Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Liu, Jianping ^a,b   Liu, Yanmei ^b   Wang, Honggang ^c   Hao, Haojie ^a   Han, Qingwang ^a   Shen, Jing ^a   Shi, Jun ^b   Li, Chunlin ^a   Mu, Yiming ^a   Han, Weidong ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b JIANGXI PROVINCIAL PEOPLE S HOSPITAL   (China)

^c INNER MONGOLIA PEOPLE S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; HYDROXAMIC ACID; INSULIN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; RETINOIC ACID; SODIUM SELENITE; TRANSACTIVATOR PROTEIN; TRANSFERRIN; TRICHOSTATIN A;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUCOSE BLOOD LEVEL; LIVER; METABOLISM; PANCREAS; PANCREAS ISLET BETA CELL; PATHOLOGY; PLURIPOTENT STEM CELL; RAT; SECRETION (PROCESS); STEM CELL; TRANSPLANTATION;

ANIMALS; BLOOD GLUCOSE; CELL DIFFERENTIATION; CELL LINE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HOMEODOMAIN PROTEINS; HYDROXAMIC ACIDS; INDUCED PLURIPOTENT STEM CELLS; INSULIN; INSULIN-SECRETING CELLS; LIVER; PANCREAS; RATS; SODIUM SELENITE; STEM CELLS; TRANS-ACTIVATORS; TRANSFERRIN; TRETINOIN;

MLCS; MLOWN;

EID: 84873656615     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep01185     Document Type: Article

References (31)

1. Shapiro, A. M. et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343, 230-8 (2000). (Pubitemid 30490390)
2. Ameri, J. et al. FGF2 specifies hESC-derived definitive endoderm into foregut/midgut cell lineages in a concentration-dependent manner. Stem Cells 28, 45-56 (2010).
3. Lammert, E., Cleaver, O. & Melton, D. Role of endothelial cells in early pancreas and liver development. Mech Dev 120, 59-64 (2003). (Pubitemid 35462096)
4. Nakajima-Nagata,N. et al. In vitro induction of adult hepatic progenitor cells into insulin-producing cells. Biochem Biophys Res Commun 318, 625-30 (2004).
5. Ber, I. et al. Functional, persistent, and extended liver to pancreas transdifferentiation. J Biol Chem 278, 31950-7 (2003). (Pubitemid 37048382)
6. Park, I. H. et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451, 141-6 (2008).
7. Kawasaki,H. et al. In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells. J Hepatobiliary Pancreat Surg 15, 310-7 (2008).
8. Takahashi, K. Cellular reprogramming-lowering gravity on Waddington's epigenetic landscape. J Cell Sci (2012).
9. Nakagawa, M. et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol 26, 101-6 (2008).
10. Wang, H. S. et al. Transplantation of insulin-producing cells derived from umbilical cord stromal mesenchymal stem cells to treat NOD mice. Cell Transplant 20, 455-66 (2011).
11. Lefebvre, B. et al. 59-AZA induces Ngn3 expression and endocrine differentiation in the PANC-1 human ductal cell line. Biochem Biophys Res Commun 391, 305-9 (2010).
12. Chang, S. et al.Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol 24, 8467-76 (2004). (Pubitemid 39245069)
13. Tomita, S. et al. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 100, II247-56 (1999). (Pubitemid 29523543)
14. Cai, J. et al. Generation of homogeneous PDX1(1) pancreatic progenitors from human ES cell-derived endoderm cells. J Mol Cell Biol 2, 50-60 (2010).
15. Ostrom, M. et al. Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells. PLoS One 3, e2841 (2008).
16. Yang, L. et al. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci USA 99, 8078-83 (2002). (Pubitemid 34651008)
17. Chen, S. et al. Asmall molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol 5, 258-65 (2009).
18. Johannesson,M. et al. FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time-and concentration- dependent manner. PLoS One 4, e4794 (2009).
19. Shen, C. N., Slack, J. M. & Tosh, D. Molecular basis of transdifferentiation of pancreas to liver. Nat Cell Biol 2, 879-87 (2000).
20. Shafritz, D. A., Oertel, M.,Menthena, A., Nierhoff, D. & Dabeva, M. D. Liver stem cells and prospects for liver reconstitution by transplanted cells. Hepatology 43, S89-98 (2006).
21. Tateno, C. & Yoshizato, K. Long-term cultivation of adult rat hepatocytes that undergo multiple cell divisions and express normal parenchymal phenotypes. Am J Pathol 148, 383-92 (1996). (Pubitemid 26056723)
22. Yamada, S. et al. In vitro transdifferentiation of mature hepatocytes into insulin-producing cells. Endocr J 53, 789-95 (2006). (Pubitemid 46045125)
23. Vaes, B. L. et al. Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism. Bone 46, 514-23 (2010).
24. Haumaitre, C., Lenoir, O.&Scharfmann, R.Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. Mol Cell Biol 28, 6373-83 (2008).
25. Chen, Y.,Wong, P. P., Sjeklocha, L., Steer, C. J. & Sahin, M. B. Mature hepatocytes exhibit unexpected plasticity by direct dedifferentiation into liver progenitor cells in culture. Hepatology 55, 563-74 (2012).
26. Micallef, S. J. et al. Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells. Diabetes 54, 301-5 (2005).
27. Shi, Y. et al. Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid. Stem Cells 23, 656-62 (2005). (Pubitemid 40647262)
28. D'Amour, K. A. et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24, 1392-401 (2006). (Pubitemid 44722103)
29. Delisle, J. C. et al. Pdx-1 or Pdx-1-VP16 protein transduction induces beta-cell gene expression in liver-stem WB cells. BMC Res Notes 2, 3 (2009).
30. Fujikawa, T. et al. Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells. Am J Pathol 166, 1781-91 (2005). (Pubitemid 40734401)
31. Sulochana, K. N., Punitham, R. & Ramakrishnan, S. Beneficial effect of lysine and amino acids on cataractogenesis in experimental diabetes through possible antiglycation of lens proteins. Exp Eye Res 67, 597-601 (1998). (Pubitemid 29005157)