-
1
-
-
0034708832
-
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phos-phorylation of Ser(307)
-
Aguirre V, Uchida T, Yenush L, Davis R, White MF (2000) The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phos-phorylation of Ser(307). J Biol Chem 275:9047-9054
-
(2000)
J Biol Chem
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
2
-
-
0015087047
-
Aging and diabetes
-
Andres R (1971) Aging and diabetes. Med Clin North Am 55:835-846
-
(1971)
Med Clin North Am
, vol.55
, pp. 835-846
-
-
Andres, R.1
-
3
-
-
84881661464
-
The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer
-
Anisimov VN, Bartke A (2013) The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol 87(3):201-223
-
(2013)
Crit Rev Oncol Hematol
, vol.87
, Issue.3
, pp. 201-223
-
-
Anisimov, V.N.1
Bartke, A.2
-
4
-
-
84911457047
-
Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging
-
Arum O, Boparai RK, Saleh JK, Wang F, Dirks AL, Turner JG, Kopchick JJ, Liu JL, Khardori RK, Bartke A (2014) Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging. Aging Cell 13:981-1000
-
(2014)
Aging Cell
, vol.13
, pp. 981-1000
-
-
Arum, O.1
Boparai, R.K.2
Saleh, J.K.3
Wang, F.4
Dirks, A.L.5
Turner, J.G.6
Kopchick, J.J.7
Liu, J.L.8
Khardori, R.K.9
Bartke, A.10
-
5
-
-
0035515278
-
Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans
-
Bachmann OP, Dahl DB, Brechtel K, Machann J, Haap M, Maier T, Loviscach M, Stumvoll M, Claussen CD, Schick F, Haring HU, Jacob S (2001) Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes 50:2579-2584
-
(2001)
Diabetes
, vol.50
, pp. 2579-2584
-
-
Bachmann, O.P.1
Dahl, D.B.2
Brechtel, K.3
Machann, J.4
Haap, M.5
Maier, T.6
Loviscach, M.7
Stumvoll, M.8
Claussen, C.D.9
Schick, F.10
Haring, H.U.11
Jacob, S.12
-
6
-
-
0242490056
-
Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice
-
Bartke A (2003) Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. Neuroendocrinology 78:210-216
-
(2003)
Neuroendocrinology
, vol.78
, pp. 210-216
-
-
Bartke, A.1
-
7
-
-
0035936147
-
Extending the lifespan of long-lived mice
-
Bartke A, Wright JC, Mattison JA, Ingram DK, Miller RA, Roth GS (2001) Extending the lifespan of long-lived mice. Nature 414:412
-
(2001)
Nature
, vol.414
-
-
Bartke, A.1
Wright, J.C.2
Mattison, J.A.3
Ingram, D.K.4
Miller, R.A.5
Roth, G.S.6
-
8
-
-
84878473064
-
Somatotropic signaling: Trade-offs between growth, reproductive development, and longevity
-
Bartke A, Sun LY, Longo V (2013) Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev 93:571-598
-
(2013)
Physiol Rev
, vol.93
, pp. 571-598
-
-
Bartke, A.1
Sun, L.Y.2
Longo, V.3
-
9
-
-
84869444066
-
Insulin resistance and aging: A cause or a protective response?
-
Barzilai N, Ferrucci L (2012) Insulin resistance and aging: a cause or a protective response? J Gerontol A Biol Sci Med Sci 67:1329-1331
-
(2012)
J Gerontol a Biol Sci Med Sci
, vol.67
, pp. 1329-1331
-
-
Barzilai, N.1
Ferrucci, L.2
-
10
-
-
84861885929
-
The critical role of metabolic pathways in aging
-
Barzilai N, Huffman DM, Muzumdar RH, Bartke A (2012) The critical role of metabolic pathways in aging. Diabetes 61(6):1315-1322. http://doi.org/10.2337/db11-1300
-
(2012)
Diabetes
, vol.61
, Issue.6
, pp. 1315-1322
-
-
Barzilai, N.1
Huffman, D.M.2
Muzumdar, R.H.3
Bartke, A.4
-
11
-
-
77950532905
-
Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism
-
Belgardt BF, Mauer J, Wunderlich FT, Ernst MB, Pal M, Spohn G, Bronneke HS, Brodesser S, Hampel B, Schauss AC, Bruning JC (2010) Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc Natl Acad Sci U S A 107(13):6028-6033
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.13
, pp. 6028-6033
-
-
Belgardt, B.F.1
Mauer, J.2
Wunderlich, F.T.3
Ernst, M.B.4
Pal, M.5
Spohn, G.6
Bronneke, H.S.7
Brodesser, S.8
Hampel, B.9
Schauss, A.C.10
Bruning, J.C.11
-
12
-
-
0034881391
-
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
-
Berg AH, Combs TP, Du X, Brownlee M, Scherer PE (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947-953
-
(2001)
Nat Med
, vol.7
, pp. 947-953
-
-
Berg, A.H.1
Combs, T.P.2
Du, X.3
Brownlee, M.4
Scherer, P.E.5
-
13
-
-
74049103564
-
Two-year body composition analyses of long-lived GHR null mice
-
Berryman DE, List EO, Palmer AJ, Chung MY, Wright-Piekarski J, Lubbers E, O'Connor P, Okada S, Kopchick JJ (2010) Two-year body composition analyses of long-lived GHR null mice. J Gerontol A Biol Sci Med Sci 65:31-40
-
(2010)
J Gerontol a Biol Sci Med Sci
, vol.65
, pp. 31-40
-
-
Berryman, D.E.1
List, E.O.2
Palmer, A.J.3
Chung, M.Y.4
Wright-Piekarski, J.5
Lubbers, E.6
O'connor, P.7
Okada, S.8
Kopchick, J.J.9
-
14
-
-
80054852170
-
Hypothalamic AMP-activated protein kinase as a media-tor of whole body energy balance
-
Martmez B, de Morentin P, Gonzalez CR, Saha AK, Martins L, Dieguez C, Vidal-Puig A, Tena-Sempere M, Lopez M (2011) Hypothalamic AMP-activated protein kinase as a media-tor of whole body energy balance. Rev Endocr Metab Disord 12(3):127-140
-
(2011)
Rev Endocr Metab Disord
, vol.12
, Issue.3
, pp. 127-140
-
-
Martmez, B.1
De Morentin, P.2
Gonzalez, C.R.3
Saha, A.K.4
Martins, L.5
Dieguez, C.6
Vidal-Puig, A.7
Tena-Sempere, M.8
Lopez, M.9
-
15
-
-
84910127339
-
Brain iron overload, insulin resistance and cognitive performance in obese subjects: A preliminary MRI case-control study
-
Blasco G, Puig J, Daunis-i-Estradella J, Molina X, Xifra G, Fernadez-Aranda F, Pedraza S, Wifredo R, Portero-Otm M, Fernadez-Real JM (2014) Brain iron overload, insulin resistance and cognitive performance in obese subjects: a preliminary MRI case-control study. Diabetes Care 37:3076-3083
-
(2014)
Diabetes Care
, vol.37
, pp. 3076-3083
-
-
Blasco, G.1
Puig, J.2
Daunis-I-Estradella, J.3
Molina, X.4
Xifra, G.5
Fernadez-Aranda, F.6
Pedraza, S.7
Wifredo, R.8
Portero-Otm, M.9
Fernadez-Real, J.M.10
-
16
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue
-
Bluher M, Kahn B, Kahn CR (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299:572-574
-
(2003)
Science
, vol.299
, pp. 572-574
-
-
Bluher, M.1
Kahn, B.2
Kahn, C.R.3
-
17
-
-
0029084869
-
Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes
-
Boden G, Chen X (1995) Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes. J Clin Invest 96:1261-1268
-
(1995)
J Clin Invest
, vol.96
, pp. 1261-1268
-
-
Boden, G.1
Chen, X.2
-
18
-
-
33646731782
-
Targeted dis-ruption of growth hormone receptor interferes with the beneficial actions of calorie restric-tion
-
Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A (2006) Targeted dis-ruption of growth hormone receptor interferes with the beneficial actions of calorie restric-tion. Proc Natl Acad Sci U S A 103:7901-7905
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 7901-7905
-
-
Bonkowski, M.S.1
Rocha, J.S.2
Masternak, M.M.3
Al Regaiey, K.A.4
Bartke, A.5
-
19
-
-
84887212549
-
Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity
-
Bonkowski MS, Dominici FP, Arum O, Rocha JS, Al Regaiey KA, Westbrook R, Spong A, Panici J, Masternak MM, Kopchick JJ, Bartke A (2009) Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. PLoS One 4:e4567
