The association of plasma IL-6 levels with functional disability in community-dwelling elderly

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 52, Issue 4, 1997, Pages

  Cohen, Harvey Jay ^a,b,d   Pieper, Carl F ^a,b   Harris, Tamara ^c   Rao, K Murali K ^a,b   Currie, Mark S ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6;

AGED; ARTHRITIS; ARTICLE; CANCER; COMMUNITY; DIABETES MELLITUS; DISABILITY; FEMALE; FUNCTIONAL DISEASE; HEART INFARCTION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0030849677     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/52A.4.M201     Document Type: Article

References (18)

1. Borecky L. Cytokines: the fourth homeostalic system. Acta Virol 1993;37:276-89.
2. Arend WP. Inhibiting the effects of cytokines in human diseases. Adv Intern Med 1995:40:365-94.
3. Van Snick J. Interleukin-6: an overview. Annu Rev Immunol 1990; 8:253-78.
4. Hirano T. The biology of interleukin-6. Mol Biol Immun 1992; 51:153-80.
5. Kishimoto T, Akira S, Narazaki M, Taga T. Interleukin-6 family of cytokines and gp 130. Blood 1995:86:1243-54.
6. Ershler WB, Sun WH, Binkley N. The role of interleukin-6 in certain age-related diseases. Drug Aging 1994;5:358-65.
7. Effros RB, Svoboda K, Walford RL. Influence of age and caloric restriction on macrophage IL-6 and TNF production. Lymphokine Res 1991;10:347-51.
8. Ershler WB, Sun WH, Binkley N, et al. Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Res 1993;12:225-30.
9. Daynes RA, Araneo BA, Ershler WB, Maloney C, Li G-Z, Ryu S-Y. Altered regulation of IL-6 production with normal aging: possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative. J Immunol 1993;150:5219-30.
10. Zhou D, Chrest FJ, Adler W, Monster A, Winchurch RA. Increased production of TGF-beta and IL-6 by aged spleen cells. Immunol Lett 1993;36:7-11.
11. Hager K, Machein U, Krieger S, Platt D, Seefried G, Bauer J. Interleukin-6 and selected plasma proteins in healthy persons of different ages. Neurobiol Aging 1994;15:771-2.
12. Sindermann J, Kruse A, Frercks H-J, Schutz RM, Kirchner H. Investigations of the lymphokine system in elderly individuals. Mech Ageing Dev 1993:70:149-59.
13. Fagiolo U, Cossarizza A, Scala E, et al. Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol 1993:23:2375-89.
14. Wei J, Xu H, Davies JL, Hemmings GP. Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci 1992:51:1953-6.
15. Ershler WB. Interleukin-6: a cytokine for gerontologists. J Am Geriatr Soc 1993;41:176-81.
16. Cornoni-Huntley J, Ostfeld AM, Taylor JO, et al. Established popula tions for epidemiologic studies of the elderly: study design and methodology. Aging Clin Exp Res 1993;5:27-37.
17. Cornoni-Huntley J, Brock DB, Ostfeld AM, Taylor JO, Wallace RB, eds. Established populations for epidemiologic studies of the elderly: resource data book (NIH pub. no. 86-2443). Washington, DC: U.S. Government Printing Office, 1986.
18. Blazer DG, Burchett BM, Service C, George LK. The association of age and depression among the elderly: an epidemiologic exploration. J Gerontol Med Sci 1991;46:M210-15.