Brain insulin lowers circulating bcaa levels by inducing hepatic bcaa catabolism

Cell Metabolism

Volumn 20, Issue 5, 2014, Pages 898-909

  Shin, Andrew C ^a   Fasshauer, Martin ^a   Filatova, Nika ^a   Grundell, Linus A ^a   Zielinski, Elizabeth ^a   Zhou, Jian Ying ^b   Scherer, Thomas ^a   Lindtner, Claudia ^a   White, Phillip J ^c   Lapworth, Amanda L ^c   Ilkayeva, Olga ^c   Knippschild, Uwe ^d   Wolf, Anna M ^d   Scheja, Ludger ^e   Grove, Kevin L ^f   Smith, Richard D ^b   Qian, Wei Jun ^b   Lynch, Christopher J ^g   Newgard, Christopher B ^c   Buettner, Christoph ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ULM   (Germany)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOACID DEHYDROGENASE; BRANCHED CHAIN AMINO ACID; INSULIN RECEPTOR; LIVER PROTEIN; 2 OXOISOVALERATE DEHYDROGENASE (LIPOAMIDE); INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN METABOLISM; CATABOLISM; CONTROLLED STUDY; FAT INTAKE; HOMEOSTASIS; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; LIVER METABOLISM; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ADVERSE EFFECTS; ANIMAL; BLOOD; BRAIN; CAENORHABDITIS ELEGANS; LIPID DIET; LIVER; MALE; METABOLISM; SPRAGUE DAWLEY RAT;

3-METHYL-2-OXOBUTANOATE DEHYDROGENASE (LIPOAMIDE); AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; BRAIN; CAENORHABDITIS ELEGANS; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; HYPERGLYCEMIA; INSULIN; LIVER; MALE; MICE; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84911002688     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.09.003     Document Type: Article

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