-
(2009)
Plos One
, vol.4
-
-
Bonkowski, M.S.1
Dominici, F.P.2
Arum, O.3
Rocha, J.S.4
Al Regaiey, K.A.5
Westbrook, R.6
Spong, A.7
Panici, J.8
Masternak, M.M.9
Kopchick, J.J.10
Bartke, A.11
-
20
-
-
39549122799
-
Remodeling phenotype of human subcutaneous adipose tissue macrophages
-
Bourlier V, Zakaroff-Girard A, Miranville A, De Barros S, Maumus M, Sengenes C, Galitzky J, Lafontan M, Karpe F, Frayn KN, Bouloumie A (2008) Remodeling phenotype of human subcutaneous adipose tissue macrophages. Circulation 117:806-815
-
(2008)
Circulation
, vol.117
, pp. 806-815
-
-
Bourlier, V.1
Zakaroff-Girard, A.2
Miranville, A.3
De Barros, S.4
Maumus, M.5
Sengenes, C.6
Galitzky, J.7
Lafontan, M.8
Karpe, F.9
Frayn, K.N.10
Bouloumie, A.11
-
21
-
-
84885828394
-
Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 induce different age-related metabolic profiles revealed by 1H-NMR spectroscopy in urine and feces of mice
-
Brasili E, Mengheri E, Tomassini A, Capuani G, Roselli M, Finamore A, Sciubba F, Marini Miccheli A (2013) Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 induce different age-related metabolic profiles revealed by 1H-NMR spectroscopy in urine and feces of mice. J Nutr 143:1549-1557
-
(2013)
J Nutr
, vol.143
, pp. 1549-1557
-
-
Brasili, E.1
Mengheri, E.2
Tomassini, A.3
Capuani, G.4
Roselli, M.5
Finamore, A.6
Sciubba, F.7
Marini Miccheli, A.8
-
22
-
-
84861021850
-
GH and IGF1: Roles in energy metabolism of long-living GH mutant mice
-
Brown-Borg HM, Bartke A (2012) GH and IGF1: roles in energy metabolism of long-living GH mutant mice. J Gerontol A Biol Sci Med Sci 67:652-660
-
(2012)
J Gerontol a Biol Sci Med Sci
, vol.67
, pp. 652-660
-
-
Brown-Borg, H.M.1
Bartke, A.2
-
23
-
-
0347367048
-
Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people
-
Bruunsgaard H, Ladelund S, Pedersen AN, Schroll M, Jorgensen T, Pedersen BK (2003) Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin Exp Immunol 132:24-31
-
(2003)
Clin Exp Immunol
, vol.132
, pp. 24-31
-
-
Bruunsgaard, H.1
Ladelund, S.2
Pedersen, A.N.3
Schroll, M.4
Jorgensen, T.5
Pedersen, B.K.6
-
25
-
-
56549124437
-
Hypothalamic control of hepatic glucose production and its potential role in insulin resistance
-
Buettner C, Camacho RC (2008) Hypothalamic control of hepatic glucose production and its potential role in insulin resistance. Endocrinol Metab Clin North Am 37(4):825-840
-
(2008)
Endocrinol Metab Clin North Am
, vol.37
, Issue.4
, pp. 825-840
-
-
Buettner, C.1
Camacho, R.C.2
-
26
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11:183-190
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
Shoelson, S.E.7
-
28
-
-
0023222361
-
Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes
-
Caro JF, Sinha MK, Raju SM, Ittoop O, Pories WJ, Flickinger EG, Meelheim D, Dohm GL (1987) Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes. J Clin Invest 79:1330-1337
-
(1987)
J Clin Invest
, vol.79
, pp. 1330-1337
-
-
Caro, J.F.1
Sinha, M.K.2
Raju, S.M.3
Ittoop, O.4
Pories, W.J.5
Flickinger, E.G.6
Meelheim, D.7
Dohm, G.L.8
-
29
-
-
84926215116
-
Secular changes in prediabetes indicators among older-adult Americans, 1999-2010
-
Caspersen CJ, Thomas GD, Beckles GL, Bullard KM (2015) Secular changes in prediabetes indicators among older-adult Americans, 1999-2010. Am J Prev Med 48:253-263
-
(2015)
Am J Prev Med
, vol.48
, pp. 253-263
-
-
Caspersen, C.J.1
Thomas, G.D.2
Beckles, G.L.3
Bullard, K.M.4
-
30
-
-
0030907213
-
Cytokine antagonists in aged subjects and their relation with cellular immunity
-
Catania A, Airaghi L, Motta P, Manfredi MG, Annoni G, Pettenati C, Brambilla F, Lipton JM (1997) Cytokine antagonists in aged subjects and their relation with cellular immunity. J Gerontol A Biol Sci Med Sci 52:B93-B97
-
(1997)
J Gerontol a Biol Sci Med Sci
, vol.52
-
-
Catania, A.1
Airaghi, L.2
Motta, P.3
Manfredi, M.G.4
Annoni, G.5
Pettenati, C.6
Brambilla, F.7
Lipton, J.M.8
-
31
-
-
84879391795
-
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
-
Chang HC, Guarente L (2013) SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell 153:1448-1460
-
(2013)
Cell
, vol.153
, pp. 1448-1460
-
-
Chang, H.C.1
Guarente, L.2
-
32
-
-
0021933723
-
Pathogenesis of age-related glucose intol-erance in man: Insulin resistance and decreased beta-cell function
-
Chen M, Bergman RN, Pacini G, Porte D (1985) Pathogenesis of age-related glucose intol-erance in man: Insulin resistance and decreased beta-cell function. J Clin Endocrinol Metab 60:13-20
-
(1985)
J Clin Endocrinol Metab
, vol.60
, pp. 13-20
-
-
Chen, M.1
Bergman, R.N.2
Pacini, G.3
Porte, D.4
-
33
-
-
84922222735
-
Type 2 diabetes and antidia-betic medications in relations to dementia and diagnosis
-
Cheng C, Lin CH, Tsai YW, Tsai CJ, Chou PH, Lan TH (2014) Type 2 diabetes and antidia-betic medications in relations to dementia and diagnosis. J Gerontol A Biol Sci Med Sci 69(10):1299-1305
-
(2014)
J Gerontol a Biol Sci Med Sci
, vol.69
, Issue.10
, pp. 1299-1305
-
-
Cheng, C.1
Lin, C.H.2
Tsai, Y.W.3
Tsai, C.J.4
Chou, P.H.5
Lan, T.H.6
-
34
-
-
81355151398
-
Insulin resistance and pathological brain ageing
-
Cholerton B, Baker LD, Craft S (2011) Insulin resistance and pathological brain ageing. Diabet Med 28:1463-1475
-
(2011)
Diabet Med
, vol.28
, pp. 1463-1475
-
-
Cholerton, B.1
Baker, L.D.2
Craft, S.3
-
35
-
-
85027917954
-
Geriatric conditions develop in middle-aged adults with diabetes
-
Cigolle CT, Lee PG, Langa KM, Lee YY, Tian Z, Blaum CS (2011) Geriatric conditions develop in middle-aged adults with diabetes. J Gen Intern Med 26:272-279
-
(2011)
J Gen Intern Med
, vol.26
, pp. 272-279
-
-
Cigolle, C.T.1
Lee, P.G.2
Langa, K.M.3
Lee, Y.Y.4
Tian, Z.5
Blaum, C.S.6
-
36
-
-
84922666525
-
Long-acting intranasal insulin detemir improves cogni-tion for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia
-
Claxton A, Baker LD, Hanson A, Trittschuh EH, Cholerton B, Morgan A, Callaghan M, Arbuckle M, Behl C, Craft S (2015) Long-acting intranasal insulin detemir improves cogni-tion for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia. J Alzheimers Dis 44:897-906
-
(2015)
J Alzheimers Dis
, vol.44
, pp. 897-906
-
-
Claxton, A.1
Baker, L.D.2
Hanson, A.3
Trittschuh, E.H.4
Cholerton, B.5
Morgan, A.6
Callaghan, M.7
Arbuckle, M.8
Behl, C.9
Craft, S.10
-
37
-
-
0030849677
-
The association of plasma IL-6 levels with functional disability in community-dwelling elderly
-
Cohen HJ, Pieper CF, Harris T, Rao KM, Currie MS (1997) The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J Gerontol A Biol Sci Med Sci 52:M201-M208
-
(1997)
J Gerontol a Biol Sci Med Sci
, vol.52
-
-
Cohen, H.J.1
Pieper, C.F.2
Harris, T.3
Rao, K.M.4
Currie, M.S.5
-
38
-
-
62449142597
-
The role of metabolic disorders in Alzheimer's disease and vascular dementia: Two roads converged
-
Craft S (2009) The role of metabolic disorders in Alzheimer's disease and vascular dementia: two roads converged. Arch Neurol 66(3):300-305
-
(2009)
Arch Neurol
, vol.66
, Issue.3
, pp. 300-305
-
-
Craft, S.1
-
39
-
-
33750918489
-
