-
2
-
-
41849151748
-
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
-
Kroon, E. et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat. Biotechnol. 26, 443-452 (2008).
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 443-452
-
-
Kroon, E.1
-
3
-
-
58749102383
-
Genes controlling pancreas ontogeny
-
Bonal, C. & Herrera, P.L. Genes controlling pancreas ontogeny. Int. J. Dev. Biol. 52, 823-835 (2008).
-
(2008)
Int. J. Dev. Biol.
, vol.52
, pp. 823-835
-
-
Bonal, C.1
Herrera, P.L.2
-
4
-
-
0034652287
-
Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
-
Gradwohl, G., Dierich, A., LeMeur, M. & Guillemot, F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. USA 97, 1607-1611 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 1607-1611
-
-
Gradwohl, G.1
Dierich, A.2
LeMeur, M.3
Guillemot, F.4
-
5
-
-
18544404101
-
Control of endodermal endocrine development by Hes-1
-
Jensen, J. et al. Control of endodermal endocrine development by Hes-1. Nat. Genet. 24, 36-44 (2000).
-
(2000)
Nat. Genet.
, vol.24
, pp. 36-44
-
-
Jensen, J.1
-
6
-
-
0033825383
-
Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
-
Schwitzgebel, V.M. et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127, 3533-3542 (2000).
-
(2000)
Development
, vol.127
, pp. 3533-3542
-
-
Schwitzgebel, V.M.1
-
7
-
-
0037097981
-
Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity
-
Lee, C.S., Perreault, N., Brestelli, J.E. & Kaestner, K.H. Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev. 16, 1488-1497 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 1488-1497
-
-
Lee, C.S.1
Perreault, N.2
Brestelli, J.E.3
Kaestner, K.H.4
-
8
-
-
2942615168
-
Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types
-
Schonhoff, S.E., Giel-Moloney, M. & Leiter, A.B. Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev. Biol. 270, 443-454 (2004).
-
(2004)
Dev. Biol.
, vol.270
, pp. 443-454
-
-
Schonhoff, S.E.1
Giel-Moloney, M.2
Leiter, A.B.3
-
9
-
-
2542446343
-
Minireview: Development and differentiation of gut endocrine cells
-
Schonhoff, S.E., Giel-Moloney, M. & Leiter, A.B. Minireview: development and differentiation of gut endocrine cells. Endocrinology 145, 2639-2644 (2004).
-
(2004)
Endocrinology
, vol.145
, pp. 2639-2644
-
-
Schonhoff, S.E.1
Giel-Moloney, M.2
Leiter, A.B.3
-
10
-
-
0036340074
-
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
-
Gu, G., Dubauskaite, J. & Melton, D.A. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129, 2447-2457 (2002).
-
(2002)
Development
, vol.129
, pp. 2447-2457
-
-
Gu, G.1
Dubauskaite, J.2
Melton, D.A.3
-
11
-
-
38749108893
-
β cells can be generated from endogenous progenitors in injured adult mouse pancreas
-
Xu, X. et al. β cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132, 197-207 (2008).
-
(2008)
Cell
, vol.132
, pp. 197-207
-
-
Xu, X.1
-
12
-
-
0015409379
-
Specification of positional information in retinal ganglion cells of Xenopus: Stability of the specified state
-
Hunt, R.K. & Jacobson, M. Specification of positional information in retinal ganglion cells of Xenopus: stability of the specified state. Proc. Natl. Acad. Sci. USA 69, 2860-2864 (1972).
-
(1972)
Proc. Natl. Acad. Sci. USA
, vol.69
, pp. 2860-2864
-
-
Hunt, R.K.1
Jacobson, M.2
-
13
-
-
2342496712
-
FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
-
Accili, D. & Arden, K.C. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117, 421-426 (2004).
-
(2004)
Cell
, vol.117
, pp. 421-426
-
-
Accili, D.1
Arden, K.C.2
-
14
-
-
0042477748
-
Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors
-
Hribal, M.L., Nakae, J., Kitamura, T., Shutter, J.R. & Accili, D. Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. J. Cell Biol. 162, 535-541 (2003).
