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Volumn 44, Issue 4, 2012, Pages 406-412

Generation of functional insulin-producing cells in the gut by Foxo1 ablation

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN; NEUROGENIN 3; STREPTOZOCIN; SULFONYLUREA; TRANSCRIPTION FACTOR FKHR;

EID: 84859350525     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2215     Document Type: Article
Times cited : (140)

References (56)
  • 2
    • 41849151748 scopus 로고    scopus 로고
    • Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
    • Kroon, E. et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat. Biotechnol. 26, 443-452 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , pp. 443-452
    • Kroon, E.1
  • 3
    • 58749102383 scopus 로고    scopus 로고
    • Genes controlling pancreas ontogeny
    • Bonal, C. & Herrera, P.L. Genes controlling pancreas ontogeny. Int. J. Dev. Biol. 52, 823-835 (2008).
    • (2008) Int. J. Dev. Biol. , vol.52 , pp. 823-835
    • Bonal, C.1    Herrera, P.L.2
  • 4
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl, G., Dierich, A., LeMeur, M. & Guillemot, F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. USA 97, 1607-1611 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 5
    • 18544404101 scopus 로고    scopus 로고
    • Control of endodermal endocrine development by Hes-1
    • Jensen, J. et al. Control of endodermal endocrine development by Hes-1. Nat. Genet. 24, 36-44 (2000).
    • (2000) Nat. Genet. , vol.24 , pp. 36-44
    • Jensen, J.1
  • 6
    • 0033825383 scopus 로고    scopus 로고
    • Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
    • Schwitzgebel, V.M. et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127, 3533-3542 (2000).
    • (2000) Development , vol.127 , pp. 3533-3542
    • Schwitzgebel, V.M.1
  • 7
    • 0037097981 scopus 로고    scopus 로고
    • Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity
    • Lee, C.S., Perreault, N., Brestelli, J.E. & Kaestner, K.H. Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev. 16, 1488-1497 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 1488-1497
    • Lee, C.S.1    Perreault, N.2    Brestelli, J.E.3    Kaestner, K.H.4
  • 8
    • 2942615168 scopus 로고    scopus 로고
    • Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types
    • Schonhoff, S.E., Giel-Moloney, M. & Leiter, A.B. Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev. Biol. 270, 443-454 (2004).
    • (2004) Dev. Biol. , vol.270 , pp. 443-454
    • Schonhoff, S.E.1    Giel-Moloney, M.2    Leiter, A.B.3
  • 9
    • 2542446343 scopus 로고    scopus 로고
    • Minireview: Development and differentiation of gut endocrine cells
    • Schonhoff, S.E., Giel-Moloney, M. & Leiter, A.B. Minireview: development and differentiation of gut endocrine cells. Endocrinology 145, 2639-2644 (2004).
    • (2004) Endocrinology , vol.145 , pp. 2639-2644
    • Schonhoff, S.E.1    Giel-Moloney, M.2    Leiter, A.B.3
  • 10
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu, G., Dubauskaite, J. & Melton, D.A. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129, 2447-2457 (2002).
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 11
    • 38749108893 scopus 로고    scopus 로고
    • β cells can be generated from endogenous progenitors in injured adult mouse pancreas
    • Xu, X. et al. β cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132, 197-207 (2008).
    • (2008) Cell , vol.132 , pp. 197-207
    • Xu, X.1
  • 12
    • 0015409379 scopus 로고
    • Specification of positional information in retinal ganglion cells of Xenopus: Stability of the specified state
    • Hunt, R.K. & Jacobson, M. Specification of positional information in retinal ganglion cells of Xenopus: stability of the specified state. Proc. Natl. Acad. Sci. USA 69, 2860-2864 (1972).
    • (1972) Proc. Natl. Acad. Sci. USA , vol.69 , pp. 2860-2864
    • Hunt, R.K.1    Jacobson, M.2
  • 13
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    • Accili, D. & Arden, K.C. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117, 421-426 (2004).
    • (2004) Cell , vol.117 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 14
    • 0042477748 scopus 로고    scopus 로고
    • Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors
    • Hribal, M.L., Nakae, J., Kitamura, T., Shutter, J.R. & Accili, D. Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. J. Cell Biol. 162, 535-541 (2003).
    • (2003) J. Cell Biol. , vol.162 , pp. 535-541
    • Hribal, M.L.1    Nakae, J.2    Kitamura, T.3    Shutter, J.R.4    Accili, D.5
  • 15
    • 0037237279 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 regulates adipocyte differentiation
    • Nakae, J. et al. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell 4, 119-129 (2003).