The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes
-
Crandall J, Schade D, Ma Y, Fujimoto WY, Barrett-Connor E, Fowler S, Dagogo-Jack S, Andres R (2006) The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes. J Gerontol A Biol Sci Med Sci 61:1075-1081
-
(2006)
J Gerontol a Biol Sci Med Sci
, vol.61
, pp. 1075-1081
-
-
Crandall, J.1
Schade, D.2
Ma, Y.3
Fujimoto, W.Y.4
Barrett-Connor, E.5
Fowler, S.6
Dagogo-Jack, S.7
Res, R.8
-
40
-
-
4043159763
-
Intramuscular and liver triglycerides are increased in the elderly
-
Cree MG, Newcomer BR, Katsanos CS, Sheffield-Moore M, Chinkes D, Aarsland A, Urban R, Wolfe RR (2004) Intramuscular and liver triglycerides are increased in the elderly. J Clin Endocrinol Metab 89:3864-3871
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 3864-3871
-
-
Cree, M.G.1
Newcomer, B.R.2
Katsanos, C.S.3
Sheffield-Moore, M.4
Chinkes, D.5
Aarsland, A.6
Urban, R.7
Wolfe, R.R.8
-
41
-
-
0033968126
-
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle
-
Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarino LJ (2000) Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest 105:311-320
-
(2000)
J Clin Invest
, vol.105
, pp. 311-320
-
-
Cusi, K.1
Maezono, K.2
Osman, A.3
Pendergrass, M.4
Patti, M.E.5
Pratipanawatr, T.6
Defronzo, R.A.7
Kahn, C.R.8
Mandarino, L.J.9
-
42
-
-
0031784544
-
Tumor necrosis factor-alpha in sera of obese patients: Fall with weight loss
-
Dandona P, Weinstock R, Thusu K, Abdel-Rahman E, Aljada A, Wadden T (1998) Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. J Clin Endocrinol Metab 83:2907-2910
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 2907-2910
-
-
Dandona, P.1
Weinstock, R.2
Thusu, K.3
Abdel-Rahman, E.4
Aljada, A.5
Wadden, T.6
-
43
-
-
0019818758
-
Glucose intolerance and aging
-
DeFronzo RA (1981) Glucose intolerance and aging. Diabetes Care 4:493-501
-
(1981)
Diabetes Care
, vol.4
, pp. 493-501
-
-
Defronzo, R.A.1
-
44
-
-
64649104158
-
Banting lecture. From the triumvirate to the ominous octet: A new para-digm for the treatment of type 2 diabetes mellitus
-
DeFronzo RA (2009) Banting lecture. From the triumvirate to the ominous octet: a new para-digm for the treatment of type 2 diabetes mellitus. Diabetes 58:773-795
-
(2009)
Diabetes
, vol.58
, pp. 773-795
-
-
Defronzo, R.A.1
-
45
-
-
79953232077
-
Pioglitazone for diabetes prevention in impaired glucose tolerance
-
DeFronzo RA, Tripathy D, Schwenke DC, Banerji M, Bray GA, Buchanan TA, Clement SC, Henry RR, Hodis HN, Kitabchi AE, Mack WJ, Mudaliar S, Ratner RE, Williams K, Stentz FB, Musi N, Reaven PD (2011) Pioglitazone for diabetes prevention in impaired glucose tolerance. N Engl J Med 364:1104-1115
-
(2011)
N Engl J Med
, vol.364
, pp. 1104-1115
-
-
Defronzo, R.A.1
Tripathy, D.2
Schwenke, D.C.3
Banerji, M.4
Bray, G.A.5
Buchanan, T.A.6
Clement, S.C.7
Henry, R.R.8
Hodis, H.N.9
Kitabchi, A.E.10
Mack, W.J.11
Mudaliar, S.12
Ratner, R.E.13
Williams, K.14
Stentz, F.B.15
Musi, N.16
Reaven, P.D.17
-
46
-
-
23644446750
-
Expression of CD68 and macrophage che- moattractant protein-1 genes in human adipose and muscle tissues: Association with cytokine expression, insulin resistance, and reduction by pioglitazone
-
Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM, Ranganathan Peterson CA, McGehee RE, Kern P (2005) Expression of CD68 and macrophage che- moattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes 54: 2305-2313
-
(2005)
Diabetes
, vol.54
, pp. 2305-2313
-
-
Di Gregorio, G.B.1
Yao-Borengasser, A.2
Rasouli, N.3
Varma, V.4
Lu, T.5
Miles, L.M.6
Ranganathan Peterson, C.A.7
McGehee, R.E.8
Kern, P.9
-
47
-
-
15444359998
-
Predictors of progression from impaired glucose tolerance to NIDDM: An analysis of six prospective studies
-
Edelstein SL, Knowler WC, Bain RP, Andres R, Barrett-Connor EL, Dowse GK, Haffner SM, Pettitt DJ, Sorkin JD, Muller DC, Collins VR, Hamman RF (1997) Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Diabetes 46(4):701-710
-
(1997)
Diabetes
, vol.46
, Issue.4
, pp. 701-710
-
-
Edelstein, S.L.1
Knowler, W.C.2
Bain, R.P.3
Res, R.4
Barrett-Connor, E.L.5
Dowse, G.K.6
Haffner, S.M.7
Pettitt, D.J.8
Sorkin, J.D.9
Muller, D.C.10
Collins, V.R.11
Hamman, R.F.12
-
48
-
-
0033923833
-
Carbohydrate metabolism in the elderly
-
Elahi D, Muller DC (2000) Carbohydrate metabolism in the elderly. Eur J Clin Nutr 54(Suppl 3):S112-S120
-
(2000)
Eur J Clin Nutr
, vol.54
, Issue.3
-
-
Elahi, D.1
Muller, D.C.2
-
49
-
-
84875331396
-
Duration of rapamycin treatment has differential effects on metabolism in mice
-
Fang Y, Westbrook R, Hill C, Boparai RK, Arum O, Spong A, Wang F, Javors MA, Chen J, Sun LY, Bartke A (2013) Duration of rapamycin treatment has differential effects on metabolism in mice. Cell Metab 17:456-462
-
(2013)
Cell Metab
, vol.17
, pp. 456-462
-
-
Fang, Y.1
Westbrook, R.2
Hill, C.3
Boparai, R.K.4
Arum, O.5
Spong, A.6
Wang, F.7
Javors, M.A.8
Chen, J.9
Sun, L.Y.10
Bartke, A.11
-
50
-
-
27144450970
-
Insulin-sensitive protein kinases (Atypical protein kinase C and protein kinase B/Akt): Actions and defects in obesity and type II diabetes
-
Farese RV, Sajan MP, Standaert ML (2005) Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes. Exp Biol Med (Maywood) 230:593-605
-
(2005)
Exp Biol Med (Maywood)
, vol.230
, pp. 593-605
-
-
Farese, R.V.1
Sajan, M.P.2
Standaert, M.L.3
-
52
-
-
0031762908
-
Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid
-
Fried SK, Bunkin DA, Greenberg AS (1998) Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83:847-850
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 847-850
-
-
Fried, S.K.1
Bunkin, D.A.2
Greenberg, A.S.3
-
53
-
-
0036846236
-
Metabolic effects of visceral fat accumulation in type 2 diabetes
-
Gastaldelli A, Miyazaki Y, Pettiti M, Matsuda M, Mahankali S, Santini E, DeFronzo RA, Ferrannini E (2002) Metabolic effects of visceral fat accumulation in type 2 diabetes. J Clin Endocrinol Metab 87:5098-5103
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 5098-5103
-
-
Gastaldelli, A.1
Miyazaki, Y.2
Pettiti, M.3
Matsuda, M.4
Mahankali, S.5
Santini, E.6
Defronzo, R.A.7
Ferrannini, E.8
-
54
-
-
0032104120
-
Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance
-
Garvey WT, Maianu L, Zhu JH, Brechtel-Hook G, Wallace P, Baron AD (1998) Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. J Clin Invest 101:2377-2386
-
(1998)
J Clin Invest
, vol.101
, pp. 2377-2386
-
-
Garvey, W.T.1
Maianu, L.2
Zhu, J.H.3
Brechtel-Hook, G.4
Wallace, P.5
Baron, A.D.6
-
55
-
-
80052830501
-
Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance
-
Ghosh S, Lertwattanarak R, Lefort N, Molina-Carrion M, Joya-Galeana J, Bowen BP, Garduno- Garcia Jde J, Abdul-Ghani M, Richardson A, DeFronzo RA, Mandarino L, Van Remmen H, Musi N (2011) Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance. Diabetes 60:2051-2060
-
(2011)
Diabetes
, vol.60
, pp. 2051-2060
-
-
Ghosh, S.1
Lertwattanarak, R.2
Lefort, N.3
Molina-Carrion, M.4
Joya-Galeana, J.5
Bowen, B.P.6
Garduno- Garcia Jde, J.7
Abdul-Ghani, M.8
Richardson, A.9
Defronzo, R.A.10
