • 0030067124 scopus 로고    scopus 로고
    • Bunting lecture 1995: A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
    • Matschinsky FM (1996) Bunting lecture 1995: a lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45: 223-241
    • (1996) Diabetes , vol.45 , pp. 223-241
    • Matschinsky, F.M.1
  • 11
    • 0025242034 scopus 로고
    • Underexpression of β cell high Km glucose transporters in noninsulin-dependent diabetes
    • Johnson JH, Ogawa A, Chen L et al. (1990) Underexpression of β cell high Km glucose transporters in noninsulin-dependent diabetes. Science 250: 546-549
    • (1990) Science , vol.250 , pp. 546-549
    • Johnson, J.H.1    Ogawa, A.2    Chen, L.3
  • 12
    • 0025736821 scopus 로고
    • Diabetic hyperglycemia: Link to impaired glucose transport in pancreatic β cells
    • Unger RH (1991) Diabetic hyperglycemia: link to impaired glucose transport in pancreatic β cells. Science 251: 1200-1205
    • (1991) Science , vol.251 , pp. 1200-1205
    • Unger, R.H.1
  • 13
    • 0026562918 scopus 로고
    • Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
    • Vionnet N, Stoffel M, Takeda J et al. (1992) Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature 356: 721-722
    • (1992) Nature , vol.356 , pp. 721-722
    • Vionnet, N.1    Stoffel, M.2    Takeda, J.3
  • 14
    • 0028826361 scopus 로고
    • Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis
    • Grupe A, Hultgren B, Ryan A, Ma YH, Bauer M, Stewart TA (1995) Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis. Cell 83: 69-78
    • (1995) Cell , vol.83 , pp. 69-78
    • Grupe, A.1    Hultgren, B.2    Ryan, A.3    Ma, Y.H.4    Bauer, M.5    Stewart, T.A.6
  • 15
    • 0029417331 scopus 로고
    • Pancreatic β-cell-specific targeted disruption of glucokinase gene
    • Terauchi Y, Sakura H, Yasuda K et al. (1995) Pancreatic β-cell-specific targeted disruption of glucokinase gene. J Biol Chem 270: 30253-30256
    • (1995) J Biol Chem , vol.270 , pp. 30253-30256
    • Terauchi, Y.1    Sakura, H.2    Yasuda, K.3
  • 16
    • 0028859374 scopus 로고
    • Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression
    • De Vos A, Heimberg H, Quartier et al. (1995) Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest 96: 2489-2495
    • (1995) J Clin Invest , vol.96 , pp. 2489-2495
    • De Vos, A.1    Heimberg, H.2    Quartier3
  • 17
    • 0028784467 scopus 로고
    • Pancreatic islet GLUT2 glucose transporter mRNA and protein expression in humans with and without NIDDM
    • Ferrer J, Benito C, Gomis R (1995) Pancreatic islet GLUT2 glucose transporter mRNA and protein expression in humans with and without NIDDM. Diabetes 44: 1369-1374
    • (1995) Diabetes , vol.44 , pp. 1369-1374
    • Ferrer, J.1    Benito, C.2    Gomis, R.3
  • 18
    • 0021024216 scopus 로고
    • Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation
    • Moore HPH, Walker MD, Lee K Kelly RB (1983) Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation. Cell 35: 531-538
    • (1983) Cell , vol.35 , pp. 531-538
    • Moore, H.P.H.1    Walker, M.D.2    Lee, K.3    Kelly, R.B.4
  • 19
    • 0022129515 scopus 로고
    • Direct identification of prohormone conversion site in insulin-secreting cells
    • Orci L, Ravazzola M, Amherdt M, Madsen O, Vassalli J-D, Perrelet A (1985) Direct identification of prohormone conversion site in insulin-secreting cells. Cell 42: 671-681
    • (1985) Cell , vol.42 , pp. 671-681
    • Orci, L.1    Ravazzola, M.2    Amherdt, M.3    Madsen, O.4    Vassalli, J.-D.5    Perrelet, A.6
  • 20
    • 0026569634 scopus 로고
    • Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells
    • Hughes SD, Johnson JH, Quaade C, Newgard CB (1992) Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells. Proc Natl Acad Sci USA 89: 688-692
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 688-692
    • Hughes, S.D.1    Johnson, J.H.2    Quaade, C.3    Newgard, C.B.4
  • 21
    • 0027337362 scopus 로고
    • Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion
    • Hughes SD, Quaade C, Johnson JH, Ferber S, Newgard CB (1993) Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. J Biol Chem 268: 15205-15212
    • (1993) J Biol Chem , vol.268 , pp. 15205-15212
    • Hughes, S.D.1    Quaade, C.2    Johnson, J.H.3    Ferber, S.4    Newgard, C.B.5
  • 23
    • 0027957282 scopus 로고
    • Human proinsulin conversion in the regulated and the constitutive pathways of transfected AtT20 cells
    • Irminger JC, Vollenweider FM, Neerman-Arbez M, Halban PA (1994) Human proinsulin conversion in the regulated and the constitutive pathways of transfected AtT20 cells. J Biol Chem 269: 1756-1762
    • (1994) J Biol Chem , vol.269 , pp. 1756-1762
    • Irminger, J.C.1    Vollenweider, F.M.2    Neerman-Arbez, M.3    Halban, P.A.4
  • 24
    • 0025773360 scopus 로고
    • Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver and pituitary
    • Liang Y, Jetton TL, Zimmerman EC, Najafi H, Matschinsky FM, Magnuson MA (1991) Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver and pituitary. J Biol Chem 266: 6999-7007
    • (1991) J Biol Chem , vol.266 , pp. 6999-7007
    • Liang, Y.1    Jetton, T.L.2    Zimmerman, E.C.3    Najafi, H.4    Matschinsky, F.M.5    Magnuson, M.A.6
  • 25
    • 0025898418 scopus 로고
    • Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells
    • Hughes SD, Quaade C, Milburn JL, Cassidy L, Newgard CB (1991) Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells. J Biol Chem 266: 4521-4530
    • (1991) J Biol Chem , vol.266 , pp. 4521-4530
    • Hughes, S.D.1    Quaade, C.2    Milburn, J.L.3    Cassidy, L.4    Newgard, C.B.5
  • 26
    • 0025281303 scopus 로고
    • Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms
    • Miyazaki J, Araki K, Yamato E et al. (1990) Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127: 126-132
    • (1990) Endocrinology , vol.127 , pp. 126-132
    • Miyazaki, J.1    Araki, K.2    Yamato, E.3
  • 28
    • 0024362504 scopus 로고
    • Expression vector system based on the chicken β-actin promoter directs efficient production of interleukin-5
    • Miyazaki J, Takaki S, Araki K et al. (1989) Expression vector system based on the chicken β-actin promoter directs efficient production of interleukin-5. Gene 79: 269-277
    • (1989) Gene , vol.79 , pp. 269-277
    • Miyazaki, J.1    Takaki, S.2    Araki, K.3
  • 30
    • 0023447252 scopus 로고
    • Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure
    • Feigner PL, Gadek TR, Holm M et al. (1987) Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 84: 7413-7417
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7413-7417
    • Feigner, P.L.1    Gadek, T.R.2    Holm, M.3
  • 32
    • 0028599515 scopus 로고
    • Utility of 3-O-methyl-N-acetyl-D-glucosamine, an N-acetylglucosamine kinase inhibitor, for accurate assay of glucokinase in pancreatic islets and liver
    • Miwa I, Mita Y, Murata T et al. (1995) Utility of 3-O-methyl-N-acetyl-D-glucosamine, an N-acetylglucosamine kinase inhibitor, for accurate assay of glucokinase in pancreatic islets and liver. Enzyme Protein 48: 135-142
    • (1995) Enzyme Protein , vol.48 , pp. 135-142
    • Miwa, I.1    Mita, Y.2    Murata, T.3
  • 33
  • 34
    • 0026726773 scopus 로고
    • Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3
    • Smeekens SP, Montag AG, Thomas G et al. (1992) Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3. Proc Natl Acad Sci USA 89: 8822-8826
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8822-8826
    • Smeekens, S.P.1    Montag, A.G.2    Thomas, G.3
  • 35
    • 0022346359 scopus 로고
    • Control of insulin gene expression in pancreatic β-cells and in an insulin-producing cell line, RIN-5F cells
    • Welsh M, Nielsen DA, MacKrell AJ, Steiner DF (1985) Control of insulin gene expression in pancreatic β-cells and in an insulin-producing cell line, RIN-5F cells. J Biol Chem 260: 13590-13594
    • (1985) J Biol Chem , vol.260 , pp. 13590-13594
    • Welsh, M.1    Nielsen, D.A.2    MacKrell, A.J.3    Steiner, D.F.4
  • 37
    • 0028338590 scopus 로고
