Suppression of epithelial-to-Mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-Producing β-Like cells

Diabetes

Volumn 62, Issue 8, 2013, Pages 2821-2833

  Lima, Maria João ^a   Muir, Kenneth R ^a   Docherty, Hilary M ^a   Drummond, Robert ^b   McGowan, Neil W A ^c   Forbes, Shareen ^d   Heremans, Yves ^e   Houbracken, Isabelle ^e   Ross, James A ^b   Forbes, Stuart J ^b   Ravassard, Philippe ^f,g   Heimberg, Harry ^e   Casey, John ^c   Docherty, Kevin ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e DIABETES RESEARCH CENTER   (Belgium)

^f INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^g SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; 5 AZA 2' DEOXYCYTIDINE; ALPHA SMOOTH MUSCLE ACTIN; BETACELLULIN; BUTYRIC ACID; CRE RECOMBINASE; CYTOKERATIN 19; EPITHELIAL CELL ADHESION MOLECULE; GLUCOSE; INSULIN; NEUROGENIN 3; STREPTOZOCIN; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SLUG; UVOMORULIN; VIMENTIN; RHO KINASE;

ACINAR CELL; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEDIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL STRUCTURE; CELL TRANSDIFFERENTIATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EX VIVO STUDY; FLOW CYTOMETRY; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; INSULIN RELEASE; ISOLATION PROCEDURE; MESENCHYMAL STROMA CELL; MESENCHYME CELL; MIDDLE AGED; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PANCREAS ISLET BETA CELL; PLASTICITY; PRIORITY JOURNAL; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; YOUNG ADULT; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; NONOBESE DIABETIC MOUSE; PANCREAS; PHYSIOLOGY; SCID MOUSE; SECRETION (PROCESS); DRUG EFFECT;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; EPITHELIAL-MESENCHYMAL TRANSITION; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED NOD; MICE, SCID; PANCREAS, EXOCRINE; RHO-ASSOCIATED KINASES;

EID: 84891668969     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1256     Document Type: Article

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