Mandarino, L.11
Van Remmen, H.12
Musi, N.13
-
56
-
-
84922443679
-
Elevated muscle TLR4 expression and metabolic endo- toxemia in human aging
-
Ghosh S, Lertwattanarak R, Garduno Jde J, Galeana JJ, Li J, Zamarripa F, Lancaster JL, Mohan S, Hussey S, Musi N (2015) Elevated muscle TLR4 expression and metabolic endo- toxemia in human aging. J Gerontol A Biol Sci Med Sci 70:232-246
-
(2015)
J Gerontol a Biol Sci Med Sci
, vol.70
, pp. 232-246
-
-
Ghosh, S.1
Lertwattanarak, R.2
Garduno Jde, J.3
Galeana, J.J.4
Li, J.5
Zamarripa, F.6
Lancaster, J.L.7
Mohan, S.8
Hussey, S.9
Musi, N.10
-
57
-
-
84868512647
-
Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice
-
Giani JF, Miquet JG, Munoz MC et al (2012) Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice. Growth Horm IGF Res 22:224-233
-
(2012)
Growth Horm IGF Res
, vol.22
, pp. 224-233
-
-
Giani, J.F.1
Miquet, J.G.2
Munoz, M.C.3
-
58
-
-
0020649489
-
Glucose uptake and insulin sensitivity in rat muscle: Changes during 3-96 weeks of age
-
Goodman MN, Dluz SM, McElaney MA, Belur E, Ruderman NB (1983) Glucose uptake and insulin sensitivity in rat muscle: changes during 3-96 weeks of age. Am J Physiol 244:E93-E100
-
(1983)
Am J Physiol
, vol.244
-
-
Goodman, M.N.1
Dluz, S.M.2
McElaney, M.A.3
Belur, E.4
Ruderman, N.B.5
-
59
-
-
84875412120
-
Mitochondrial deficiency is associated with insulin resistance
-
Goodpaster BH (2013) Mitochondrial deficiency is associated with insulin resistance. Diabetes 62(4):1032-1035
-
(2013)
Diabetes
, vol.62
, Issue.4
, pp. 1032-1035
-
-
Goodpaster, B.H.1
-
60
-
-
0034112806
-
Intramuscular lipid content is increased in obesity and decreased by weight loss
-
Goodpaster BH, Theriault R, Watkins SC, Kelley DE (2000) Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism 49:467-472
-
(2000)
Metabolism
, vol.49
, pp. 467-472
-
-
Goodpaster, B.H.1
Theriault, R.2
Watkins, S.C.3
Kelley, D.E.4
-
61
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente L, Kenyon C (2000) Genetic pathways that regulate ageing in model organisms. Nature 408(6809):255-262
-
(2000)
Nature
, vol.408
, Issue.6809
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
62
-
-
0019084534
-
Age-dependent development of insulin resis-tance of soleus muscle in genetically obese (Ob/ob) mice
-
Grundleger ML, Godbole VY, Thenen SW (1980) Age-dependent development of insulin resis-tance of soleus muscle in genetically obese (ob/ob) mice. Am J Physiol 239:E363-E371
-
(1980)
Am J Physiol
, vol.239
, pp. E363-E371
-
-
Grundleger, M.L.1
Godbole, V.Y.2
Thenen, S.W.3
-
63
-
-
0035133331
-
Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells
-
Hajduch E, Balendran A, Batty IH, Litherland GJ, Blair AS, Downes CP, Hundal HS (2001) Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. Diabetologia 44:173-183
-
(2001)
Diabetologia
, vol.44
, pp. 173-183
-
-
Hajduch, E.1
Balendran, A.2
Batty, I.H.3
Litherland, G.J.4
Blair, A.S.5
Downes, C.P.6
Hundal, H.S.7
-
64
-
-
33845596500
-
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism
-
Handschin C, Speigelman BM (2006) Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev 27(7):728-735
-
(2006)
Endocr Rev
, vol.27
, Issue.7
, pp. 728-735
-
-
Handschin, C.1
Speigelman, B.M.2
-
65
-
-
0015383617
-
Free radical theory of aging: Dietary implications
-
Harman D (1972) Free radical theory of aging: dietary implications. Am J Clin Nutr 25(8):839-843
-
(1972)
Am J Clin Nutr
, vol.25
, Issue.8
, pp. 839-843
-
-
Harman, D.1
-
66
-
-
0031897103
-
Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. Adults. The third national health and nutrition examination survey, 1988-1994
-
Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR, Wiedmeyer HM, Byrd-Holt DD (1998) Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The third national health and nutrition examination survey, 1988-1994. Diabetes Care 21:518-524
-
(1998)
Diabetes Care
, vol.21
, pp. 518-524
-
-
Harris, M.I.1
Flegal, K.M.2
Cowie, C.C.3
Eberhardt, M.S.4
Goldstein, D.E.5
Little, R.R.6
Wiedmeyer, H.M.7
Byrd-Holt, D.D.8
-
67
-
-
0001001689
-
Effects of food restriction on aging: Separation of food intake and adiposity
-
Harrison DE, Archer JR, Astle CM (1984) Effects of food restriction on aging: separation of food intake and adiposity. Proc Natl Acad Sci U S A 81:1835-1838
-
(1984)
Proc Natl Acad Sci U S A
, vol.81
, pp. 1835-1838
-
-
Harrison, D.E.1
Archer, J.R.2
Astle, C.M.3
-
68
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392-395
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
Pahor, M.11
Javors, M.A.12
Fernandez, E.13
Miller, R.A.14
-
69
-
-
84959881102
-
Inflammatory and glutamatergic homeo-stasis are involved in successful aging
-
Hascup ER, Wang F, Kopchick JJ, Bartke A (2015) Inflammatory and glutamatergic homeo-stasis are involved in successful aging. J Gerontol A Biol Sci Med Sci Pii: doi:10.1093/gerona/glv010.PubMed PMID:25711529
-
(2015)
J Gerontol a Biol Sci Med Sci
-
-
Hascup, E.R.1
Wang, F.2
Kopchick, J.J.3
Bartke, A.4
-
70
-
-
0031849916
-
Evidence for 5' amp- activated protein kinase mediation of the effect of muscle contraction on glucose transport
-
Hayashi T, Hirshman MF, Kurth EJ, Winder WW, Goodyear LJ (1998) Evidence for 5' amp- activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes 47:1369-1373
-
(1998)
Diabetes
, vol.47
, pp. 1369-1373
-
-
Hayashi, T.1
Hirshman, M.F.2
Kurth, E.J.3
Winder, W.W.4
Goodyear, L.J.5
-
71
-
-
79551607887
-
Effects of insulin on brain glucose metabolism in impaired glucose tolerance
-
Hirvonen J, Virtanen KA, Nummenmaa L, Hannukainen JC, Honka MJ, Bucci M, Nesterov SV, Parkkola R, Rinne J, Iozzo P, Nuutila P (2011) Effects of insulin on brain glucose metabolism in impaired glucose tolerance. Diabetes 60:443-447
-
(2011)
Diabetes
, vol.60
, pp. 443-447
-
-
Hirvonen, J.1
Virtanen, K.A.2
Nummenmaa, L.3
Hannukainen, J.C.4
Honka, M.J.5
Bucci, M.6
Nesterov, S.V.7
Parkkola, R.8
Rinne, J.9
Iozzo, P.10
Nuutila, P.11
-
72
-
-
84875440537
-
Deficiency" of mitochondria in muscle does not cause insulin resistance
-
Holloszy JO (2013) "Deficiency" of mitochondria in muscle does not cause insulin resistance. Diabetes 62(4):1036-1040
-
(2013)
Diabetes
, vol.62
, Issue.4
, pp. 1036-1040
-
-
Holloszy, J.O.1
-
73
-
-
65549149453
-
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice
-
Ikeno Y, Hubbard GB, Lee S et al (2009) Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci 64:522-529
-
(2009)
J Gerontol a Biol Sci Med Sci
, vol.64
, pp. 522-529
-
-
Ikeno, Y.1
Hubbard, G.B.2
Lee, S.3
-
74
-
-
84890158547
-
Do Ames dwarf and calorie-restricted mice share common effects on age-related pathology
-
Ikeno Y, Hubbard GB, Lee S et al (2013) Do Ames dwarf and calorie-restricted mice share common effects on age-related pathology? Pathobiol Aging Age Relat Dis 3. http://www.pathobiologyofaging.net/index.php/pba/article/view/20833
-
(2013)
Pathobiol Aging Age Relat Dis
, vol.3
-
-
Ikeno, Y.1
Hubbard, G.B.2
Lee, S.3
-
75
-
-
7044220612
-
A possible link between skeletal muscle mitochondrial efficiency and age-induced insulin resistance