    • (2003) Dev. Cell , vol.4 , pp. 119-129
    • Nakae, J.1
  • 16
    • 70350497348 scopus 로고    scopus 로고
    • FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
    • Paik, J.H. et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5, 540-553 (2009).
    • (2009) Cell Stem Cell , vol.5 , pp. 540-553
    • Paik, J.H.1
  • 17
    • 34848838902 scopus 로고    scopus 로고
    • A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
    • Kitamura, T. et al. A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J. Clin. Invest. 117, 2477-2485 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 2477-2485
    • Kitamura, T.1
  • 18
    • 68949157228 scopus 로고    scopus 로고
    • Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1
    • Kitamura, T. et al. Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1. Mol. Cell. Biol. 29, 4417-4430 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 4417-4430
    • Kitamura, T.1
  • 19
    • 0036950665 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth
    • Kitamura, T. et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth. J. Clin. Invest. 110, 1839-1847 (2002).
    • (2002) J. Clin. Invest. , vol.110 , pp. 1839-1847
    • Kitamura, T.1
  • 20
    • 33644660954 scopus 로고    scopus 로고
    • Role of the forkhead protein FoxO1 in β cell compensation to insulin resistance
    • Okamoto, H. et al. Role of the forkhead protein FoxO1 in β cell compensation to insulin resistance. J. Clin. Invest. 116, 775-782 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 775-782
    • Okamoto, H.1
  • 21
    • 33644865024 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation
    • Kawamori, D. et al. The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J. Biol. Chem. 281, 1091-1098 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 1091-1098
    • Kawamori, D.1
  • 22
    • 27744518040 scopus 로고    scopus 로고
    • FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction
    • Kitamura, Y.I. et al. FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction. Cell Metab. 2, 153-163 (2005).
    • (2005) Cell Metab. , vol.2 , pp. 153-163
    • Kitamura, Y.I.1
  • 23
    • 77949272720 scopus 로고    scopus 로고
    • Effect of forkhead box O1 (FOXO1) on β cell development in the human fetal pancreas
    • Al-Masri, M. et al. Effect of forkhead box O1 (FOXO1) on β cell development in the human fetal pancreas. Diabetologia 53, 699-711 (2010).
    • (2010) Diabetologia , vol.53 , pp. 699-711
    • Al-Masri, M.1
  • 24
    • 0035029838 scopus 로고    scopus 로고
    • Regulation of the pancreatic pro-endocrine gene neurogenin3
    • Lee, J.C. et al. Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes 50, 928-936 (2001).
    • (2001) Diabetes , vol.50 , pp. 928-936
    • Lee, J.C.1
  • 25
    • 33745214464 scopus 로고    scopus 로고
    • Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas
    • Fukuda, A. et al. Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J. Clin. Invest. 116, 1484-1493 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 1484-1493
    • Fukuda, A.1
  • 26
    • 0034728261 scopus 로고    scopus 로고
    • The bHLH gene Hes1 regulates differentiation of multiple cell types
    • Kageyama, R., Ohtsuka, T. & Tomita, K. The bHLH gene Hes1 regulates differentiation of multiple cell types. Mol. Cells 10, 1-7 (2000).
    • (2000) Mol. Cells , vol.10 , pp. 1-7
    • Kageyama, R.1    Ohtsuka, T.2    Tomita, K.3
  • 27
    • 67651159312 scopus 로고    scopus 로고
    • Stem cells, self-renewal, and differentiation in the intestinal epithelium
    • van der Flier, L.G. & Clevers, H. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu. Rev. Physiol. 71, 241-260 (2009).
    • (2009) Annu. Rev. Physiol. , vol.71 , pp. 241-260
    • Van Der Flier, L.G.1    Clevers, H.2
  • 28
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • Hingorani, S.R. et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4, 437-450 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1
  • 29
    • 77951675095 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet α-cells and promotes insulin secretion
    • Fujita, Y. et al. Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet α-cells and promotes insulin secretion. Gastroenterology 138, 1966-1975 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 1966-1975
    • Fujita, Y.1
  • 30
    • 67649865643 scopus 로고    scopus 로고
    • Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
    • Wang, S. et al. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc. Natl. Acad. Sci. USA 106, 9715-9720 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9715-9720
    • Wang, S.1
  • 31
    • 0034781057 scopus 로고    scopus 로고
    • Regulation of pancreatic (-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα
    • Tuttle, R.L. et al. Regulation of pancreatic (-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα. Nat. Med. 7, 1133-1137 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 1133-1137
    • Tuttle, R.L.1
  • 32
    • 0033511648 scopus 로고    scopus 로고
    • β-cell maturation leads to in vitro sensitivity to cytotoxins
    • Nielsen, K. et al. β-cell maturation leads to in vitro sensitivity to cytotoxins. Diabetes 48, 2324-2332 (1999).