-
(2003)
J. Cell Biol.
, vol.162
, pp. 535-541
-
-
Hribal, M.L.1
Nakae, J.2
Kitamura, T.3
Shutter, J.R.4
Accili, D.5
-
15
-
-
0037237279
-
The forkhead transcription factor Foxo1 regulates adipocyte differentiation
-
Nakae, J. et al. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell 4, 119-129 (2003).
-
(2003)
Dev. Cell
, vol.4
, pp. 119-129
-
-
Nakae, J.1
-
16
-
-
70350497348
-
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
-
Paik, J.H. et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5, 540-553 (2009).
-
(2009)
Cell Stem Cell
, vol.5
, pp. 540-553
-
-
Paik, J.H.1
-
17
-
-
34848838902
-
A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
-
Kitamura, T. et al. A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J. Clin. Invest. 117, 2477-2485 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2477-2485
-
-
Kitamura, T.1
-
18
-
-
68949157228
-
Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1
-
Kitamura, T. et al. Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1. Mol. Cell. Biol. 29, 4417-4430 (2009).
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 4417-4430
-
-
Kitamura, T.1
-
19
-
-
0036950665
-
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth
-
Kitamura, T. et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth. J. Clin. Invest. 110, 1839-1847 (2002).
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1839-1847
-
-
Kitamura, T.1
-
20
-
-
33644660954
-
Role of the forkhead protein FoxO1 in β cell compensation to insulin resistance
-
Okamoto, H. et al. Role of the forkhead protein FoxO1 in β cell compensation to insulin resistance. J. Clin. Invest. 116, 775-782 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 775-782
-
-
Okamoto, H.1
-
21
-
-
33644865024
-
The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation
-
Kawamori, D. et al. The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J. Biol. Chem. 281, 1091-1098 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 1091-1098
-
-
Kawamori, D.1
-
22
-
-
27744518040
-
FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction
-
Kitamura, Y.I. et al. FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction. Cell Metab. 2, 153-163 (2005).
-
(2005)
Cell Metab.
, vol.2
, pp. 153-163
-
-
Kitamura, Y.I.1
-
23
-
-
77949272720
-
Effect of forkhead box O1 (FOXO1) on β cell development in the human fetal pancreas
-
Al-Masri, M. et al. Effect of forkhead box O1 (FOXO1) on β cell development in the human fetal pancreas. Diabetologia 53, 699-711 (2010).
-
(2010)
Diabetologia
, vol.53
, pp. 699-711
-
-
Al-Masri, M.1
-
24
-
-
0035029838
-
Regulation of the pancreatic pro-endocrine gene neurogenin3
-
Lee, J.C. et al. Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes 50, 928-936 (2001).
-
(2001)
Diabetes
, vol.50
, pp. 928-936
-
-
Lee, J.C.1
-
25
-
-
33745214464
-
Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas
-
Fukuda, A. et al. Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J. Clin. Invest. 116, 1484-1493 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1484-1493
-
-
Fukuda, A.1
-
26
-
-
0034728261
-
The bHLH gene Hes1 regulates differentiation of multiple cell types
-
Kageyama, R., Ohtsuka, T. & Tomita, K. The bHLH gene Hes1 regulates differentiation of multiple cell types. Mol. Cells 10, 1-7 (2000).
-
(2000)
Mol. Cells
, vol.10
, pp. 1-7
-
-
Kageyama, R.1
Ohtsuka, T.2
Tomita, K.3
-
27
-
-
67651159312
-
Stem cells, self-renewal, and differentiation in the intestinal epithelium
-
van der Flier, L.G. & Clevers, H. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu. Rev. Physiol. 71, 241-260 (2009).
-
(2009)
Annu. Rev. Physiol.
, vol.71
, pp. 241-260
-
-
Van Der Flier, L.G.1
Clevers, H.2
-
28
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
Hingorani, S.R. et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4, 437-450 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
-
29
-
-
77951675095
-
Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet α-cells and promotes insulin secretion
-
Fujita, Y. et al. Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet α-cells and promotes insulin secretion. Gastroenterology 138, 1966-1975 (2010).
-
(2010)
Gastroenterology
, vol.138
, pp. 1966-1975
-
-
Fujita, Y.1
-
30
-
-
67649865643
-
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
-
Wang, S. et al. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc. Natl. Acad. Sci. USA 106, 9715-9720 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 9715-9720
-
-
Wang, S.1
-
31
-
-
0034781057
-
Regulation of pancreatic (-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα
-
Tuttle, R.L. et al. Regulation of pancreatic (-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα. Nat. Med. 7, 1133-1137 (2001).