-
Iossa S, Mollica MP, Lionetti L, Crescenzo R, Tasso R, Liverini G (2004) A possible link between skeletal muscle mitochondrial efficiency and age-induced insulin resistance. Diabetes 53:2861-2866
-
(2004)
Diabetes
, vol.53
, pp. 2861-2866
-
-
Iossa, S.1
Mollica, M.P.2
Lionetti, L.3
Crescenzo, R.4
Tasso, R.5
Liverini, G.6
-
76
-
-
0033861608
-
Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity
-
Itani SI, Zhou Q, Pories WJ, MacDonald KG, Dohm GL (2000) Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. Diabetes 49:1353-1358
-
(2000)
Diabetes
, vol.49
, pp. 1353-1358
-
-
Itani, S.I.1
Zhou, Q.2
Pories, W.J.3
Macdonald, K.G.4
Dohm, G.L.5
-
77
-
-
0020283612
-
Influence of ageing on glucose homeostasis
-
Jackson RA, Blix PM, Matthews JA, Hamling JB, Din BM, Brown DC, Belin J, Rubenstein AH, Nabarro JD (1982) Influence of ageing on glucose homeostasis. J Clin Endocrinol Metab 55:840-848
-
(1982)
J Clin Endocrinol Metab
, vol.55
, pp. 840-848
-
-
Jackson, R.A.1
Blix, P.M.2
Matthews, J.A.3
Hamling, J.B.4
Din, B.M.5
Brown, D.C.6
Belin, J.7
Rubenstein, A.H.8
Nabarro, J.D.9
-
78
-
-
84896805392
-
Elevated systolic blood pressure in male GH transgenic mice is age dependent
-
Jara A, Benner CM, Sim D, Liu X, List EO, Householder LA, Berryman DE, Kopchick JJ (2014) Elevated systolic blood pressure in male GH transgenic mice is age dependent. Endocrinology 155(3):975-986. doi:10.1210/en.2013-1899
-
(2014)
Endocrinology
, vol.155
, Issue.3
, pp. 975-986
-
-
Jara, A.1
Benner, C.M.2
Sim, D.3
Liu, X.4
List, E.O.5
Householder, L.A.6
Berryman, D.E.7
Kopchick, J.J.8
-
80
-
-
20044389885
-
Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects
-
Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H (2005) Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes 54:1692-1697
-
(2005)
Diabetes
, vol.54
, pp. 1692-1697
-
-
Karlsson, H.K.1
Zierath, J.R.2
Kane, S.3
Krook, A.4
Lienhard, G.E.5
Wallberg-Henriksson, H.6
-
81
-
-
0035023128
-
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
-
Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G (2001) Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280:E745-E751
-
(2001)
Am J Physiol Endocrinol Metab
, vol.280
-
-
Kern, P.A.1
Ranganathan, S.2
Li, C.3
Wood, L.4
Ranganathan, G.5
-
82
-
-
0345862310
-
Gene expression profiling of adipose tissue: Individual, depot- dependent, and sex-dependent variabilities
-
Klaus S, Keijer J (2004) Gene expression profiling of adipose tissue: Individual, depot- dependent, and sex-dependent variabilities. Nutrition 20:115-120
-
(2004)
Nutrition
, vol.20
, pp. 115-120
-
-
Klaus, S.1
Keijer, J.2
-
83
-
-
84903173931
-
Insulin action on brain regulates systemic metabolism and brain function
-
Kleinridders A, Ferris Ham Cai W, Kahn CR (2014) Insulin action on brain regulates systemic metabolism and brain function. Diabetes 63(7):2232-2243
-
(2014)
Diabetes
, vol.63
, Issue.7
, pp. 2232-2243
-
-
Kleinridders, A.1
Ferris Ham Cai, W.2
Kahn, C.R.3
-
84
-
-
0037034257
-
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
-
Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403
-
(2002)
N Engl J Med
, vol.346
, pp. 393-403
-
-
Knowler, W.C.1
Barrett-Connor, E.2
Fowler, S.E.3
Hamman, R.F.4
Lachin, J.M.5
Walker, E.A.6
Nathan, D.M.7
-
85
-
-
15744403834
-
Age and muscle-type modulated role of intramyocellular lipids in the progression of insulin resistance in nondiabetic Zucker rats
-
Korach-Andre M, Gounarides J, Deacon R, Beil M, Sun D, Gao J, Laurent D (2005) Age and muscle-type modulated role of intramyocellular lipids in the progression of insulin resistance in nondiabetic Zucker rats. Metabolism 54:522-528
-
(2005)
Metabolism
, vol.54
, pp. 522-528
-
-
Korach-Andre, M.1
Gounarides, J.2
Deacon, R.3
Beil, M.4
Sun, D.5
Gao, J.6
Laurent, D.7
-
86
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M (2005) Suppression of aging in mice by the hormone Klotho. Science 309:1829-1833
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
Pastor, J.V.4
Nandi, A.5
Gurnani, P.6
McGuinness, O.P.7
Chikuda Yamaguchi, M.8
Kawaguchi, H.9
Shimomura, I.10
Takayama, Y.11
Herz, J.12
Kahn, C.R.13
Rosenblatt, K.P.14
Kuro-O, M.15
-
87
-
-
0034767176
-
Effect of aging and obesity on insulin responsiveness and GLUT-4 glucose transporter content in skeletal muscle of Fischer 344 x brown Norway rats
-
Larkin LM, Reynolds TH, Supiano MA, Kahn BB, Halter JB (2001) Effect of aging and obesity on insulin responsiveness and GLUT-4 glucose transporter content in skeletal muscle of Fischer 344 x brown Norway rats. J Gerontol A Biol Sci Med Sci 56:B486-B492
-
(2001)
J Gerontol a Biol Sci Med Sci
, vol.56
-
-
Larkin, L.M.1
Reynolds, T.H.2
Supiano, M.A.3
Kahn, B.B.4
Halter, J.B.5
-
88
-
-
84870756683
-
Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise
-
Li M, Verdijk LB, Sakamoto K, Ely B, van Loon LJ, Musi N (2012) Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise. Mech Ageing Dev 133:655-664
-
(2012)
Mech Ageing Dev
, vol.133
, pp. 655-664
-
-
Li, M.1
Verdijk, L.B.2
Sakamoto, K.3
Ely, B.4
Van Loon, L.J.5
Musi, N.6
-
89
-
-
34249799917
-
The physiology of obese-hyperglycemic mice [ob/ob mice]
-
Lindstrom P (2007) The physiology of obese-hyperglycemic mice [ob/ob mice]. ScientificWorldJournal 7:666-685
-
(2007)
Scientificworldjournal
, vol.7
, pp. 666-685
-
-
Lindstrom, P.1
-
90
-
-
79958243025
-
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse
-
List EO, Sackmann-Sala L, Berryman DE, Funk K, Kelder B, Gosney ES, Okada S, Ding J, Cruz-Topete D, Kopchick JJ (2011) Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. Endocr Rev 32:356-386
-
(2011)
Endocr Rev
, vol.32
, pp. 356-386
-
-
List, E.O.1
Sackmann-Sala, L.2
Berryman, D.E.3
Funk, K.4
Kelder, B.5
Gosney, E.S.6
Okada, S.7
Ding, J.8
Cruz-Topete, D.9
Kopchick, J.J.10
-
91
-
-
84875067801
-
Adiponectin in mice with altered GH action: Links to insulin sensitivity and longevity?
-
Lubbers ER, List EO, Jara A, Sackman-Sala L et al (2013) Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity? J Endocrinol 216:363-374
-
(2013)
J Endocrinol
, vol.216
, pp. 363-374
-
-
Lubbers, E.R.1
List, E.O.2
Jara, A.3
Sackman-Sala, L.4
-
92
-
-
58149347227
-
Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
-
Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR (2008) Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 57:3239-3246
-
(2008)
Diabetes
, vol.57
, pp. 3239-3246
-
-
Lumeng, C.N.1
Delproposto, J.B.2
Westcott, D.J.3
Saltiel, A.R.4
-
93
-
-
84881347302
-
Metformin improves healthspan and lifespan in mice
-
Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R (2013) Metformin improves healthspan and lifespan in mice. Nat Commun 4:2192
-
(2013)
Nat Commun
, vol.4
-
-
Martin-Montalvo, A.1
Mercken, E.M.2
Mitchell, S.J.3
Palacios, H.H.4
Mote, P.L.5
Scheibye-Knudsen, M.6
Gomes, A.P.7
Ward, T.M.8
Minor, R.K.9
Blouin, M.J.10
Schwab, M.11
Pollak, M.12
Zhang, Y.13
Yu, Y.14
Becker, K.G.15
Bohr, V.A.16
Ingram, D.K.17
Sinclair, D.A.18
Wolf, N.S.19
Spindler, S.R.20
Bernier, M.21
De Cabo, R.22
more..