    • (1999) Diabetes , vol.48 , pp. 2324-2332
    • Nielsen, K.1
  • 33
    • 0030268113 scopus 로고    scopus 로고
    • Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
    • Sommer, L., Ma, Q. & Anderson, D.J. neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol. Cell. Neurosci. 8, 221-241 (1996).
    • (1996) Mol. Cell. Neurosci. , vol.8 , pp. 221-241
    • Sommer, L.1    Ma, Q.2    Anderson, D.J.3
  • 34
    • 11144315998 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells
    • Gershengorn, M.C. et al. Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 306, 2261-2264 (2004).
    • (2004) Science , vol.306 , pp. 2261-2264
    • Gershengorn, M.C.1
  • 35
    • 0030886674 scopus 로고    scopus 로고
    • Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
    • Naya, F.J. et al. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 11, 2323-2334 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 2323-2334
    • Naya, F.J.1
  • 36
    • 64549114508 scopus 로고    scopus 로고
    • Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
    • Gao, N., White, P. & Kaestner, K.H. Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev. Cell 16, 588-599 (2009).
    • (2009) Dev. Cell , vol.16 , pp. 588-599
    • Gao, N.1    White, P.2    Kaestner, K.H.3
  • 37
    • 34648814084 scopus 로고    scopus 로고
    • Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision
    • Nakamura, T., Tsuchiya, K. & Watanabe, M. Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision. J. Gastroenterol. 42, 705-710 (2007).
    • (2007) J. Gastroenterol. , vol.42 , pp. 705-710
    • Nakamura, T.1    Tsuchiya, K.2    Watanabe, M.3
  • 38
    • 18844382368 scopus 로고    scopus 로고
    • Functional interaction between β-catenin and FOXO in oxidative stress signaling
    • Essers, M.A. et al. Functional interaction between β-catenin and FOXO in oxidative stress signaling. Science 308, 1181-1184 (2005).
    • (2005) Science , vol.308 , pp. 1181-1184
    • Essers, M.A.1
  • 39
    • 0032931768 scopus 로고    scopus 로고
    • C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins
    • Sewalt, R.G., Gunster, M.J., van der Vlag, J., Satijn, D.P. & Otte, A.P. C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. Mol. Cell. Biol. 19, 777-787 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 777-787
    • Sewalt, R.G.1    Gunster, M.J.2    Van Der Vlag, J.3    Satijn, D.P.4    Otte, A.P.5
  • 40
    • 52649149203 scopus 로고    scopus 로고
    • Expression of Groucho/TLE proteins during pancreas development
    • Hoffman, B.G., Zavaglia, B., Beach, M. & Helgason, C.D. Expression of Groucho/TLE proteins during pancreas development. BMC Dev. Biol. 8, 81 (2008).
    • (2008) BMC Dev. Biol. , vol.8 , pp. 81
    • Hoffman, B.G.1    Zavaglia, B.2    Beach, M.3    Helgason, C.D.4
  • 41
    • 0035937415 scopus 로고    scopus 로고
    • Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
    • Muhr, J., Andersson, E., Persson, M., Jessell, T.M. & Ericson, J. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. Cell 104, 861-873 (2001).
    • (2001) Cell , vol.104 , pp. 861-873
    • Muhr, J.1    Andersson, E.2    Persson, M.3    Jessell, T.M.4    Ericson, J.5
  • 42
    • 78651446926 scopus 로고    scopus 로고
    • Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling
    • Sonoshita, M. et al. Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling. Cancer Cell 19, 125-137 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 125-137
    • Sonoshita, M.1
  • 43
    • 0034623757 scopus 로고    scopus 로고
    • Glucose-dependent insulin release from genetically engineered K cells
    • Cheung, A.T. et al. Glucose-dependent insulin release from genetically engineered K cells. Science 290, 1959-1962 (2000).