-
(2001)
Nat. Med.
, vol.7
, pp. 1133-1137
-
-
Tuttle, R.L.1
-
32
-
-
0033511648
-
β-cell maturation leads to in vitro sensitivity to cytotoxins
-
Nielsen, K. et al. β-cell maturation leads to in vitro sensitivity to cytotoxins. Diabetes 48, 2324-2332 (1999).
-
(1999)
Diabetes
, vol.48
, pp. 2324-2332
-
-
Nielsen, K.1
-
33
-
-
0030268113
-
Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
-
Sommer, L., Ma, Q. & Anderson, D.J. neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol. Cell. Neurosci. 8, 221-241 (1996).
-
(1996)
Mol. Cell. Neurosci.
, vol.8
, pp. 221-241
-
-
Sommer, L.1
Ma, Q.2
Anderson, D.J.3
-
34
-
-
11144315998
-
Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells
-
Gershengorn, M.C. et al. Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 306, 2261-2264 (2004).
-
(2004)
Science
, vol.306
, pp. 2261-2264
-
-
Gershengorn, M.C.1
-
35
-
-
0030886674
-
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
-
Naya, F.J. et al. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 11, 2323-2334 (1997).
-
(1997)
Genes Dev.
, vol.11
, pp. 2323-2334
-
-
Naya, F.J.1
-
36
-
-
64549114508
-
Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
-
Gao, N., White, P. & Kaestner, K.H. Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev. Cell 16, 588-599 (2009).
-
(2009)
Dev. Cell
, vol.16
, pp. 588-599
-
-
Gao, N.1
White, P.2
Kaestner, K.H.3
-
37
-
-
34648814084
-
Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision
-
Nakamura, T., Tsuchiya, K. & Watanabe, M. Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision. J. Gastroenterol. 42, 705-710 (2007).
-
(2007)
J. Gastroenterol.
, vol.42
, pp. 705-710
-
-
Nakamura, T.1
Tsuchiya, K.2
Watanabe, M.3
-
38
-
-
18844382368
-
Functional interaction between β-catenin and FOXO in oxidative stress signaling
-
Essers, M.A. et al. Functional interaction between β-catenin and FOXO in oxidative stress signaling. Science 308, 1181-1184 (2005).
-
(2005)
Science
, vol.308
, pp. 1181-1184
-
-
Essers, M.A.1
-
39
-
-
0032931768
-
C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins
-
Sewalt, R.G., Gunster, M.J., van der Vlag, J., Satijn, D.P. & Otte, A.P. C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. Mol. Cell. Biol. 19, 777-787 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 777-787
-
-
Sewalt, R.G.1
Gunster, M.J.2
Van Der Vlag, J.3
Satijn, D.P.4
Otte, A.P.5
-
40
-
-
52649149203
-
Expression of Groucho/TLE proteins during pancreas development
-
Hoffman, B.G., Zavaglia, B., Beach, M. & Helgason, C.D. Expression of Groucho/TLE proteins during pancreas development. BMC Dev. Biol. 8, 81 (2008).
-
(2008)
BMC Dev. Biol.
, vol.8
, pp. 81
-
-
Hoffman, B.G.1
Zavaglia, B.2
Beach, M.3
Helgason, C.D.4
-
41
-
-
0035937415
-
Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
-
Muhr, J., Andersson, E., Persson, M., Jessell, T.M. & Ericson, J. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. Cell 104, 861-873 (2001).
-
(2001)
Cell
, vol.104
, pp. 861-873
-
-
Muhr, J.1
Andersson, E.2
Persson, M.3
Jessell, T.M.4
Ericson, J.5
-
42
-
-
78651446926
-
Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling
-
Sonoshita, M. et al. Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling. Cancer Cell 19, 125-137 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 125-137
-
-
Sonoshita, M.1
-
43
-
-
0034623757
-
Glucose-dependent insulin release from genetically engineered K cells
-
Cheung, A.T. et al. Glucose-dependent insulin release from genetically engineered K cells. Science 290, 1959-1962 (2000).