-
94
-
-
84855832253
-
Metabolic effects of intra-abdominal fat in GHRKO mice
-
Masternak MM, Bartke A, Wang F, Spong A, Gesing A, Fang Y, Salmon AB, Hughes LF, Liberati T, Boparai R, Kopchick JJ, Westbrook R (2012) Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell 11:73-81
-
(2012)
Aging Cell
, vol.11
, pp. 73-81
-
-
Masternak, M.M.1
Bartke, A.2
Wang, F.3
Spong, A.4
Gesing, A.5
Fang, Y.6
Salmon, A.B.7
Hughes, L.F.8
Liberati, T.9
Boparai, R.10
Kopchick, J.J.11
Westbrook, R.12
-
95
-
-
84884193931
-
Mechanisms of obesity-induced inflammation and insulin resistance: Insights into the emerg-ing role of nutritional strategies
-
McArdle MA, Finucane OM, Connaughton RM, McMorrow AM, Roche HM (2013) Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerg-ing role of nutritional strategies. Front Endocrinol 4:52
-
(2013)
Front Endocrinol
, vol.4
-
-
McArdle, M.A.1
Finucane, O.M.2
Connaughton, R.M.3
McMorrow, A.M.4
Roche, H.M.5
-
96
-
-
84861918690
-
Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver
-
Milanski M, Arruda AP, Coope A, Ignacio-Souza LM, Nunez CE, Roman EA, Romanatto T, Pascoal LB, Caricilli AM, Torsoni MA, Prada PO, Saad MJ, Velloso LA (2012) Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes 61:1455-1462
-
(2012)
Diabetes
, vol.61
, pp. 1455-1462
-
-
Milanski, M.1
Arruda, A.P.2
Coope, A.3
Ignacio-Souza, L.M.4
Nunez, C.E.5
Roman, E.A.6
Romanatto, T.7
Pascoal, L.B.8
Caricilli, A.M.9
Torsoni, M.A.10
Prada, P.O.11
Saad, M.J.12
Velloso, L.A.13
-
97
-
-
0019160038
-
Mitochondrial role in cell aging
-
Miquel J, Economos AC, Flemming J, Johnson JE (1980) Mitochondrial role in cell aging. Exp Gerontol 15(6):575-591
-
(1980)
Exp Gerontol
, vol.15
, Issue.6
, pp. 575-591
-
-
Miquel, J.1
Economos, A.C.2
Flemming, J.3
Johnson, J.E.4
-
98
-
-
0030735542
-
Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor- alpha, in vivo
-
Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S, Coppack SW (1997) Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor- alpha, in vivo. J Clin Endocrinol Metab 82:4196-4200
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 4196-4200
-
-
Mohamed-Ali, V.1
Goodrick, S.2
Rawesh, A.3
Katz, D.R.4
Miles, J.M.5
Yudkin, J.S.6
Klein, S.7
Coppack, S.W.8
-
99
-
-
84891885282
-
Brain atrophy in type 2 diabetes: Regional distribution and influence on cognition
-
Moran C, Phan TG, Chen J, Blizzard L, Beare R, Venn A, Munch G, Wood AG, Forbes J, Greenaway TM, Pearson S, Srikanth V (2013) Brain atrophy in type 2 diabetes: regional distribution and influence on cognition. Diabetes Care 36(12):4036-4042
-
(2013)
Diabetes Care
, vol.36
, Issue.12
, pp. 4036-4042
-
-
Moran, C.1
Phan, T.G.2
Chen, J.3
Blizzard, L.4
Beare, R.5
Venn, A.6
Munch, G.7
Wood, A.G.8
Forbes, J.9
Greenaway, T.M.10
Pearson, S.11
Srikanth, V.12
-
100
-
-
70349627817
-
Genetic and metabolic effects on skeletal muscle AMPK in young and older twins
-
Mortensen B, Poulsen P, Wegner L, Stender-Petersen KL, Ribel-Madsen R, Friedrichsen M, Birk JB, Vaag A, Wojtaszewski JF (2009) Genetic and metabolic effects on skeletal muscle AMPK in young and older twins. Am J Physiol Endocrinol Metab 297: E956-E964
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
-
-
Mortensen, B.1
Poulsen, P.2
Wegner, L.3
Stender-Petersen, K.L.4
Ribel-Madsen, R.5
Friedrichsen, M.6
Birk, J.B.7
Vaag, A.8
Wojtaszewski, J.F.9
-
101
-
-
0036065628
-
Central administration of oleic acid inhibits glucose production and food intake
-
Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L (2002) Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51(2):271-275
-
(2002)
Diabetes
, vol.51
, Issue.2
, pp. 271-275
-
-
Obici, S.1
Feng, Z.2
Morgan, K.3
Stein, D.4
Karkanias, G.5
Rossetti, L.6
-
102
-
-
84888639952
-
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
-
Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (2013) A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503:493-499
-
(2013)
Nature
, vol.503
, pp. 493-499
-
-
Okada-Iwabu, M.1
Yamauchi, T.2
Iwabu, M.3
Honma, T.4
Hamagami, K.5
Matsuda, K.6
Yamaguchi, M.7
Tanabe, H.8
Kimura-Someya, T.9
Shirouzu, M.10
Ogata, H.11
Tokuyama, K.12
Ueki, K.13
Nagano, T.14
Tanaka, A.15
Yokoyama, S.16
Kadowaki, T.17
-
103
-
-
62749144043
-
Age- related changes in body composition of bovine growth hormone transgenic mice
-
Palmer AJ, Chung MY, List EO, Walker J, Okada S, Kopchick JJ, Berryman DE (2009) Age- related changes in body composition of bovine growth hormone transgenic mice. Endocrinology 150:1353-1360
-
(2009)
Endocrinology
, vol.150
, pp. 1353-1360
-
-
Palmer, A.J.1
Chung, M.Y.2
List, E.O.3
Walker, J.4
Okada, S.5
Kopchick, J.J.6
Berryman, D.E.7
-
104
-
-
84875467633
-
Methods for assessing mitochondrial func-tion in diabetes
-
Perry CG, Kane DA, Lanza IR, Neufer PD (2013) Methods for assessing mitochondrial func-tion in diabetes. Diabetes 62(4):1041-1053
-
(2013)
Diabetes
, vol.62
, Issue.4
, pp. 1041-1053
-
-
Perry, C.G.1
Kane, D.A.2
Lanza, I.R.3
Neufer, P.D.4
-
105
-
-
0038025371
-
Mitochondrial dysfunction in the elderly: Possible role in insulin resis-tance
-
Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI (2003) Mitochondrial dysfunction in the elderly: possible role in insulin resis-tance. Science 300:1140-1142
-
(2003)
Science
, vol.300
, pp. 1140-1142
-
-
Petersen, K.F.1
Befroy, D.2
Dufour, S.3
Dziura, J.4
Ariyan, C.5
Rothman, D.L.6
Dipietro, L.7
Cline, G.W.8
Shulman, G.I.9
-
106
-
-
0029898677
-
Glucose tolerance and insulin action in healthy centenarians
-
:10.1186/ar2719, ar2719[pii],:10.1007/s12015-014-9559-3,:10.1002/jor.22029, 5 Pt
-
Paolisso G, Fambardella A, Ammendola S, D'Amore A, Balbi V, Varricchio M, M'Onofrio F (1996) Glucose tolerance and insulin action in healthy centenarians. Am J Physiol 270(5 Pt 1):E890-E894
-
(1996)
Am J Physiol
, vol.270
, Issue.1
-
-
Paolisso, G.1
Fambardella, A.2
Ammendola, S.3
D'amore, A.4
Balbi, V.5
Varricchio, M.6
M'onofrio, F.7
-
107
-
-
0024406276
-
Effect of age on glucose tolerance and glucose uptake in healthy individuals
-
Reaven GM, Chen N, Hollenbeck C, Chen YD (1989) Effect of age on glucose tolerance and glucose uptake in healthy individuals. J Am Geriatr Soc 37:735-740
-
(1989)
J am Geriatr Soc
, vol.37
, pp. 735-740
-
-
Reaven, G.M.1
Chen, N.2
Hollenbeck, C.3
Chen, Y.D.4
-
108
-
-
40349091597
-
Intranasal insulin improves cognition and modulates beta-amyloid in early AD
-
Reger MA, Watson GS, Green PS, Wilkinson CW, Baker LD, Cholerton B, Fishel MA, Plymate SR, Breitner JC, DeGroodt W, Mehta P, Craft S (2008) Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology 70:440-448
-
(2008)
Neurology
, vol.70
, pp. 440-448
-
-
Reger, M.A.1
Watson, G.S.2
Green, P.S.3
Wilkinson, C.W.4
Baker, L.D.5
Cholerton, B.6
Fishel, M.A.7
Plymate, S.R.8
Breitner, J.C.9
Degroodt, W.10
Mehta, P.11
Craft, S.12
-
109
-
-
84871830937
-
Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila
-
Rera M, Clark RI, Walker DW (2012) Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proc Natl Acad Sci USA 109:21528-21533
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 21528-21533
