In vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 38, 2012, Pages 15336-15341

  Banga, Anannya ^a   Akinci, Ersin ^a   Greder, Lucas V ^a   Dutton, James R ^a   Slack, Jonathan M W ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; TRANSCRIPTION FACTOR SOX9;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT; CELL LABELING; CELL SELECTION; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENE EXPRESSION; IN VIVO STUDY; INSULIN RELEASE; LIVER CELL; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PANCREAS CELL; PANCREAS DUCT; PRIORITY JOURNAL; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; CELL DIFFERENTIATION; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; INSULIN; INSULIN-SECRETING CELLS; LIVER; MALE; MICE; MICE, INBRED NOD; MICE, SCID; MICROSCOPY, ELECTRON; MODELS, GENETIC; PANCREAS; SOX9 TRANSCRIPTION FACTOR;

MUS;

EID: 84866550121     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1201701109     Document Type: Article

References (44)

1. Ieda M, et al. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142:375-386.
2. Vierbuchen T, et al. (2010) Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463:1035-1041.
3. Huang P, et al. (2011) Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature 475:386-389.
4. Sekiya S, Suzuki A (2011) Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 475:390-393.
5. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defi ned factors. Cell 126:663-676. (Pubitemid 44233629)
6. Meissner A, Wernig M, Jaenisch R (2007) Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol 25:1177-1181. (Pubitemid 47538112)
7. Okita K, Ichisaka T, Yamanaka S (2007) Generation of germline-competent induced pluripotent stem cells. Nature 448:313-317. (Pubitemid 47080336)
8. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA (2008) In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455:627-632.
9. Murtaugh LC, Melton DA (2003) Genes, signals, and lineages in pancreas development. Annu Rev Cell Dev Biol 19:71-89. (Pubitemid 37487343)
10. Gittes GK (2009) Developmental biology of the pancreas: A comprehensive review. Dev Biol 326:4-35.
11. McKnight KD, Wang P, Kim SK (2010) Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell 6:300-308.
12. Deutsch G, Jung J, Zheng M, Lóra J, Zaret KS (2001) A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 128:871-881. (Pubitemid 32288198)
13. Zaret KS (2008) Genetic programming of liver and pancreas progenitors: Lessons for stem-cell differentiation. Nat Rev Genet 9:329-340.
14. Zaret KS, Grompe M (2008) Generation and regeneration of cells of the liver and pancreas. Science 322:1490-1494.
15. Slack JMW (1985) Homoeotic transformations in man: Implications for the mechanism of embryonic development and for the organization of epithelia. J Theor Biol 114:463-490.
16. Slack JMW (2007) Metaplasia and transdifferentiation: From pure biology to the clinic. Nat Rev Mol Cell Biol 8:369-378.
17. Shiojiri N (1997) Development and differentiation of bile ducts in the mammalian liver. Microsc Res Tech 39:328-335.
18. Antoniou A, et al. (2009) Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology 136:2325-2333.
19. Carpentier R, et al. (2011) Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. Gastroenterology 141:1432-1438.
20. Yang Y, et al. (1994) Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 91:4407-4411. (Pubitemid 24143442)
21. Grossman EJ, et al. (2010) Glycemic control promotes pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice. PLoS ONE 5:e8749.
22. Lemaire K, et al. (2009) Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci USA 106:14872-14877.
23. Lukowiak B, et al. (2001) Identification and purification of functional human beta-cells by a new specific zinc-fluorescent probe. J Histochem Cytochem 49:519-528.
24. Dutton JR, et al. (2007) Beta cells occur naturally in extrahepatic bile ducts of mice. J Cell Sci 120:239-245.
25. Eberhard D, Tosh D, Slack JMW (2008) Origin of pancreatic endocrine cells from biliary duct epithelium. Cell Mol Life Sci 65:3467-3480.
26. Gu D, Sarvetnick N (1993) Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. Development 118:33-46. (Pubitemid 23191608)
27. Lipsett M, Finegood DT (2002) β-cell neogenesis during prolonged hyperglycemia in rats. Diabetes 51:1834-1841. (Pubitemid 34564296)
28. Dorrell C, et al. (2011) Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev 25:1193-1203.
29. Shin S, et al. (2011) Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes Dev 25:1185-1192.
30. Nakanuma Y, Hoso M, Sanzen T, Sasaki M (1997) Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply. Microsc Res Tech 38:552-570. (Pubitemid 27426381)
31. Carpino G, et al. (2012) Biliary tree stem/progenitor cells in glands of extrahepatic and intraheptic bile ducts: An anatomical in situ study yielding evidence of maturational lineages. J Anat 220:186-199.
32. Furuyama K, et al. (2011) Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet 43:34-41.
33. Ferber S, et al. (2000) Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 6:568-572. (Pubitemid 30305908)
34. Ber I, et al. (2003) Functional, persistent, and extended liver to pancreas transdifferentiation. J Biol Chem 278:31950-31957. (Pubitemid 37048382)
35. Miyatsuka T, et al. (2003) Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem Biophys Res Commun 310:1017-1025. (Pubitemid 37188724)
36. Kojima H, et al. (2003) NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 9:596-603. (Pubitemid 36597107)
37. Kaneto H, et al. (2005) PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes 54:1009-1022. (Pubitemid 40446314)
38. Yechoor V, et al. (2009) Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell 16:358-373.
39. Efrat S (2002) Cell replacement therapy for type 1 diabetes. Trends Mol Med 8:334-339.
40. Meivar-Levy I, Ferber S (2003) New organs from our own tissues: Liver-to-pancreas transdifferentiation. Trends Endocrinol Metab 14:460-466. (Pubitemid 37517347)
41. Sapir T, et al. (2005) Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells. Proc Natl Acad Sci USA 102:7964-7969. (Pubitemid 40781046)
42. Akinci E, Banga A, Greder LV, Dutton JR, Slack JMW (2012) Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1, Ngn3 and MafA. Biochem J 442:539-550.
43. de Felipe P (2004) Skipping the co-expression problem: The new 2A "CHYSEL" technology. Genet Vaccines Ther 2:13.
44. Muzumdar MD, Tasic B, Miyamichi K, Li L, Luo LQ (2007) A global double-fluorescent Cre reporter mouse. Genesis 45:593-605. (Pubitemid 350013057)