Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages

Cell Stem Cell

Volumn 14, Issue 2, 2014, Pages 228-236

  Li, Ke ^a   Zhu, Saiyong ^a   Russ, Holger A ^b   Xu, Shaohua ^a   Xu, Tao ^a   Zhang, Yu ^a   Ma, Tianhua ^a   Hebrok, Matthias ^b   Ding, Sheng ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR LIBRARY;

ANIMAL; ANIMAL EMBRYO; CELL DIFFERENTIATION; CELL LINEAGE; CYTOLOGY; DRUG EFFECTS; ENDODERM; FIBROBLAST; METABOLISM; MOLECULAR LIBRARY; MOUSE; NUCLEAR REPROGRAMMING; PANCREAS; PANCREAS ISLET BETA CELL; PHARMACOLOGY; PLURIPOTENT STEM CELL;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CELLULAR REPROGRAMMING; EMBRYO, MAMMALIAN; ENDODERM; FIBROBLASTS; INDUCED PLURIPOTENT STEM CELLS; INSULIN-SECRETING CELLS; MICE; PANCREAS; SMALL MOLECULE LIBRARIES;

EID: 84893777704     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2014.01.006     Document Type: Article

References (14)

1. K.A. D'Amour, A.G. Bang, S. Eliazer, O.G. Kelly, A.D. Agulnick, N.G. Smart, M.A. Moorman, E. Kroon, M.K. Carpenter, and E.E. Baetge Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells Nat. Biotechnol. 24 2006 1392 1401
2. J.A. Efe, S. Hilcove, J. Kim, H. Zhou, K. Ouyang, G. Wang, J. Chen, and S. Ding Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy Nat. Cell Biol. 13 2011 215 222
3. S. Ferber, A. Halkin, H. Cohen, I. Ber, Y. Einav, I. Goldberg, I. Barshack, R. Seijffers, J. Kopolovic, N. Kaiser, and A. Karasik Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia Nat. Med. 6 2000 568 572
4. W. Jiang, Y. Shi, D. Zhao, S. Chen, J. Yong, J. Zhang, T. Qing, X. Sun, P. Zhang, and M. Ding et al. In vitro derivation of functional insulin-producing cells from human embryonic stem cells Cell Res. 17 2007 333 344
5. O.G. Kelly, M.Y. Chan, L.A. Martinson, K. Kadoya, T.M. Ostertag, K.G. Ross, M. Richardson, M.K. Carpenter, K.A. D'Amour, and E. Kroon et al. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells Nat. Biotechnol. 29 2011 750 756
6. J. Kim, J.A. Efe, S. Zhu, M. Talantova, X. Yuan, S. Wang, S.A. Lipton, K. Zhang, and S. Ding Direct reprogramming of mouse fibroblasts to neural progenitors Proc. Natl. Acad. Sci. USA 108 2011 7838 7843
7. F. Li, Z. He, Y. Li, P. Liu, F. Chen, M. Wang, H. Zhu, X. Ding, K.J. Wangensteen, Y. Hu, and X. Wang Combined activin A/LiCl/Noggin treatment improves production of mouse embryonic stem cell-derived definitive endoderm cells J. Cell. Biochem. 112 2011 1022 1034
8. J. Li, N.F. Huang, J. Zou, T.J. Laurent, J.C. Lee, J. Okogbaa, J.P. Cooke, and S. Ding Conversion of human fibroblasts to functional endothelial cells by defined factors Arterioscler. Thromb. Vasc. Biol. 33 2013 1366 1375
9. S.B. Nelson, A.E. Schaffer, and M. Sander The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells Development 134 2007 2491 2500
10. M.C. Nostro, F. Sarangi, S. Ogawa, A. Holtzinger, B. Corneo, X. Li, S.J. Micallef, I.H. Park, C. Basford, and M.B. Wheeler et al. Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells Development 138 2011 861 871
11. A. Rezania, J.E. Bruin, J. Xu, K. Narayan, J.K. Fox, J.J. O'Neil, and T.J. Kieffer Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo Stem Cells 31 2013 2432 2442
12. I.S. Schroeder, A. Rolletschek, P. Blyszczuk, G. Kania, and A.M. Wobus Differentiation of mouse embryonic stem cells to insulin-producing cells Nat. Protoc. 1 2006 495 507
13. M. Wernig, C.J. Lengner, J. Hanna, M.A. Lodato, E. Steine, R. Foreman, J. Staerk, S. Markoulaki, and R. Jaenisch A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types Nat. Biotechnol. 26 2008 916 924
14. Q. Zhou, J. Brown, A. Kanarek, J. Rajagopal, and D.A. Melton In vivo reprogramming of adult pancreatic exocrine cells to beta-cells Nature 455 2008 627 632