-
-
Rera, M.1
Clark, R.I.2
Walker, D.W.3
-
110
-
-
33846580517
-
Aging- associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
-
Reznick RM, Zong H, Li J, Morino K, Moore IK, Yu HJ, Liu ZX, Dong J, Mustard KJ, Hawley SA, Befroy D, Pypaert M, Hardie DG, Young LH, Shulman GI (2007) Aging- associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metab 5:151-156
-
(2007)
Cell Metab
, vol.5
, pp. 151-156
-
-
Reznick, R.M.1
Zong, H.2
Li, J.3
Morino, K.4
Moore, I.K.5
Yu, H.J.6
Liu, Z.X.7
Dong, J.8
Mustard, K.J.9
Hawley, S.A.10
Befroy, D.11
Pypaert, M.12
Hardie, D.G.13
Young, L.H.14
Shulman, G.I.15
-
111
-
-
84856115639
-
Hypothalamic JNK1 and IKKp activation and impaired early postnatal glucose metabolism after maternal perinatal high-fat feeding
-
Rother E, Kuschewski R, Alcazar MA, Oberthuer A, Bae-Gart I, Vohlen C, Roth B, Dotsch J Hypothalamic JNK1 and IKKp activation and impaired early postnatal glucose metabolism after maternal perinatal high-fat feeding. Endocrinology 153(2):770-781
-
Endocrinology
, vol.153
, Issue.2
, pp. 770-781
-
-
Rother, E.1
Kuschewski, R.2
Alcazar, M.A.3
Oberthuer, A.4
Bae-Gart, I.5
Vohlen, C.6
Roth, B.7
Dotsch, J.8
-
113
-
-
0032829745
-
Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects
-
Santomauro AT, Boden G, Silva ME, Rocha DM, Santos RF, Ursich MJ, Strassmann PG, Wajchenberg BL (1999) Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes 48(9):1836-1841
-
(1999)
Diabetes
, vol.48
, Issue.9
, pp. 1836-1841
-
-
Santomauro, A.T.1
Boden, G.2
Silva, M.E.3
Rocha, D.M.4
Santos, R.F.5
Ursich, M.J.6
Strassmann, P.G.7
Wajchenberg, B.L.8
-
114
-
-
84927556120
-
Aerobic exercise and other healthy lifestyle factors that influence vascular aging
-
Santos-Parker JR, LaRocca TJ, Seals DR (2014) Aerobic exercise and other healthy lifestyle factors that influence vascular aging. Adv Physiol Educ 38:296-307
-
(2014)
Adv Physiol Educ
, vol.38
, pp. 296-307
-
-
Santos-Parker, J.R.1
Larocca, T.J.2
Seals, D.R.3
-
115
-
-
84925862799
-
A heme oxygenase-1 transducer model of degenerative and developmental brain disorders
-
Schipper HM, Song W (2015) A heme oxygenase-1 transducer model of degenerative and developmental brain disorders. Int J Mol Sci 16(3):5400-5419
-
(2015)
Int J Mol Sci
, vol.16
, Issue.3
, pp. 5400-5419
-
-
Schipper, H.M.1
Song, W.2
-
116
-
-
40449142493
-
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
-
Selman C, Lingard S, Choudhury AI et al (2008) Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J 22:807-818
-
(2008)
FASEB J
, vol.22
, pp. 807-818
-
-
Selman, C.1
Lingard, S.2
Choudhury, A.I.3
-
117
-
-
79551506567
-
Brain insulin controls adipose tissue lipolysis and lipogenesis
-
Scherer T, O'Hare J, Diggs-Andrews K, Schweiger M, Cheng B, Lindtner C, Zielinski E, Vempati P, Su K, Dighe S, Milsom T, Puchowicz M, Scheja L, Zechner R, Fisher SJ, Previs SF, Buettner C (2011) Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metab 13:183-194
-
(2011)
Cell Metab
, vol.13
, pp. 183-194
-
-
Scherer, T.1
O'hare, J.2
Diggs-Andrews, K.3
Schweiger, M.4
Cheng, B.5
Lindtner, C.6
Zielinski, E.7
Vempati, P.8
Su, K.9
Dighe, S.10
Milsom, T.11
Puchowicz, M.12
Scheja, L.13
Zechner, R.14
Fisher, S.J.15
Previs, S.F.16
Buettner, C.17
-
118
-
-
0026067919
-
Age as independent determinant of glucose tolerance
-
Shimokata H, Muller DC, Fleg JL, Sorkin J, Ziemba AW, Andres R (1991) Age as independent determinant of glucose tolerance. Diabetes 40:44-51
-
(1991)
Diabetes
, vol.40
, pp. 44-51
-
-
Shimokata, H.1
Muller, D.C.2
Fleg, J.L.3
Sorkin, J.4
Ziemba, A.W.5
Res, R.6
-
119
-
-
84911002688
-
Brain insulin lowers circulating bcaa levels by inducing hepatic bcaa catabolism
-
Shin AC, Fasshauer M, Filatova N, Grundell LA, Zielinski E, Zhou JY, Scherer T, Lindtner C, White PJ, Lapworth AL, Ilkayeva O, Knippschild U, Wolf AM, Scheja L, Grove KL, Smith RD, Qian WJ, Lynch CJ, Newgard CB, Buettner C (2014) Brain insulin lowers circulating bcaa levels by inducing hepatic bcaa catabolism. Cell Metab 20:898-909
-
(2014)
Cell Metab
, vol.20
, pp. 898-909
-
-
Shin, A.C.1
Fasshauer, M.2
Filatova, N.3
Grundell, L.A.4
Zielinski, E.5
Zhou, J.Y.6
Scherer, T.7
Lindtner, C.8
White, P.J.9
Lapworth, A.L.10
Ilkayeva, O.11
Knippschild, U.12
Wolf, A.M.13
Scheja, L.14
Grove, K.L.15
Smith, R.D.16
Qian, W.J.17
Lynch, C.J.18
Newgard, C.B.19
Buettner, C.20
more..
-
120
-
-
0042266366
-
Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity
-
Short KR, Vittone JL, Bigelow ML, Proctor DN, Rizza RA, Coenen-Schimke JM, Nair KS (2003) Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes 52:1888-1896
-
(2003)
Diabetes
, vol.52
, pp. 1888-1896
-
-
Short, K.R.1
Vittone, J.L.2
Bigelow, M.L.3
Proctor, D.N.4
Rizza, R.A.5
Coenen-Schimke, J.M.6
Nair, K.S.7
-
121
-
-
0026070429
-
Body weight and longevity in genetically obese and non-obese mice fed fat-modified diets
-
Smith BA, Edwards MS, Ballachey BE, Cramer DA, Sutherland TM (1991) Body weight and longevity in genetically obese and non-obese mice fed fat-modified diets. Growth Dev Aging 55:81-89
-
(1991)
Growth Dev Aging
, vol.55
, pp. 81-89
-
-
Smith, B.A.1
Edwards, M.S.2
Ballachey, B.E.3
Cramer, D.A.4
Sutherland, T.M.5
-
122
-
-
47149104321
-
Effects of aging on basal fat oxidation in obese humans
-
Solomon TP, Marchetti CM, Krishnan RK, Gonzalez F, Kirwan JP (2008) Effects of aging on basal fat oxidation in obese humans. Metabolism 57:1141-1147
-
(2008)
Metabolism
, vol.57
, pp. 1141-1147
-
-
Solomon, T.P.1
Marchetti, C.M.2
Krishnan, R.K.3
Gonzalez, F.4
Kirwan, J.P.5
-
123
-
-
67650719713
-
Expression of pIRS-1 (S312 and S616) is elevated in MCI and AD and correlates with cognitive impairment and neurofibrillary pathology
-
Talbot K, Han L, Schneider JA, Wilson RS, Bennett DA, Arnold SE (2006) Expression of pIRS-1 (S312 and S616) is elevated in MCI and AD and correlates with cognitive impairment and neurofibrillary pathology. Alzheimers Dement 2:S54
-
(2006)
Alzheimers Dement
, vol.2
-
-
Talbot, K.1
Han, L.2
Schneider, J.A.3
Wilson, R.S.4
Bennett, D.A.5
Arnold, S.E.6
-
124
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
Tartar M, Barke A, Antebi A (2003) The endocrine regulation of aging by insulin-like signals. Science 299(5611):1346-1351
-
(2003)
Science
, vol.299
, Issue.5611
, pp. 1346-1351
-
-
Tartar, M.1
Barke, A.2
Antebi, A.3
-
125
-
-
78349299099
-
Fat tissue, aging, and cellular senescence
-
Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen MD, Kirkland JL (2010) Fat tissue, aging, and cellular senescence. Aging Cell 9:667-684
-
(2010)
Aging Cell
, vol.9
, pp. 667-684
-
-
Tchkonia, T.1
Morbeck, D.E.2
Von Zglinicki, T.3
Van Deursen, J.4
Lustgarten, J.5
Scrable, H.6
Khosla, S.7
Jensen, M.D.8
Kirkland, J.L.9
-
126
-
-
0141571164
-
Aging is associated with elevated muscle triglyceride content and increased insulin-stimulated fatty acid uptake
-
Tucker MZ, Turcotte LP (2003) Aging is associated with elevated muscle triglyceride content and increased insulin-stimulated fatty acid uptake. Am J Physiol Endocrinol Metab 285:E827-E835
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