    • (2000) Science , vol.290 , pp. 1959-1962
    • Cheung, A.T.1
  • 44
    • 34250756516 scopus 로고    scopus 로고
    • Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes
    • Nielsen, L.B. et al. Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes. Eur. J. Endocrinol. 156, 663-671 (2007).
    • (2007) Eur. J. Endocrinol. , vol.156 , pp. 663-671
    • Nielsen, L.B.1
  • 45
    • 33750846133 scopus 로고    scopus 로고
    • Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
    • D'Amour, K.A. et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 24, 1392-1401 (2006).
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1392-1401
    • D'Amour, K.A.1
  • 46
    • 79951522621 scopus 로고    scopus 로고
    • Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates
    • Mundell, N.A. & Labosky, P.A. Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates. Development 138, 641-652 (2011).
    • (2011) Development , vol.138 , pp. 641-652
    • Mundell, N.A.1    Labosky, P.A.2
  • 47
    • 71149095052 scopus 로고    scopus 로고
    • Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation
    • Uhlenhaut, N.H. et al. Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell 139, 1130-1142 (2009).
    • (2009) Cell , vol.139 , pp. 1130-1142
    • Uhlenhaut, N.H.1
  • 48
    • 33751404918 scopus 로고    scopus 로고
    • Neurogenin 3 and the enteroendocrine cell lineage in the adult mouse small intestinal epithelium
    • Bjerknes, M. & Cheng, H. Neurogenin 3 and the enteroendocrine cell lineage in the adult mouse small intestinal epithelium. Dev. Biol. 300, 722-735 (2006).
    • (2006) Dev. Biol. , vol.300 , pp. 722-735
    • Bjerknes, M.1    Cheng, H.2
  • 49
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker, D.J. The biology of incretin hormones. Cell Metab. 3, 153-165 (2006).
    • (2006) Cell Metab. , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 50
    • 33845907380 scopus 로고    scopus 로고
    • Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
    • Ridgway, J. et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444, 1083-1087 (2006).
    • (2006) Nature , vol.444 , pp. 1083-1087
    • Ridgway, J.1
  • 51
    • 33846295218 scopus 로고    scopus 로고
    • FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
    • Paik, J.H. et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128, 309-323 (2007).
    • (2007) Cell , vol.128 , pp. 309-323
    • Paik, J.H.1
  • 52
    • 4043106461 scopus 로고    scopus 로고
    • Transgenic rescue of insulin receptor-deficient mice
    • Okamoto, H. et al. Transgenic rescue of insulin receptor-deficient mice. J. Clin. Invest. 114, 214-223 (2004).
    • (2004) J. Clin. Invest. , vol.114 , pp. 214-223
    • Okamoto, H.1
  • 53
    • 0015040994 scopus 로고
    • Circulating insulin: The proinsulin-like properties of "big" insulin in patients without islet cell tumors
    • Sherman, B.M., Gorden, P., Roth, J. & Freychet, P. Circulating insulin: the proinsulin-like properties of "big" insulin in patients without islet cell tumors. J. Clin. Invest. 50, 849-858 (1971).
    • (1971) J. Clin. Invest. , vol.50 , pp. 849-858
    • Sherman, B.M.1    Gorden, P.2    Roth, J.3    Freychet, P.4
  • 54
    • 34848928983 scopus 로고    scopus 로고
    • Establishment and characterization of a primary canine duodenal epithelial cell culture
    • Golaz, J.L., Vonlaufen, N., Hemphill, A. & Burgener, I.A. Establishment and characterization of a primary canine duodenal epithelial cell culture. In Vitro Cell. Dev. Biol. Anim. 43, 176-185 (2007).
    • (2007) In Vitro Cell. Dev. Biol. Anim. , vol.43 , pp. 176-185
    • Golaz, J.L.1    Vonlaufen, N.2    Hemphill, A.3    Burgener, I.A.4
  • 55
    • 34548850613 scopus 로고    scopus 로고
    • Foxa2 controls vesicle docking and insulin secretion in mature β cells
    • Gao, N. et al. Foxa2 controls vesicle docking and insulin secretion in mature β cells. Cell Metab. 6, 267-279 (2007).
    • (2007) Cell Metab. , vol.6 , pp. 267-279
    • Gao, N.1
  • 56
    • 0037628628 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells
    • Suzuki, A., Nakauchi, H. & Taniguchi, H. Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells. Proc. Natl. Acad. Sci. USA 100, 5034-5039 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 5034-5039
    • Suzuki, A.1    Nakauchi, H.2    Taniguchi, H.3


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