Stable insulin-secreting ducts formed by reprogramming of cells in the liver using a three-gene cocktail and a PPAR agonist

Gene Therapy

Volumn 21, Issue 1, 2014, Pages 19-27

  Banga, A ^a   Greder, L V ^a   Dutton, J R ^a   Slack, J M W ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

diabetes; insulin; MafA; Neurogenin3; Pdx1; WY14643

Indexed keywords

ADENOVIRUS VECTOR; C PEPTIDE; GLUCOSE; INSULIN; NEUROGENIN 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PIRINIXIC ACID; STREPTOZOCIN; TACROLIMUS; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIVISION; CELL FATE; CELL PROLIFERATION; CELL REPROGRAMMING; COMPARATIVE STUDY; CONTROLLED STUDY; GENE COMBINATION; GENETIC ENGINEERING AND GENE TECHNOLOGY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; IMMUNOSUPPRESSIVE TREATMENT; INSULIN RELEASE; LIVER; LIVER CELL; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROCEDURES CONCERNING CELLS; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; VIRAL GENE DELIVERY SYSTEM;

MUS;

ANIMALS; ANTICHOLESTEREMIC AGENTS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOOD GLUCOSE; COMBINED MODALITY THERAPY; DEPENDOVIRUS; DIABETES MELLITUS, EXPERIMENTAL; GENETIC THERAPY; GENETIC VECTORS; HOMEODOMAIN PROTEINS; INSULIN; INSULIN-SECRETING CELLS; LIVER; MAF TRANSCRIPTION FACTORS, LARGE; MICE; NERVE TISSUE PROTEINS; PYRIMIDINES; TRANS-ACTIVATORS;

EID: 84891735789     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2013.50     Document Type: Article

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