, pp. E827-E835
-
-
Tucker, M.Z.1
Turcotte, L.P.2
-
127
-
-
84866054662
-
Adiponectin: Anti-inflammatory and cardio-protective effects
-
Villarreal-Molina MT, Antuna-Puente B (2012) Adiponectin: anti-inflammatory and cardio-protective effects. Biochimie 94:2143-2149
-
(2012)
Biochimie
, vol.94
, pp. 2143-2149
-
-
Villarreal-Molina, M.T.1
Antuna-Puente, B.2
-
128
-
-
0035487317
-
Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle
-
Virkamaki A, Korsheninnikova E, Seppala-Lindroos A, Vehkavaara S, Goto T, Halavaara J, Hakkinen AM, Yki-Jarvinen H (2001) Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. Diabetes 50:2337-2343
-
(2001)
Diabetes
, vol.50
, pp. 2337-2343
-
-
Virkamaki, A.1
Korsheninnikova, E.2
Seppala-Lindroos, A.3
Vehkavaara, S.4
Goto, T.5
Halavaara, J.6
Hakkinen, A.M.7
Yki-Jarvinen, H.8
-
129
-
-
0026743890
-
The GH-transgenic mouse as an experimental model for growth research: Clinical and pathological studies
-
Wanke R, Wolf E, Hermanns W, Folger S, Buchmuller T, Brem G (1992) The GH-transgenic mouse as an experimental model for growth research: clinical and pathological studies. Horm Res 37:74-87
-
(1992)
Horm Res
, vol.37
, pp. 74-87
-
-
Wanke, R.1
Wolf, E.2
Hermanns, W.3
Folger, S.4
Buchmuller, T.5
Brem, G.6
-
130
-
-
0029762274
-
Simultaneous increase of mitochondrial DNA deletions and lipid peroxidation in human aging
-
Wei YH, Kao SH, Lee HC (1996) Simultaneous increase of mitochondrial DNA deletions and lipid peroxidation in human aging. Ann N Y Acad Sci 786:24-43
-
(1996)
Ann N Y Acad Sci
, vol.786
, pp. 24-43
-
-
Wei, Y.H.1
Kao, S.H.2
Lee, H.C.3
-
131
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante, A.W.6
-
132
-
-
0031918624
-
The IRS-signalling system: A network of docking proteins that mediate insulin action
-
White MF (1998) The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol Cell Biochem 182:3-11
-
(1998)
Mol Cell Biochem
, vol.182
, pp. 3-11
-
-
White, M.F.1
-
133
-
-
78651269359
-
Familial longevity is marked by enhanced insulin sensitivity
-
Leiden Logevity Study group
-
Wijsman CA, Rozing MP, Streefland TC, Cessie S, Mooijaart SP, Slagboom PE, Westendorp RG, Pijl H, van Heemst D, Leiden Logevity Study group (2011) Familial longevity is marked by enhanced insulin sensitivity. Aging Cell 10(1):114-121
-
(2011)
Aging Cell
, vol.10
, Issue.1
, pp. 114-121
-
-
Wijsman, C.A.1
Rozing, M.P.2
Streefland, T.C.3
Cessie, S.4
Mooijaart, S.P.5
Slagboom, P.E.6
Westendorp, R.G.7
Pijl, H.8
Van Heemst, D.9
-
134
-
-
0033547260
-
Physiological consequences of ectopic agouti gene expression: The yellow obese mouse syndrome
-
Wolff GL, Roberts DW, Mountjoy KG (1999) Physiological consequences of ectopic agouti gene expression: the yellow obese mouse syndrome. Physiol Genomics 1:151-163
-
(1999)
Physiol Genomics
, vol.1
, pp. 151-163
-
-
Wolff, G.L.1
Roberts, D.W.2
Mountjoy, K.G.3
-
135
-
-
0041707843
-
Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase
-
Xing Y, Musi N, Fujii N, Zou L, Luptak I, Hirshman MF, Goodyear LJ, Tian R (2003) Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase. J Biol Chem 278:28372-28377
-
(2003)
J Biol Chem
, vol.278
, pp. 28372-28377
-
-
Xing, Y.1
Musi, N.2
Fujii, N.3
Zou, L.4
Luptak, I.5
Hirshman, M.F.6
Goodyear, L.J.7
Tian, R.8
-
136
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112(12):1821-1830. 1821-1830. doi:10.1172/JCI19451
-
(2003)
J Clin Invest
, vol.112
, Issue.12
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
Chou, C.J.6
Sole, J.7
Nichols, A.8
Ross, J.S.9
Tartaglia, L.A.10
Chen, H.11
-
137
-
-
17944365228
-
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
-
Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941-946
-
(2001)
Nat Med
, vol.7
, pp. 941-946
-
-
Yamauchi, T.1
Kamon, J.2
Waki, H.3
Terauchi, Y.4
Kubota, N.5
Hara, K.6
Mori, Y.7
Ide, T.8
Murakami, K.9
Tsuboyama-Kasaoka, N.10
Ezaki, O.11
Akanuma, Y.12
Gavrilova, O.13
Vinson, C.14
Reitman, M.L.15
Kagechika, H.16
Shudo, K.17
Yoda, M.18
Nakano, Y.19
Tobe, K.20
Nagai, R.21
Kimura, S.22
Tomita, M.23
Froguel, P.24
Kadowaki, T.25
more..
-
138
-
-
84872431424
-
Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes
-
Yang Y, Ma D, Wang Y, Jiang T, Hu S, Zhang M, Yu X, Gong CX (2013) Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes. J Alzheimers Dis 33:329-338
-
(2013)
J Alzheimers Dis
, vol.33
, pp. 329-338
-
-
Yang, Y.1
Ma, D.2
Wang, Y.3
Jiang, T.4
Hu, S.5
Zhang, M.6
Yu, X.7
Gong, C.X.8
-
139
-
-
84903194920
-
Repurposing diabetes drugs for brain insulin resistance in alzheimer disease
-
Yarchoan M, Arnold SE (2014) Repurposing diabetes drugs for brain insulin resistance in alzheimer disease. Diabetes 63:2253-2261
-
(2014)
Diabetes
, vol.63
, pp. 2253-2261
-
-
Yarchoan, M.1
Arnold, S.E.2
-
140
-
-
84885167222
-
Canonical NIrp3 inflammasome links systemic low-grade inflammation to functional decline in aging
-
Youm YH, Grant RW, McCabe LR, Albarado DC, Nguyen KY, Ravussin A, Pistell P, Newman S, Carter R, Laque A, Munzberg H, Rosen CJ, Ingram DK, Salbaum JM, Dixit VD Canonical NIrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab 18:519-532
-
Cell Metab
, vol.18
, pp. 519-532
-
-
Youm, Y.H.1
Grant, R.W.2
McCabe, L.R.3
Albarado, D.C.4
Nguyen, K.Y.5
Ravussin, A.6
Pistell, P.7
Newman, S.8
Carter, R.9
Laque, A.10
Munzberg, H.11
Rosen, C.J.12
Ingram, D.K.13
Salbaum, J.M.14
Dixit, V.D.15
-
141
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (Irs-1)-associated phos- phatidylinositol 3-kinase activity in muscle
-
Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI (2002) Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (irs-1)-associated phos- phatidylinositol 3-kinase activity in muscle. J Biol Chem 277:50230-50236
-
(2002)
J Biol Chem
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
Zhang, D.4
Zong, H.5
Wang, Y.6
Bergeron, R.7
Kim, J.K.8
Cushman, S.W.9
Cooney, G.J.10
Atcheson, B.11
White, M.F.12
Kraegen, E.W.13
Shulman, G.I.14
-
142
-
-
48149100986
-
Insulin action on glucose transporters through molecular switches, tracks and tethers
-
Zaid H, Antonescu CN, Randhawa VK, Klip A (2008) Insulin action on glucose transporters through molecular switches, tracks and tethers. Biochem J 413(2):201-215
-
(2008)
Biochem J
, vol.413
, Issue.2
, pp. 201-215
-
-
Zaid, H.1
Antonescu, C.N.2
Randhawa, V.K.3
Klip, A.4
-
143
-
-
4644300287
-
Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS 160
-
Zeigerer A, McBrayer MK, McGraw TE (2004) Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS 160. Mol Biol Cell 15:4406-4415
-
(2004)
Mol Biol Cell
, vol.15
, pp. 4406-4415
-
-
Zeigerer, A.1
McBrayer, M.K.2
McGraw, T.E.3
-
144
-
-
84877734347
-
Hypothalamic programming of systemic ageing involving IKKp, NF-kB and GnRH
-
Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, Li B, Liu G, Cai D (2013) Hypothalamic programming of systemic ageing involving IKKp, NF-kB and GnRH. Nature 497(7448):211-216
-
(2013)
Nature
, vol.497
, Issue.7448
, pp. 211-216
-
-
Zhang, G.1
Li, J.2
Purkayastha, S.3
Tang, Y.4
Zhang, H.5
Yin, Y.6
Li, B.7
Liu, G.8
Cai, D.9
|