    • Short-term control of glucokinase activity: Role of a regulatory protein
    • Van Schaftingen E, Detheux M, Da Cunha MV (1994) Short-term control of glucokinase activity: role of a regulatory protein. FASEB J 8: 414-419
    • (1994) FASEB J , vol.8 , pp. 414-419
    • Van Schaftingen, E.1    Detheux, M.2    Da Cunha, M.V.3
  • 38
    • 0029662109 scopus 로고    scopus 로고
    • The βHC-9 pancreatic β-cell line preserves the characteristics of progenitor mouse islets
    • Noda M, Komatsu M, Sharp GWG (1996) The βHC-9 pancreatic β-cell line preserves the characteristics of progenitor mouse islets. Diabetes 45: 1766-1773
    • (1996) Diabetes , vol.45 , pp. 1766-1773
    • Noda, M.1    Komatsu, M.2    Sharp, G.W.G.3
  • 39
    • 0028214676 scopus 로고
    • Dependence of cholecystokinin-8-stimulated insulin release on high glucose levels is evidenced by pseudo-alpha-D-glucose in rat pancreas and islets
    • Kimura I, Nakashima N, Kompri T, Kameda Y, Kimura M (1994) Dependence of cholecystokinin-8-stimulated insulin release on high glucose levels is evidenced by pseudo-alpha-D-glucose in rat pancreas and islets. Jpn J Pharmacol 64: 103-107
    • (1994) Jpn J Pharmacol , vol.64 , pp. 103-107
    • Kimura, I.1    Nakashima, N.2    Kompri, T.3    Kameda, Y.4    Kimura, M.5
  • 40
    • 0019984298 scopus 로고
    • Diazoxide and D600 inhibition of insulin release. Distinct mechanisms explain the specificity for different stimuli
    • Henquin JC, Charles S, Nenquin M, Mathot F, Tamagawa T (1982) Diazoxide and D600 inhibition of insulin release. Distinct mechanisms explain the specificity for different stimuli. Diabetes 31: 776-783
    • (1982) Diabetes , vol.31 , pp. 776-783
    • Henquin, J.C.1    Charles, S.2    Nenquin, M.3    Mathot, F.4    Tamagawa, T.5
  • 41
    • 0019491439 scopus 로고
    • Calcium-antagonists and islets function. XII. Comparison between nifedipine and chemically related drugs
    • Malaisse WJ, Sener A (1981) Calcium-antagonists and islets function. XII. Comparison between nifedipine and chemically related drugs. Biochem Pharmacol 30: 1039-1041
    • (1981) Biochem Pharmacol , vol.30 , pp. 1039-1041
    • Malaisse, W.J.1    Sener, A.2
  • 43
    • 0028972501 scopus 로고
    • Reconstitution of IKATP: An inward rectifier subunit plus the sulfonylurea receptor
    • Inagaki N, Gonoi T, Clement IV JP et al. (1995) Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 270: 1166-1170
    • (1995) Science , vol.270 , pp. 1166-1170
    • Inagaki, N.1    Gonoi, T.2    Clement IV, J.P.3
  • 44
    • 0030446722 scopus 로고    scopus 로고
    • The high-affinity sufonylurea receptor: Distribution, glycosylation, purification, and immunoprecipitation of two forms from endocrine and neuroendocrine cell lines
    • Nelson DA, Bryan J, Wechsler S, Clement IV JP, Aguilar-Bryan L (1996) The high-affinity sufonylurea receptor: distribution, glycosylation, purification, and immunoprecipitation of two forms from endocrine and neuroendocrine cell lines. Biochemistry 35: 14793-14799
    • (1996) Biochemistry , vol.35 , pp. 14793-14799
    • Nelson, D.A.1    Bryan, J.2    Wechsler, S.3    Clement IV, J.P.4    Aguilar-Bryan, L.5
  • 45
    • 0029926206 scopus 로고    scopus 로고
    • Calcium currents in a pituitary cell line (AtT-20): Differential roles in stimulus-secretion coupling
    • Loechner KJ, Kream RM, Dunlap K (1996) Calcium currents in a pituitary cell line (AtT-20): differential roles in stimulus-secretion coupling. Endocrinology 137: 1429-1437
    • (1996) Endocrinology , vol.137 , pp. 1429-1437
    • Loechner, K.J.1    Kream, R.M.2    Dunlap, K.3
  • 47
    • 0030036874 scopus 로고    scopus 로고
    • Regulation of insulin secretion by phosphoinositide-specific phospholipase C and protein kinase C activation
    • Zawalich WS (1996) Regulation of insulin secretion by phosphoinositide-specific phospholipase C and protein kinase C activation. Diabetes Rev 4: 160-176
    • (1996) Diabetes Rev , vol.4 , pp. 160-176
    • Zawalich, W.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.