GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Fomina Yadlin, Dina ^a,b   Kubicek, Stefan ^c   Vetere, Amedeo ^a   He, Kaihui Hu ^a   Schreiber, Stuart L ^a,d   Wagner, Bridget K ^a  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HARVARD UNIVERSITY   (United States)

^c ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^d HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2 INHIBITOR; GW 8510; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; GW8510; INDOLE DERIVATIVE; PROTEIN MDM2;

ANIMAL CELL; ARTICLE; CELL CYCLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; GENE; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; INS2 GENE; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CYTOLOGY; DNA RESPONSIVE ELEMENT; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MIDDLE AGED; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ANIMALS; CELL CYCLE; CELL LINE; GLUCAGON-SECRETING CELLS; HUMANS; INDOLES; INSULIN; MICE; MIDDLE AGED; MODELS, BIOLOGICAL; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-MDM2; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84855361818     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028808     Document Type: Article

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