Generation and regeneration of cells of the liver and pancreas

Science

Volumn 322, Issue 5907, 2008, Pages 1490-1494

  Zaret, Kenneth S ^a   Grompe, Markus ^b  

^a FOX CHASE CANCER CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; UVOMORULIN;

CELL ORGANELLE; DIABETES; GENETIC ANALYSIS; MODEL;

CELL DIFFERENTIATION; CELL REGENERATION; EMBRYONAL TISSUE; INSULIN DEPENDENT DIABETES MELLITUS; LIVER CELL; LIVER DEVELOPMENT; LIVER FAILURE; MESODERM; MORPHOGENESIS; NONHUMAN; ORGANOGENESIS; PANCREAS CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; REVIEW; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; CELL TRANSDIFFERENTIATION; ENDODERM; HEPATOCYTES; HUMANS; INSULIN-SECRETING CELLS; LIVER; LIVER REGENERATION; MORPHOGENESIS; ORGANOGENESIS; PANCREAS; REGENERATION; SIGNAL TRANSDUCTION; STEM CELLS; TRANSCRIPTION FACTORS;

VERTEBRATA;

EID: 57349112286     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1161431     Document Type: Review

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82. We apologize to many in the field whose work we could not cite because of space constraints. We thank D. Freedman-Cass for comments and E. Pytko for help in preparing the manuscript. K.S.Z. is supported by NIH grants R37 GM36477, U01 DK072503, and P30CA06927, and M.G. by grants U01 DK072477 and ROI DK05192 and Juvenile Diabetes Research Foundation grant 18508680-36749. The authors have patents pending related to the work in this article. M.G. is a cofounder of DNA Repair Company and the founder of Yecuris and has equities in both. K.S.Z. is on a scientific advisory board for Johnson and Johnson.