-
(2000)
Science
, vol.290
, pp. 1959-1962
-
-
Cheung, A.T.1
-
44
-
-
34250756516
-
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes
-
Nielsen, L.B. et al. Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes. Eur. J. Endocrinol. 156, 663-671 (2007).
-
(2007)
Eur. J. Endocrinol.
, vol.156
, pp. 663-671
-
-
Nielsen, L.B.1
-
45
-
-
33750846133
-
Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
-
D'Amour, K.A. et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 24, 1392-1401 (2006).
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 1392-1401
-
-
D'Amour, K.A.1
-
46
-
-
79951522621
-
Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates
-
Mundell, N.A. & Labosky, P.A. Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates. Development 138, 641-652 (2011).
-
(2011)
Development
, vol.138
, pp. 641-652
-
-
Mundell, N.A.1
Labosky, P.A.2
-
47
-
-
71149095052
-
Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation
-
Uhlenhaut, N.H. et al. Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell 139, 1130-1142 (2009).
-
(2009)
Cell
, vol.139
, pp. 1130-1142
-
-
Uhlenhaut, N.H.1
-
48
-
-
33751404918
-
Neurogenin 3 and the enteroendocrine cell lineage in the adult mouse small intestinal epithelium
-
Bjerknes, M. & Cheng, H. Neurogenin 3 and the enteroendocrine cell lineage in the adult mouse small intestinal epithelium. Dev. Biol. 300, 722-735 (2006).
-
(2006)
Dev. Biol.
, vol.300
, pp. 722-735
-
-
Bjerknes, M.1
Cheng, H.2
-
49
-
-
33644618433
-
The biology of incretin hormones
-
Drucker, D.J. The biology of incretin hormones. Cell Metab. 3, 153-165 (2006).
-
(2006)
Cell Metab.
, vol.3
, pp. 153-165
-
-
Drucker, D.J.1
-
50
-
-
33845907380
-
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
-
Ridgway, J. et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444, 1083-1087 (2006).
-
(2006)
Nature
, vol.444
, pp. 1083-1087
-
-
Ridgway, J.1
-
51
-
-
33846295218
-
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
-
Paik, J.H. et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128, 309-323 (2007).
-
(2007)
Cell
, vol.128
, pp. 309-323
-
-
Paik, J.H.1
-
52
-
-
4043106461
-
Transgenic rescue of insulin receptor-deficient mice
-
Okamoto, H. et al. Transgenic rescue of insulin receptor-deficient mice. J. Clin. Invest. 114, 214-223 (2004).
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 214-223
-
-
Okamoto, H.1
-
53
-
-
0015040994
-
Circulating insulin: The proinsulin-like properties of "big" insulin in patients without islet cell tumors
-
Sherman, B.M., Gorden, P., Roth, J. & Freychet, P. Circulating insulin: the proinsulin-like properties of "big" insulin in patients without islet cell tumors. J. Clin. Invest. 50, 849-858 (1971).
-
(1971)
J. Clin. Invest.
, vol.50
, pp. 849-858
-
-
Sherman, B.M.1
Gorden, P.2
Roth, J.3
Freychet, P.4
-
54
-
-
34848928983
-
Establishment and characterization of a primary canine duodenal epithelial cell culture
-
Golaz, J.L., Vonlaufen, N., Hemphill, A. & Burgener, I.A. Establishment and characterization of a primary canine duodenal epithelial cell culture. In Vitro Cell. Dev. Biol. Anim. 43, 176-185 (2007).
-
(2007)
In Vitro Cell. Dev. Biol. Anim.
, vol.43
, pp. 176-185
-
-
Golaz, J.L.1
Vonlaufen, N.2
Hemphill, A.3
Burgener, I.A.4
-
55
-
-
34548850613
-
Foxa2 controls vesicle docking and insulin secretion in mature β cells
-
Gao, N. et al. Foxa2 controls vesicle docking and insulin secretion in mature β cells. Cell Metab. 6, 267-279 (2007).
-
(2007)
Cell Metab.
, vol.6
, pp. 267-279
-
-
Gao, N.1
-
56
-
-
0037628628
-
Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells
-
Suzuki, A., Nakauchi, H. & Taniguchi, H. Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells. Proc. Natl. Acad. Sci. USA 100, 5034-5039 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 5034-5039
-
-
Suzuki, A.1
Nakauchi, H.2
Taniguchi, H.3
|